DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Lrp3

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001019878.1 Gene:Lrp3 / 435965 MGIID:3584516 Length:790 Species:Mus musculus


Alignment Length:340 Identity:78/340 - (22%)
Similarity:104/340 - (30%) Gaps:141/340 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 RTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNR-------TTCTDEHFTCNDG---YC 318
            :|:|..|:|.|.||.|:|..|.|:..::|.|.|||.:|:.       :.|....|.|:..   .|
Mouse   184 QTSCQTDEFRCDNGKCLPGPWQCNMVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRC 248

  Fly   319 ISLAFRCDGEHDCNDNSDELKCAAVINSCPE------GEFKCRGGLGGAGGPS------------ 365
            :.:..||||..||.|.|||..|..:  :|..      |.|......|.|.|||            
Mouse   249 LPVERRCDGTQDCGDGSDEAGCPDL--ACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQD 311

  Fly   366 ----------------------------------------------------------------- 365
                                                                             
Mouse   312 PRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAG 376

  Fly   366 ------------------------------GQ--CILNRFRCDGDNDCGDWSDEENCPQKPSLCT 398
                                          |:  |.....||||...|....||:.||    .|.
Mouse   377 HGFNATYQVKGYCLPWEQPCGSSEGDDDSTGEQGCFSEPQRCDGWWHCASGRDEQGCP----ACP 437

  Fly   399 SNEYKC--ADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLC 461
            .::|.|  ..|.|.....:|:.::.|..|.||.:|        .:|....|.|....||.:||.|
Mouse   438 PDQYPCEGGSGLCYAPADRCNNQKSCPDGADEKNC--------FSCQPGTFHCGTNLCIFETWRC 494

  Fly   462 DGYPDCAAGEDEVEC 476
            ||..||..|.||..|
Mouse   495 DGQEDCQDGSDEHGC 509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 15/33 (45%)
LDLa 306..340 CDD:238060 14/36 (39%)
LDLa 347..390 CDD:238060 17/157 (11%)
LDLa 397..431 CDD:238060 10/35 (29%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342
LY 634..671 CDD:214531
NHL <656..793 CDD:302697
LY 680..714 CDD:214531
NHL repeat 681..722 CDD:271320
NHL repeat 726..760 CDD:271320
LY 761..803 CDD:214531
NHL repeat 769..793 CDD:271320
FXa_inhibition 882..912 CDD:291342
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
Lrp3NP_001019878.1 CUB 64..177 CDD:238001
LDLa 187..221 CDD:238060 15/33 (45%)
LDLa 233..270 CDD:238060 14/36 (39%)
CUB 275..385 CDD:238001 8/109 (7%)
LDLa 436..472 CDD:238060 10/35 (29%)
LDLa 475..509 CDD:238060 15/33 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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