DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Lrp6

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001388749.1 Gene:Lrp6 / 312781 RGDID:1304749 Length:1613 Species:Rattus norvegicus


Alignment Length:1273 Identity:507/1273 - (39%)
Similarity:753/1273 - (59%) Gaps:55/1273 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   594 GYILRPDLRS--CKALGGAMTLLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMF 654
            |.:||..|..  |..|..|..||.|||.|:|.|..:|.:.:|  :|.||.:|.|:||....||::
  Rat     2 GAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIY 66

  Fly   655 WSDVSTDVIKMVYMNGTR-VRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTV 718
            |||||.:.||....|.|. |::|:..||.||.|:|.||:.:.|:||||.|.|:||||..|:||.|
  Rat    67 WSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKV 131

  Fly   719 IASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKI 783
            :...:||:||||.:.|.....:|:|||..||||||.|||:.|.|||:..:.|||||.:|:...|:
  Rat   132 LFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYEERKL 196

  Fly   784 YWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAV 848
            ||||||.:.|..|||||::|..::...|||||||||||||:|||||||.::.|.:|.||:..|.:
  Rat   197 YWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREI 261

  Fly   849 HENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKT 911
            |.|...||||||:...|||...:.|..|    .||||||||  |.|...:|.||.|:.|.|.|||
  Rat   262 HSNIFSPMDIHAFSQQRQPNATNPCGID----NGGCSHLCLMSPVKPFYQCACPTGVKLLESGKT 322

  Fly   912 CKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERST 976
            ||..|.:|:|:|||.|:|    |.:...|:..|:::.|::::||:|:|:.....::||||.|...
  Rat   323 CKDGATELLLLARRTDLR----RISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYVYWTDDEVRA 383

  Fly   977 INKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKP 1041
            |.::.::||..|.||.:.:..|.|:|:||:...|||||..|:||||...||.||.:||.|.|.:|
  Rat   384 IRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEP 448

  Fly  1042 RDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKT 1106
            |.||::|:.|:|:|:|||:.|.||||.:||.:||.:.:..|.:|||||:||::..||:.|..|..
  Rat   449 RAIVLDPMAGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDK 513

  Fly  1107 LENMNFDGSGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMD 1170
            :|.||.||:||:|:: :.:.|.||..:....|:||||..:|:...:|.:. :..|||....|||.
  Rat   514 IEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSA-EREVIIDQLPDLMG 577

  Fly  1171 IRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRID 1235
            ::.....|....|.|.:.|||||||||..|....|||.:|.:|..|..||.. |..::||:.|.|
  Rat   578 LKATSVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTCIV-PEAFLLFSRRAD 641

  Fly  1236 IRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLE 1300
            ||:|||:.:: .:|.:||..:..|.|||.|.....|||:|.....|..:..:|..::.:|...|:
  Rat   642 IRRISLETNN-NNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLD 705

  Fly  1301 NPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHY 1365
            .|:|:.||.:|:.:||||.|.:.|||:.|||.:|.|:.:|||:|||.||||...|.::||:||..
  Rat   706 YPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGK 770

  Fly  1366 RKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHH 1430
            .||:|:.:||:||:.:| .|:|..|||::|...:|:||.|.....|:|.:..|..|::|...|.|
  Rat   771 PKIDRAAMDGSERTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPH 834

  Fly  1431 PYALALSDDNIYWTDWKSKALHMTERRNISA--KRDIIT-NIDGLMDIKIIYQNQNQSTMKNACG 1492
            |:.|....|.||||||..:::   ||.|.::  .|.||. ::|.:||| :::.:..|:.. |.|.
  Rat   835 PFGLTQYQDYIYWTDWSRRSI---ERANKTSGQNRTIIQGHLDYVMDI-LVFHSSRQAGW-NECA 894

  Fly  1493 NNNGNCSHLCLRNP-SGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDV 1556
            ::||:||||||..| .|:.|.||....|..::.| | :.|..:||.:.:|.|..:.::.....|:
  Rat   895 SSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRT-C-SAPTTFLLFSQKSAINRMVIDEQQSPDI 957

