DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and LpR2

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001097928.1 Gene:LpR2 / 43105 FlyBaseID:FBgn0051092 Length:1064 Species:Drosophila melanogaster


Alignment Length:893 Identity:325/893 - (36%)
Similarity:440/893 - (49%) Gaps:159/893 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 SQEVHH--SGEGRLHTMESSVPSKT-------------RISGGTNSNDTPKFRNIGAQRGRTEIA 151
            :.|:.|  ||...|..:::|....|             .||.||.|.     ..||.....:.|.
  Fly   103 ASEIMHNLSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTGSG-----MGIGMGHFGSSIN 162

  Fly   152 GIRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNCQNSNESDENCNPEEDA 216
            .:...:.:......|.||      .|..::|.:                  ||..||.       
  Fly   163 SVLNGNPLKFLNVSGKIG------TPLDISLGL------------------SNYCDEK------- 196

  Fly   217 VPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDE--THCG-ARTNCTDDQFECLNGF 278
                |..|.          |..||...::|||..||.|:|||  ..|. ..:.|:.:||.|.||.
  Fly   197 ----QFQCS----------TGECIPIRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGK 247

  Fly   279 CIPRTWVCDGENDCKDFSDE--THCNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELK 339
            ||||.||||.||||.|.|||  :.|...||:.|.|.|  .:|.||.|::.||...||.|.|||.:
  Fly   248 CIPRRWVCDRENDCADGSDESTSQCRSHTCSPEEFACKSGEGECIPLSWMCDQNKDCRDGSDEAQ 312

  Fly   340 CAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKC 404
            |.   .:|...||.|         .:|:||.|||:||.|:||||.|||:||.:| :.|.||.:.|
  Fly   313 CN---RTCRSDEFTC---------GNGRCIQNRFKCDDDDDCGDGSDEKNCGEK-AKCGSNFFAC 364

  Fly   405 ADGTCIPKRWKCDKEQDCDGGEDE--NDCGSLGSEHPLTCGSDEFTCNNG-RCILKTWLCDGYPD 466
            ..|.|||.:|.||.:.||..||||  |...||.:    .|.:.||.|::. .|:.|:|:|||..|
  Fly   365 KSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLN----FCQAGEFQCSDRITCLHKSWVCDGEAD 425

  Fly   467 CAAGEDE-------VEC---------------HLQCD--------LGQFLC-----PTKQNLTNL 496
            |..||||       |.|               ||.|:        ..:.:|     |...|.|..
  Fly   426 CPDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISATPRTCNATTE 490

  Fly   497 -----KICVHQKHICDGHNECPAGEDE--ADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYV 554
                 .:|:....:|:...:||.||||  ..|......|:...|...|:....| ..|.|..||.
  Fly   491 FDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVG-YRCECHDGYK 554

  Fly   555 MDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGY--ILRPDLRSCKALGGAMTLLVAN 617
            :..::..|.|||||:  |..:|||.|.|.:|:|||.||.||  :|:...| |||..|..:||:|.
  Fly   555 LGADQHTCVDIDECE--TPGICSQVCVNEIGAFKCECEAGYMRLLKNHTR-CKASEGHASLLLAR 616

  Fly   618 RWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVI--KWG 680
            |.|||::.|.....::||.....|.||||..|.|::|||||:|..|....::....|.|:  |..
  Fly   617 RHDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSS 681

  Fly   681 LESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWG 745
            :.| .|:|||||::.:::||:....:|::||:|::..|:....||.||:|.:.|.|...:|||||
  Fly   682 VTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWG 745

  Fly   746 PNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--S 808
            .:|:||||.||||.|..||:..|.||||:.:|....::||.|.|.:.|..||.|||.|:::|  .
  Fly   746 ASPRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSG 810

  Fly   809 THLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFR---AVHENFHFPMDIHAYHPARQPEYA 870
            .:|.|||::|.|||.:|||||:.:.|..|:|..|.:..   |.|...| ||.:|.|||.|||:..
  Fly   811 EYLRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEH-PMVVHVYHPYRQPDGV 874

  Fly   871 DRCQKDRRGLRGGCSHLCLP----NKTSRR--CGCPIGLSLKEDGKTC 912
            :.||    .:.|.|||||||    |:.|.|  |.||.||.|..||..|
  Fly   875 NHCQ----SVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMC 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 22/35 (63%)
LDLa 306..340 CDD:238060 16/35 (46%)
LDLa 347..390 CDD:238060 20/42 (48%)
LDLa 397..431 CDD:238060 18/35 (51%)
LDLa 442..476 CDD:238060 17/41 (41%)
LDLa 480..521 CDD:238060 13/60 (22%)
FXa_inhibition 576..604 CDD:464251 15/29 (52%)
LY 634..671 CDD:214531 16/36 (44%)
LY 680..714 CDD:214531 12/33 (36%)
LY 718..760 CDD:214531 22/41 (54%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 18/41 (44%)
LY 806..838 CDD:214531 15/33 (45%)
FXa_inhibition 882..912 CDD:464251 19/35 (54%)
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271333
NHL repeat 1038..1080 CDD:271333
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
LpR2NP_001097928.1 LDLa 193..224 CDD:197566 14/51 (27%)
LDLa 235..267 CDD:197566 20/31 (65%)
LDLa 277..313 CDD:238060 16/35 (46%)
LDLa 356..388 CDD:197566 15/31 (48%)
LDLa 400..432 CDD:197566 14/31 (45%)
LDLa 442..476 CDD:238060 4/33 (12%)
LDLa 484..517 CDD:197566 8/32 (25%)
FXa_inhibition 527..562 CDD:464251 8/35 (23%)
EGF_CA 564..594 CDD:214542 18/31 (58%)
LY 675..715 CDD:214531 15/40 (38%)
LY 717..760 CDD:214531 22/42 (52%)
LY 763..803 CDD:214531 18/39 (46%)
Ldl_recept_b 782..828 CDD:459654 20/45 (44%)
Ldl_recept_b 824..866 CDD:459654 16/42 (38%)
FXa_inhibition 877..918 CDD:464251 21/44 (48%)
Blue background indicates that the domain is not in the aligned region.

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