DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Lrp5

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001424443.1 Gene:Lrp5 / 293649 RGDID:1309329 Length:1615 Species:Rattus norvegicus


Alignment Length:1532 Identity:497/1532 - (32%)
Similarity:779/1532 - (50%) Gaps:161/1532 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 CKALGGAMT--LLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMFWSDVSTDVIK 664
            |..:..|.:  ||.|||.|:|.|.....:..:  :..||.:|.|:||...||.::|:|||.:.||
  Rat    24 CSLVPAAASPLLLFANRRDVRLVDAGGVKLESTIVASGLEDAAAVDFQFSKGAVYWTDVSEEAIK 88

  Fly   665 MVYMN--GTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKP 727
            ..|:|  |...::::..||.||.|:|.||:...|:||||.|.|:||:|..|..|.|:...|||:|
  Rat    89 QTYLNQTGAAAQNIVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQP 153

  Fly   728 RAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHA 792
            |||.:.|.....:|:|||..|:||||.|||:.||:|:...:.|||||.||....|:||||||...
  Rat   154 RAIALDPAHGYMYWTDWGEAPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSF 218

  Fly   793 IECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMD 857
            |..:|||||.|.|::...|.|||||||..||:|||||.|:::.|.:|.||::.:.:....:.|||
  Rat   219 IHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKWTGEKRKEILSALYSPMD 283

  Fly   858 IHAYHPARQPEYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTADKLV 920
            |......|||.:...|::.    .||||||||  |.:....|.||.|:.|:::|||||:.|::::
  Rat   284 IQVLSQERQPHFHTPCEEG----NGGCSHLCLLSPREPFYSCACPTGVQLQDNGKTCKAGAEEVL 344

  Fly   921 LVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGS 985
            |:|||.|:|    |.:...|:..|:::.:.:::||:|:|:.....::||||.|...|.:|:|:||
  Rat   345 LLARRTDLR----RISLDTPDFTDIVLQVGDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS 405

  Fly   986 YQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIE 1050
            ..|.:|::.:..|.|:|:||:...|||||..|:||||...||..|.:|:.|.|.:||.||::|:.
  Rat   406 GAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIVLHPVM 470

  Fly  1051 GFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGS 1115
            |.|:|:|||::|.||.||:||.:|..:.:..|.:|||||:|.::.|:|:.|..|..:|.:|.||:
  Rat   471 GLMYWTDWGENPKIECANLDGRDRHVLVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVINIDGT 535

  Fly  1116 GRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRR 1179
            .||.:| :.|.|.||..:....::||||..:|:...:|:.. ..:|||....|||.::..:..:.
  Rat   536 KRQTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKA-SRDVIIDQLPDLMGLKAVNVAKV 599

  Fly  1180 RIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFD 1244
            ...|.|...||||||||...|.:..|.|.:|::|..|..||.. |..:::|..|..|.:|||:.:
  Rat   600 VGTNPCADGNGGCSHLCFFTPHATKCGCPIGLELLSDMKTCII-PEAFLVFTSRATIHRISLETN 663

  Fly  1245 HLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDS 1309
            : .||.:||..:..|.|||.|....:|||:|.....|..:..:|..|:.::...|:.|:|:.||.
  Rat   664 N-NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGLDYPEGMAVDW 727

  Fly  1310 IGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLD 1374
            :|:.:||||.|.:.||||.|||..|.|:.::||::||.||||...|.::||:||...:|.|:.:|
  Rat   728 MGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMD 792

  Fly  1375 GNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDD 1439
            |.....:|. .:|..|.|::|...:|:||.|.....|:|.:..|.:|.:|...|.:|:.|....|
  Rat   793 GTNCMTLVD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERMVIADDLPYPFGLTQYSD 856

  Fly  1440 NIYWTDWKSKALHMTERRNISAKRD---IITNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHL 1501
            .||||||.   ||..||.:.::.|:   |..::|.:||| :::.:..|..: |.|.::||.|..|
  Rat   857 YIYWTDWN---LHSIERADKTSGRNRTLIQGHLDFVMDI-LVFHSSRQDGL-NDCVHSNGQCGQL 916

  Fly  1502 CLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGA 1566
            ||..|.|:.|.|.....| ..|:..| :.|..:||.:.:..|..:..:.....|::||::|:...
  Rat   917 CLAIPGGHRCGCASHYTL-DPSSRNC-SPPSTFLLFSQKFAISRMIPDDQLSPDLILPLHGLRNV 979

