Protein Alignment Lrp4 and arr

DIOPT Version :10

• Sequence 1: NP_727914.1
• Gene: Lrp4 / 32552
• FlyBaseID: FBgn0030706
• Length: 2009
• Species: Drosophila melanogaster
• Sequence 2: NP_524737.2
• Gene: arr / 44279
• FlyBaseID: FBgn0000119
• Length: 1678
• Species: Drosophila melanogaster
• Alignment Length: 1609
• Identity: 490/1609 - (30%)
• Similarity: 776/1609 - (48%)
• Gaps: 193/1609 - (11%)

  Fly   536 LCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQK--------CHNTMGSFK---- 588
            :.:|....|.|...:|..|:|.|:...|...:|....|.|..::        |.....|::
  Fly     1 MALEPYTKSAEIEPQLCQVIDNNEDVTTKATKCTKSNSGVGWRQMLIGFLLICFGISNSWQYKNV 65

  Fly   589 -CSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLS----NNRYSAIVKGLHNAIALDFHH 648
             ....:..|..|.  :...:....|||...|.||:...::    ..:...||:.|..|:|:||::
  Fly    66 HMPSSSSLIASPP--ASAFVNTPATLLFTTRHDIQVANITRPTGGPQIDVIVRDLAEAMAIDFYY 128

  Fly   649 RKGLMFWSDVSTDVIKMVYMNGTRV--------RDVIKWGLESPGGIAVDWIHDLLFWTDSGTRR 705
            .|.|:.|:|...::|:....|.:.:        :.||..||:.|.|:|:||..|.::|||....|
  Fly   129 AKNLVCWTDSGREIIECAQTNSSALQPLLRAPKQTVISTGLDKPEGLAMDWYTDKIYWTDGEKNR 193

  Fly   706 VEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDG--TQRKVIISKGV 768
            :||:...|..:.|:...|||:|||:.|.|...|..|:|||..||||||.|||  ..|..::.:.|
  Fly   194 IEVATLDGRYQKVLFWTDLDQPRAVAVVPARKLLIWTDWGEYPKIERASMDGDPLSRMTLVKEHV 258

  Fly   769 TWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKT 833
            .||||||:|..|..|||.|.|.|.|:...||||.|..|:: :|.:||:||.::|.:|||||...:
  Fly   259 FWPNGLAVDLKNELIYWTDGKHHFIDVMRLDGSSRRTIVN-NLKYPFSLTFYDDRLYWTDWQRGS 322

  Fly   834 VSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--PNKTSRR 896
            ::|.|..| :|.:.:.:....|..:.|:.|:.||...:.|..:    .|.||||||  .|.....
  Fly   323 LNALDLQT-RELKELIDTPKAPNSVRAWDPSLQPYEDNPCAHN----NGNCSHLCLLATNSQGFS 382

  Fly   897 CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMI-VPLDNLKHAVALDW 960
            |.||.|:.| ....||.:.:.:::.:.:|..|....|     |..|..:. :||..:|:|:|:|:
  Fly   383 CACPTGVKL-ISANTCANGSQEMMFIVQRTQISKISL-----DSPDYTIFPLPLGKVKYAIAIDY 441

  Fly   961 CSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATT 1025
            ....:.|||:|||..||.:||.:|:.....|.|.:..|.||||||:...|||||..|:||||...
  Fly   442 DPVEEHIYWSDVETYTIKRAHADGTGVTDFVTSEVRHPDGLALDWLARNLYWTDTVTDRIEVCRL 506

  Fly  1026 NGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGD-DPMIERANMDGHERVTITSKKLIYPNGLA 1089
            :|..|.:||:|.|.:||.|.|.|..|:||||||.: .|.:|||::||.|||.:.|:.|.:|||:|
  Fly   507 DGTARKVLIYEHLEEPRAIAVAPSLGWMFWSDWNERKPKVERASLDGSERVVLVSENLGWPNGIA 571

  Fly  1090 IDYEKSKIYFVDGGTKTLENMNFDGSGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKL 1153
            :|.|...||:.||.|..:|..|.|||||:|:: :.|.|.|||.:.:..::||||..:|:..|:|:
  Fly   572 LDIEAKAIYWCDGKTDKIEVANMDGSGRRVVISDNLKHLFGLSILDDYLYWTDWQRRSIDRAHKI 636

