DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and rme-2

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_500815.2	Gene:	rme-2 / 177329	WormBaseID:	WBGene00004374	Length:	925	Species:	Caenorhabditis elegans

Alignment Length:	993	Identity:	242/993 - (24%)
Similarity:	378/993 - (38%)	Gaps:	267/993 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 ARTNCTDDQ---FECLNG--FCIPRTWVCDGENDCKDFSDETHCNRT-TCTDEHFTCNDGYCISL 321
            |..|.|.||   |:|.||  .|||..|.||...||.:..||:.|:.. .|:.....|.:|.|::.
Worm    26 AVNNSTCDQAKEFDCGNGRLRCIPAEWQCDNVADCDNGRDESGCSYAHHCSTSFMLCKNGLCVAN 90

  Fly   322 AFRCDGEHDCNDNSDELKCA-AVINS--------------------CPEGEFKCRGGLGGAGGPS 365
            .|:||||.||.|.|||..|. .::.|                    |.....:||         |
Worm    91 EFKCDGEDDCRDGSDEQHCEYNILKSRFDGSNPSAPTTFVGHNGPECHPPRLRCR---------S 146

  Fly   366 GQCILNRFRCDGDNDCGDWSDEENCPQK-------------------PSLCTSNEYKCADG---- 407
            ||||.....|||..||....||.||.::                   |:...:.:.||..|
Worm   147 GQCIQPDLVCDGHTDCSGGDDEVNCTRRGHENMQSSTDFHDDVHLVDPTFFANEDNKCRSGYTMC 211

  Fly   408 ----TCIPKRWKCDKEQDCDGGEDENDC-GSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDC 467
                .|||..:.||.:.|||...||.:| .:..||.....|.                .|....|
Worm   212 HSGDVCIPDSFLCDGDLDCDDASDEKNCQTNAPSEEEYLSGQ----------------ADHMHSC 260

  Fly   468 AAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE----ADCPKERKCS 528
            :|.            |.:.|.||.  :.:.:|:.....|:|..|||.|:||    ::|.::|
Worm   261 SAA------------GMYSCGTKG--SEIGVCIPMNATCNGIKECPLGDDESKHCSECARKR--- 308

  Fly   529 EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCET 593
                |:..|:.|..|: .|.|:.||.:..:.:.|.|.|||. ....:|...|.:.:|||.|.|..
Worm   309 ----CDHTCMNTPHGA-RCICQEGYKLADDGLTCEDEDECA-THGHLCQHFCEDRLGSFACKCAN 367

  Fly   594 GYILRPDLRSCK-------------ALGGAMTLLVANRWDIRRVTLSN----NRYSAIVK-GLHN 640
            ||.|..|..|||             :|||          ::|::.|::    :.||.|.| ..|.
Worm   368 GYELETDGHSCKYETTTTPEGYLFISLGG----------EVRQMPLADFTDGSNYSPIQKFAGHG 422

  Fly   641 AI-ALDFHHRKGLMFW--SDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTD-- 700
            .| ::||.||...||.  ||...|....:.::...:..|::..:.....:|||||...:|:|.
Worm   423 TIRSIDFMHRNNKMFMSISDEHGDPTGELSVSDNGLMRVLRENVIGVSNVAVDWIGGNVFFTQKS 487

  Fly   701 -SGTRRVEVSNFQGNL-RTVIASYDLDKP-RAIVVHPGEALAFWSD-WGPNPKIERAYMDGTQRK 761
             |.:..:.:....|.. |.||...:..:. |.:||||...|..|.| :....:|..|.|||:|.:
Worm   488 PSPSAGISICTMSGMFCRRVIEGKEQGQSYRGLVVHPMRGLIIWIDSYQKYHRIMMANMDGSQVR 552

  Fly   762 VIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYW 826
            :::...:..|:.||||:....:|:.|.::..||..|:|..:|..::|..:.||:.:..|...:||
Worm   553 ILLDNKLEVPSALAIDYIRHDVYFGDVERQLIERVNIDTKERRVVISNGVHHPYDMAYFNGFLYW 617

