DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Sspo

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001007017.1 Gene:Sspo / 474348 RGDID:1549716 Length:5141 Species:Rattus norvegicus


Alignment Length:2077 Identity:384/2077 - (18%)
Similarity:569/2077 - (27%) Gaps:921/2077 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 AVLVQDDPSQPGETYSNCQNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCD 247
            |||.:|        ..|| ...||..:|||.......::..|.:.  ..:|..:..|:...||||
  Rat  1349 AVLQKD--------CGNC-TCQESQWHCNPSGAPCEEMEPGCAEG--EALCRESGHCVPLEWLCD 1402

  Fly   248 GDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFT 312
            ..|||||.|||..|.... |.:.|..|.:|.|:|.:.:|||::||.|.:||..|   .|......
  Rat  1403 NQDDCGDGSDEEGCDTSV-CGEGQMSCQSGRCLPLSLICDGQDDCGDGTDEQGC---LCPQGFLA 1463

  Fly   313 CNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDG 377
            |.||.|:..|..|||..||.|.:||..|...: ||..||..|         ..|.||.....|||
  Rat  1464 CADGRCLPPALLCDGHPDCLDAADEESCLGWV-SCTSGEVSC---------VDGPCIRTIQLCDG 1518

  Fly   378 DNDCGDWSDE--ENCP------------QKPSL------------------CTSNEYKCADGTCI 410
            ..||.|.:||  .:|.            |.||.                  |:.:|::|..|.|.
  Rat  1519 VWDCPDGADEGPVHCSSPSLPTPPAGIGQNPSTSSPDTSPSPVGSASPASPCSLSEFQCNSGECT 1583

  Fly   411 PKRWKCDKEQDCDGGEDENDCGSLGSEHPLTC---------------------GSD--------- 445
            |:.|:||:|:||..|.||.|||.....:.:.|                     |||         
  Rat  1584 PRGWRCDREEDCTDGSDELDCGGPCKLYQMPCAHGPHCLSPGQLCDGVAQCPDGSDEDPDVCEER 1648

  Fly   446 --------------EFTCNNGRCILKTWLCDGYPDCAAGE------DEVECHLQCDLGQF----- 485
                          ||:|.||.||....:|||.|||...:      ||..|......|.:     
  Rat  1649 SASGGPNGTAVPCPEFSCPNGTCIDFLLVCDGSPDCELADETEPSLDEQGCGTWGSWGPWEPCSQ 1713

  Fly   486 LCPTKQNLTNLKICVHQKHICDGHNECPAGEDEAD------CPKERKCSE---PSPCEQLCIETT 541
            .|.......|....:...|:.   ..||..:.::.      ||.:.:.|.   .|||.:.|..|.
  Rat  1714 TCGPGIQSRNRNCSISSLHVL---QNCPGLQHQSQSCFTEACPVDGEWSSWSLWSPCSEPCGGTM 1775

  Fly   542 A----------GSNECACRLGYVMDKNK---------VNCTDIDECQYLTSPVCSQKCHNTMGSF 587
            .          |..:||...|.....::         :|.|...|..:.....|...|.:..|..
  Rat  1776 TRHRQCRPPQNGGQDCALLPGSTHSTHQTSPCPQEGCLNVTCFGELVFRPCAPCPLTCDDISGEA 1840

  Fly   588 KCS-----------CETGYIL-------RPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAI 634
            .||           |..|.:|       ||  |.|..|                           
  Rat  1841 VCSPDRPCSSPGCWCPEGKVLGTEGRCVRP--RQCPCL--------------------------- 1876

  Fly   635 VKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWT 699
                     :|     |:.:|.             |.|::              :|.  .|.|..
  Rat  1877 ---------VD-----GIRYWP-------------GQRIK--------------MDC--QLCFCQ 1898

  Fly   700 DSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAF---WSDWGPNPKIERAYMDGTQRK 761
            |....|                          ..|....|.   ||.|.|               
  Rat  1899 DGQPHR--------------------------CRPNPECAVDCGWSSWSP--------------- 1922

