DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and LRP3

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_005259002.1 Gene:LRP3 / 4037 HGNCID:6695 Length:785 Species:Homo sapiens


Alignment Length:341 Identity:77/341 - (22%)
Similarity:103/341 - (30%) Gaps:142/341 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 RTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNR-------TTCTDEHFTCNDG---YC 318
            :.:|..|:|.|.||.|:|..|.|:..::|.|.|||.:|:.       :.|....|.|:..   .|
Human   163 QASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARSTRC 227

  Fly   319 ISLAFRCDGEHDCNDNSDELKCAAVINSCPE------GEFKCRGGLGGAGGPS------------ 365
            :.:..||||..||.|.|||..|..:  :|..      |.|......|.|.|||            
Human   228 LPVERRCDGLQDCGDGSDEAGCPDL--ACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQD 290

  Fly   366 ------------------------GQ--------------------------------------- 367
                                    |:                                       
Human   291 SRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSAG 355

  Fly   368 -----------------------------------CILNRFRCDGDNDCGDWSDEENCPQKPSLC 397
                                               |.....||||...|....||:.||    .|
Human   356 HGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP----AC 416

  Fly   398 TSNEYKC--ADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWL 460
            ..::|.|  ..|.|.....:|:.::.|..|.||.:|        .:|....|.|....||.:||.
Human   417 PPDQYPCEGGSGLCYTPADRCNNQKSCPDGADEKNC--------FSCQPGTFHCGTNLCIFETWR 473

  Fly   461 CDGYPDCAAGEDEVEC 476
            |||..||..|.||..|
Human   474 CDGQEDCQDGSDEHGC 489

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 15/33 (45%)
LDLa 306..340 CDD:238060 14/36 (39%)
LDLa 347..390 CDD:238060 17/158 (11%)
LDLa 397..431 CDD:238060 10/35 (29%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251
LY 634..671 CDD:214531
LY 680..714 CDD:214531
LY 718..760 CDD:214531
Ldl_recept_b 740..777 CDD:459654
LY 761..803 CDD:214531
LY 806..838 CDD:214531
FXa_inhibition 882..912 CDD:464251
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271333
NHL repeat 1038..1080 CDD:271333
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
LRP3XP_005259002.1 CUB 43..156 CDD:238001
LDLa 166..200 CDD:238060 15/33 (45%)
LDLa 212..249 CDD:238060 14/36 (39%)
CUB 254..364 CDD:238001 9/109 (8%)
LDLa 416..452 CDD:238060 10/35 (29%)
LDLa 455..489 CDD:238060 15/33 (45%)
PHA03247 <527..772 CDD:223021
Blue background indicates that the domain is not in the aligned region.

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