DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and ldlra

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_001025454.1	Gene:	ldlra / 387529	ZFINID:	ZDB-GENE-031217-1	Length:	911	Species:	Danio rerio

Alignment Length:	709	Identity:	242/709 - (34%)
Similarity:	350/709 - (49%)	Gaps:	113/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 RCISKYWLCDGDDDCGDYSDE--THCGARTNCTDDQFEC---LNGFCIPRTWVCDGENDCKDFSD 297
            :||:..|:||..|||||.:||  ..|.|:| |...||.|   ||. |||::|.|||:.||::.:|
Zfish    35 KCITARWVCDETDDCGDGTDELPAACLAKT-CRPSQFSCGGRLNQ-CIPKSWKCDGKADCENNAD 97

  Fly   298 ETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAG 362
            |..|:...|.|..|.|..|.|::.||.||.|.||.|.|||:.|..  .:|....|:|.
Zfish    98 EEGCDPRQCHDGEFRCGSGQCVTAAFVCDDEIDCEDGSDEVSCPP--TTCGSSSFRCN------- 153

  Fly   363 GPSGQCILNRFRCDGDNDCGDWSDE--ENC---PQKPSL--CTSNEYKCADGTCIPKRWKCDKEQ 420
              :.||:...:.||||.||.|.|||  |.|   ..||:.  |||.|:.|..|.||...||||...
Zfish   154 --NAQCVPRLWVCDGDADCADNSDELPEKCGPGTSKPTKNPCTSMEFHCGSGECIHGSWKCDGGA 216

  Fly   421 DCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC--------- 476
            ||....||.:| ||.     ||..|||.|.:|.||..:..|:...||....||:.|
Zfish   217 DCLDHSDEQNC-SLP-----TCRPDEFQCGDGSCIHGSRQCNHVYDCKDMSDELGCVNATHCEPP 275

  Fly   477 -HLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE--ADCPKERKCSEPSPCEQLCI 538
             ..:|..|:              |:..:.:|:...:|....||  .:|...........|..:|.
Zfish   276 YRFKCRSGE--------------CISMEKVCNKQRDCRDWSDEPLRECDSNECLYNNGGCSHICN 326

  Fly   539 ETTAGSNECACRLGY-VMDKNKVNCTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDL 601
            :...| .||.|..|: ::||.:  |.|||||   .:| .|||.|.|.|||:||.||.||.:.|..
Zfish   327 DLKIG-YECLCPTGFRLVDKRR--CEDIDEC---ANPDTCSQICVNQMGSYKCECEDGYQMDPAS 385

  Fly   602 RSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMV 666
            ::|||:|....|...||.::|::||..:.|..::..|.|.:|||.:.....::|||:|   :|.:
Zfish   386 KACKAIGTIAYLFFTNRHEVRKMTLDRSEYIRVIPRLKNVVALDMNIASRDIYWSDLS---LKKI 447

  Fly   667 YMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIV 731
            |    .:|          |.|:|.        |..|:||..:  |:.||.         ||||||
Zfish   448 Y----SIR----------GAISVA--------TADGSRRKTL--FKENLA---------KPRAIV 479

  Fly   732 VHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECS 796
            |.|.:...||:|||...|||::.::|..|..:::..:.||||:.:|....::||.|:|.|.:...
Zfish   480 VDPIKNFMFWTDWGTPAKIEKSGLNGVDRSTLVADDIVWPNGITLDLLTERLYWVDSKLHTLSSI 544

  Fly   797 NLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIH 859
            ::.|..|..::  ...|.||.:||:||:.::|||.:...:.:|:::||.:...|.|:...|.||.
Zfish   545 SVQGDGRRTLIIDQGKLAHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKVAEHLSSPEDIV 609

  Fly   860 AYHPARQPEYADRCQKDRRGLRGGCSHLCLP----NKTSRR--CGCPIGLSLKEDGKTC 912
            .:|..:||...:.|:.:    .|||..|||.    |:.|.:  |.||..:.|..|.:.|
Zfish   610 LFHNLKQPTGINWCRIN----NGGCEFLCLAAPQINRFSPKYTCACPDNMMLARDMRKC 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	17/36 (47%)
		LDLa	306..340	CDD:238060	17/33 (52%)
		LDLa	347..390	CDD:238060	16/44 (36%)
		LDLa	397..431	CDD:238060	16/33 (48%)
		LDLa	442..476	CDD:238060	13/33 (39%)
		LDLa	480..521	CDD:238060	7/42 (17%)
		FXa_inhibition	576..604	CDD:291342	15/27 (56%)
		LY	634..671	CDD:214531	11/36 (31%)
		NHL	<656..793	CDD:302697	44/136 (32%)
		LY	680..714	CDD:214531	8/33 (24%)
		NHL repeat	681..722	CDD:271320	10/40 (25%)
		NHL repeat	726..760	CDD:271320	17/33 (52%)
		LY	761..803	CDD:214531	11/41 (27%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	13/35 (37%)
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
ldlra	NP_001025454.1	LDLa	23..55	CDD:197566	10/19 (53%)
		Ldl_recept_a	63..101	CDD:365841	18/39 (46%)
		LDLa	106..140	CDD:238060	17/33 (52%)
		LDLa	144..176	CDD:197566	13/40 (33%)
		Ldl_recept_a	192..227	CDD:365841	16/34 (47%)
		Ldl_recept_a	231..266	CDD:365841	14/34 (41%)
		LDLa	274..304	CDD:238060	5/43 (12%)
		FXa_inhibition	314..348	CDD:373209	9/36 (25%)
		EGF_CA	350..380	CDD:214542	19/32 (59%)
		Ldl_recept_b	437..481	CDD:278487	23/79 (29%)
		Ldl_recept_b	485..525	CDD:278487	14/39 (36%)
		LY	510..551	CDD:214531	11/40 (28%)
		Ldl_recept_b	572..611	CDD:278487	11/38 (29%)
		FXa_inhibition	623..664	CDD:373209	14/44 (32%)
		PHA03247	<666..808	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810