DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and rme-2

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_500815.2 Gene:rme-2 / 177329 WormBaseID:WBGene00004374 Length:925 Species:Caenorhabditis elegans


Alignment Length:993 Identity:242/993 - (24%)
Similarity:378/993 - (38%) Gaps:267/993 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   263 ARTNCTDDQ---FECLNG--FCIPRTWVCDGENDCKDFSDETHCNRT-TCTDEHFTCNDGYCISL 321
            |..|.|.||   |:|.||  .|||..|.||...||.:..||:.|:.. .|:.....|.:|.|::.
 Worm    26 AVNNSTCDQAKEFDCGNGRLRCIPAEWQCDNVADCDNGRDESGCSYAHHCSTSFMLCKNGLCVAN 90

  Fly   322 AFRCDGEHDCNDNSDELKCA-AVINS--------------------CPEGEFKCRGGLGGAGGPS 365
            .|:||||.||.|.|||..|. .::.|                    |.....:||         |
 Worm    91 EFKCDGEDDCRDGSDEQHCEYNILKSRFDGSNPSAPTTFVGHNGPECHPPRLRCR---------S 146

  Fly   366 GQCILNRFRCDGDNDCGDWSDEENCPQK-------------------PSLCTSNEYKCADG---- 407
            ||||.....|||..||....||.||.::                   |:...:.:.||..|    
 Worm   147 GQCIQPDLVCDGHTDCSGGDDEVNCTRRGHENMQSSTDFHDDVHLVDPTFFANEDNKCRSGYTMC 211

  Fly   408 ----TCIPKRWKCDKEQDCDGGEDENDC-GSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDC 467
                .|||..:.||.:.|||...||.:| .:..||.....|.                .|....|
 Worm   212 HSGDVCIPDSFLCDGDLDCDDASDEKNCQTNAPSEEEYLSGQ----------------ADHMHSC 260

  Fly   468 AAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE----ADCPKERKCS 528
            :|.            |.:.|.||.  :.:.:|:.....|:|..|||.|:||    ::|.::|   
 Worm   261 SAA------------GMYSCGTKG--SEIGVCIPMNATCNGIKECPLGDDESKHCSECARKR--- 308

  Fly   529 EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCET 593
                |:..|:.|..|: .|.|:.||.:..:.:.|.|.|||. ....:|...|.:.:|||.|.|..
 Worm   309 ----CDHTCMNTPHGA-RCICQEGYKLADDGLTCEDEDECA-THGHLCQHFCEDRLGSFACKCAN 367

  Fly   594 GYILRPDLRSCK-------------ALGGAMTLLVANRWDIRRVTLSN----NRYSAIVK-GLHN 640
            ||.|..|..|||             :|||          ::|::.|::    :.||.|.| ..|.
 Worm   368 GYELETDGHSCKYETTTTPEGYLFISLGG----------EVRQMPLADFTDGSNYSPIQKFAGHG 422

  Fly   641 AI-ALDFHHRKGLMFW--SDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTD-- 700
            .| ::||.||...||.  ||...|....:.::...:..|::..:.....:|||||...:|:|.  
 Worm   423 TIRSIDFMHRNNKMFMSISDEHGDPTGELSVSDNGLMRVLRENVIGVSNVAVDWIGGNVFFTQKS 487

  Fly   701 -SGTRRVEVSNFQGNL-RTVIASYDLDKP-RAIVVHPGEALAFWSD-WGPNPKIERAYMDGTQRK 761
             |.:..:.:....|.. |.||...:..:. |.:||||...|..|.| :....:|..|.|||:|.:
 Worm   488 PSPSAGISICTMSGMFCRRVIEGKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMMANMDGSQVR 552

  Fly   762 VIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYW 826
            :::...:..|:.||||:....:|:.|.::..||..|:|..:|..::|..:.||:.:..|...:||
 Worm   553 ILLDNKLEVPSALAIDYIRHDVYFGDVERQLIERVNIDTKERRVVISNGVHHPYDMAYFNGFLYW 617

