DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and EGF

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_016863334.1	Gene:	EGF / 1950	HGNCID:	3229	Length:	1223	Species:	Homo sapiens

Alignment Length:	1469	Identity:	308/1469 - (20%)
Similarity:	521/1469 - (35%)	Gaps:	474/1469 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 SCETGYILRPDLRSCKAL------GGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHH 648
            ||..|.:......:|...      |.|..|:.::...|.|:......|..:|.....::.:|||:
Human    27 SCPEGTLAGNGNSTCVVWSLSSHPGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGVSVIMDFHY 91

  Fly   649 RKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLE-SPGGIAVDWIHDLLFWTDSGTRRVEVSNFQ 712
            .:..::|.|:...:::.|::||:|...|.  .:| :..|:|::||::.:.|::.....:.|::.:
Human    92 NEKRIYWVDLERQLLQRVFLNGSRQERVC--NIEKNVSGMAINWINEEVIWSNQQEGIITVTDMK 154

  Fly   713 GNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVII--SKGVTWPNGLA 775
            ||...::.| .|..|..:.|.|.|...|||..... .:.||.:||...|.::  |:.:|   .::
Human   155 GNNSHILLS-ALKYPANVAVDPVERFIFWSSEVAG-SLYRADLDGVGVKALLETSEKIT---AVS 214

  Fly   776 IDFPNSKIYWADAKQ---HAIECS-NLDGSDRNKILSTHL-PHP-----FALTLFEDTMYWTDWN 830
            :|..:.:::|....:   :::.|| :.||.      |.|: .||     ||::||.|.::::.|.
Human   215 LDVLDKRLFWIQYNREGSNSLICSCDYDGG------SVHISKHPTQHNLFAMSLFGDRIFYSTWK 273

  Fly   831 TKTVSAADKITGKEFRAV--HENFHFPM-DIHAYHPARQPEYADRCQKDRRGL----RGGCSH-L 887
            .||:..|:|.|||:...:  |.:| .|: ::...||..||:..|...:..:.|    :|.||. :
Human   274 MKTIWIANKHTGKDMVRINLHSSF-VPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTV 337

  Fly   888 CLPNKTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNL 952
            |..:..|..|.|..|.:|..|.|.|:                         |.|:
Human   338 CGQDLQSHLCMCAEGYALSRDRKYCE-------------------------DVNE---------- 367

  Fly   953 KHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPST 1017
                    |:     :|.  ...|:...:..|||.       ...|||..|
Human   368 --------CA-----FWN--HGCTLGCKNTPGSYY-------CTCPVGFVL-------------- 396

  Fly  1018 NRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKL 1082
                  ..:||....|:    ..||::                       :...|:.|..:...|
Human   397 ------LPDGKRCHQLV----SCPRNV-----------------------SECSHDCVLTSEGPL 428

  Fly  1083 IY-PNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKS 1146
            .: |.|..::.        ||.|                .:|...|.
Human   429 CFCPEGSVLER--------DGKT----------------CSGCSSPD------------------ 451

  Fly  1147 VMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCL-LNPTSYTCACTVG 1210
                                                      |||||.||: |:|.|:.|.|..|
Human   452 ------------------------------------------NGGCSQLCVPLSPVSWECDCFPG 474

  Fly  1211 VQLKEDRHTC-SEGPTQYILFAHRIDIRQI---SLDFDHLIDVVLPLPPISNAVALDVDRKTGYI 1271
            ..|:.|..:| :.||..::|||:..|||.:   ..|:..|:...:.:     ..|||.|.....|
Human   475 YDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGM-----VYALDHDPVENKI 534

  Fly  1272 YWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHV 1336
            |::.|....|..::.||...::::.:.::.|:||.||.|||..||.|.|:..|..:.|:|....:
Human   535 YFAHTALKWIERANMDGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKI 599

  Fly  1337 IAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRI 1401
            |..:::..|||:|:...|..|||||.|...:||.|.|.|..|..|.:::|.||:|:::|..:.::
Human   600 ITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKL 664

  Fly  1402 YWVDARLKTIDSCDYTGN-QRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNISAKRDI 1465
            ||.||:...|:..:..|: :|:|..:.:.||:|:|:.:|.::::||   |:....|.|....:|.
Human   665 YWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDW---AMPSVMRVNKRTGKDR 726

