DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp-1

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001379135.1 Gene:lrp-1 / 172520 WormBaseID:WBGene00003071 Length:4753 Species:Caenorhabditis elegans


Alignment Length:2036 Identity:585/2036 - (28%)
Similarity:879/2036 - (43%) Gaps:377/2036 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 HKQLHSDARIGHLEAGNESR--EDQLSEELSKFGEKLFPVSNYP-PYQQNNEDSQEVHHSGEGRL 113
            |::.:|..|: |.:.|..|:  .:..::|.|.|..|.....|.| |     :||:|         
 Worm   949 HQRPYSIRRV-HKKNGGGSKIVREFGADERSIFSLKACSHQNQPIP-----DDSRE--------- 998

  Fly   114 HTMESSVPSKTRISGGTNSNDTPKFRNIGAQRGRTEIAGIRETDRISSRGRDGFIGGPSNKQKPF 178
            |...:|  ..|::...|.|...|           .|:       ......|.||:....|...  
 Worm   999 HPCRAS--QCTQLCFATPSESHP-----------NEL-------EAKCACRQGFMINKENNHS-- 1041

  Fly   179 RVNLAVLVQDDPSQPGE-------TYSNCQNSN--------ESDENCNPEEDAVPNLQRDC---- 224
                   .|.||::..|       |...|:|..        :.:.:|..|.|.:......|    
 Worm  1042 -------CQKDPAEKIEQLCSSNSTQFQCKNGRCIPKEWKCDGENDCLDESDEIDEKGDKCFHET 1099

  Fly   225 ---EKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDE--THC--GARTNCTDDQFECLNGFCIPR 282
               |.|   :.|..|.:||...:.||||:||||||||  .:|  |.:..|...:|:|.|..|||.
 Worm  1100 ECAENT---IKCRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKPVCAAKKFQCDNHRCIPE 1161

  Fly   283 TWVCDGENDCKDFSDE--THCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELK--CAAV 343
            .|.||.:|||.|.|||  ..|...||....|:|.:|.||.:.:.|||::||.|.:||.|  |..|
 Worm  1162 QWKCDSDNDCGDGSDEKLEMCGNATCAANQFSCANGRCIPIYWLCDGDNDCYDGTDEDKERCPPV 1226

  Fly   344 INSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKC-ADG 407
              .|...:|:|..|        .||:..|..|||.:||.|.|||::|......||.:::|| :.|
 Worm  1227 --QCSALQFRCANG--------RQCVPLRNHCDGQSDCEDGSDEDSCAVTAESCTPDQFKCVSSG 1281

  Fly   408 TCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGED 472
            .|||..||||.:||||.|.||...|......   |.||:|.|.||||||..|||||..||..|.|
 Worm  1282 LCIPASWKCDGQQDCDDGSDEPKFGCTSGRQ---CSSDQFKCGNGRCILNNWLCDGENDCGDGSD 1343

  Fly   473 EV------------EC---HLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEAD-C 521
            |.            :|   |:.|:..|..|          |.:||  :|||...||.|.||.. |
 Worm  1344 ESSERGCKTSMNARKCPFEHVACENDQETC----------IPLHQ--LCDGKTHCPGGTDEGGRC 1396

  Fly   522 PKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGS 586
            .::...::.:.|...|..:..|. .|:|..|..: .||..|...:||  |.|..|||:|.:....
 Worm  1397 ARDLCSADRAGCSFKCHNSPNGP-ICSCPFGEQL-VNKTKCEPENEC--LDSSSCSQRCKDEKHG 1457

  Fly   587 FKCSCETGYILRPDLRSCKALGGA--MTLLVANRWDIRRVTLSNNR------YSAIVKGLHNAIA 643
            |.|||:.||.|..|.|:||.....  ..:.|:||   .|:..|:::      :.|||:   ||||
 Worm  1458 FTCSCDEGYELDVDKRTCKVADNVKDTRIYVSNR---NRIYYSDHKLDNWHTFGAIVE---NAIA 1516

  Fly   644 LDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEV 708
            |.:......::|||:....|.....|||.....|..||:...|||:||:...|:|.||....:||
 Worm  1517 LAWDSLTDRIYWSDIREKKILSANRNGTNATVFIADGLDITEGIALDWVGRNLYWVDSSLNTIEV 1581