  Fly   827 TDWNTKTVSAADKITGKEF-RAVHENFHFPMDI---HAYHPARQPEYADRCQKDRRGLRGGCSHL 887
            .||.::::...:....... :.:|....:|..|   |:.:....|  ::.|      |...|..|
Worm   618 ADWGSESLKVQEMTHHHSSPQVIHTFNRYPYGIAVNHSLYQTGPP--SNPC------LELECPWL 674

  Fly   888 C--LPNK---TSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADP----NDV 943
            |  :|..   .:.:|.||       ||.|...|                   :|...|    .|.
Worm   675 CVIVPKSDFIMTAKCVCP-------DGYTHSVT-------------------ENSCIPPVTIEDE 713

  Fly   944 DMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTIN------------KAH---------LNGSYQ 987
            :.:..|.::..|:..::|         :...:.:|            :||         .:|.|.
Worm   714 ENLEKLSHIGSALMAEYC---------EAGVACMNGGACRELQNEHGRAHRIVCDCEGPYDGQYC 769

  Fly   988 QR----------------------VVHSNLVSPVG-LALDWITDKLYWTDP-STNRIEVATTNGK 1028
            :|                      ::...:|:.|| :|..|.:.:.:..|. ||.|:.|.....|
Worm   770 ERLNPEKFSAMEEEDSSLWLIVLLLIFLIIVAVVGIIAFLWFSQQEHMKDVISTARVRVDNMARK 834

  Fly  1029 MRTLL--IWEKLYKPRD--IVVNPIEGFMFWSDWGDDPMIERANMD-------GHERVTITSKKL 1082
            .....  |.||..|..|  ....|.||..           ...|:|       ..:|:.:.|...
Worm   835 AEDAAAPIVEKFRKVTDKQRSTPPREGCQ-----------TATNVDFVSYETNAEKRIRMDSSPT 888

  Fly  1083 IYPNGLAIDYEKSKIYFV 1100
            .|.|.:..:..:|...||
Worm   889 SYGNPMYDEVPESSTGFV 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	17/38 (45%)
		LDLa	306..340	CDD:238060	15/33 (45%)
		LDLa	347..390	CDD:238060	15/42 (36%)
		LDLa	397..431	CDD:238060	13/41 (32%)
		LDLa	442..476	CDD:238060	4/33 (12%)
		LDLa	480..521	CDD:238060	13/44 (30%)
		FXa_inhibition	576..604	CDD:291342	11/27 (41%)
		LY	634..671	CDD:214531	13/40 (33%)
		NHL	<656..793	CDD:302697	37/142 (26%)
		LY	680..714	CDD:214531	8/36 (22%)
		NHL repeat	681..722	CDD:271320	12/44 (27%)
		NHL repeat	726..760	CDD:271320	13/35 (37%)
		LY	761..803	CDD:214531	11/41 (27%)
		NHL repeat	769..793	CDD:271320	7/23 (30%)
		FXa_inhibition	882..912	CDD:291342	9/34 (26%)
		LY	946..985	CDD:214531	6/59 (10%)
		NHL	<967..1142	CDD:302697	34/190 (18%)
		LY	988..1030	CDD:214531	12/65 (18%)
		NHL repeat	998..1037	CDD:271320	11/42 (26%)
		NHL repeat	1038..1080	CDD:271320	8/50 (16%)
		NHL repeat	1084..1119	CDD:271320	5/17 (29%)
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
rme-2	NP_500815.2	LDLa	37..69	CDD:238060	14/31 (45%)
		LDLa	75..109	CDD:238060	15/33 (45%)
		LDLa	137..171	CDD:238060	15/42 (36%)
		FXa_inhibition	309..337	CDD:291342	8/28 (29%)
		vWFA	<337..375	CDD:294047	15/38 (39%)
		Ldl_recept_b	527..568	CDD:278487	12/40 (30%)
		LY	552..594	CDD:214531	11/41 (27%)
		LY	595..634	CDD:214531	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740