  Fly   827 TDWNTKTVSAADKITGKEF-RAVHENFHFPMDI---HAYHPARQPEYADRCQKDRRGLRGGCSHL 887
            .||.::::...:....... :.:|....:|..|   |:.:....|  ::.|      |...|..|
 Worm   618 ADWGSESLKVQEMTHHHSSPQVIHTFNRYPYGIAVNHSLYQTGPP--SNPC------LELECPWL 674

  Fly   888 C--LPNK---TSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADP----NDV 943
            |  :|..   .:.:|.||       ||.|...|                   :|...|    .|.
 Worm   675 CVIVPKSDFIMTAKCVCP-------DGYTHSVT-------------------ENSCIPPVTIEDE 713

  Fly   944 DMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTIN------------KAH---------LNGSYQ 987
            :.:..|.::..|:..::|         :...:.:|            :||         .:|.|.
 Worm   714 ENLEKLSHIGSALMAEYC---------EAGVACMNGGACRELQNEHGRAHRIVCDCEGPYDGQYC 769

  Fly   988 QR----------------------VVHSNLVSPVG-LALDWITDKLYWTDP-STNRIEVATTNGK 1028
            :|                      ::...:|:.|| :|..|.:.:.:..|. ||.|:.|.....|
 Worm   770 ERLNPEKFSAMEEEDSSLWLIVLLLIFLIIVAVVGIIAFLWFSQQEHMKDVISTARVRVDNMARK 834

  Fly  1029 MRTLL--IWEKLYKPRD--IVVNPIEGFMFWSDWGDDPMIERANMD-------GHERVTITSKKL 1082
            .....  |.||..|..|  ....|.||..           ...|:|       ..:|:.:.|...
 Worm   835 AEDAAAPIVEKFRKVTDKQRSTPPREGCQ-----------TATNVDFVSYETNAEKRIRMDSSPT 888

  Fly  1083 IYPNGLAIDYEKSKIYFV 1100
            .|.|.:..:..:|...||
 Worm   889 SYGNPMYDEVPESSTGFV 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/38 (45%)
LDLa 306..340 CDD:238060 15/33 (45%)
LDLa 347..390 CDD:238060 15/42 (36%)
LDLa 397..431 CDD:238060 13/41 (32%)
LDLa 442..476 CDD:238060 4/33 (12%)
LDLa 480..521 CDD:238060 13/44 (30%)
FXa_inhibition 576..604 CDD:464251 11/27 (41%)
LY 634..671 CDD:214531 13/40 (33%)
LY 680..714 CDD:214531 8/36 (22%)
LY 718..760 CDD:214531 15/43 (35%)
Ldl_recept_b 740..777 CDD:459654 11/37 (30%)
LY 761..803 CDD:214531 11/41 (27%)
LY 806..838 CDD:214531 8/31 (26%)
FXa_inhibition 882..912 CDD:464251 9/34 (26%)
LY 946..985 CDD:214531 6/59 (10%)
NHL <967..1142 CDD:302697 34/190 (18%)
LY 988..1030 CDD:214531 12/65 (18%)
NHL repeat 998..1037 CDD:271333 11/42 (26%)
NHL repeat 1038..1080 CDD:271333 8/50 (16%)
NHL repeat 1084..1119 CDD:271333 5/17 (29%)
FXa_inhibition 1185..1220 CDD:464251
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
LY 1292..1334 CDD:214531
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:464251
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
rme-2NP_500815.2 LDLa 37..69 CDD:238060 14/31 (45%)
LDLa 75..109 CDD:238060 15/33 (45%)
LDLa 137..171 CDD:238060 15/42 (36%)
FXa_inhibition 309..337 CDD:464251 8/28 (29%)
vWFA <337..375 CDD:469594 15/38 (39%)
Ldl_recept_b 527..569 CDD:459654 13/41 (32%)
LY 552..594 CDD:214531 11/41 (27%)
LY 595..634 CDD:214531 8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

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