  Fly   709 SNFQG-NLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPN 772
            :|.:. ..||::...::.:||.|.|.|.:.:.||:|||.||.||||.||||.|::|:...:.|||
 Worm  1582 ANLEDPKQRTLLVHQNVSQPRGIAVDPRKGVMFWTDWGQNPCIERASMDGTDRQIIVKTKIYWPN 1646

  Fly   773 GLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVS 835
            .:|:|:...::|:||:|...|:..|.|||.|.::|  |..:.||.||.:|||.||::|...:.:.
 Worm  1647 TIALDYTTDRVYFADSKLDFIDFVNYDGSGRTQVLASSKFVQHPHALAIFEDMMYYSDRRLQKLQ 1711

  Fly   836 AADKI---TGKEFRAVHENFHFPMDIHAYHPARQPEYADR-CQKDRRGLRGGCSHLC-LPNKTSR 895
            ...|.   |..|:.:  ..|...:.:.|.||..||...:. |..:      .||||| |.||.:.
 Worm  1712 VYPKYPNGTTSEYPS--HTFSKALGVVAVHPVLQPVIKNNPCSTN------PCSHLCLLNNKNTF 1768

  Fly   896 RCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMI---VPLDNLKHA-- 955
            .|.||:|..|...||.|...|...:::.::.::  ..:..|.|...:..::   |||..|.:|  
 Worm  1769 TCKCPMGEKLDASGKKCIDDAKPFLVIIQKTNV--FGIEMNSASEKETPVLAGMVPLSGLGNAFD 1831

  Fly   956 VALDWCSDTDFI------------YWTDVERSTINKAHLNGSYQQRVVHSNLVSPV-GLALDWIT 1007
            .|.|..|:..||            ..||   |.|.::.:||..:.::..|.:.... .|..||..
 Worm  1832 AAYDALSEEMFILEHTNHAKTLAQITTD---SAIYRSTVNGGNKTKMFSSAVPDDAYCLGFDWNG 1893

  Fly  1008 DKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPI-------EGFMFWSDWGD---DP 1062
            ..|...:..|..||:..|.||....:|......| ..||.|:       :|::||.|.|.   |.
 Worm  1894 RNLVVGNKITQTIEIIRTQGKQYRSVILSNDQSP-TAVVTPVAIAVDADKGYVFWLDRGGGAADA 1957

  Fly  1063 MIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLG-H 1126
            .:.||.:||...:.|.|..|...:.:|||...:::||.:.....:.::.:||..|..:|:..| .
 Worm  1958 KVARAGLDGSNPLVIASNDLAELDHIAIDTTNTRVYFSEAKAGRISSVTYDGQDRHYVLSDGGRQ 2022

  Fly  1127 PFGLDVNEGRVFWTD--WDTKSVMSANKLTG-----------KDTNVIIANSTDLMDIRVFHRTR 1178
            |.||.....|:|:.|  :|:..|.:.|   |           ||..       :|.:|:......
 Worm  2023 PNGLAFYGDRLFYADSAFDSIEVATIN---GDSQPPQWTHFKKDVE-------NLANIKALQPRA 2077

  Fly  1179 RRIFNACDKLNGGCSHLCLLNPTSY---TCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQIS 1240
            ....:.|...||.|.|:|:  |..:   ||.|..| .:|:.:.:|......:::.|.:..:  |.
 Worm  2078 SSSGHPCHINNGNCDHICI--PLMFAQRTCTCANG-YVKDGQTSCKLFDESFVIVATKTKV--IG 2137

  Fly  1241 LDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGL 1305
            ...|......:.:.||.......||    |.|.|.||.....|....|:....| |:|  :|..:
 Worm  2138 YPIDETQSKGVAMEPIGGLSITGVD----YDYESKTIYVAEASGINKGITAYTI-GES--SPRAV 2195

  Fly  1306 VVDSIGR------TIYWA---------DAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAG 1355
            :.||||.      .|.|.         ||.|..|||:.|||:.|.::.....|:|..:|:|..:.
 Worm  2196 IRDSIGSLTIKSLAIDWINYNMYFINHDAERTNIEVSKLDGTYRKILLTTKTETPSSIAVDPVSR 2260

  Fly  1356 LLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQ 1420
            .|:|.|.|....|:||.|||:.|..||::.:..|..|.:|:.||.|||.||::..|.....||..
 Worm  2261 YLYWADQGQKPTIQRSFLDGSRREVIVSSGIAEPTDLVVDVASKMIYWSDAKMDGIYRVRSTGGT 2325