  Fly  1154 TGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRH 1218
            ||.:..|::....|||.::|......|..|||...|||||||||..|..|.|.|.:..:|..|:.
  Fly   637 TGNNRIVVVDQYPDLMGLKVTRLREVRGQNACAVRNGGCSHLCLNRPRDYVCRCAIDYELANDKR 701

  Fly  1219 TCSEGPTQYILFAHRIDIRQISLDFD--HLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVI 1281
            ||.. |..::||:.:..|.:||::::  :..|..:|...:.:|.||||......|||:|.....|
  Fly   702 TCVV-PAAFLLFSRQEHIGRISIEYNEGNHNDERIPFKDVRDAHALDVSVAERRIYWTDQKSKCI 765

  Fly  1282 MSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPR 1346
            ..:..:|.:||:||...|..|||:.||.:...|||:||....||||.||||:|.|:.:|.:|.||
  Fly   766 FRAFLNGSYVQRIVDSGLIGPDGIAVDWLANNIYWSDAEARRIEVARLDGSSRRVLLWKGVEEPR 830

  Fly  1347 GLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYW-VDARLKT 1410
            .|.|:...|.::||: .....|.|:.:||::...|| |......||:.|.:::|:|| ..:|...
  Fly   831 SLVLEPRRGYMYWTE-SPTDSIRRAAMDGSDLQTIV-AGANHAAGLTFDQETRRLYWATQSRPAK 893

  Fly  1411 IDSCDYTGNQRKLIM-SSLHHPYALALSDDNIYWTDWKS---KALHMTERRNISAKRDIITNIDG 1471
            |:|.|:.|.:|:::: |.:..|||::|..|.:||:||.:   :.:|.|..:|.|.....:|.|..
  Fly   894 IESADWDGKKRQILVGSDMDEPYAVSLYQDYVYWSDWNTGDIERVHKTTGQNRSLVHSGMTYITS 958

  Fly  1472 LMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPS--GYSCQCPIGLRLRQNSTTQCQNLPEDY 1534
            |:..     |..:.|..|.|..|||.||||||..|.  |.:|.||...:|.::..:...  |.:|
  Fly   959 LLVF-----NDKRQTGVNPCKVNNGGCSHLCLAQPGRRGMTCACPTHYQLAKDGVSCIP--PRNY 1016

  Fly  1535 LLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTES 1599
            ::.:.|:..|.:..|:.|..::.||::|.:...| ||....:.:::.:.....|:| :|.|.|:.
  Fly  1017 IIFSQRNCFGRLLPNTTDCPNIPLPVSGKNIRAV-DYDPITHHIYWIEGRSHSIKR-SLANGTKV 1079

  Fly  1600 KVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAY 1664
            .::..:.  .|..:|:|.|...|:|:.:....|.|:...|.....|...:...||::.||..|..
  Fly  1080 SLLANSG--QPFDLAIDIIGRLLFWTCSQSNSINVTSFLGESVGVIDTGDSEKPRNIAVHAMKRL 1142

  Fly  1665 LFWSDWSSPAKIERSYLDGSNRTVII--TSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGK 1727
            |||:|..|...|.|:.:||:.|..:.  ..|:   |.|.:|..:..:.:|..  ..|..:|.|||
  Fly  1143 LFWTDVGSHQAIIRARVDGNERVELAYKLEGV---TALALDQQSDMIYYAHG--KRIDAIDINGK 1202

  Fly  1728 RRQTIVP-YAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSL 1791
            .::|:|. :......:......::|.|  :|:  ..:::..:|.....|:: .|....||||| .
  Fly  1203 NKKTLVSMHISQVINIAALGGFVYWLD--DKT--GVERITVNGERRSAELQ-RLPQITDIRAV-W 1261

  Fly  1792 SRQPKSV-NH-CAQDNGGCTHLC------LNRNVDYVCACPD---VMDPKDVACSIKP------- 1838
            :..||.: || |......|:|:|      :.|..| ||:||.   :::.|: .|...|
  Fly  1262 TPDPKVLRNHTCMHSRTKCSHICIASGEGIARTRD-VCSCPKHLMLLEDKE-NCGAFPACGPDHF 1324

  Fly  1839 -------------KVLVHANLENDQLLEYSDESTDDSTPP-----------ELLGES-------- 1871
                         |..:.|:...|...:..|:|.:...|.           |.:.:|
  Fly  1325 TCAAPVSGISDVNKDCIPASWRCDGQKDCPDKSDEVGCPTCRADQFSCQSGECIDKSLVCDGTTN 1389

