DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Sorl1

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_445971.1 Gene:Sorl1 / 300652 RGDID:619914 Length:2215 Species:Rattus norvegicus


Alignment Length:1102 Identity:263/1102 - (23%)
Similarity:390/1102 - (35%) Gaps:400/1102 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   199 NCQNSN--------ESDENCNPEEDAVPNLQRDCEKT----GIHVMCPRTFRCISKYWLCDGDDD 251
            :|.|.|        :.|.:|....|     :|:|..|    .....|..:..||...:.||.:||
  Rat  1084 HCSNGNCINSIWWCDFDNDCGDMSD-----ERNCPTTICDADTQFRCQESGTCIPLSYKCDLEDD 1143

  Fly   252 CGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRT--TCTDEHFTCN 314
            |||.|||:||... .|..|:|.|.:|.||..:|||||:|||:|:|||.:|...  ||...:|.|:
  Rat  1144 CGDNSDESHCEMH-QCRSDEFNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCH 1207

  Fly   315 DGYCISLAFRCDGEHDCNDNSDE--LKCAAVIN--------------------SCPEGE------ 351
            :|:||...:.|||:.||.|.|||  :.|....|                    .||:|.      
  Rat  1208 NGHCIPQRWACDGDADCQDGSDEDPISCEKKCNGFHCPNGTCIPSSKHCDGLRDCPDGSDEQHCE 1272

  Fly   352 ---------------------------FKCRGG-------LGGAGGP--------------SGQC 368
                                       .:||.|       .|.:..|              :|.|
  Rat  1273 PFCTRFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDATFAGCSQDPEFHKECDEFGFQCQNGVC 1337

  Fly   369 ILNRFRCDGDNDCGDWSDEENC---PQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDEND 430
            |...::|||.:||||:|||.||   .:.|:.....::.|.:|.|||.|||||:|.||....||.|
  Rat  1338 ISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFHCENGRCIPNRWKCDRENDCGDWSDEKD 1402

  Fly   431 CGSLGSEH--------PLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHL--------- 478
            |   |..|        |.||..:.|.|::|.|::.||:||||.|||.|.||..|..         
  Rat  1403 C---GDSHIFPSPTPGPSTCLPNYFRCSSGACVMGTWVCDGYRDCADGSDEEACPSLANSTAAST 1464

  Fly   479 -----QCDLGQFLC--PTKQNLTNLKICVHQKHICDGHNECPAGEDEADCP---------KERKC 527
                 |||..:|.|  |.|        |:.....||||.:|..|:|||:||         :|.||
  Rat  1465 PTQLGQCDRFEFECRQPKK--------CIPNWKRCDGHQDCQDGQDEANCPTHSTLTCMSREFKC 1521

  Fly   528 SEPSPC---EQLC---IETTAGSNECAC----------RLGYVMD-KNKVNCT-------DIDEC 568
            .:...|   .:.|   ::.:..|:|.||          .|.::.| ...|..|       ....|
  Rat  1522 EDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWIADFSGDVTLTWTRPKKMPSASC 1586

  Fly   569 QY--------------------LTSPV-----------------CSQKCHNT------------- 583
            .|                    .||.|                 |..|.|||             
  Rat  1587 VYNVYYRVVGESIWKTLETHSNKTSTVLKVLKPDTTYQVKVQVHCLSKVHNTNDFVTLRTPEGLP 1651

  Fly   584 ------------------MGSFKCSCETGYILRPDLRSCKALGGAM---TLLVANRWDIRRVTLS 627
                              :|.:.....|..::|..:......|..|   ....:|..:|:.:.| 
  Rat  1652 DAPRNLQLSLNSEEEGVILGHWAPPVHTHGLIREYIVEYSRSGSKMWASQRAASNSTEIKNLLL- 1715

  Fly   628 NNRYSAIVKGLHNAIALDFHHRKGLMFWSD---VSTDVIKMVYMNGTRV----RDVIKWGLESPG 685
            |..|:..|..:.:         :|:..|||   ::|...|::......:    .:.:.:.|...|
  Rat  1716 NALYTVRVAAVTS---------RGIGNWSDSKSITTTKGKVIQAPNIHIDSYDENSLSFTLTMDG 1771

  Fly   686 GIAVDWIHDLLFWT-DSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFW--SDWGPN 747
            .|.|:.....|||: |:..:..:..||:|      .|....|...:..|....::.|  :|.|.:
  Rat  1772 DIKVNGYVVNLFWSFDAHKQEKKTLNFRG------GSSLSHKVSNLTAHTSYEVSAWAKTDLGDS 1830