  Fly  1421 RKLIMSSLHHPYALALSDDNIYWTDWK-SKALHMTERRN----ISAKRDIITNIDGLMDIKIIYQ 1480
            .:|:.|.:.....:||...|:||||.: .|....|.:.|    :.:...:..::..:.|: .::.
 Worm  2326 PELVRSDIASAAGVALHGQNMYWTDNRLEKLFRATSKPNQTSLLLSPTTVAASLKDIGDV-AVFS 2389

  Fly  1481 NQNQSTMKNAC----GNNNGNCSHLCLRNPSGY--SCQCPIGLRLRQNSTTQCQNLPEDYLLIAL 1539
            :.||....:.|    ......|:.||...|...  :|.|..|: |:..:   |:. |:.|::   
 Worm  2390 SNNQPRASSPCQITDNLRKSPCTQLCFATPGTQTPTCSCARGV-LKGRT---CEE-PDTYIM--- 2446

  Fly  1540 RSGIGMISLNSGD-FMDVVL--------PINGVHGAVVLDYHYRKNL-LFFADVNLDVIRRV--- 1591
                    .:.|| .:||.:        |:......:       .|| .|..||||   |||   
 Worm  2447 --------FSDGDKIIDVAIEPDVKASRPLKDPFPEI-------SNLQTFDVDVNL---RRVYFV 2493

  Fly  1592 ------------NLLNLTESKVIVGT-------DVLTPNGIAVDWIADNLYWSDTDRKLIEVSRL 1637
                        ::.|....:::.|.       ::...:.:.:||:...:|::            
 Worm  2494 VESPVGVNISWFSMNNAENPRLVFGASKQPHAKEIRHISDMKLDWLTQKIYFT------------ 2546

  Fly  1638 DGSCRKRIVEDNLGDPRS----------LIVHPKKAYLFWSDWSSPA-------KIERSYLDGSN 1685
            .|...|.:..|..|:..|          |.:.|....|||||.....       :||||.|.|.:
 Worm  2547 TGRGGKVMAIDTAGEHLSTIASGDWTYALAIDPCSGLLFWSDSGYKTSGGLYEPRIERSNLAGGS 2611

  Fly  1686 RTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVP-YAPHPFGLTLFENSI 1749
            |.||::..|..|..:.:||.|:::.|||....||...|::|:.|:.|.. |...  .|.:::..:
 Worm  2612 RKVIVSESISLPAAIAVDFRNQKIYWADVNRLNIEVADYDGQNRKVIASGYRAK--SLDIWDRWL 2674

  Fly  1750 FWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGAL-------DIRAVSLSRQPKSVNHCAQDNGG 1807
            :.:|..:..|:|..|.:.||..|....| .:.|||       |:|..:......:...|..||||
 Worm  2675 YMSDPLSNGVFRIDKESGSGLENVVSDR-RIPGALRVFASESDVRTRNQVCNALTSQLCKTDNGG 2738

  Fly  1808 CTHLCLNRNVD-------YVCACPD----VMDP-KD--VACSIKPKVLVHANLE--NDQLLEYSD 1856
            |..||.....|       ..|:|.|    |.:| ||  ..|     ||..:|.|  .:.|..|:.
 Worm  2739 CDQLCTVVADDIGLAASKVQCSCNDTYELVQEPGKDYPTQC-----VLRGSNSEPAKECLPPYNF 2798

