DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Sspo

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_017177063.1 Gene:Sspo / 243369 MGIID:2674311 Length:5197 Species:Mus musculus


Alignment Length:2004 Identity:380/2004 - (18%)
Similarity:572/2004 - (28%) Gaps:827/2004 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   220 LQRDCEKTGIHVMCPRTFRCISKYWLCD-GDDDCGDYSDETHCG-ARTNCTDDQFECLNGFCIPR 282
            ||:||..      |    .|....|.|| |...|.|.  |..|. ..|.|.:      ||.|:|.
Mouse  1386 LQKDCGN------C----TCQGSQWHCDRGGAPCEDM--EPGCAEGETLCRE------NGHCVPL 1432

  Fly   283 TWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSC 347
            .|:||.::||.|.|||..|..:.|.:...:|..|:|:.|:..|||:.||.|.:||..|.     |
Mouse  1433 EWLCDNQDDCGDGSDEEGCATSVCGEGQMSCQSGHCLPLSLICDGQDDCGDGTDEQGCL-----C 1492

  Fly   348 PEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPK 412
            |.|...|         ..|:|:.....|:|..||.|.:|||:| ..|..|.|.|..|.||||:..
Mouse  1493 PHGSLAC---------ADGRCLPPALLCNGHPDCLDAADEESC-LGPVSCISGEVSCVDGTCVRT 1547

  Fly   413 RWKCDKEQDCDGGEDE--NDC---------GSLGSEHPLT------------------CGSDEFT 448
            ...||...||..|.||  :.|         |.:| ::|.|                  |...||.
Mouse  1548 IQLCDGVWDCPDGADEGPSHCSLPSLPTPPGGIG-QNPSTSSLDTAPSPVGSTSPASPCSLLEFQ 1611

  Fly   449 CNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECP 513
            ||:|.|..:.|.||...||..|.||::|...|.|.|..|....:      ||....:|||..:||
Mouse  1612 CNSGECTPRGWRCDQEEDCTDGSDELDCGGPCMLYQVPCAHSPH------CVSPGQLCDGVTQCP 1670

  Fly   514 AGEDEADCPKERKCSEPSPCEQLCIETTAGSN-------ECACRLGYVMDKNKVNCTDIDECQYL 571
            .|.||          :|..||:.  ..:.|:|       |.:|..|..:|...| |....:|:..
Mouse  1671 DGSDE----------DPDVCEEQ--SASGGANRTGAPCPEFSCPDGTCIDFLLV-CDGNPDCELA 1722

  Fly   572 --TSPVCSQKCHNTMGSF----KCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNR 630
              |.|...::.....||:    .||...|...|...|:|.                         
Mouse  1723 DETEPSLDEQGCGAWGSWGPWAPCSQTCGSGTRSRNRNCS------------------------- 1762

  Fly   631 YSAIVKGLHNAIALDFHHRKGLMF---------WSDVSTDVIKMVYMNGTRVRDVIKWGLESP-- 684
             ::.::.|.|...|  .|:....|         ||                     .|...||  
Mouse  1763 -TSSLQVLQNCPGL--QHQSQACFTEACPVDGEWS---------------------SWSPWSPCS 1803

  Fly   685 ---GGIAVDWIH-------------DLLFWTDSGTRRVEVSNFQGNLRTVI-------------- 719
               ||....  |             .||..:...||:......:|.|....              
Mouse  1804 EPCGGTTTR--HRQCRPPQNGGQDCALLPGSTHSTRQTSPCPQEGCLNATCFGELVFRTCAPCPL 1866

  Fly   720 --------ASYDLDKPRAIVVHPGEALAFWSDWGPNPKI---ERAYMDGTQRKVIISKGVTWPNG 773
                    |:...|:|.:   .||       .|.|:.|:   |...:...|...::.....|| |
Mouse  1867 TCDDISGQAACPPDRPCS---SPG-------CWCPDGKVLNTEGQCVRPRQCPCLVDGAHYWP-G 1920

  Fly   774 LAIDFPNSKIYWADAKQH--------AIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDW- 829
            ..|.......:..|.:.|        |::|.....|            |:|..|...:.....| 
Mouse  1921 QRIKMDCQLCFCQDGQPHRCRPNPECAVDCGWSSWS------------PWAECLGPCSSQSLQWS 1973

  Fly   830 ----NTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQK------DRRGL---- 880
                |...:|.    .|::.|.:|..                  |.|||.      ::.||    
Mouse  1974 FRSPNNPRLSG----HGRQCRGIHRK------------------ARRCQTEACEGCEQWGLMYNV 2016

  Fly   881 ----RGG-------------------------------------CSHLCLPNK------------ 892
                |||                                     |.|..||.|            
Mouse  2017 GERWRGGPCMVCECLHSSITHCSPYCPIGSCPQGWVLVEGMGESCCHCALPEKNQTVIHMTTPAP 2081

  Fly   893 ---------------------TSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDN 936
                                 |:..|..|:||:             .|.:.|..:  ...|:  .
Mouse  2082 APASAPSPQIGAHLVTYVLPPTADACYSPLGLA-------------GLPMWAPSQ--HWEHI--T 2129

