DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Vldlr

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_037287.2 Gene:Vldlr / 25696 RGDID:3963 Length:873 Species:Rattus norvegicus


Alignment Length:920 Identity:284/920 - (30%)
Similarity:415/920 - (45%) Gaps:193/920 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 RCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDET--H 300
            |||:..|.||||:||.|.|||.:|..:| |.:..|.|.||.|:|..|.|||:.||:|.|||:  .
  Rat    44 RCITLLWKCDGDEDCTDGSDEKNCVKKT-CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQ 107

  Fly   301 CNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGG 363
            |:..||.....:|  ....||..::|||||:||::..||..|..:  :|...||.|         
  Rat   108 CHMRTCRINEISCGARSTQCIPESWRCDGENDCDNGEDEENCGNI--TCSADEFTC--------- 161

  Fly   364 PSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDE 428
            .||:|:...|.|:|.:||.|.|||.:|  .|..|.::|::|:..:|||..|.||.:.||....||
  Rat   162 SSGRCVSRNFVCNGQDDCDDGSDELDC--APPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224

  Fly   429 N--DCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQ-CDLGQFLCPTK 490
            :  .||.....| ..|.:.|..|.:|.||.|.|.|||.|||..|.|||.|..: |...||.|...
  Rat   225 SLEQCGRQPVIH-TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG 288

  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSP----------------------- 532
            .       |:|....|:|..:|..|.||.:|....:|..|..                       
  Rat   289 S-------CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDITKVCDQEQDCRD 346

  Fly   533 --------------------CEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSP-VC 576
                                |..:|.:...| .||.|..|:.:...| .|.||||||   :| :|
  Rat   347 WSDEPLKECHINECLVNNGGCSHICKDLVIG-YECDCAAGFELIDRK-TCGDIDECQ---NPGIC 406

  Fly   577 SQKCHNTMGSFKCSCETGYILRPDLRS--CKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLH 639
            ||.|.|..|.:||.|..||  :.||.:  |||:|...:|:..||.|||::.|....|..:|:.|.
  Rat   407 SQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469

  Fly   640 NAIALDFHHRKGLMFWSDVSTDVI-------------KMVYMNGTRVRDVIKWGLESPGGIAVDW 691
            |.:|||.......:||:|:|...|             ||:.            .:.:|..|||||
  Rat   470 NTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMID------------NVYNPAAIAVDW 522

  Fly   692 IHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMD 756
            ::..::|||:.::.:.|:...|..|..:.:.||.:|.:|.|.|.....:|||||...|||:|.|:
  Rat   523 VYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587

  Fly   757 GTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST--HLPHPFALTL 819
            |..|:.::::.:.||||:.:|...|::||.|:|.|.:...:|:|.||..:|.:  .|.||.|||:
  Rat   588 GFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652

  Fly   820 FEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGC 884
            |||.:||.|...:.|..|:|.||.|...:..|.:...||..||...||...:.|::|..  .|||
  Rat   653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIIYHELVQPSGKNWCEEDME--NGGC 715

  Fly   885 SHLCLP----NKTSRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRH-LRDNQADPND 942
            .:||||    |..|.:  |.||.|.:|:|:|:.|:||:.. |..:..||:.... ||.:...|..
  Rat   716 EYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTP-VTYSETKDVNTTDILRTSGLVPGG 779

  Fly   943 VDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWIT 1007
            :::...:..:.                                          |.|.|.:..|  
  Rat   780 INVTTAVSEVS------------------------------------------VPPKGTSAAW-- 800

  Fly  1008 DKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGH 1072
                                .:..||:         :|:..:.|::.|.:|....| :..|.|..
  Rat   801 --------------------AILPLLL---------LVMAAVGGYLMWRNWQHKNM-KSMNFDNP 835

  Fly  1073 ERVTITSKKL 1082
            ..:..|.:.|
  Rat   836 VYLKTTEEDL 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/35 (49%)
LDLa 306..340 CDD:238060 13/35 (37%)
LDLa 347..390 CDD:238060 16/42 (38%)
LDLa 397..431 CDD:238060 13/35 (37%)
LDLa 442..476 CDD:238060 18/33 (55%)
LDLa 480..521 CDD:238060 12/40 (30%)
FXa_inhibition 576..604 CDD:291342 13/29 (45%)
LY 634..671 CDD:214531 13/49 (27%)
NHL <656..793 CDD:302697 46/149 (31%)
LY 680..714 CDD:214531 10/33 (30%)
NHL repeat 681..722 CDD:271320 12/40 (30%)
NHL repeat 726..760 CDD:271320 15/33 (45%)
LY 761..803 CDD:214531 13/41 (32%)
NHL repeat 769..793 CDD:271320 11/23 (48%)
FXa_inhibition 882..912 CDD:291342 16/35 (46%)
LY 946..985 CDD:214531 0/38 (0%)
NHL <967..1142 CDD:302697 15/116 (13%)
LY 988..1030 CDD:214531 4/41 (10%)
NHL repeat 998..1037 CDD:271320 5/38 (13%)
NHL repeat 1038..1080 CDD:271320 8/41 (20%)
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
VldlrNP_037287.2 LDLa 33..67 CDD:238060 14/22 (64%)
LDLa 71..103 CDD:197566 16/32 (50%)
Ldl_recept_a 111..149 CDD:395011 14/37 (38%)
Ldl_recept_a 153..188 CDD:395011 16/43 (37%)
LDLa 192..224 CDD:197566 11/31 (35%)
Ldl_recept_a 237..273 CDD:395011 18/35 (51%)
Ldl_recept_a 276..312 CDD:395011 12/42 (29%)
Ldl_recept_a 320..350 CDD:395011 1/29 (3%)
FXa_inhibition 360..394 CDD:405372 8/35 (23%)
EGF_CA 396..426 CDD:214542 18/34 (53%)
LDL-receptor class B 1 439..480 14/40 (35%)
LY 461..499 CDD:214531 12/37 (32%)
LDL-receptor class B 2 481..524 13/54 (24%)
Ldl_recept_b 481..521 CDD:395012 10/51 (20%)
LY 508..547 CDD:214531 12/50 (24%)
LDL-receptor class B 3 525..567 12/41 (29%)
LDL-receptor class B 4 568..611 17/42 (40%)
Ldl_recept_b 568..608 CDD:395012 16/39 (41%)
LY 592..634 CDD:214531 13/41 (32%)
LDL-receptor class B 5 612..654 17/41 (41%)
LDL-receptor class B 6 655..697 15/41 (37%)
Ldl_recept_b 655..694 CDD:395012 13/38 (34%)
FXa_inhibition 706..749 CDD:405372 18/44 (41%)
Clustered O-linked oligosaccharides 751..790 8/39 (21%)
Endocytosis signal. /evidence=ECO:0000255 832..837 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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