DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp2

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_110454.2 Gene:Lrp2 / 29216 RGDID:68407 Length:4660 Species:Rattus norvegicus


Alignment Length:1803 Identity:578/1803 - (32%)
Similarity:847/1803 - (46%) Gaps:244/1803 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 VLVQDDPSQPGETYSNCQNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCP-------------- 234
            |...|...|.|..|  |..:..::.:|:.....|||.||.|.       ||              
  Rat   959 VKAYDADLQTGSNY--CSQTTHANGDCSHFCFPVPNFQRVCG-------CPYGMKLQRDQMTCEG 1014

  Fly   235 ------------------RTFRCISKYWLCDGDDDCGDYSDETHCGARTN--------------- 266
                              ...:|:..::.|||.|||.|.|||..||...|               
  Rat  1015 DPAREPPTQQCGSLSFPCNNGKCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQC 1079

  Fly   267 ------------------------------CTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHC 301
                                          |....|.|.|..|||:.||||.:|||.|.|||.:|
  Rat  1080 IPGQWHCDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNC 1144

  Fly   302 NRT-TCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPS 365
            ..: ||....|.|.|..|||..:.|||:.||.|.|||..|  |:| |...:|||..|        
  Rat  1145 QASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGC--VLN-CTSAQFKCADG-------- 1198

  Fly   366 GQCILNRFRCDGDNDCGDWSDEENCPQK-PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDE 428
            ..||.:|:||||..||.|.|||..||.: |.:|..:|::| .||||||..|:||...||..|.||
  Rat  1199 SSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHLDEFQCQGDGTCIPNTWECDGHPDCIHGSDE 1263

  Fly   429 NDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQ---CDLGQFLCPTK 490
            : .|.:    |.||....|.|:||.||.|.|:|||..||....||.:|..|   |...|:.||  
  Rat  1264 H-TGCV----PKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDEKDCPTQPFHCPSTQWQCP-- 1321

  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSE-PSPCEQLCIETTAGSNECACRLGYV 554
                ....|::...:|||..:||.|.||:....:..||. ...|...|::...|:. |.|.|||.
  Rat  1322 ----GYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHFNGGCTHQCMQGPFGAT-CLCPLGYQ 1381

  Fly   555 MDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRW 619
            :..:...|.||:||.  ....|||.|.|..|||:|:|:..|.|..|.|:||..|....|||....
  Rat  1382 LANDTKTCEDINECD--IPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASR 1444

  Fly   620 D---IRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGL 681
            |   :..:|...:...::|:.:...:||||....|.:||||:.......|:.|||..|.|...||
  Rat  1445 DKIIVDNITAHTHNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDSGL 1509

  Fly   682 ESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHP--GEALAFWSDW 744
            .....||||||...|:|||.....:|||...|:.|||:.|.::.|||.:.:.|  |:.:.|||||
  Rat  1510 SVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDW 1574

  Fly   745 GPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST 809
            |.:|:||||.||||.|.||:.:.:.||.||:||:||..||:.||....||..:.||.:|.:::::
  Rat  1575 GHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGHNRRQVIAS 1639

  Fly   810 H--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADR 872
            .  |.||.|||||||.:||||..|:.|..|:|..|.....|..:.|.|:.|.|.||:|||...:.
  Rat  1640 DLVLHHPHALTLFEDFVYWTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNP 1704

  Fly   873 CQKDRRGLRGGCSHLCLPNKTSRR---CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLR 934
            |..      ..||||||.:..:.|   |.||.|.:|.:|...| ...|:..|::.|.:|......
  Rat  1705 CAS------ASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNC-VRGDQPFLMSVRDNIIFGISL 1762

  Fly   935 DNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVH---SNLV 996
            |.:...||.  :||:..::|...:::.....||||.: ....|::...:||  .|.|.   |.|.
  Rat  1763 DPEVKSNDA--MVPISGIQHGYDVEFDDSEQFIYWVE-NPGEIHRVKTDGS--NRTVFAPLSLLG 1822

  Fly   997 SPVGLALDWITDKLYWTDPSTNRIEVATTNGKMR---TLLIWE----KLYKPRDIVVNPIEGFMF 1054
            |.:||||||::..:|:|.|::..|||.|..|..|   ||:..:    .:..|..|.|:|..|.::
  Rat  1823 SSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRYGKTLIANDGTPLGVGFPVGIAVDPARGKLY 1887

  Fly  1055 WSDWGDD----PMIERANMDGHERVTITSKKLIYPNGL------AIDYEKSKIYFVDGGTKTLEN 1109
            |||.|.|    ..|..|||||      ||.|:::...|      .:|.::.|:|:.......:|.
  Rat  1888 WSDHGTDSGVPAKIASANMDG------TSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIER 1946

