DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Ldlr

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_786938.2 Gene:Ldlr / 300438 RGDID:2998 Length:879 Species:Rattus norvegicus


Alignment Length:762 Identity:261/762 - (34%)
Similarity:381/762 - (50%) Gaps:87/762 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   235 RTFRCISKYWLCDGDDDCGDYSDET--HCGARTNCTDDQFECLN--GFCIPRTWVCDGENDCKDF 295
            |..:||...|:|||..:|.|.|||:  .|.:.| |...:|.|..  ..|||.:|.|||..||::.
  Rat    35 RDGKCIVSKWVCDGSRECPDGSDESPETCMSVT-CRSGEFSCGGRVSRCIPDSWRCDGRTDCENG 98

  Fly   296 SDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGG 360
            |||..|:..||:.:.|.|.||.|||..|.||.:.||.|.|||..|||  .:|....|:|.     
  Rat    99 SDELDCSPKTCSLDEFRCQDGKCISRQFVCDQDWDCLDGSDEAHCAA--TTCGPAHFRCN----- 156

  Fly   361 AGGPSGQCILNRFRCDGDNDCGDWSDE--ENCPQK-------PSLCTSNEYKCADGTCIPKRWKC 416
                |..||.:.:.||||.||.|.|||  :||..:       .|.|:|.|:.|....||.:.|.|
  Rat   157 ----SSSCIPSLWACDGDRDCDDGSDEWPQNCGGRDTAAEVVSSPCSSLEFHCGSSECIHRSWVC 217

  Fly   417 DKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC--HLQ 479
            |...||....||.:|.      ..||..|||.|.:|.||..:..||...||....||:.|  ..|
  Rat   218 DGAADCKDKSDEENCA------VTTCRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCINVTQ 276

  Fly   480 CD-LGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE--ADCPKERKCSEPS-PCEQLCIET 540
            || ..:|.|.:.:       |:....:|:...:|....||  .:| |..:|.:.: .|..:|.:.
  Rat   277 CDGPNKFKCHSGE-------CISLDKVCNSARDCRDWSDEPIKEC-KTNECLDNNGGCSHICKDL 333

  Fly   541 TAGSNECACRLGY-VMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSC 604
            ..| .||.|..|: ::|.::  |.||||||  ....|||.|.|..|||||.|..|:.:.|..|.|
  Rat   334 KIG-YECLCPSGFRLVDGHQ--CEDIDECQ--EPDTCSQLCVNLEGSFKCECRAGFHMDPHTRVC 393

  Fly   605 KALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMN 669
            ||:|....||..||.::|::||..:.|::::..|.|.:|||.......::|||:|...|....|:
  Rat   394 KAVGSIGFLLFTNRHEVRKMTLDRSEYTSLIPNLKNVVALDTEVANNRIYWSDLSQRKIYSAVMD 458

  Fly   670 -GTRVR--DVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIV 731
             ||.:.  .:|...|.:|.|:||||||..::||||....|.|::.:|..|..:......:|||||
  Rat   459 QGTSLSYDAIISGDLHAPDGLAVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIV 523

  Fly   732 VHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECS 796
            |.|.....:|:|||...||::..::|.....::::.:.||||:.:|.|:.::||.|:|.|:|...
  Rat   524 VDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSI 588

  Fly   797 NLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIH 859
            :::|..|..||  ...|.|||:|.::||.:||||...:.:.:|:::||.:...|.:|...|.||.
  Rat   589 DVNGGGRKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVNLVAKNLMSPEDIV 653

  Fly   860 AYHPARQPEYADRCQKDRRGLRGGCSHLCLP------NKTSRRCGCPIGLSLKEDGKTCKSTADK 918
            .:|...||...:.|:..... .|||.::|||      :.....|.||.|:.|.:|.::|....|.
  Rat   654 LFHNVTQPRGVNWCEATVLP-NGGCQYMCLPAPQISAHSPKFTCACPDGMLLAKDMRSCLPEVDT 717

  Fly   919 L------------------VLVARRKD-IRLRHLRDNQA-----DPN 941
            :                  |.:.|::| ...||..|..|     ||:
  Rat   718 VPTTQGTSTIGPVVTTSAAVSLKRKEDPSATRHKEDPSATRHKEDPS 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 15/35 (43%)
LDLa 306..340 CDD:238060 17/33 (52%)
LDLa 347..390 CDD:238060 16/44 (36%)
LDLa 397..431 CDD:238060 13/33 (39%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 480..521 CDD:238060 9/43 (21%)
FXa_inhibition 576..604 CDD:291342 14/27 (52%)
LY 634..671 CDD:214531 11/37 (30%)
NHL <656..793 CDD:302697 50/139 (36%)
LY 680..714 CDD:214531 15/33 (45%)
NHL repeat 681..722 CDD:271320 17/40 (43%)
NHL repeat 726..760 CDD:271320 14/33 (42%)
LY 761..803 CDD:214531 13/41 (32%)
NHL repeat 769..793 CDD:271320 11/23 (48%)
FXa_inhibition 882..912 CDD:291342 12/35 (34%)
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
LdlrNP_786938.2 Ldl_recept_a 25..58 CDD:395011 10/22 (45%)
Ldl_recept_a 66..104 CDD:395011 16/38 (42%)
Ldl_recept_a 107..143 CDD:395011 18/35 (51%)
Ldl_recept_a 196..232 CDD:395011 14/35 (40%)
Ldl_recept_a 235..271 CDD:395011 15/35 (43%)
Ldl_recept_a 279..309 CDD:395011 5/36 (14%)
FXa_inhibition 319..353 CDD:405372 9/36 (25%)
EGF_CA 355..389 CDD:214542 18/35 (51%)
LDL-receptor class B 1 398..439 13/40 (33%)
NHL <435..628 CDD:302697 67/192 (35%)
NHL repeat 435..469 CDD:271320 8/33 (24%)
LDL-receptor class B 2 440..485 16/44 (36%)
NHL repeat 476..514 CDD:271320 16/37 (43%)
LDL-receptor class B 3 486..528 15/41 (37%)
LDL-receptor class B 4 529..572 12/42 (29%)
Ldl_recept_b 529..569 CDD:395012 11/39 (28%)
NHL repeat 555..600 CDD:271320 15/44 (34%)
LDL-receptor class B 5 573..615 15/41 (37%)
NHL repeat 606..628 CDD:271320 10/21 (48%)
LDL-receptor class B 6 616..658 14/41 (34%)
Ldl_recept_b 616..655 CDD:395012 13/38 (34%)
FXa_inhibition 674..711 CDD:405372 12/36 (33%)
Clustered O-linked oligosaccharides 717..788 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..797 9/47 (19%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 830..879
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 842..847
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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