  Fly   937 QADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGL 1001
            :|||.:..|..|  ..:...:.:|.:...::. .|:.|    ..:|.|...|| ..|:......|
Mouse  2130 RADPVEAPMAGP--GPREGASAEWHTQPLYLQ-LDLRR----PRNLTGIIVQR-AGSSAAYVSTL 2186

  Fly  1002 ALDWITDKLYW----------------TDPSTNR----------------IEVATTNGKMR---- 1030
            :|.:.:|.|.|                :..|:|.                |.|...:|.:|    
Mouse  2187 SLQFSSDNLQWHNYVNSLSSTLSPPKPSPESSNHMAPEVWTFDQMVQARYIRVWPHSGHLRDNNQ 2251

  Fly  1031 -TLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMI----------ERANMDGHERVTITSKKLIY 1084
             .:.:|.:|...:...|:|:.           |:.          |.|...|             
Mouse  2252 HDIFLWVELLGCKPGTVSPLA-----------PLCPGSRHRCASGECAPKGG------------- 2292

  Fly  1085 PNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLG----------HPF----------- 1128
            |...|:|.:                   |||..:    |.|          ||.           
Mouse  2293 PCDGAVDCD-------------------DGSDEE----GCGSLHASTTSRVHPMTRTPALSPTQP 2334

  Fly  1129 GLDVNEGRVFWTDWDTKSVMSANKL--TGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGG 1191
            |....||   ..|.:.:.....:.|  .|:....:.|.||              .......|:.|
Mouse  2335 GKFPREG---LPDTEPQQPKQESSLPGAGQPMQTLSATST--------------FPPGAKSLHPG 2382

  Fly  1192 CSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQISLDFDHLIDVVLPLPPI 1256
            .:.:.:..|.|.|....||       .|.|..|..                         |:|..
Mouse  2383 MAAVTVHPPHSVTPGAPVG-------QTVSPRPFP-------------------------PMPCG 2415

  Fly  1257 SNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGR 1321
            ...|..||            :..|......||..      |.|:..|         ..:.|.|..
Mouse  2416 PGQVPCDV------------LGCVEQEQLCDGRE------DCLDGSD---------EQHCASAEP 2453

  Fly  1322 HTIEVASLDG--SNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTA 1384
            .|:...:|.|  :::.:.:...|....|..|.:|          |...::.:..||::....|..
Mouse  2454 FTVPTTALPGLPASKALCSPSQLRCGSGECLPFE----------HRCDLQVNCQDGSDEDNCVDC 2508

  Fly  1385 NL----GWPN-----GLSLDLKSKRIYWVDARLKTI-DSC--DYTGNQRKLIMSSLHHPYALALS 1437
            .|    ||.:     ||.|..:.:.:    .||... .||  |...:|...:.:.   |.|.|.:
Mouse  2509 VLAPWSGWSDCSRSCGLGLIFQHREL----LRLPLPGGSCLLDQFRSQSCFVQAC---PVAGAWA 2566

  Fly  1438 DDNIYWTDWKSKAL-----HMTERRNI--------------SAKRDIITNID---GLMDIK--II 1478
            :    |..|.:.::     |.:.:|:.              .:......|:.   |..|.:  ::
Mouse  2567 E----WGPWTACSVSCGGGHQSRQRSCVDPPPKNGGAPCPGPSHEKAPCNLQLCPGDTDCEPGLV 2627

  Fly  1479 YQNQN--QSTMKNACGNN------NGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYL 1535
            :.|..  |..:...|..:      |.:||..|:.     .|:||.||.|:.   :.|..|.|...
Mouse  2628 HVNAELCQKGLVPPCPPSCLDPEANRSCSGHCME-----GCRCPPGLLLQD---SHCLPLSECPC 2684

  Fly  1536 LIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESK 1600
            |:..:               ::.|                .|.|..|            |.::..
Mouse  2685 LVGQK---------------LIQP----------------RLAFLLD------------NCSQCI 2706

  Fly  1601 VIVGTDVLTPNGI--AVDWIADNLYWS--------------------------------DTDRKL 1631
            ...||.:..|...  :..|.|    ||                                :.||:.
Mouse  2707 CEKGTLLCKPGACSQSCGWSA----WSPWTACDRSCGSGVRARFRSPTNPPVAFGGSPCEGDRQE 2767

  Fly  1632 IEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSS-----------PAKIERSYLDGSN 1685
            ::....|  |...|                ..:..|:.|||           |...:||.|..|:
Mouse  2768 LQACYTD--CGTEI----------------PGWTPWTSWSSCSQSCLVPGGDPGWRQRSRLCPSS 2814

  Fly  1686 RTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLFENSIF 1750
            |.....                            |:..........:.| .|..:||        
Mouse  2815 RDTFCP----------------------------GEATQEEPCSPPVCP-VPSAWGL-------- 2842

  Fly  1751 WTDWYNKSV-------YRSQKLARSGYGNPF------EVRDALSGALDIRAVSLSRQP------- 1795
            |..|...|.       .|.:..:.|..|||.      :.||.            :..|       
Mouse  2843 WASWSTCSASCNGGIQTRGRSCSGSAPGNPVCLGPHTQTRDC------------NMHPCTAQCPG 2895