  Fly  1110 MNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVF 1174
            .|.||:.|.::::.|.||:||.|....::::|...:.:...:|.:|.:..|:..|...|..:||:
  Rat  1947 GNVDGTERMILVHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGLRVY 2011

  Fly  1175 HRTRRRIFNACDKLNG------GCSHLCLLNPTS-YTCACTVGVQLKEDRHTCSEGP-TQYILFA 1231
            ||.     ||.|..||      .|..:||..|.. ::|||..|.:|..|..:||  | ..:::.:
  Rat  2012 HRR-----NAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCS--PYNSFMVVS 2069

  Fly  1232 HRIDIRQISLDFDHLIDVVLPLPPIS-NAVALDVDRKTGYIYWSDTIENVIMSS-----SPDGLH 1290
            ....:|..||:.....:.::|:.... |.:..|||...|:|||.|...:|..|:     .|||.:
  Rat  2070 MLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPDGSN 2134

  Fly  1291 VQKIV--GDSLENPDGLVVDSIGRTIYWADAGRH--TIEVASLDGSNRHVIAYKDLESPRGLALD 1351
            ...:|  |.......|:.:|.....:|:.:|..:  .|||..::.:.|.|:....::.||.:.:|
  Rat  2135 FTNVVTYGIGANGIRGVALDWAAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVD 2199

  Fly  1352 YEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY 1416
            .:...|||.|:|...|||||.||...|:.:|:..:..|.||::|..:..|||||..|..|.....
  Rat  2200 PKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLDLIARIHL 2264

  Fly  1417 TGNQRKLIM--SSLHHPYALALSDDNIYWTDWKSKALHMTERR--NISAKRDIITNIDGLMDIKI 1477
            .|.:.:::.  |....||.:.:..::|.|.|...|.:....::  |......|...|:.|.|:.|
  Rat  2265 DGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQPGNTDPPVVIRDKINLLRDVTI 2329

  Fly  1478 IYQNQN----QSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIA 1538
            ..::..    .....|.|..:||.|||.|...|...:.:|........|....|....||:|:.:
  Rat  2330 FDEHAQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYS 2394

  Fly  1539 LRSGIGMISLNSGD----FMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIR----RVNLLN 1595
            |.:.:..:..:..|    |.  |:.:.|.  |:.|||..|.|.:||.. .|:.:|    .|:|.:
  Rat  2395 LNNSLRSLHFDPRDHSLPFQ--VISVAGT--AIALDYDRRNNRIFFTQ-KLNSLRGQISYVSLYS 2454

  Fly  1596 LTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHP 1660
            .:.|..::.:::...:|||.|||...:|:||...:.|.....|||  .|.|...:..||::::.|
  Rat  2455 GSSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGS--NRAVIARVSKPRAIVLDP 2517

  Fly  1661 KKAYLFWSDWSSPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFN 1725
            .:.|::|:||.:.|||||:.|.|:.|..|:.:.:.:|.||.:|.....|.||||....|.:....
  Rat  2518 CRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLALDLETDLLYWADASLQKIERSTLT 2582

  Fly  1726 GKRRQTIVPYAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVS 1790
            |..|:.:|..|.|.||||::...|:|||.|.:.:||:.|...|                |:.|::
  Rat  2583 GTNREVVVSTAFHSFGLTVYGQYIYWTDLYTRKIYRANKYDGS----------------DLVAMT 2631

