DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and LRP4

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_002325.2 Gene:LRP4 / 4038 HGNCID:6696 Length:1905 Species:Homo sapiens


Alignment Length:1808 Identity:780/1808 - (43%)
Similarity:1089/1808 - (60%) Gaps:116/1808 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 ESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTD 269
            :.|.:|....|....:...|.....|  |... :||.:.|:||||:||.|.|||..|..| .|.:
Human    52 DGDNDCGDHSDEDGCILPTCSPLDFH--CDNG-KCIRRSWVCDGDNDCEDDSDEQDCPPR-ECEE 112

  Fly   270 DQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDN 334
            |:|.|.||:||...|.|||:|||.|.||| .|:...|:|:.|.|:||.||:..:.|||:.||.|.
Human   113 DEFPCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDG 176

  Fly   335 SDELKCAAVINS--CPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENC-PQKPSL 396
            |||..|.:.:.:  |...||:|         ..|:|||:.:.||||:||||||||.:| ..:|  
Human   177 SDEENCPSAVPAPPCNLEEFQC---------AYGRCILDIYHCDGDDDCGDWSDESDCSSHQP-- 230

  Fly   397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLC 461
            |.|.|:.|..|.||...|:||.:.|||...||.:|.:      ..|.:::|.|::|||:..:|.|
Human   231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTT------SMCTAEQFRCHSGRCVRLSWRC 289

  Fly   462 DGYPDCAAGEDEVECH----LQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEA--- 519
            ||..|||...||..|.    .||.|.||||...:       |:.|:.:|:|.|:|....||:   
Human   290 DGEDDCADNSDEENCENTGSPQCALDQFLCWNGR-------CIGQRKLCNGVNDCGDNSDESPQQ 347

  Fly   520 DC-PK--ERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKC 580
            :| |:  |..|: ....|.|.| :...|:.:|.|..||.:.::...|.|::||  .....|||.|
Human   348 NCRPRTGEENCNVNNGGCAQKC-QMVRGAVQCTCHTGYRLTEDGHTCQDVNEC--AEEGYCSQGC 409

  Fly   581 HNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALD 645
            .|:.|:|:|.|||||.||||.|||||||....||.|||.|||:|....:.|:.::..|.||||||
Human   410 TNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALD 474

  Fly   646 FHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSN 710
            ||||:.|:|||||:.|.|....:||:.|.:|:..|||||||:||||:||.|:||||||.|:||:|
Human   475 FHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVAN 539

  Fly   711 FQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLA 775
            ..|..|.|:...:|:|||||.:||.|...:|:|||..|:||.:.|||:.|::|....:.|||||.
Human   540 LDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLT 604

  Fly   776 IDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKI 840
            ||:...::||.|||.|.||.:|||||.|..::|..||||||:|:|||::|||||:||::::|:|.
Human   605 IDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 669

  Fly   841 TGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRRCGCPIGLSL 905
            |||....:....|||||||..||.|||...:||..:    .|||:|||||:..:..|.||.|.. 
Human   670 TGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDN----NGGCTHLCLPSGQNYTCACPTGFR- 729

  Fly   906 KEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDV-DMIVPLDNLKHAVALDWCSDTDFIYW 969
            |.....|..:.||.:|.|||.|||....     |..|: |.::||.:::.||||||.|..|.:||
Human   730 KISSHACAQSLDKFLLFARRMDIRRISF-----DTEDLSDDVIPLADVRSAVALDWDSRDDHVYW 789

  Fly   970 TDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLI 1034
            |||...||::|..:|:.|:.||.::|.||.|||:||:|:||||||..|:|||||.|:|.|||:||
Human   790 TDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLI 854

  Fly  1035 WEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYF 1099
            ||.|.:||||||.|:.|:|:|:|||..|.||||.||...|..|.|..|.:||||||||...::|:
Human   855 WENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYW 919

  Fly  1100 VDGGTKTLENMNFDGSGRQVILNG-LGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIA 1163
            .|.|.||:|....|||.|:|::.. |.|||||.:...|::||||.|||:.||::|||.|...:..
Human   920 ADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQE 984

  Fly  1164 NSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLL--NPTSYTCACTVGVQLKEDRHTCSEGPTQ 1226
            |..:||||.||||.|..:...|...|||||||||.  ||:.::|.|..|:.|..|..|||.|...
Human   985 NLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNS 1049

  Fly  1227 YILFAHRIDIRQISLDFDHLIDVVLPLP-PISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLH 1290
            :::||.|||||.:|||..:..|||:|:. .:.|.:|:.||.:.|.:||||:..:.|..::.||..
Human  1050 FLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQ 1114

