DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Vldlr

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_038731.2 Gene:Vldlr / 22359 MGIID:98935 Length:873 Species:Mus musculus


Alignment Length:920 Identity:285/920 - (30%)
Similarity:415/920 - (45%) Gaps:193/920 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 RCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDET--H 300
            |||:..|.||||:||.|.|||.:|..:| |.:..|.|.||.|:|..|.|||:.||:|.|||:  .
Mouse    44 RCITLLWKCDGDEDCADGSDEKNCVKKT-CAESDFVCKNGQCVPNRWQCDGDPDCEDGSDESPEQ 107

  Fly   301 CNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGG 363
            |:..||.....:|  ....||.:::|||||:||::..||..|..:  :|...||.|         
Mouse   108 CHMRTCRINEISCGARSTQCIPVSWRCDGENDCDNGEDEENCGNI--TCSADEFTC--------- 161

  Fly   364 PSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDE 428
            .||:|:...|.|:|.:||.|.|||.:|  .|..|.::|::|:..:|||..|.||.:.||....||
Mouse   162 SSGRCVSRNFVCNGQDDCDDGSDELDC--APPTCGAHEFQCSTSSCIPLSWVCDDDADCSDQSDE 224

  Fly   429 N--DCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQ-CDLGQFLCPTK 490
            :  .||.....| ..|.:.|..|.:|.||.|.|.|||.|||..|.|||.|..: |...||.|...
Mouse   225 SLEQCGRQPVIH-TKCPTSEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG 288

  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSEPSP----------------------- 532
            .       |:|....|:|..:|..|.||.:|....:|..|..                       
Mouse   289 S-------CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDMSKVCDQEQDCRD 346

  Fly   533 --------------------CEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSP-VC 576
                                |..:|.:...| .||.|..|:.:...| .|.||||||   :| :|
Mouse   347 WSDEPLKECHINECLVNNGGCSHICKDLVIG-YECDCAAGFELIDRK-TCGDIDECQ---NPGIC 406

  Fly   577 SQKCHNTMGSFKCSCETGYILRPDLRS--CKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLH 639
            ||.|.|..|.:||.|..||  :.||.:  |||:|...:|:..||.|||::.|....|..:|:.|.
Mouse   407 SQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469

  Fly   640 NAIALDFHHRKGLMFWSDVSTDVI-------------KMVYMNGTRVRDVIKWGLESPGGIAVDW 691
            |.:|||.......:||:|:|...|             ||:.            .:.:|..|||||
Mouse   470 NTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHFKMID------------NVYNPAAIAVDW 522

  Fly   692 IHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMD 756
            ::..::|||:.::.:.|:...|..|..:.:.||.:|.:|.|.|.....:|||||...|||:|.|:
Mouse   523 VYKTIYWTDAASKTISVATLDGAKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMN 587

  Fly   757 GTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST--HLPHPFALTL 819
            |..|:.::::.:.||||:.:|...|::||.|:|.|.:...:|:|.||..:|.:  .|.||.|||:
Mouse   588 GFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652

  Fly   820 FEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGC 884
            |||.:||.|...:.|..|:|.||.|...:..|.:...||..||...||...:.|:.|..  .|||
Mouse   653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEDDME--NGGC 715

  Fly   885 SHLCLP----NKTSRR--CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRH-LRDNQADPND 942
            .:||||    |..|.:  |.||.|.:|:|:|:.|:||:.. |..:..|||.... ||.:...|..
Mouse   716 EYLCLPAPQINDHSPKYTCSCPNGYNLEENGRECQSTSTP-VTYSETKDINTTDILRTSGLVPGG 779

  Fly   943 VDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWIT 1007
            :::...:..:.                                          |.|.|.:..|  
Mouse   780 INVTTAVSEVS------------------------------------------VPPKGTSAAW-- 800

  Fly  1008 DKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGH 1072
                                .:..||:         :|:..:.|::.|.:|....| :..|.|..
Mouse   801 --------------------AILPLLL---------LVMAAVGGYLMWRNWQHKNM-KSMNFDNP 835

  Fly  1073 ERVTITSKKL 1082
            ..:..|.:.|
Mouse   836 VYLKTTEEDL 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/35 (49%)
LDLa 306..340 CDD:238060 13/35 (37%)
LDLa 347..390 CDD:238060 16/42 (38%)
LDLa 397..431 CDD:238060 13/35 (37%)
LDLa 442..476 CDD:238060 18/33 (55%)
LDLa 480..521 CDD:238060 12/40 (30%)
FXa_inhibition 576..604 CDD:464251 13/29 (45%)
LY 634..671 CDD:214531 13/49 (27%)
LY 680..714 CDD:214531 10/33 (30%)
LY 718..760 CDD:214531 17/41 (41%)
Ldl_recept_b 740..777 CDD:459654 16/36 (44%)
LY 761..803 CDD:214531 13/41 (32%)
LY 806..838 CDD:214531 14/33 (42%)
FXa_inhibition 882..912 CDD:464251 16/35 (46%)
LY 946..985 CDD:214531 0/38 (0%)
NHL <967..1142 CDD:302697 15/116 (13%)
LY 988..1030 CDD:214531 4/41 (10%)
NHL repeat 998..1037 CDD:271333 5/38 (13%)
NHL repeat 1038..1080 CDD:271333 8/41 (20%)
NHL repeat 1084..1119 CDD:271333
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
VldlrNP_038731.2 LDLa 33..67 CDD:238060 14/22 (64%)
LDLa 71..103 CDD:197566 16/32 (50%)
Ldl_recept_a 111..149 CDD:395011 14/37 (38%)
Ldl_recept_a 153..188 CDD:395011 16/43 (37%)
Ldl_recept_a 192..224 CDD:395011 11/31 (35%)
Ldl_recept_a 237..273 CDD:395011 18/35 (51%)
Ldl_recept_a 276..312 CDD:395011 12/42 (29%)
Ldl_recept_a 320..350 CDD:395011 1/29 (3%)
FXa_inhibition 360..394 CDD:464251 8/35 (23%)
EGF_CA 396..426 CDD:214542 18/34 (53%)
LDL-receptor class B 1 439..480 14/40 (35%)
LDL-receptor class B 2 481..524 13/54 (24%)
Ldl_recept_b 481..522 CDD:459654 11/52 (21%)
LDL-receptor class B 3 525..567 12/41 (29%)
Ldl_recept_b 527..565 CDD:459654 11/37 (30%)
LDL-receptor class B 4 568..611 17/42 (40%)
Ldl_recept_b 568..608 CDD:459654 16/39 (41%)
LY 592..634 CDD:214531 13/41 (32%)
LDL-receptor class B 5 612..654 17/41 (41%)
LDL-receptor class B 6 655..697 15/41 (37%)
Ldl_recept_b 655..695 CDD:459654 13/39 (33%)
FXa_inhibition 706..749 CDD:464251 18/44 (41%)
Clustered O-linked oligosaccharides 751..790 9/39 (23%)
Endocytosis signal. /evidence=ECO:0000255 832..837 1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

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