DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and Lrp8

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_006238632.1	Gene:	Lrp8 / 362558	RGDID:	1305729	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	956	Identity:	294/956 - (30%)
Similarity:	436/956 - (45%)	Gaps:	159/956 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 DAVPNLQ---RDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLN 276
            |.:|..|   ::||:.  ...| |..|||...|.||.|:||.|.|||..|..|| |||..|.|.|
  Rat    32 DPLPGGQGPVKECEED--QFRC-RNERCIPSVWRCDEDNDCSDNSDEDDCPKRT-CTDSDFTCDN 92

  Fly   277 GFCIPRTWVCDGENDCKDFSDETH--CNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDE 337
            |.|||..|.||||.:|.|.|||:.  |:...|..|..:|  ....|:..::|||||.||...:||
  Rat    93 GHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 157

  Fly   338 LKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEY 402
            ..|..:   |...||:|         .:..|:.:.|.||||:||||.|||..| ..|: |...|:
  Rat   158 AGCPTL---CAPHEFQC---------SNRSCLASVFVCDGDDDCGDGSDERGC-SDPA-CPPREF 208

  Fly   403 KC-ADGTCIPKRWKCDKEQDCDGGEDE--NDCGSLG---SEHPLTCG-SDEFTCNNGRCILKTWL 460
            :| ..|||||:||.||.:.||:...||  ..||..|   :..|..|. :.:|||.:|.||...|.
  Rat   209 RCGGGGTCIPERWVCDGQFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSGECIHLGWR 273

  Fly   461 CDGYPDCAAGEDEVECHL--QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNE------------ 511
            |||..||....||.:|..  .|....|.|.....:..:|.|..::...||.:|
  Rat   274 CDGDRDCKDKSDEADCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGCLQESTCEGP 338

  Fly   512 ----CPAGE---------DEADC-----PKERKCSEP-------------------SPCEQLCIE 539
                |.:||         |:.||     ..::.|..|                   ..|..:|.:
  Rat   339 RRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLHNNGGCSHICTD 403

  Fly   540 TTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSC 604
            ...|. ||.|..|:.:...| .|.||||||  ....|||.|.|..|.|||.|..||.:....::|
  Rat   404 LKIGF-ECTCPAGFQLLDQK-TCGDIDECQ--DPDACSQICVNYKGYFKCECHPGYEMDTLTKNC 464

  Fly   605 KALGG-AMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYM 668
            ||:.| :.:|:..||.::||:.|....||.::..|.|.:|||.......::|.|:|...|...:|
  Rat   465 KAVAGRSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHM 529

  Fly   669 NGTRVRD--VIKWG--LESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRA 729
            :...:.|  |:..|  |.||.|:||||:|..::|||||.:.|.|:...|..|..:.:.||.:|||
  Rat   530 DKASIPDEQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRA 594

  Fly   730 IVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIE 794
            |.|.|.....:|||||...|||:|.::|..|:.::|..:.||||:.:|..:.::||.|:|.|.:.
  Rat   595 IAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS 659

  Fly   795 CSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMD 857
            ..:.:|.:|..::  :..|.|||.:.:|||.::|||...:.:.:|:::.|.|...:.||.:.|.|
  Rat   660 SIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHD 724

  Fly   858 IHAYHPARQPEYADRCQKDRRGLRGGCSHLCLP------NKTSRRCGCPIGLSLKEDGKTC---- 912
            |..:|..:||:.||.|:...:. .|||.:||||      :.....|.||..:.|..|.|.|
  Rat   725 IVIFHELKQPKAADACELSAQP-NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAP 788

  Fly   913 KSTADKLVLVARRKDIRL------RHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTD 971
            .||:...:..|..:.:..      ..:.|:....:..:|......:.|:|.:.....|
  Rat   789 PSTSTTTLASAMTRTVPATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHST------- 846

  Fly   972 VERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWE 1036
             ..||::.|..|.|..    :.|..|.:|..:                  .|...|.:..:::
  Rat   847 -SPSTLSPATSNHSQH----YGNEGSQMGSTV------------------TAAVIGIIVPIVV-- 886

  Fly  1037 KLYKPRDIVVNPIEGFMFWSDWG---------DDPMIERANMDGHE 1073
                   |.:..:.|::.|.:|.         |:|:..:...:..|
  Rat   887 -------IALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEEE 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	20/35 (57%)
		LDLa	306..340	CDD:238060	13/35 (37%)
		LDLa	347..390	CDD:238060	17/42 (40%)
		LDLa	397..431	CDD:238060	16/36 (44%)
		LDLa	442..476	CDD:238060	15/34 (44%)
		LDLa	480..521	CDD:238060	12/65 (18%)
		FXa_inhibition	576..604	CDD:291342	12/27 (44%)
		LY	634..671	CDD:214531	10/36 (28%)
		NHL	<656..793	CDD:302697	55/140 (39%)
		LY	680..714	CDD:214531	17/35 (49%)
		NHL repeat	681..722	CDD:271320	18/40 (45%)
		NHL repeat	726..760	CDD:271320	16/33 (48%)
		LY	761..803	CDD:214531	12/41 (29%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	13/35 (37%)
		LY	946..985	CDD:214531	7/38 (18%)
		NHL	<967..1142	CDD:302697	17/116 (15%)
		LY	988..1030	CDD:214531	5/41 (12%)
		NHL repeat	998..1037	CDD:271320	3/38 (8%)
		NHL repeat	1038..1080	CDD:271320	7/45 (16%)
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060	17/36 (47%)
		LDLa	82..114	CDD:197566	19/32 (59%)
		LDLa	124..160	CDD:238060	13/35 (37%)
		LDLa	203..235	CDD:197566	14/31 (45%)
		LDLa	256..289	CDD:238060	14/32 (44%)
		LDLa	295..329	CDD:238060	8/33 (24%)
		LDLa	333..369	CDD:294076	6/35 (17%)
		FXa_inhibition	390..424	CDD:291342	8/35 (23%)
		EGF_CA	426..456	CDD:214542	17/31 (55%)
		LY	495..530	CDD:214531	9/34 (26%)
		LY	540..581	CDD:214531	18/40 (45%)
		Ldl_recept_b	602..642	CDD:278487	16/39 (41%)
		LY	626..668	CDD:214531	12/41 (29%)
		Ldl_recept_b	689..728	CDD:278487	12/38 (32%)
		FXa_inhibition	747..784	CDD:291342	13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810