  Fly  1291 VQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAG 1355
            .:.|:...|:..|||.||:|||.:||.|.|.:.|||.:||||.|.|:.:::|:|||.:.|.:|.|
Human  1115 HEDIITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMG 1179

  Fly  1356 LLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQ 1420
            .::|||||...|:|||.:||::|:.::..||||||||::|..|.::.|.||..:.|::.|..|..
Human  1180 FMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGAN 1244

  Fly  1421 RKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDGLMDIKIIYQNQNQS 1485
            |..::|.:.|||.|.|.|..||||||:::::|..::...|....:.:|:.||||::.:  ::.|.
Human  1245 RHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV--DRAQP 1307

  Fly  1486 TMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNS 1550
            ...|.||:.||.||||||..|||:||.||.|::|:.:..| |...||.|||.:.|..|..|||::
Human  1308 LGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKT-CDPSPETYLLFSSRGSIRRISLDT 1371

  Fly  1551 GDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGIAV 1615
            .|..||.:|:..::..:.|||......:::.||.||||||.: ||.:..:.::|..:.|.:|:||
Human  1372 SDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRAD-LNGSNMETVIGRGLKTTDGLAV 1435

  Fly  1616 DWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAKIERSY 1680
            ||:|.||||:||.|..||.|||||||||.::.::|.:||::.|.|:|.||||:||...|||||:.
Human  1436 DWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERAN 1500

  Fly  1681 LDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLF 1745
            ||||.|.|:|.:.:|:|.|||:|:..||:.|.||..|.|...|.|||.||.:|.:..|||.||..
Human  1501 LDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQ 1565

  Fly  1746 ENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTH 1810
            :..|:||||..||:.|..|.  || .|...|...:.|.:||..||..|| ...|.|..:||||||
Human  1566 DRWIYWTDWQTKSIQRVDKY--SG-RNKETVLANVEGLMDIIVVSPQRQ-TGTNACGVNNGGCTH 1626

  Fly  1811 LCLNRNVDYVCACPDVMDPKDVACSIKPKVLVHANLENDQLLEYSDES-TDDSTPPELLGESNDH 1874
            ||..|..|:||||||  :|....||:.|.::..|    .:....|::| ...:|||..|..|.. 
Human  1627 LCFARASDFVCACPD--EPDSRPCSLVPGLVPPA----PRATGMSEKSPVLPNTPPTTLYSSTT- 1684

  Fly  1875 GDDGHTKKSDQERE---------------------------FFVLVALGVVIVMVVIIILVIFML 1912
                .|:.|.:|.|                           ..:..|:|.::.:::|::::..::
Human  1685 ----RTRTSLEEVEGRCSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALM 1745