  Fly   762 VIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLD-----GSDRNKILSTHLPHPFALTLFE 821
                                   ||:...   .||:..     .|..|..||.|           
  Rat  1923 -----------------------WAECLG---PCSSQSLQWSFRSPNNPRLSGH----------- 1950

  Fly   822 DTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQK------DRRGL 880
                                |::.|.:|..                  |.|||.      ::.||
  Rat  1951 --------------------GRQCRGIHRK------------------ARRCQTEPCEGCEQWGL 1977

  Fly   881 --------RGGCSHLC-LPNKTSRRCG--CPIG------LSLKEDGKTCKSTA-----DKLVLVA 923
                    |||...:| ..:::..||.  ||||      :.::..|::|...|     ..::.|.
  Rat  1978 TYHVGERWRGGPCTVCECLHRSITRCSPYCPIGSCPQSWVLVEGMGESCCHCALPGKNQTMIPVT 2042

  Fly   924 RRKDIR--------------LRHLRDNQADPNDVDMI---VPLDNLKHAVA-------------- 957
            ....:.              |..:.|....|..:..:   .|...|:|:..              
  Rat  2043 TPAPVPTPSPQIGASLVTYVLPPMSDACYSPLGLAGLPTWAPSQPLEHSTRAAPVEAPTAGPGPR 2107

  Fly   958 ----LDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYW------ 1012
                .:|  .|..:|   ::...:...:|.|...|| ..|:......|:|.:.:|.|.|      
  Rat  2108 EDAYAEW--HTQPLY---LQLDLLWPRNLTGIMVQR-AGSSAAYISNLSLQFSSDGLQWHSVLNS 2166

  Fly  1013 ----------TDPSTNRI--EVAT-------------------TNGKMRTLLIWEKLY--KP--- 1041
                      :..|:|.:  ||.|                   .:...:.:.:|.:|.  ||   
  Rat  2167 LSSTLPPPKPSPESSNHMVPEVWTFDQMVQARYIRVWPHGSHLRDNNQQDIFLWVELLGCKPVPP 2231

  Fly  1042 --------RDIVVN--------PIEGFMFWSDWGDD----PMIERANMDGHERVTITSKKL---- 1082
                    |....|        |.:|.:...|..|:    |:  ||:.......|..:..|    
  Rat  2232 LAPLCPGTRHRCANGDCALKGGPCDGAVDCEDGSDEEGCGPL--RASTASRVHSTARTPALSPTQ 2294

  Fly  1083 -----IYP-NGLAIDYE----KSKIYFVDGGTKTLEN---MNFDGSGRQVILNGLGHPFGL-DVN 1133
                 .:| .||| |.|    |.:......|.....:   :...|...|.:......|.|| .::
  Rat  2295 PGKFPFHPREGLA-DMEHQQPKQESPMPSAGVSPSASEGLLPVSGQSMQTLTTTSTFPPGLKSLH 2358

  Fly  1134 EGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGC---SHL 1195
            .|....|.....|||....         :..|.......:......::  .||.|  ||   ..|
  Rat  2359 PGMAAVTVHSPHSVMPGTP---------VGQSVSPRPFPLMRCGPGQV--PCDVL--GCVEQEQL 2410

  Fly  1196 C--------------LLNPTSYTCACTVGVQLKEDRHTCSE-----GPTQYILFAHRIDIR---Q 1238
            |              ..:|..:|...|....|...|..||.     |..:.:...||.|::   |
  Rat  2411 CDGREDCLDGSDEQHCASPEPFTVPTTALPGLPASRALCSPSQLSCGSGECLPLEHRCDLQVNCQ 2475

  Fly  1239 ISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPD 1303
            ...|.|..:|.|  |.|                 ||.                            
  Rat  2476 DGSDEDDCVDCV--LAP-----------------WSG---------------------------- 2493

  Fly  1304 GLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKI 1368
                        |:|..|..                       ||      ||:|     .:|::
  Rat  2494 ------------WSDCSRSC-----------------------GL------GLIF-----QHREL 2512

