DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and F14B4.1

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_492474.2	Gene:	F14B4.1 / 172750	WormBaseID:	WBGene00008779	Length:	722	Species:	Caenorhabditis elegans

Alignment Length:	647	Identity:	176/647 - (27%)
Similarity:	276/647 - (42%)	Gaps:	94/647 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   409 CIPKRWKCDKEQDCDGGEDEND-----C-----GSLGSEHPLTCGSDEFTCNNGRCILKTWLCDG 463
            |.||.....||:.....|.|||     |     .:|..|.|.|..:   ...|..|.    :...
Worm   138 CEPKFAAIMKEEQACLLEVENDKNVKECFVNKTNTLRDETPDTVSN---PTQNYECT----VIQA 195

  Fly   464 YPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCS 528
            |.||....:|..|.         ...|..::.|.:...:    :..:.|   |...:..|.|..:
Worm   196 YVDCLIEREETSCR---------DAEKIEISFLSMLAKR----NSESRC---ELNTNAIKSRPKA 244

  Fly   529 EPSPCEQLCIETTAGSNECACRL-GYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCE 592
            :|       :|.......|.||| ||..:..:..|.|:|||:.|:| .|||||.|..|:|:|:|:
Worm   245 QP-------LEECDTQGNCKCRLPGYYYEAARKKCLDVDECESLSS-ACSQKCVNLPGTFECTCD 301

  Fly   593 -TGYILRPDLRSCKALG-GAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFW 655
             ..|.|..|.::|:.:. ..|.|..|:...:..::.....:.....||.....:|...::..:::
Worm   302 PRTYKLATDNKTCERIDQSPMWLFFAHGQSVWNISTDGKSFQLQRAGLQKTAMIDIDVKENRLYY 366

  Fly   656 SDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRR--VEVSNFQGNLRTV 718
            :|:..:||:.:.:.||..:.|.::.::...|||||||...|:    ..||  :.|.:..|..|..
Worm   367 ADIGANVIERMNIEGTFPQAVQRFDVDGLEGIAVDWIGRNLY----SLRREDILVQSLDGRFRQP 427

  Fly   719 IASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKI 783
            :....:..||:|.:||.:.:.|.:||..|..|..|.|||:..:.||::.:||||.:|:|....||
Worm   428 LYKNVMTLPRSITLHPAKGIMFVTDWSANAFIAAASMDGSHFRKIITERITWPNAVAVDIFAEKI 492

  Fly   784 YWADAKQHAIECSNLDGSDRNKILST--HLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFR 846
            |||||....||.:|:||:.|..|::.  .:||.|.|.:.:|.:|||||..:.:..|:|..|:...
Worm   493 YWADAFLDTIESANMDGTGRRVIIADAGSVPHVFGLAIADDYLYWTDWTYRGILRANKHNGENIT 557

  Fly   847 AVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKT-SRRCGCPIGLSLKEDGK 910
            .:.:....|..:..:|.:.|||....|:      ..||..|||..:. :..|.|..|..|..|||
Worm   558 VLAQTALLPYSLKVFHKSLQPEETSTCE------TRGCDQLCLLGENGAATCACGEGFDLLNDGK 616

  Fly   911 TCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERS 975
            .|.|...:            ..:....|||..:..|...|.|..      ||:.     .|.|:.
Worm   617 KCSSNCSE------------SQIECGGADPKCISKIYLCDGLAQ------CSNQ-----ADEEKC 658

  Fly   976 TINKAHLNGSYQQRVVHSNLVSPVGLALDWIT------DKLYWTDPST---NRIEVATTNGK 1028
            . .:..|.|.:|....|..|  |.|...|.:|      |::|.....|   .:..:.||.||
Worm   659 P-PRICLPGQFQCHDNHKCL--PPGGLCDKVTDCSDSSDEIYCEYQKTTEKGQFVLNTTKGK 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060
		LDLa	347..390	CDD:238060
		LDLa	397..431	CDD:238060	9/26 (35%)
		LDLa	442..476	CDD:238060	6/33 (18%)
		LDLa	480..521	CDD:238060	4/40 (10%)
		FXa_inhibition	576..604	CDD:291342	13/28 (46%)
		LY	634..671	CDD:214531	6/36 (17%)
		NHL	<656..793	CDD:302697	48/138 (35%)
		LY	680..714	CDD:214531	11/35 (31%)
		NHL repeat	681..722	CDD:271320	13/42 (31%)
		NHL repeat	726..760	CDD:271320	14/33 (42%)
		LY	761..803	CDD:214531	20/41 (49%)
		NHL repeat	769..793	CDD:271320	13/23 (57%)
		FXa_inhibition	882..912	CDD:291342	12/30 (40%)
		LY	946..985	CDD:214531	8/38 (21%)
		NHL	<967..1142	CDD:302697	18/71 (25%)
		LY	988..1030	CDD:214531	13/50 (26%)
		NHL repeat	998..1037	CDD:271320	11/40 (28%)
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
F14B4.1	NP_492474.2	vWFA	<272..313	CDD:294047	20/41 (49%)
		LY	343..383	CDD:214531	7/39 (18%)
		LY	391..425	CDD:214531	12/37 (32%)
		Ldl_recept_b	448..486	CDD:278487	16/37 (43%)
		LY	470..512	CDD:214531	20/41 (49%)
		LY	513..549	CDD:214531	11/35 (31%)
		FXa_inhibition	588..618	CDD:291342	12/29 (41%)
		LDLa	622..658	CDD:238060	10/58 (17%)
		LDLa	663..698	CDD:238060	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810