DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and LpR1

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	778	Identity:	304/778 - (39%)
Similarity:	419/778 - (53%)	Gaps:	83/778 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 SNC-QNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHC 261
            |:| ..|:|::|.|   .:|.||.:..|:...         :||.:.|||||.:||.|.|||.||
  Fly   202 SDCADGSDEANELC---MNACPNNEFKCQTVD---------QCIPRSWLCDGSNDCRDKSDEAHC 254

  Fly   262 GARTNCTDDQFECLN--GFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFR 324
            .||| |:.|::.|.:  |.|:|..|:||...||.|.|||.:||: ||..:.|||.:|.||...::
  Fly   255 RART-CSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQ-TCRADEFTCGNGRCIQKRWK 317

  Fly   325 CDGEHDCNDNSDELKCAAVINSCPE-GEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEE 388
            ||.:.||.|.|||.:|..|  .|.. .|..|         .:|.||..|:.||||.||.|.|||.
  Fly   318 CDHDDDCGDGSDEKECPVV--PCDSVAEHTC---------TNGACIAKRWVCDGDPDCSDGSDER 371

  Fly   389 NC---PQKPSLCTSNEYKCADG-TCIPKRWKCDKEQDCDGGEDEN--DCGSLGSEHPLTCGSDEF 447
            :|   .:..:.|.|:||:|.|. ||:...|.||.::||..|:||:  :|.:      :||.:|:|
  Fly   372 SCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKN------VTCRADQF 430

  Fly   448 TCNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLG----------QFLCPTKQNLTNLKICVHQ 502
            .|.:..||.....|:|..|||.|.||.:|.|...||          :|.|...|       ||..
  Fly   431 QCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQ-------CVPL 488

  Fly   503 KHICDGHNECPAGEDE--ADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDI 565
            ..:||...:||.||||  ..|......|:...|...||:...| :.|.|..||.:..:|.||.||
  Fly   489 SKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVG-HHCECHEGYKLSPDKRNCQDI 552

  Fly   566 DECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRS-CKALGGAMTLLVANRWDIRRVTLSNN 629
            :||:  ....|||.|.|.:|.|||.||.||:..|...: |||..|..:||:|.|.|||::.|.:.
  Fly   553 NECE--VPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHM 615

  Fly   630 RYSAIVKGLHNAIALDFHHRKGLMFWSDVST-DVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIH 693
            ..::||.....|.||||..|.|::|||||:| .:.|.....|.....|:.....:..|:|||||:
  Fly   616 EMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIY 680

  Fly   694 DLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGT 758
            :.:::||:....:|::||:|::..|:....||.||:|.:.|.|...:|||||.:|:||||.|||:
  Fly   681 NHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGS 745

  Fly   759 QRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFE 821
            .|..|||..|.||||:.:|....:|||.|.|.:.|..:|.|||.|:::|  ..:|.|||::|.||
  Fly   746 HRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFE 810

  Fly   822 DTMYWTDWNTKTVSAADKITGKEFR---AVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGG 883
            |.:|||||:.:.|..|:|.||::..   |:|...| ||.:|.|||.|||:..:.||    .:.|.
  Fly   811 DNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQH-PMVVHVYHPYRQPDGVNHCQ----SVNGH 870

  Fly   884 CSHLCLP----NKTSRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADP 940
            |||||||    |:.|.|  |.||.||.|..||..|  ..|.|.|....:..|.|..:.....|
  Fly   871 CSHLCLPAPRINERSPRISCACPTGLKLMVDGLMC--VEDPLYLPPVTRPPRARKTKPRPKSP 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	15/35 (43%)
		LDLa	306..340	CDD:238060	15/33 (45%)
		LDLa	347..390	CDD:238060	17/43 (40%)
		LDLa	397..431	CDD:238060	16/36 (44%)
		LDLa	442..476	CDD:238060	14/33 (42%)
		LDLa	480..521	CDD:238060	15/52 (29%)
		FXa_inhibition	576..604	CDD:291342	14/28 (50%)
		LY	634..671	CDD:214531	16/37 (43%)
		NHL	<656..793	CDD:302697	55/137 (40%)
		LY	680..714	CDD:214531	11/33 (33%)
		NHL repeat	681..722	CDD:271320	13/40 (33%)
		NHL repeat	726..760	CDD:271320	18/33 (55%)
		LY	761..803	CDD:214531	19/41 (46%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	19/35 (54%)
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566	3/7 (43%)
		LDLa	219..254	CDD:238060	16/43 (37%)
		LDLa	259..295	CDD:238060	15/35 (43%)
		LDLa	343..373	CDD:238060	16/38 (42%)
		LDLa	383..415	CDD:197566	14/31 (45%)
		Ldl_recept_a	423..459	CDD:278486	15/35 (43%)
		LDLa	476..504	CDD:197566	11/34 (32%)
		FXa_inhibition	514..549	CDD:291342	10/35 (29%)
		EGF_CA	551..581	CDD:214542	16/31 (52%)
		LY	662..702	CDD:214531	13/39 (33%)
		LY	704..747	CDD:214531	21/42 (50%)
		LY	749..790	CDD:214531	19/40 (48%)
		FXa_inhibition	864..905	CDD:291342	21/44 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940