  Fly   748 PKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADA-KQHAIECSNLDGSDRNKILSTHL 811
            |   .|:      :.|:::|::.|      .|:.|   |.| .|.|:||  :....:|.:...  
  Rat  1831 P---LAF------EHILTRGISPP------APSLK---AKAINQTAVEC--IWTGPKNVVYGI-- 1873

  Fly   812 PHPFALTLFEDTMY------WTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYA 870
               |..|.|.| :|      .|..:.|||     |..|:     |.:.|.:.:...:.....:| 
  Rat  1874 ---FYATSFLD-LYRNPKSLTTSLHNKTV-----IVSKD-----EQYLFLVRVLIPYQGPSSDY- 1923

  Fly   871 DRCQKDRRGLRGGCSHLCLPNKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRL--RHL 933
                                                             |:|....|.||  |||
  Rat  1924 -------------------------------------------------VVVKMIPDSRLPPRHL 1939

  Fly   934 RDNQ----------ADPNDVDMIVPLDNLKHAVAL-DWCSDTDFIYWTDVERSTI----NKAHLN 983
            ...|          ..|.|    .|..:|.:|:|: |....||..|......||:    :|....
  Rat  1940 HAVQIGKTSAVIKWESPYD----SPDQDLFYAIAVKDLIRKTDRSYKVRSRNSTVEYSLSKLEPG 2000

  Fly   984 GSYQQRVVHSNL-------VSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKL 1038
            |.|...|...|:       ::.|.|:             :.:.:::.|.|.  ..||.|:.|
  Rat  2001 GKYHIIVQLGNMSKDSSIKITTVSLS-------------APDALKIITEND--HVLLFWKSL 2047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 19/33 (58%)
LDLa 306..340 CDD:238060 15/35 (43%)
LDLa 347..390 CDD:238060 21/96 (22%)
LDLa 397..431 CDD:238060 15/33 (45%)
LDLa 442..476 CDD:238060 17/33 (52%)
LDLa 480..521 CDD:238060 16/42 (38%)
FXa_inhibition 576..604 CDD:464251 8/58 (14%)
LY 634..671 CDD:214531 7/39 (18%)
LY 680..714 CDD:214531 10/34 (29%)
LY 718..760 CDD:214531 8/43 (19%)
Ldl_recept_b 740..777 CDD:459654 8/38 (21%)
LY 761..803 CDD:214531 11/42 (26%)
LY 806..838 CDD:214531 9/37 (24%)
FXa_inhibition 882..912 CDD:464251 0/29 (0%)
LY 946..985 CDD:214531 11/43 (26%)
NHL <967..1142 CDD:302697 16/83 (19%)
LY 988..1030 CDD:214531 6/48 (13%)
NHL repeat 998..1037 CDD:271333 7/38 (18%)
NHL repeat 1038..1080 CDD:271333 1/1 (100%)
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
Sorl1NP_445971.1 Cell attachment site. /evidence=ECO:0000255 63..65
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 844..887
LY 868..910 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 888..930
Ldl_recept_b 890..929 CDD:459654
LY 913..953 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 931..972
LY 953..987 CDD:214531
LDLa 1078..1112 CDD:238060 7/32 (22%)
LDLa 1117..1153 CDD:238060 13/35 (37%)
Ldl_recept_a 1157..1192 CDD:395011 19/34 (56%)
Ldl_recept_a 1198..1230 CDD:395011 14/31 (45%)
LDLa 1240..1271 CDD:238060 4/30 (13%)
LDLa 1281..1308 CDD:197566 3/26 (12%)
LDLa 1325..1359 CDD:238060 13/33 (39%)
LDLa 1373..1403 CDD:238060 15/29 (52%)
LDLa 1419..1453 CDD:238060 17/33 (52%)
LDLa 1471..1506 CDD:238060 16/42 (38%)
LDLa 1514..1549 CDD:238060 7/34 (21%)
FN3 <1542..1830 CDD:442628 52/303 (17%)
FN3 1651..1742 CDD:238020 15/100 (15%)
FN3 <1815..2169 CDD:442628 65/338 (19%)
FN3 1935..2022 CDD:238020 21/90 (23%)
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250|UniProtKB:Q92673 2162..2165
Endocytosis signal. /evidence=ECO:0000255 2173..2178
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250|UniProtKB:Q92673 2191..2215
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250|UniProtKB:Q92673 2202..2215
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250|UniProtKB:Q92673 2209..2213
Blue background indicates that the domain is not in the aligned region.

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