  Fly  1913 AFNTSKKKNKRNSRGSSRSVLTFSNPNYNVDGTPME----PKTNIWKRFKYDK 1961
            .:...|.|......|:    ||:|||:|......::    ||..::.:..|.|
Human  1746 LYRHKKSKFTDPGMGN----LTYSNPSYRTSTQEVKIEAIPKPAMYNQLCYKK 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 19/33 (58%)
LDLa 306..340 CDD:238060 17/33 (52%)
LDLa 347..390 CDD:238060 20/42 (48%)
LDLa 397..431 CDD:238060 15/33 (45%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060 14/43 (33%)
FXa_inhibition 576..604 CDD:291342 18/27 (67%)
LY 634..671 CDD:214531 20/36 (56%)
NHL <656..793 CDD:302697 70/136 (51%)
LY 680..714 CDD:214531 24/33 (73%)
NHL repeat 681..722 CDD:271320 26/40 (65%)
NHL repeat 726..760 CDD:271320 18/33 (55%)
LY 761..803 CDD:214531 21/41 (51%)
NHL repeat 769..793 CDD:271320 13/23 (57%)
FXa_inhibition 882..912 CDD:291342 13/29 (45%)
LY 946..985 CDD:214531 18/38 (47%)
NHL <967..1142 CDD:302697 95/175 (54%)
LY 988..1030 CDD:214531 25/41 (61%)
NHL repeat 998..1037 CDD:271320 27/38 (71%)
NHL repeat 1038..1080 CDD:271320 23/41 (56%)
NHL repeat 1084..1119 CDD:271320 18/34 (53%)
FXa_inhibition 1185..1220 CDD:291342 17/36 (47%)
NHL 1260..>1445 CDD:302697 80/184 (43%)
NHL repeat 1260..1296 CDD:271320 12/35 (34%)
NHL repeat 1302..1337 CDD:271320 20/34 (59%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:291342 14/25 (56%)
LY 1600..1640 CDD:214531 21/39 (54%)
LY 1643..1686 CDD:214531 22/42 (52%)
LY 1688..1729 CDD:214531 19/40 (48%)
FXa_inhibition 1801..>1825 CDD:291342 15/23 (65%)
LRP4NP_002325.2 LDLa 27..66 CDD:238060 3/13 (23%)
Ldl_recept_a 70..105 CDD:278486 16/37 (43%)
LDLa 110..142 CDD:238060 19/32 (59%)
LDLa 148..182 CDD:238060 17/33 (52%)
LDLa 231..265 CDD:238060 15/33 (45%)
LDLa 270..304 CDD:238060 15/33 (45%)
LDLa 311..343 CDD:197566 13/38 (34%)
FXa_inhibition 358..393 CDD:291342 9/35 (26%)
EGF_CA 395..434 CDD:214542 22/40 (55%)
NHL <471..622 CDD:302697 81/150 (54%)
NHL repeat 471..507 CDD:271320 20/35 (57%)
LDL-receptor class B 1 480..522 23/41 (56%)
LY 505..545 CDD:214531 26/39 (67%)
NHL repeat 510..550 CDD:271320 26/39 (67%)
LDL-receptor class B 2 523..565 23/41 (56%)
NHL repeat 555..589 CDD:271320 18/33 (55%)
LDL-receptor class B 3 566..609 19/42 (45%)
LY 590..632 CDD:214531 21/41 (51%)
NHL repeat 598..622 CDD:271320 13/23 (57%)
LDL-receptor class B 4 610..652 24/41 (59%)
LY 633..673 CDD:214531 22/39 (56%)
LDL-receptor class B 5 653..693 20/39 (51%)
FXa_inhibition 702..>729 CDD:291342 13/30 (43%)
LY 766..806 CDD:214531 19/39 (49%)
LDL-receptor class B 6 785..827 21/41 (51%)
LY 808..850 CDD:214531 25/41 (61%)
LDL-receptor class B 7 828..870 29/41 (71%)
LDL-receptor class B 8 871..914 25/42 (60%)
Ldl_recept_b 871..911 CDD:278487 22/39 (56%)
LY 895..937 CDD:214531 20/41 (49%)
LDL-receptor class B 9 915..956 17/40 (43%)
LY 938..979 CDD:214531 20/40 (50%)
LDL-receptor class B 10 957..998 22/40 (55%)
FXa_inhibition 1006..1043 CDD:291342 17/36 (47%)
NHL <1085..1277 CDD:302697 83/191 (43%)
NHL repeat 1085..1123 CDD:271320 12/37 (32%)
LDL-receptor class B 11 1093..1135 15/41 (37%)
NHL repeat 1128..1161 CDD:271320 19/32 (59%)
LDL-receptor class B 12 1136..1178 19/41 (46%)
NHL repeat 1166..1203 CDD:271320 18/36 (50%)
LDL-receptor class B 13 1179..1222 22/42 (52%)
Ldl_recept_b 1179..1219 CDD:278487 21/39 (54%)
NHL repeat 1212..1244 CDD:271320 13/31 (42%)
LDL-receptor class B 14 1223..1263 13/39 (33%)
NHL repeat 1253..1277 CDD:271320 12/23 (52%)
LDL-receptor class B 15 1264..1306 13/43 (30%)
FXa_inhibition 1313..1348 CDD:291342 20/35 (57%)
LY 1379..1418 CDD:214531 14/39 (36%)
LDL-receptor class B 16 1397..1439 17/42 (40%)
LY 1420..1460 CDD:214531 21/39 (54%)
LDL-receptor class B 17 1440..1482 23/41 (56%)
LDL-receptor class B 18 1483..1526 24/42 (57%)
Ldl_recept_b 1483..1523 CDD:278487 23/39 (59%)
LY 1507..1547 CDD:214531 17/39 (44%)
LDL-receptor class B 19 1527..1568 19/40 (48%)
LY 1549..1589 CDD:214531 19/42 (45%)
LDL-receptor class B 20 1569..1610 18/43 (42%)
FXa_inhibition 1617..>1641 CDD:291342 15/23 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1686 7/31 (23%)
Endocytosis signal. /evidence=ECO:0000255 1766..1769 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1852..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 81 1.000 Domainoid score I8554
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H17964
Inparanoid 1 1.050 1525 1.000 Inparanoid score I98
Isobase 1 0.950 - 0 Normalized mean entropy S4998
OMA 1 1.010 - - QHG47399
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0008268
OrthoInspector 1 1.000 - - oto89893
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - LDO PTHR24270
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5720
SonicParanoid 1 1.000 - - X1256
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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