DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and Lrp12

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_006520965.1	Gene:	Lrp12 / 239393	MGIID:	2443132	Length:	859	Species:	Mus musculus

Alignment Length:	507	Identity:	120/507 - (23%)
Similarity:	172/507 - (33%)	Gaps:	202/507 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GRTEIAGIRETDRISS------------RGRDGFI---GGPSNKQKPFRVNLAVLVQDDPSQ--- 192
            |...:|.:.|...||.            |...|.|   |.||:  .|.:||.:.|::.:|.:
Mouse    27 GNGALAELSENVHISGVSTACGESPEQIRAPSGIITSPGWPSD--YPAQVNCSWLIRANPGEIIT 89

  Fly   193 --------PG-----------ETYSNCQNSNESDENCNP--------------EEDAV------- 217
                    .|           |||.|.::.........|              .:|:|
Mouse    90 ISFQDFDIQGSRRCTLDWLTIETYKNIESYRACGSTIPPPYISSQDHVWIRFHSDDSVSRKGFRL 154

  Fly   218 ------PNLQRDCEKTGIHVMCPRTFR-----CISKYWLCDGDDDCGDYSDETHCGARTN----- 266
                  .:.|.||       .|.: ||     ||.:.|.|:..|:|||.|||..|.:..:
Mouse   155 AYFSAGKSEQPDC-------ACDQ-FRCGNGKCIPEAWKCNSMDECGDSSDEEVCASDAHPPTTT 211

  Fly   267 ----CTDDQFECLNGF-----CIPRTWVCDGENDCKDFSDETHCNRTTCTD--EHF--TCN---- 314
                |..:||:||:.|     |:|.:..|||..||.|..||..|:..||..  ::|  |.|
Mouse   212 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDMPTCGQWLKYFYGTFNSPNY 276

  Fly   315 -DGY-----CISLA--------------FRCDGE------------------------------- 328
             |.|     |..|.              |:.||.
Mouse   277 PDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPRKLLRVLTAFDSHAP 341

  Fly   329 ------------HDCNDNSDELKCAAVINS-------CPEGEFKCRGGLGGAGGPSGQCILNRFR 374
                        |.|   :|::..|...|:       |...|..|.|..|        |...:.|
Mouse   342 LTVVSSSGQIRVHFC---ADKVNAARGFNATYQVDGFCLPWEIPCGGNWG--------CYTEQQR 395

  Fly   375 CDGDNDCGDWSDEENCPQKPSLCTSNEYKCA-DGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEH 438
            |||...|.:..||.||    ::|...|:.|: :|.|.|:..:|:.:..|..|.||.:|
Mouse   396 CDGYWHCPNGRDEINC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC------- 449

  Fly   439 PLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTK 490
             ..|....|.|.|.||:.::|:||...||..|.||..|.:       :.||:
Mouse   450 -FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV-------IVPTR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	16/38 (42%)
		LDLa	306..340	CDD:238060	14/104 (13%)
		LDLa	347..390	CDD:238060	13/42 (31%)
		LDLa	397..431	CDD:238060	11/34 (32%)
		LDLa	442..476	CDD:238060	14/33 (42%)
		LDLa	480..521	CDD:238060	2/11 (18%)
		FXa_inhibition	576..604	CDD:291342
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Lrp12	XP_006520965.1	CUB	47..156	CDD:366096	19/110 (17%)
		LDLa	167..201	CDD:238060	15/41 (37%)
		LDLa	216..255	CDD:238060	16/38 (42%)
		CUB	268..372	CDD:238001	14/106 (13%)
		LDLa	376..411	CDD:238060	13/42 (31%)
		LDLa	414..449	CDD:238060	11/34 (32%)
		LDLa	452..486	CDD:238060	14/33 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900