  Fly  1791 --LSRQPKSV------------NHCAQDNGGCTHLCLNRNVDYVCACP 1824
              |..||..:            |.|.|.||||:|:|........|.||
  Rat  2632 TRLPTQPSGISTVVKTQRQQCSNPCDQFNGGCSHICAPGPNGAECQCP 2679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 18/33 (55%)
LDLa 306..340 CDD:238060 16/33 (48%)
LDLa 347..390 CDD:238060 18/42 (43%)
LDLa 397..431 CDD:238060 17/34 (50%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 480..521 CDD:238060 13/40 (33%)
FXa_inhibition 576..604 CDD:464251 14/27 (52%)
LY 634..671 CDD:214531 12/36 (33%)
LY 680..714 CDD:214531 15/33 (45%)
LY 718..760 CDD:214531 22/43 (51%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 18/41 (44%)
LY 806..838 CDD:214531 16/33 (48%)
FXa_inhibition 882..912 CDD:464251 13/32 (41%)
LY 946..985 CDD:214531 8/38 (21%)
NHL <967..1142 CDD:302697 62/194 (32%)
LY 988..1030 CDD:214531 19/44 (43%)
NHL repeat 998..1037 CDD:271333 17/45 (38%)
NHL repeat 1038..1080 CDD:271333 17/45 (38%)
NHL repeat 1084..1119 CDD:271333 9/40 (23%)
FXa_inhibition 1185..1220 CDD:464251 13/41 (32%)
NHL 1260..>1445 CDD:302697 58/195 (30%)
NHL repeat 1260..1296 CDD:271320 14/42 (33%)
LY 1292..1334 CDD:214531 9/45 (20%)
NHL repeat 1302..1337 CDD:271320 8/36 (22%)
NHL repeat 1345..1383 CDD:271320 16/37 (43%)
FXa_inhibition <1499..1525 CDD:464251 6/25 (24%)
LY 1600..1640 CDD:214531 11/39 (28%)
LY 1643..1686 CDD:214531 16/42 (38%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:464251 11/24 (46%)
Lrp2NP_110454.2 LDLa 28..62 CDD:238060
LDLa 67..103 CDD:238060
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
YncE <427..576 CDD:442618
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520
LY 502..547 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567
LY 550..590 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794
LY 775..817 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880
Ldl_recept_b 837..878 CDD:459654
LY 863..903 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924
FXa_inhibition 980..1012 CDD:464251 9/38 (24%)
LDLa 1025..1059 CDD:238060 11/33 (33%)
Ldl_recept_a 1065..1101 CDD:395011 0/35 (0%)
LDLa 1110..1144 CDD:238060 18/33 (55%)
LDLa 1150..1184 CDD:238060 16/33 (48%)
LDLa 1188..1223 CDD:238060 18/42 (43%)
LDLa 1231..1263 CDD:197566 15/31 (48%)
LDLa 1272..1306 CDD:238060 16/33 (48%)
LDLa 1313..1345 CDD:197566 11/37 (30%)
FXa_inhibition 1354..1389 CDD:464251 10/35 (29%)
EGF_CA 1391..1430 CDD:214542 18/40 (45%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521 18/41 (44%)
LY 1502..1544 CDD:214531 18/41 (44%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564 16/41 (39%)
LY 1546..1590 CDD:214531 22/43 (51%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610 24/42 (57%)
LY 1592..1633 CDD:214531 18/40 (45%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655 18/43 (42%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696 15/39 (38%)
FXa_inhibition 1710..1741 CDD:464251 13/30 (43%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833 18/44 (41%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883 15/48 (31%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931 17/52 (33%)
Ldl_recept_b 1884..1929 CDD:459654 16/50 (32%)
LY 1912..1954 CDD:214531 9/41 (22%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973 13/40 (33%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014 9/39 (23%)
YncE 2035..2253 CDD:442618 64/219 (29%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157 14/48 (29%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202 10/43 (23%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246 18/42 (43%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290 11/42 (26%)
FXa_inhibition 2347..2383 CDD:464251 10/35 (29%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478 13/46 (28%)
LY 2460..2501 CDD:214531 13/42 (31%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519 12/41 (29%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563 17/42 (40%)
Ldl_recept_b 2520..2560 CDD:459654 16/39 (41%)
LY 2546..2586 CDD:214531 12/39 (31%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605 15/40 (38%)
LY <2595..2626 CDD:214531 14/46 (30%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647 14/56 (25%)
FXa_inhibition 2656..2693 CDD:464251 11/24 (46%)
LDLa 2700..2732 CDD:197566
LDLa 2742..2776 CDD:238060
LDLa 2783..2818 CDD:238060
LDLa 2822..2855 CDD:197566
LDLa 2864..2897 CDD:197566
LDLa 2907..2939 CDD:197566
LDLa 2950..2986 CDD:197566
LDLa 2995..3029 CDD:238060
LDLa 3034..3065 CDD:197566
LDLa 3077..3111 CDD:238060
FXa_inhibition 3124..3152 CDD:464251
EGF_CA 3154..3193 CDD:214542
LY 3221..3263 CDD:214531
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283
LY 3264..3306 CDD:214531
Ldl_recept_b 3284..3332 CDD:459654
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378
Ldl_recept_b 3335..3376 CDD:459654
LY 3360..3401 CDD:214531
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421
LY 3402..3443 CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462
FXa_inhibition 3471..>3500 CDD:464251
LDLa 3514..3548 CDD:238060
LDLa 3555..3586 CDD:197566
LDLa 3595..3627 CDD:197566
LDLa 3636..3668 CDD:197566
LDLa 3684..3716 CDD:238060
LDLa 3723..3756 CDD:238060
LDLa 3761..3795 CDD:238060
LDLa 3800..3834 CDD:238060
LDLa 3844..3876 CDD:238060
LDLa 3887..3917 CDD:197566
LDLa 3930..3964 CDD:238060
EGF_CA 4009..4049 CDD:214542
LY 4143..4178 CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242
Ldl_recept_b 4199..4240 CDD:459654
LY 4224..4266 CDD:214531
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285
FXa_inhibition 4340..>4358 CDD:464251
SH3-binding. /evidence=ECO:0000255 4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000269|PubMed:22649097 4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000269|PubMed:22649097 4460..4465
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4559..4582
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4617..4660
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.

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