  Fly  1369 ERSHLDGNERSRIVTANLGWPNGLSL--DLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHP 1431
            .|..|               |.|..|  .|:|:..:        :.:|...|...|         
  Rat  2513 LRPPL---------------PGGSCLLDQLRSQPCF--------VQACPVAGAWAK--------- 2545

  Fly  1432 YALALSDDNIYWTDWKSKAL-----HMTERRNI--------------SAKRDIITNID---GLMD 1474
                       |..|:..::     |.:.:|:.              .:...::.|:.   |..|
  Rat  2546 -----------WGPWEPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKVLCNLQLCPGDTD 2599

  Fly  1475 IK--IIYQNQN--QSTMKNACGNN------NGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQN 1529
            .:  .::.|..  |..:...|..:      |.:||..|:.     .|:||.||.|:         
  Rat  2600 CEPGRVHVNAELCQKGLLPPCPPSCLDPEANRSCSGHCVE-----GCRCPPGLFLQ--------- 2650

  Fly  1530 LPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLL 1594
                                                    |.|                    .|
  Rat  2651 ----------------------------------------DSH--------------------CL 2655

  Fly  1595 NLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVH 1659
            .|:|...:||..::.| |:|  ::.||                   |.:.|.|..:     |:..
  Rat  2656 PLSECPCLVGQKLMQP-GLA--FLLDN-------------------CSQCICESGI-----LLCK 2693

  Fly  1660 PKK-----AYLFWSDWSS-------------------PAKIERSYLDGSNRTV---IITSGIGFP 1697
            |..     .:..||.|::                   ||....|..:|..:.:   ....|...|
  Rat  2694 PAACSQSCGWSAWSPWTACDHSCGSGVRARFRSPTNPPAAFGGSPCEGDRQELQACYTDCGTDIP 2758

  Fly  1698 TGLTIDFTNRRLLWADALEDNIGQVDFNGKR---------RQTIVP--------------YAPHP 1739
             |.| .:|:    |:...:..:......|:|         |.|..|              ..|..
  Rat  2759 -GWT-PWTS----WSSCSQSCLVPGGDPGRRQRSRLCPSSRDTFCPGEATQEEPCSPSLCPVPSA 2817

  Fly  1740 FGLTLFENSIFWTDWYNKSV-------YRSQKLARSGYGNPF------EVRDA--------LSGA 1783
            :||        |..|...|.       .|.:..:.|..|||.      :.||.        ..|.
  Rat  2818 WGL--------WASWSACSASCNGGIQTRGRSCSGSAPGNPVCLGPHTQTRDCNVHPCTAQCPGN 2874

