DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and egg-1

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_498237.2	Gene:	egg-1 / 175804	WormBaseID:	WBGene00015083	Length:	551	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	130/440 - (29%)
Similarity:	186/440 - (42%)	Gaps:	97/440 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 NCQNSNESDENC-----------NPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDC 252
            :|::.:: :|||           .|||::        :|.|...:.| |..|::...|||..::|
Worm   149 DCEDGSD-EENCKECQSVFSCKLRPEEES--------KKKGRSTVQP-TLICLTAQHLCDNVENC 203

  Fly   253 GDYSDETHCGARTNCTDDQFECL-NGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDG 316
            .|.|||..|  :::|:.|||:|. :..|:|.:..|||.|||.|.|||.:|::  |.:....|..
Worm   204 PDGSDEAVC--KSSCSKDQFKCPGSNACLPLSAKCDGINDCADASDEKNCSK--CQNNAHKCGK- 263

  Fly   317 YCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDC 381
            .||..:..|||...|.|.|||.:|     .|.    :| .|...|....|.||:....|||..||
Worm   264 QCIKASHVCDGVAQCADGSDEQQC-----DCQ----RC-SGTDKALCDDGTCIMRTQVCDGKKDC 318

  Fly   382 GDWSDEENCPQKPSLCTSNEYK-------CADGTCIPKRWKCDKE-QDCDGGEDENDCGSLGSEH 438
            .|..|||:|   |..||...:.       |:||....:...|... :.||     :||.: ...|
Worm   319 TDGMDEEDC---PGSCTIESFSPKLKMVTCSDGKQYTEAEACSGSFESCD-----HDCPN-SKCH 374

  Fly   439 PLTCGSDEFTCNNGR-----CILKTWLCDGYPDCAAGEDEVECH--LQCDLG---QFLCPTKQNL 493
            |...    |||...:     ||.:..:|||.|||..|.||:.|.  .:|.:.   ||.|..|
Worm   375 PKLA----FTCPASKEARKMCISRRKVCDGTPDCDDGADEINCTPIKECGIAKNTQFKCDHK--- 432

  Fly   494 TNLKICVHQKHICDGHNECPAGEDEADCPK----------ERKCSEPSPCEQLC---IETTAGSN 545
                 |:.....|||..:|....||..|.|          ::||   .|....|   .:.:.||:
Worm   433 -----CLDSSRRCDGVWDCEDKSDEKGCDKCPSGTIKCAADKKC---LPAFTRCNGVADCSDGSD 489

  Fly   546 E--CACRLGYVMDKNKVNCTDIDECQYLTSPVCS--QKCHNTMGSFKCSC 591
            |  |:|:....:..|...|.:.:.| .....|||  ..|.|...:.|..|
Worm   490 ELKCSCQECLGVHSNTYMCNESNRC-LKRDEVCSPYSMCPNATYTDKAFC 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	17/34 (50%)
		LDLa	306..340	CDD:238060	12/33 (36%)
		LDLa	347..390	CDD:238060	16/42 (38%)
		LDLa	397..431	CDD:238060	8/41 (20%)
		LDLa	442..476	CDD:238060	14/38 (37%)
		LDLa	480..521	CDD:238060	12/43 (28%)
		FXa_inhibition	576..604	CDD:291342	6/18 (33%)
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
egg-1	NP_498237.2	LDLa	123..159	CDD:238060	2/10 (20%)
		LDLa	216..251	CDD:238060	17/34 (50%)
		LDLa	254..287	CDD:238060	12/33 (36%)
		LDLa	300..327	CDD:238060	12/26 (46%)
		LDLa	<391..413	CDD:238060	11/21 (52%)
		LDLa	425..455	CDD:238060	11/37 (30%)
		LDLa	458..493	CDD:238060	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900