DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and LDLR

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens


Alignment Length:955 Identity:283/955 - (29%)
Similarity:424/955 - (44%) Gaps:207/955 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   198 SNCQN-SNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHC 261
            :.||: |:||.|.|         |...| |:|......|..|||.::|.|||..||.:.|||..|
Human    50 AECQDGSDESQETC---------LSVTC-KSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC 104

  Fly   262 GARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCD 326
            ..:| |:.|:|.|.:|.||.|.:|||.:.||.|.|||..|...||....|.||...||...:.||
Human   105 PPKT-CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACD 168

  Fly   327 GEHDCNDNSDE--LKCAAVI------NSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGD 383
            .:.||.|.|||  .:|..:.      :.|...||.|.         ||:||.:.:||||..||.|
Human   169 NDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL---------SGECIHSSWRCDGGPDCKD 224

  Fly   384 WSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFT 448
            .||||||  ..:.|..:|::|:||.||....:||:|.||....||..|.::    .|..|.::|.
Human   225 KSDEENC--AVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV----TLCEGPNKFK 283

  Fly   449 CNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECP 513
            |::|.||....:|:...||....||              |.|:              | |.||| 
Human   284 CHSGECITLDKVCNMARDCRDWSDE--------------PIKE--------------C-GTNEC- 318

  Fly   514 AGEDEADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQ 578
                         ......|..:|.:...| .||.|..|:.:...: .|.||||||  ....|||
Human   319 -------------LDNNGGCSHVCNDLKIG-YECLCPDGFQLVAQR-RCEDIDECQ--DPDTCSQ 366

  Fly   579 KCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIA 643
            .|.|..|.:||.||.|:.|.|..::|||:|....|...||.::|::||..:.|::::..|.|.:|
Human   367 LCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVA 431

  Fly   644 LDFHHRKGLMFWSDVSTDVI---KMVYMNGTRVRD-VIKWGLESPGGIAVDWIHDLLFWTDSGTR 704
            ||.......::|||:|..:|   ::...:|....| ||...:::|.|:||||||..::||||...
Human   432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLG 496

  Fly   705 RVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVT 769
            .|.|::.:|..|..:...:..|||||||.|.....:|:|||...||::..::|.....::::.:.
Human   497 TVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQ 561

  Fly   770 WPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTK 832
            ||||:.:|..:.::||.|:|.|:|...:::|.:|..||  ...|.|||:|.:|||.::|||...:
Human   562 WPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINE 626

  Fly   833 TVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLP----NKT 893
            .:.:|:::||.:...:.||...|.|:..:|...||...:.|::.... .|||.:||||    |..
Human   627 AIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLS-NGGCQYLCLPAPQINPH 690

  Fly   894 SRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAV 956
            |.:  |.||.|:.|..|.::|.:.|:..|.......:||:                         
Human   691 SPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLK------------------------- 730

  Fly   957 ALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIE 1021
                           |..:.:...|            ....||.     .|.:|....|....:|
Human   731 ---------------VSSTAVRTQH------------TTTRPVP-----DTSRLPGATPGLTTVE 763

  Fly  1022 VATTN--------GKMRTLLIWEKLYKPRDI----VVNPI--------EGFMFWSDWG------- 1059
            :.|.:        |:..     ||  ||..:    :|.||        ..|:.|.:|.       
Human   764 IVTMSHQALGDVAGRGN-----EK--KPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSI 821

  Fly  1060 --DDPMIERA---------NMDGHERVTITSKKLIYPNGLAIDYE 1093
              |:|:.::.         |.||:.          ||:...:..|
Human   822 NFDNPVYQKTTEDEVHICHNQDGYS----------YPSRQMVSLE 856

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/33 (52%)
LDLa 306..340 CDD:238060 14/35 (40%)
LDLa 347..390 CDD:238060 19/42 (45%)
LDLa 397..431 CDD:238060 14/33 (42%)
LDLa 442..476 CDD:238060 11/33 (33%)
LDLa 480..521 CDD:238060 7/40 (18%)
FXa_inhibition 576..604 CDD:464251 13/27 (48%)
LY 634..671 CDD:214531 10/39 (26%)
LY 680..714 CDD:214531 14/33 (42%)
LY 718..760 CDD:214531 15/41 (37%)
Ldl_recept_b 740..777 CDD:459654 11/36 (31%)
LY 761..803 CDD:214531 12/41 (29%)
LY 806..838 CDD:214531 13/33 (39%)
FXa_inhibition 882..912 CDD:464251 15/35 (43%)
LY 946..985 CDD:214531 2/38 (5%)
NHL <967..1142 CDD:302697 28/165 (17%)
LY 988..1030 CDD:214531 8/49 (16%)
NHL repeat 998..1037 CDD:271333 8/46 (17%)
NHL repeat 1038..1080 CDD:271333 13/71 (18%)
NHL repeat 1084..1119 CDD:271333 3/10 (30%)
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 3/7 (43%)
Ldl_recept_a 66..104 CDD:395011 16/38 (42%)
Ldl_recept_a 107..143 CDD:395011 18/36 (50%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 37/97 (38%)
Ldl_recept_a 147..179 CDD:395011 13/31 (42%)
Ldl_recept_a 195..231 CDD:395011 19/44 (43%)
Ldl_recept_a 235..270 CDD:395011 14/34 (41%)
Ldl_recept_a 278..308 CDD:395011 9/29 (31%)
FXa_inhibition 318..>346 CDD:464251 8/42 (19%)
EGF_CA 354..388 CDD:214542 18/35 (51%)
LDL-receptor class B 1 397..438 12/40 (30%)
LY 419..457 CDD:214531 11/37 (30%)
LDL-receptor class B 2 439..485 15/45 (33%)
Ldl_recept_b 439..483 CDD:459654 13/43 (30%)
LDL-receptor class B 3 486..528 16/41 (39%)
Ldl_recept_b 487..526 CDD:459654 15/38 (39%)
LDL-receptor class B 4 529..572 12/42 (29%)
Ldl_recept_b 529..569 CDD:459654 11/39 (28%)
LY 553..595 CDD:214531 12/41 (29%)
LDL-receptor class B 5 573..615 15/41 (37%)
LDL-receptor class B 6 616..658 12/41 (29%)
Ldl_recept_b 616..656 CDD:459654 11/39 (28%)
FXa_inhibition 671..711 CDD:464251 15/40 (38%)
Clustered O-linked oligosaccharides 721..768 11/103 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755 5/37 (14%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860 9/56 (16%)
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828 2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

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