  Fly  1796 ----KSVNHCAQDNGGCTHLCLNRNVDYVC--ACPDVMDPKDVACSIKPKVLVH 1843
                :|...|.::.|.|..|||.::....|  :|..       :|:..|.:.:|
Mouse  2896 NMVFRSAEQCLEEGGPCPQLCLAQDPGVECTGSCAP-------SCNCPPGLFLH 2942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 14/33 (42%)
LDLa 306..340 CDD:238060 13/33 (39%)
LDLa 347..390 CDD:238060 14/42 (33%)
LDLa 397..431 CDD:238060 15/35 (43%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060 14/40 (35%)
FXa_inhibition 576..604 CDD:291342 7/31 (23%)
LY 634..671 CDD:214531 7/45 (16%)
NHL <656..793 CDD:302697 29/187 (16%)
LY 680..714 CDD:214531 9/51 (18%)
NHL repeat 681..722 CDD:271320 12/80 (15%)
NHL repeat 726..760 CDD:271320 7/36 (19%)
LY 761..803 CDD:214531 9/49 (18%)
NHL repeat 769..793 CDD:271320 6/31 (19%)
FXa_inhibition 882..912 CDD:291342 12/99 (12%)
LY 946..985 CDD:214531 5/38 (13%)
NHL <967..1142 CDD:302697 39/242 (16%)
LY 988..1030 CDD:214531 13/73 (18%)
NHL repeat 998..1037 CDD:271320 12/75 (16%)
NHL repeat 1038..1080 CDD:271320 7/51 (14%)
NHL repeat 1084..1119 CDD:271320 6/34 (18%)
FXa_inhibition 1185..1220 CDD:291342 7/34 (21%)
NHL 1260..>1445 CDD:302697 38/198 (19%)
NHL repeat 1260..1296 CDD:271320 6/35 (17%)
NHL repeat 1302..1337 CDD:271320 6/36 (17%)
NHL repeat 1345..1383 CDD:271320 6/37 (16%)
FXa_inhibition <1499..1525 CDD:291342 8/25 (32%)
LY 1600..1640 CDD:214531 10/73 (14%)
LY 1643..1686 CDD:214531 10/53 (19%)
LY 1688..1729 CDD:214531 1/40 (3%)
FXa_inhibition 1801..>1825 CDD:291342 8/25 (32%)
SspoXP_017177063.1 VWD 229..378 CDD:214566
C8 434..505 CDD:370094
TIL 509..564 CDD:366828
VWD 593..753 CDD:214566
C8 791..863 CDD:214843
TIL 866..919 CDD:366828
VWD 1054..1201 CDD:365869
C8 1245..1311 CDD:370094
TIL 1315..1371 CDD:366828
LDLa 1416..1451 CDD:238060 16/40 (40%)
LDLa 1456..1490 CDD:238060 13/33 (39%)
LDLa 1492..1526 CDD:238060 14/42 (33%)
LDLa 1532..1563 CDD:197566 13/30 (43%)
Ldl_recept_a 1603..1639 CDD:365841 15/35 (43%)
TSP1 1737..1788 CDD:214559 13/78 (17%)
TIL 1857..1908 CDD:366828 9/60 (15%)
TSP1 1952..2005 CDD:214559 14/86 (16%)
FA58C <2142..2262 CDD:330301 21/125 (17%)
LDLa 2275..2309 CDD:238060 9/69 (13%)
LDLa 2414..2448 CDD:238060 9/60 (15%)
LDLa 2471..2505 CDD:238060 7/43 (16%)
TSP1 2565..2617 CDD:214559 5/55 (9%)
TIL 2640..2682 CDD:366828 13/49 (27%)
TSP1 2725..2774 CDD:214559 6/52 (12%)
TSP_1 2841..2889 CDD:365867 12/67 (18%)
TIL 2893..2952 CDD:366828 12/57 (21%)
VWC_out 2954..3001 CDD:214565
TSP1 2994..3045 CDD:214559
TIL 3097..3149 CDD:366828
TSP1 3193..3256 CDD:214559
TSP1 3262..3314 CDD:214559
TIL 3322..3372 CDD:366828
TSP1 3418..>3458 CDD:214559
TSP1 3482..3526 CDD:214559
TIL 3536..3592 CDD:366828
TSP1 3655..3699 CDD:214559
TSP1 3832..3884 CDD:214559
TSP1 3901..3949 CDD:214559
TSP1 3967..4020 CDD:214559
TSP1 4025..4077 CDD:214559
TIL 4080..4135 CDD:366828
TSP1 4180..4230 CDD:214559
TSP1 4274..4325 CDD:214559
TSP1 4389..4440 CDD:214559
TIL 4444..4499 CDD:366828
TSP1 4639..4687 CDD:214559
TIL 4701..4747 CDD:366828
TSP1 4791..4840 CDD:214559
TIL 4842..4896 CDD:366828
TIL 4948..5006 CDD:366828
VWC 5008..5063 CDD:327433
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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