  Fly  1872 --NDHGD--------------------------------DGHTKKSD-----------QEREFFV 1891
              |.|.:                                ||..:.||           .:|.|.:
  Fly  1390 CANGHDEADCCKRPGEFQCPINKLCISAALLCDGWENCADGADESSDICLQRRMAPATDKRAFMI 1454

  Fly  1892 LVALGVVIVMVVIIILVIFMLAFNTSKKKNKRNSRGSSRSVLTFSNPN------YNVDGTPMEPK 1950
            |:...::.:..::.:|.........|:.:.|.:......|..|.|...      ...|...|...
  Fly  1455 LIGATMITIFSIVYLLQFCRTRIGKSRTEPKDDQATDPLSPSTLSKSQRVSKIASVADAVRMSTL 1519

  Fly  1951 TNIWKRFKYDKTHQERAGVYEERSLTTETASSSLFVPTPSPMASPSTKT 1999
            .:......||:.|...|      |.:|...||.:..|. :|..||:|::
  Fly  1520 NSRNSMNSYDRNHITGA------SSSTTNGSSMVAYPI-NPPPSPATRS 1561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:464251	4/40 (10%)
		LY	634..671	CDD:214531	13/36 (36%)
		LY	680..714	CDD:214531	14/33 (42%)
		LY	718..760	CDD:214531	23/43 (53%)
		Ldl_recept_b	740..777	CDD:459654	21/38 (55%)
		LY	761..803	CDD:214531	20/41 (49%)
		LY	806..838	CDD:214531	13/31 (42%)
		FXa_inhibition	882..912	CDD:464251	13/31 (42%)
		LY	946..985	CDD:214531	16/39 (41%)
		NHL	<967..1142	CDD:302697	85/176 (48%)
		LY	988..1030	CDD:214531	20/41 (49%)
		NHL repeat	998..1037	CDD:271333	21/38 (55%)
		NHL repeat	1038..1080	CDD:271333	22/42 (52%)
		NHL repeat	1084..1119	CDD:271333	18/34 (53%)
		FXa_inhibition	1185..1220	CDD:464251	16/34 (47%)
		NHL	1260..>1445	CDD:302697	71/186 (38%)
		NHL repeat	1260..1296	CDD:271320	13/35 (37%)
		LY	1292..1334	CDD:214531	22/41 (54%)
		NHL repeat	1302..1337	CDD:271320	19/34 (56%)
		NHL repeat	1345..1383	CDD:271320	12/37 (32%)
		FXa_inhibition	<1499..1525	CDD:464251	11/27 (41%)
		LY	1600..1640	CDD:214531	8/39 (21%)
		LY	1643..1686	CDD:214531	15/42 (36%)
		LY	1688..1729	CDD:214531	10/42 (24%)
		FXa_inhibition	1801..>1825	CDD:464251	9/29 (31%)
arr	NP_524737.2	LY	162..201	CDD:214531	16/38 (42%)
		NHL	168..503	CDD:302697	136/346 (39%)
		NHL repeat	172..237	CDD:271320	27/64 (42%)
		LY	252..293	CDD:214531	20/40 (50%)
		NHL repeat	261..298	CDD:271320	20/36 (56%)
		NHL repeat	303..339	CDD:271320	14/36 (39%)
		NHL repeat	341..419	CDD:271320	24/87 (28%)
		NHL repeat	428..476	CDD:271320	19/47 (40%)
		LY	472..511	CDD:214531	20/38 (53%)
		NHL repeat	477..503	CDD:271320	15/25 (60%)
		Ldl_recept_b	534..574	CDD:459654	21/39 (54%)
		LY	558..599	CDD:214531	18/40 (45%)
		LY	600..641	CDD:214531	15/40 (38%)
		FXa_inhibition	668..703	CDD:464251	16/34 (47%)
		YncE	<736..886	CDD:442618	58/151 (38%)
		LY	776..818	CDD:214531	22/41 (54%)
		LY	905..946	CDD:214531	12/40 (30%)
		FXa_inhibition	973..1010	CDD:464251	16/36 (44%)
		YncE	<1047..1191	CDD:442618	38/150 (25%)
		LDLa	1319..1362	CDD:238060	5/42 (12%)
		LDLa	1365..1399	CDD:238060	4/33 (12%)
		LDLa	1399..1433	CDD:197566	2/33 (6%)