  Fly  1567 VVLDYHYRKNLLFFADVNLDVIRR----VNLLNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDT 1627
            ..::|......:::.|...::.|.    .....||.....:..| ..|:.:::|..:..|:|:..
  Rat   980 KAINYDPLDKFIYWVDGRQNIKRAKDDGTQPSMLTSPSQSLSPD-RQPHDLSIDIYSRTLFWTCE 1043

  Fly  1628 DRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSS-PAKIERSYLDGSNRTVIIT 1691
            ....|.|.||||.....::..:...||::.|:.::.|:::::... .|||||:.|||:.|.|:.|
  Rat  1044 ATNTINVHRLDGDAMGVVLRGDRDRPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFT 1108

  Fly  1692 SGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQT-----IVPYAPHPFGLTLFENSIFW 1751
            :|:..|..|.:|....:|.|.||....|...|.:|..|.|     ||    .|.|||:....::|
  Rat  1109 TGLIRPVALVVDNALGKLFWVDADLKRIESCDLSGANRLTLEDANIV----QPVGLTVLGRHLYW 1169

  Fly  1752 TDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAV-SLSRQPKSVNHCAQDNGGCTHLCLNR 1815
            .|...:.:.|.:|....   ....|:..::....|.|| .:|.:..|.:.||:|||||:|:|:.:
  Rat  1170 IDRQQQMIERVEKTTGD---KRTRVQGRVTHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAK 1231

  Fly  1816 NVDYV--CAC---------------PDVMDPKDVACSIKPKVLVHANLENDQLLEYSDESTDDST 1863
            . |..  |:|               |....|...||:......:......|...|.:|:|.::..
  Rat  1232 G-DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECADQSDEEGC 1295

  Fly  1864 P-------PELLGESND------------HGDD-----------------GHTKKSDQEREFFVL 1892
            |       |...|:..|            .|.|                 |......|:.:.|..
  Rat  1296 PVCSASQFPCARGQCVDLRLRCDGEADCQDGSDEANCDAVCLPNQFRCASGQCVLIKQQCDSFPD 1360

  Fly  1893 VALGVVIVM--------------------VVIIILVIFMLA---FNTSKKKNKRNSRGSSRSVLT 1934
            .|.|...:|                    |:.|||.:|::.   |...:...:|.:..|.     
  Rat  1361 CADGSDELMCEINKPPSDDVPAHSSAIGPVIGIILSLFVMGGVYFVCQRVMCQRYTGASG----- 1420

  Fly  1935 FSNPNYNVDGTPMEPKTNI---------WKRFKYDKTHQERAG---------VYEERSLTTETAS 1981
             ..|:..|.|||..|...|         :......|:......         :|:...:|..::|
  Rat  1421 -PFPHEYVGGTPHVPLNFIAPGGSQHGPFPGIPCSKSMMSSVSLVGGRGSVPLYDRNHVTGASSS 1484

  Fly  1982 SS----------LFVPTPSPMASPSTKTIQLTTLSTI 2008
            ||          :..|.|||...||...:.:...|.|
  Rat  1485 SSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNI 1521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251 497/1532 (32%)
LY 634..671 CDD:214531 16/38 (42%)
LY 680..714 CDD:214531 18/33 (55%)
LY 718..760 CDD:214531 21/41 (51%)
Ldl_recept_b 740..777 CDD:459654 20/36 (56%)
LY 761..803 CDD:214531 22/41 (54%)
LY 806..838 CDD:214531 17/31 (55%)
FXa_inhibition 882..912 CDD:464251 16/31 (52%)
LY 946..985 CDD:214531 12/38 (32%)
NHL <967..1142 CDD:302697 76/175 (43%)
LY 988..1030 CDD:214531 19/41 (46%)
NHL repeat 998..1037 CDD:271333 19/38 (50%)
NHL repeat 1038..1080 CDD:271333 20/41 (49%)
NHL repeat 1084..1119 CDD:271333 15/34 (44%)
FXa_inhibition 1185..1220 CDD:464251 15/34 (44%)
NHL 1260..>1445 CDD:302697 69/184 (38%)
NHL repeat 1260..1296 CDD:271320 11/35 (31%)
LY 1292..1334 CDD:214531 18/41 (44%)
NHL repeat 1302..1337 CDD:271320 18/34 (53%)
NHL repeat 1345..1383 CDD:271320 15/37 (41%)
FXa_inhibition <1499..1525 CDD:464251 9/25 (36%)
LY 1600..1640 CDD:214531 10/39 (26%)
LY 1643..1686 CDD:214531 12/43 (28%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:464251 12/40 (30%)
Lrp5NP_001424443.1 None
Blue background indicates that the domain is not in the aligned region.

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