DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and LRP12

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_038465.1	Gene:	LRP12 / 29967	HGNCID:	31708	Length:	859	Species:	Homo sapiens

Alignment Length:	526	Identity:	119/526 - (22%)
Similarity:	179/526 - (34%)	Gaps:	205/526 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 NSNDTPKFRN------IGAQRGRTEIAGIRETDRISS------------RGRDGFI---GGPSNK 174
            ::.::|::|:      :....|...:|...|...||.            |...|.|   |.||
Human     6 STKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPS-- 68

  Fly   175 QKPFRVNLAVLVQDDPSQ-----------PG-----------ETYSNCQNSN------------- 204
            :.|.::|.:..::.:|.:           .|           |||.|.::..
Human    69 EYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISS 133

  Fly   205 --------ESDENCNPE---------EDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDC 252
                    .||:|.:.:         :...||...|..:.|       ..:||.:.|.|:..|:|
Human   134 QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG-------NGKCIPEAWKCNNMDEC 191

  Fly   253 GDYSDETHCGARTN---------CTDDQFECLNGF-----CIPRTWVCDGENDCKDFSDETHCNR 303
            ||.|||..|....|         |..:||:||:.|     |:|.:..|||..||.|..||..|:.
Human   192 GDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 256

  Fly   304 TTCTD--EHF--TCN-----DGY-----CISLA--------------FRCDGE------------ 328
            .||..  ::|  |.|     |.|     |..|.              |:.||.
Human   257 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 321

  Fly   329 -------------------------------HDCNDNSDELKCAAVINS-------CPEGEFKCR 355
                                           |.|   :|::..|...|:       |...|..|.
Human   322 EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFC---ADKVNAARGFNATYQVDGFCLPWEIPCG 383

  Fly   356 GGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCA-DGTCIPKRWKCDKE 419
            |..|        |...:.||||...|.:..||.||    ::|...|:.|: :|.|.|:..:|:.:
Human   384 GNWG--------CYTEQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSDRCNYQ 436

  Fly   420 QDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQ 484
            ..|..|.||.:|        ..|....|.|.|.||:.::|:||...||..|.||..|.:
Human   437 NHCPNGSDEKNC--------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV------ 487

  Fly   485 FLCPTK 490
             :.||:
Human   488 -IVPTR 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	16/38 (42%)
		LDLa	306..340	CDD:238060	14/104 (13%)
		LDLa	347..390	CDD:238060	13/42 (31%)
		LDLa	397..431	CDD:238060	11/34 (32%)
		LDLa	442..476	CDD:238060	14/33 (42%)
		LDLa	480..521	CDD:238060	2/11 (18%)
		FXa_inhibition	576..604	CDD:291342
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
LRP12	NP_038465.1	CUB	47..158	CDD:238001	17/112 (15%)
		LDLa	166..200	CDD:238060	13/40 (33%)
		LDLa	215..254	CDD:238060	16/38 (42%)
		CUB	267..371	CDD:238001	14/106 (13%)
		LDLa	375..410	CDD:238060	13/42 (31%)
		LDLa	413..448	CDD:238060	11/34 (32%)
		LDLa	451..485	CDD:238060	14/33 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..678
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..770
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..823
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900