  Fly  1466 ITNIDGLM----DIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQ 1526
            : .:.|.|    .:.:::.......  :.|...||.|.|:|.:......|.|..|.....:..|
Human   727 V-RLQGSMLKPSSLVVVHPLAKPGA--DPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKT- 787

  Fly  1527 CQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRV 1591
                                                   .:.||.|
Human   788 ---------------------------------------CLALDGH------------------- 794

  Fly  1592 NLLNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSL 1656
                    :::.|.:|...|                     :|:.||...:.|:.|||:.:.:.:
Human   795 --------QLLAGGEVDLKN---------------------QVTPLDILSKTRVSEDNITESQHM 830

  Fly  1657 IVHPKKAYLFWSDWSSPAKI-----ERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALE 1716
            :|    |.:..||....|.:     .|...:|.:.|.....|          |.....|.:|..|
Human   831 LV----AEIMVSDQDDCAPVGCSMYARCISEGEDATCQCLKG----------FAGDGKLCSDIDE 881

  Fly  1717 DNIGQVDFNGKRRQTIVPYAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALS 1781
            ..:|            ||..|.                      .|.|...:..|......:...
Human   882 CEMG------------VPVCPP----------------------ASSKCINTEGGYVCRCSEGYQ 912

  Fly  1782 G----ALDIRAVSLSRQPKSVN-HCAQDNGGCTHLCLNRNVDYVCACPDVMDPKDVACSIKPKVL 1841
            |    .|||....|.......| .|....||.|.:|..|..:....|||...|..:.
Human   913 GDGIHCLDIDECQLGEHSCGENASCTNTEGGYTCMCAGRLSEPGLICPDSTPPPHLR-------- 969

  Fly  1842 VHANLENDQLLEYSDESTDDSTPPE---------------------------LLGESNDHGD--- 1876
                 |:|.  .||..::|...|..                           .:||...:.|
Human   970 -----EDDH--HYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGYIGERCQYRDLKW 1027

  Fly  1877 -----DGHTKKSDQEREFFVLVALGVVIVMVVIIILVIFMLA-------FNTSK--KKNKRNS-R 1926
                 .||   ..|::         |::|.|.:::||:.:|.       :.|.|  .||.:|. .
Human  1028 WELRHAGH---GQQQK---------VIVVAVCVVVLVMLLLLSLWGAHYYRTQKLLSKNPKNPYE 1080

  Fly  1927 GSSRSVLTFSNPNYNVDGTPMEPKTNIWKRFKYDKTHQE 1965
            .|||.|.: ..|....||....|:.  |  |...|.||:
Human  1081 ESSRDVRS-RRPADTEDGMSSCPQP--W--FVVIKEHQD 1114

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:291342	3/13 (23%)
		LY	634..671	CDD:214531	8/36 (22%)
		NHL	<656..793	CDD:302697	33/142 (23%)
		LY	680..714	CDD:214531	7/34 (21%)
		NHL repeat	681..722	CDD:271320	9/41 (22%)
		NHL repeat	726..760	CDD:271320	11/33 (33%)
		LY	761..803	CDD:214531	9/47 (19%)
		NHL repeat	769..793	CDD:271320	3/26 (12%)
		FXa_inhibition	882..912	CDD:291342	11/30 (37%)
		LY	946..985	CDD:214531	3/38 (8%)
		NHL	<967..1142	CDD:302697	24/175 (14%)
		LY	988..1030	CDD:214531	6/41 (15%)
		NHL repeat	998..1037	CDD:271320	7/38 (18%)
		NHL repeat	1038..1080	CDD:271320	4/41 (10%)
		NHL repeat	1084..1119	CDD:271320	5/35 (14%)
		FXa_inhibition	1185..1220	CDD:291342	15/35 (43%)
		NHL	1260..>1445	CDD:302697	62/185 (34%)
		NHL repeat	1260..1296	CDD:271320	10/35 (29%)
		NHL repeat	1302..1337	CDD:271320	15/34 (44%)
		NHL repeat	1345..1383	CDD:271320	18/37 (49%)
		FXa_inhibition	<1499..1525	CDD:291342	5/25 (20%)
		LY	1600..1640	CDD:214531	6/39 (15%)
		LY	1643..1686	CDD:214531	11/47 (23%)
		LY	1688..1729	CDD:214531	6/40 (15%)
		FXa_inhibition	1801..>1825	CDD:291342	7/23 (30%)
EGF	XP_016863334.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160391
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740