  Fly  1857 ESTDDSTPPELLGESNDHGDD 1877
            :..|.|.  .|||.:.|...|
 Worm  2799 QCGDGSC--ILLGATCDSKPD 2817

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/35 (49%)
LDLa 306..340 CDD:238060 15/35 (43%)
LDLa 347..390 CDD:238060 16/42 (38%)
LDLa 397..431 CDD:238060 19/34 (56%)
LDLa 442..476 CDD:238060 21/45 (47%)
LDLa 480..521 CDD:238060 14/41 (34%)
FXa_inhibition 576..604 CDD:291342 13/27 (48%)
LY 634..671 CDD:214531 12/36 (33%)
NHL <656..793 CDD:302697 54/137 (39%)
LY 680..714 CDD:214531 14/34 (41%)
NHL repeat 681..722 CDD:271320 15/41 (37%)
NHL repeat 726..760 CDD:271320 20/33 (61%)
LY 761..803 CDD:214531 15/41 (37%)
NHL repeat 769..793 CDD:271320 9/23 (39%)
FXa_inhibition 882..912 CDD:291342 15/30 (50%)
LY 946..985 CDD:214531 15/55 (27%)
NHL <967..1142 CDD:302697 52/200 (26%)
LY 988..1030 CDD:214531 11/42 (26%)
NHL repeat 998..1037 CDD:271320 11/39 (28%)
NHL repeat 1038..1080 CDD:271320 15/51 (29%)
NHL repeat 1084..1119 CDD:271320 8/34 (24%)
FXa_inhibition 1185..1220 CDD:291342 12/37 (32%)
NHL 1260..>1445 CDD:302697 66/199 (33%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
NHL repeat 1302..1337 CDD:271320 17/49 (35%)
NHL repeat 1345..1383 CDD:271320 15/37 (41%)
FXa_inhibition <1499..1525 CDD:291342 7/27 (26%)
LY 1600..1640 CDD:214531 4/46 (9%)
LY 1643..1686 CDD:214531 17/59 (29%)
LY 1688..1729 CDD:214531 14/40 (35%)
FXa_inhibition 1801..>1825 CDD:291342 11/30 (37%)
lrp-1NP_001379135.1 LDLa 53..87 CDD:238060
LDLa 92..131 CDD:238060
LDLa 140..173 CDD:238060
LDLa 182..216 CDD:238060
LDLa 223..257 CDD:238060
LDLa 262..297 CDD:238060
LY 463..505 CDD:214531
LY 507..546 CDD:214531
LY 547..589 CDD:214531
LY 883..925 CDD:214531
exchanger_TraA <1054..1451 CDD:411343 154/428 (36%)
LDLa 1057..1087 CDD:197566 5/29 (17%)
LDLa 1146..1177 CDD:197566 15/30 (50%)
LDLa 1187..1219 CDD:238060 13/31 (42%)
LDLa 1228..1263 CDD:238060 16/42 (38%)
LDLa 1270..1302 CDD:238060 17/31 (55%)
LDLa 1313..1344 CDD:238060 19/30 (63%)
FXa_inhibition 1447..1475 CDD:405372 13/27 (48%)
LY 1511..1545 CDD:214531 12/36 (33%)
LY 1548..1585 CDD:214531 15/36 (42%)
LY 1590..1634 CDD:214531 22/43 (51%)
LY 1635..1677 CDD:214531 15/41 (37%)
Ldl_recept_b 1943..1986 CDD:423042 14/42 (33%)
LY 1971..2012 CDD:214531 10/40 (25%)
LY 2015..2052 CDD:214531 12/39 (31%)
LY 2193..2239 CDD:214531 15/45 (33%)
LY 2240..2283 CDD:214531 14/42 (33%)
LY 2284..2325 CDD:214531 15/40 (38%)
LY 2570..2612 CDD:214531 13/41 (32%)
LY 2613..2655 CDD:214531 14/41 (34%)
LDLa 2794..2824 CDD:197566 8/26 (31%)
LDLa 2834..2868 CDD:238060
LDLa 2874..2907 CDD:197566
LDLa 2961..2994 CDD:238060
LDLa 3012..3038 CDD:238060
LDLa 3048..3088 CDD:197566
LDLa 3099..3131 CDD:197566
LDLa 3140..3174 CDD:238060
LDLa 3186..3218 CDD:197566
FXa_inhibition 3276..3305 CDD:405372
LY 3382..3424 CDD:214531
Ldl_recept_b 3445..3490 CDD:395012
LY 3476..3516 CDD:214531
FXa_inhibition 3586..3623 CDD:405372
LDLa 3627..3660 CDD:197566
LDLa 3671..3705 CDD:238060
LDLa 3792..3825 CDD:197566
LDLa 3837..3868 CDD:238060
LDLa 3878..3912 CDD:238060
LDLa 3917..3951 CDD:238060
LDLa 3958..3990 CDD:197566
LDLa 4049..4083 CDD:238060
FXa_inhibition 4097..>4121 CDD:405372
EGF_CA 4132..4163 CDD:214542
NHL 4219..>4431 CDD:302697
NHL repeat 4219..4257 CDD:271320
NHL repeat 4267..4330 CDD:271320
NHL repeat 4333..4371 CDD:271320
NHL repeat 4373..4410 CDD:271320
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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