  Fly  1557 VLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNL-----LNLTESKVIVGTDVLTPNGIAVD 1616
            :|||:.:.....:||......|::.|...::||:...     ..:..|.|......:.|..:::|
  Rat   958 ILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFTVVVSSVPNQNLEIQPYDLSID 1022

  Fly  1617 WIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIERS 1679
            ..:..:||:.....:|:|:||||.....:::.....||:::|:|:|.|:::::..  || ||||:
  Rat  1023 IYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSP-KIERA 1086

  Fly  1680 YLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRR-----QTIVPYAPHP 1739
            .|||:.|.|:..||:..|..|.:|....||.|||:....|...|.:|..|     ..|:    .|
  Rat  1087 ALDGTEREVLFFSGLSKPVALALDSKLSRLFWADSDLRRIESSDLSGANRIVLEDSNIL----QP 1147

  Fly  1740 FGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAV-SLSRQPKSVNHCAQ 1803
            .|||:|||   |..|.:|.....:|:..:|.....:|:..::...||.|| .|:.|....:.|||
  Rat  1148 VGLTVFEN---WLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQ 1209

  Fly  1804 DNGGCTHLCLNRNVDYV-CACPD--VMDPKDVACSIKP 1838
            |||||:|:||.:..... |:||.  |:...:::|...|
  Rat  1210 DNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPP 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251 4/11 (36%)
LY 634..671 CDD:214531 17/36 (47%)
LY 680..714 CDD:214531 19/33 (58%)
LY 718..760 CDD:214531 21/41 (51%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 22/41 (54%)
LY 806..838 CDD:214531 21/31 (68%)
FXa_inhibition 882..912 CDD:464251 18/31 (58%)
LY 946..985 CDD:214531 11/38 (29%)
NHL <967..1142 CDD:302697 80/175 (46%)
LY 988..1030 CDD:214531 20/41 (49%)
NHL repeat 998..1037 CDD:271333 21/38 (55%)
NHL repeat 1038..1080 CDD:271333 21/41 (51%)
NHL repeat 1084..1119 CDD:271333 18/34 (53%)
FXa_inhibition 1185..1220 CDD:464251 17/34 (50%)
NHL 1260..>1445 CDD:302697 76/184 (41%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
LY 1292..1334 CDD:214531 18/41 (44%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 18/37 (49%)
FXa_inhibition <1499..1525 CDD:464251 11/26 (42%)
LY 1600..1640 CDD:214531 10/39 (26%)
LY 1643..1686 CDD:214531 15/44 (34%)
LY 1688..1729 CDD:214531 14/40 (35%)
FXa_inhibition 1801..>1825 CDD:464251 13/24 (54%)
Lrp6NP_001388749.1 YncE 1..204 CDD:442618 97/201 (48%)
LY 89..127 CDD:214531 20/37 (54%)
Ldl_recept_b 150..191 CDD:459654 22/40 (55%)
LY 175..216 CDD:214531 22/40 (55%)
LY 217..251 CDD:214531 21/33 (64%)
FXa_inhibition 286..323 CDD:464251 20/40 (50%)
LY 353..393 CDD:214531 12/39 (31%)
LY 397..437 CDD:214531 19/39 (49%)
Ldl_recept_b 458..499 CDD:459654 21/40 (53%)
LY 483..524 CDD:214531 17/40 (43%)
LY 525..558 CDD:214531 10/32 (31%)
FXa_inhibition 592..627 CDD:464251 17/34 (50%)
YncE <654..813 CDD:442618 67/159 (42%)
LY 697..739 CDD:214531 18/41 (44%)
LY 827..866 CDD:214531 15/41 (37%)
FXa_inhibition 893..929 CDD:464251 16/36 (44%)
LY 958..998 CDD:214531 9/39 (23%)
YncE <968..1075 CDD:442618 24/106 (23%)
LY 1094..1136 CDD:214531 14/41 (34%)
FXa_inhibition 1207..1243 CDD:464251 15/35 (43%)
LDLa 1249..1285 CDD:238060
LDLa 1288..1322 CDD:238060
LDLa 1326..1360 CDD:238060
Blue background indicates that the domain is not in the aligned region.

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