DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and CG6553

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_610911.1	Gene:	CG6553 / 36537	FlyBaseID:	FBgn0033880	Length:	319	Species:	Drosophila melanogaster

Alignment Length:	303	Identity:	77/303 - (25%)
Similarity:	100/303 - (33%)	Gaps:	107/303 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 NRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSG 366
            |.|:|...   |..|.||.|...|||..:|.|.|||.........||...|:|         ..|
  Fly    28 NATSCGHR---CGGGDCIQLDQLCDGSANCLDGSDETVAMCEKVWCPGYAFRC---------SYG 80

  Fly   367 QCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDC 431
            .||.:...|||..||.|.|||:.                        |.|..:.
  Fly    81 ACIASTAVCDGVQDCVDGSDEQG------------------------WLCRAQM----------- 110

  Fly   432 GSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLC--------- 487
                  ....|.:.|..|::|:|:..:.||||..||..|:||:|.         ||
  Fly   111 ------QQANCDNWEMYCSSGQCMTYSKLCDGIRDCRDGDDELES---------LCEGVTIPTTT 160

  Fly   488 --PTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSPCEQLCIETTAGSNECAC- 549
              .|....|...|          |...|.      .|..||.|.|:|.::        :.||..
  Fly   161 VSSTTSTTTESSI----------HRITPT------VPVTRKASRPNPLQE--------NGECVVP 201

  Fly   550 RLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCE 592
            :|..||.|   :.||    ..||  |.|:..:.|...:.|..|
  Fly   202 QLPNVMVK---HFTD----AILT--VGSRVANGTRIYYDCPAE 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060	14/33 (42%)
		LDLa	347..390	CDD:238060	16/42 (38%)
		LDLa	397..431	CDD:238060	2/33 (6%)
		LDLa	442..476	CDD:238060	14/33 (42%)
		LDLa	480..521	CDD:238060	7/51 (14%)
		FXa_inhibition	576..604	CDD:291342	4/17 (24%)
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
CG6553	NP_610911.1	LDLa	34..60	CDD:197566	11/28 (39%)
		LDLa	70..101	CDD:197566	14/39 (36%)
		LDLa	115..146	CDD:197566	12/30 (40%)
		Frag1	<260..>303	CDD:287278
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900