  Fly  1784 LDIRAVSLSRQPKSVNHCAQDNGGCTHLCLNRNVDYVC--ACPDVMDPKDVACSIKPKVLVH 1843
            :..|         |...|.::.|.|..|||.::....|  :|..       .||..|.:.:|
  Rat  2875 MVFR---------SAEKCLEEGGPCPQLCLAQDPGVECTGSCAP-------GCSCPPGLFLH 2920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 14/33 (42%)
LDLa 306..340 CDD:238060 14/33 (42%)
LDLa 347..390 CDD:238060 15/44 (34%)
LDLa 397..431 CDD:238060 15/33 (45%)
LDLa 442..476 CDD:238060 19/83 (23%)
LDLa 480..521 CDD:238060 6/51 (12%)
FXa_inhibition 576..604 CDD:291342 11/45 (24%)
LY 634..671 CDD:214531 3/36 (8%)
NHL <656..793 CDD:302697 15/139 (11%)
LY 680..714 CDD:214531 5/33 (15%)
NHL repeat 681..722 CDD:271320 5/40 (13%)
NHL repeat 726..760 CDD:271320 6/36 (17%)
LY 761..803 CDD:214531 5/46 (11%)
NHL repeat 769..793 CDD:271320 2/23 (9%)
FXa_inhibition 882..912 CDD:291342 10/38 (26%)
LY 946..985 CDD:214531 7/59 (12%)
NHL <967..1142 CDD:302697 46/254 (18%)
LY 988..1030 CDD:214531 13/78 (17%)
NHL repeat 998..1037 CDD:271320 11/75 (15%)
NHL repeat 1038..1080 CDD:271320 13/66 (20%)
NHL repeat 1084..1119 CDD:271320 9/42 (21%)
FXa_inhibition 1185..1220 CDD:291342 12/51 (24%)
NHL 1260..>1445 CDD:302697 22/186 (12%)
NHL repeat 1260..1296 CDD:271320 2/35 (6%)
NHL repeat 1302..1337 CDD:271320 3/34 (9%)
NHL repeat 1345..1383 CDD:271320 8/37 (22%)
FXa_inhibition <1499..1525 CDD:291342 8/25 (32%)
LY 1600..1640 CDD:214531 7/39 (18%)
LY 1643..1686 CDD:214531 11/66 (17%)
LY 1688..1729 CDD:214531 8/52 (15%)
FXa_inhibition 1801..>1825 CDD:291342 8/25 (32%)
SspoNP_001007017.1 VWD 192..341 CDD:214566
C8 393..468 CDD:285899
TIL 472..527 CDD:280072
VWD 556..716 CDD:214566
C8 769..826 CDD:285899
TIL 830..883 CDD:280072
VWD 1019..1168 CDD:278521
C8 1206..1276 CDD:285899
TIL 1280..1336 CDD:280072
LDLa 1381..1416 CDD:238060 15/36 (42%)
LDLa 1421..1455 CDD:238060 14/33 (42%)
LDLa 1457..1491 CDD:238060 14/33 (42%)
LDLa 1497..1528 CDD:197566 13/39 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1533..1567 4/33 (12%)
Ldl_recept_a 1568..1604 CDD:278486 15/35 (43%)
TSP1 1702..1753 CDD:214559 6/53 (11%)
TSP1 1758..1812 CDD:214559 10/53 (19%)
TIL 1822..1873 CDD:280072 11/52 (21%)
TSP1 1917..1970 CDD:214559 20/142 (14%)
FA58C 2070..2226 CDD:214572 24/161 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2087..2109 2/21 (10%)
FA58C <2111..2225 CDD:238014 20/119 (17%)
LDLa 2236..2270 CDD:238060 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2262..2335 15/75 (20%)
LDLa 2392..2426 CDD:238060 7/37 (19%)
LDLa 2449..2483 CDD:238060 9/33 (27%)
TSP1 2490..2538 CDD:214559 19/161 (12%)
TSP1 2543..2595 CDD:214559 6/71 (8%)
TIL 2618..2660 CDD:280072 15/115 (13%)
TSP1 2703..2752 CDD:214559 7/48 (15%)
TSP1 2760..2813 CDD:214559 8/57 (14%)
TSP_1 2819..2867 CDD:278517 12/55 (22%)
TIL 2871..2930 CDD:280072 15/66 (23%)
VWC_out 2932..2979 CDD:214565
TSP1 2972..3023 CDD:214559
TIL 3075..3127 CDD:280072
TSP1 3240..3292 CDD:214559
TIL 3300..3350 CDD:280072
TSP1 3396..3439 CDD:214559
TSP1 3460..3504 CDD:214559
TIL 3514..3570 CDD:280072
TSP1 3633..3677 CDD:214559
TSP1 3810..3862 CDD:214559
TSP1 3879..3927 CDD:214559
TSP1 3945..3998 CDD:214559
TSP1 4003..4055 CDD:214559
TIL 4058..4113 CDD:280072
TSP1 4158..4208 CDD:214559
TSP1 4252..4303 CDD:214559
TSP1 4367..4418 CDD:214559
TIL 4422..4477 CDD:280072
TSP1 4611..4659 CDD:214559
TIL 4673..4719 CDD:280072
TSP1 4763..4812 CDD:214559
TIL 4814..4868 CDD:280072
TIL 4920..4978 CDD:280072
VWC 4980..5035 CDD:302663
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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