DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp-2

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:2064 Identity:535/2064 - (25%)
Similarity:853/2064 - (41%) Gaps:425/2064 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 NKHKQLHSDARIGHLE------AGNESREDQLSEELSKFGEKLFPVSNYPPYQQNNEDSQEVHHS 108
            ::.:::.:..|:.:|.      :||.|....::..::|  ..||    :..:.::|.|.:::...
 Worm   689 DQRRKIITVQRLSNLSIQKVVVSGNMSNPRAIAIHIAK--SYLF----WGSWNEDNNDDEKIPAM 747

  Fly   109 GE-GRLHTME-SSVPSKTR--ISGGT--NSND----TPKFRNI-------GAQRGRTEIAGIRET 156
            .| .:|...| .::.||..  |:|.|  ..||    ...:||:       ||.|   |:. :...
 Worm   748 IERSKLDGSERKTLVSKNAMWINGLTLDLKNDYLYWCDAYRNVIERIRWNGADR---EVV-VHGA 808

  Fly   157 DRISSRGRDGF-------------------IGGPSNKQKPFRVNLAV--LVQDDPSQPGETYSNC 200
            |:||......|                   :..|.:.|:.|:.:..|  |:....|.| ||.|.|
 Worm   809 DKISHPYGLAFFDNHIFYTEFKKGAVKRVNVDFPDDVQEVFQYSATVFELLVFKNSNP-ETTSPC 872

  Fly   201 QNSNESDEN------------CNP--------------------EEDAVPNLQRDCEKTGIHVMC 233
            ..|:...|:            |.|                    ||...||.   |:.. |...|
 Worm   873 STSSNICEHFCFASSCKGSVGCEPVKCGCADGMKVLKNGKCVKDEEWVDPNA---CDNE-IEFTC 933

  Fly   234 PRTFRCISKYWLCDGDDDCGDYSDETHCGARTN--CTDDQFECLNGFCIPRTWVCDGENDCKDFS 296
            ..:.:|:.|..||||||||||.|||...|...:  |..::|:|....|:|..::|||::||.|.:
 Worm   934 LNSKKCVPKSNLCDGDDDCGDGSDEDANGICKDYKCVGNKFQCDGTTCLPMEFICDGKSDCYDGT 998

  Fly   297 DETH--CNR---TTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRG 356
            ||..  |.:   ..|:...|.|:...||..:.||:|..:|::.:||..|.. ...|...||:|..
 Worm   999 DELEKICKKAPIVKCSVSQFQCSKTKCIIKSKRCNGVQECDNGADEEDCPR-SKLCDPDEFRCGT 1062

  Fly   357 GLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADG--TCIPKRWKCDKE 419
            ||         ||.....|||...|.|..|||:|.::.......:::||:|  ||:...::||..
 Worm  1063 GL---------CIKQSQVCDGKMQCLDGLDEEHCNEEEKCLQGRQFRCANGKSTCLDLIFRCDGV 1118

  Fly   420 QDCDGGEDEND--CGSLGSEHPLTCGS-DEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC----- 476
            .||:...||:|  |....|.   |||. ::|.|.:|:|:....||||:|||..||||.||     
 Worm  1119 ADCEDSSDESDEFCKGNSSS---TCGKMNQFMCADGKCLRSFQLCDGFPDCLTGEDETECPPSMC 1180

  Fly   477 ----HLQCDLGQFLCPTKQ----------------NLTNLKI--------------------CVH 501
                ||.|..|| .|.:||                :.|.:::                    |:.
 Worm  1181 DSTTHLSCLNGQ-KCISKQLECDGVDDCGDNSDEKHCTEIRLDEAALRCQSPMYQCDGPNFKCIS 1244

  Fly   502 QKHICDGHNECPAGEDEA-----DCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVN 561
            .||:|||.|:|..|:||.     :|..    ::...|...|..|..|. .|:|...:.:|||.|.
 Worm  1245 DKHLCDGTNDCEEGDDEGLWCTFNCTD----ADDLGCSHTCRPTPVGP-ICSCPDDHYLDKNGVT 1304

  Fly   562 CTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLV-ANRWDIRRVT 625
            |:..|.|::   ..|||.|.....|..|.||..:.|..|..||.:.......|: :||.:||.: 
 Worm  1305 CSKKDPCRF---GQCSQYCSPHGSSHFCYCEDSFKLGADRSSCISDDPRKPFLIYSNRHEIRMI- 1365

  Fly   626 LSNNRYSA---IVKGLHNAIALDF-HHRKG--LMFWSDVSTDVIKMVYMNGTRV---RDVIKWGL 681
              .::|..   ::..|.||||||| :|:.|  .::|:|:|.|.|....::...:   |.::.:|:
 Worm  1366 --QSKYPGSLPMITNLVNAIALDFKYHQNGSVSIYWTDLSADKIYTGLVDQRTILYQRTIVSYGV 1428

  Fly   682 ESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDW-G 745
            .:..|||||||...::|.||....::|.:..|..|..:.:.::...|::.:...|...||:|| .
 Worm  1429 FNAEGIAVDWISGNIYWIDSFLDTIQVVSEDGTKRATVINQNMGNARSLAIDVEEGFMFWTDWEE 1493

  Fly   746 PNPKIERAYMDGTQRKVI--ISK--GVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKI 806
            .||:||||.:.|..|.:|  ||.  ...||||:|:|....::||||||..:|.....||.|...:
 Worm  1494 SNPRIERASLAGNNRAIIWKISNIAQAGWPNGIALDTIAKRVYWADAKSDSIHTITYDGRDHVIV 1558

  Fly   807 L--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQP-E 868
            .  ...|.|.|.:.::|..:|::||.|.|:|..||..|.....:......|..:...|.::|. :
 Worm  1559 FRDPERLGHCFGIDVYEGHVYFSDWRTNTISKVDKWFGSNVSIIERVATQPFSLKIVHRSKQKMQ 1623

  Fly   869 YADRCQKDRRGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDIRLRH 932
            ..:.|.    |.:  |:.:||.| |....|.|....|..:||  |.. ..:::|||.:..:    
 Worm  1624 IKNSCD----GFK--CNGICLNNGKNKATCQCTNLQSTTDDG--CVD-IQQVLLVATKNGV---- 1675

  Fly   933 LRDNQADPNDVDMIVPL------DNLKHAVA-----LDWCSDTDFIYWTDVERSTINKAHLNGSY 986
             |....||...... ||      :|:: ||.     |....|    |.|.:  :|:|   |.|:.
 Worm  1676 -RGFSTDPPHPHAF-PLVSGKQYENIR-AVGSFNNRLQVLDD----YTTHI--ATVN---LTGTA 1728

  Fly   987 QQRVV--HSNLVSPVGLALDWITDKLYWT--DPSTNRIEVATTNGKMRTLLIWEK----LYKPRD 1043
            ...|:  .|:|....|:|:|.:....|.|  ......:||.:.:||.|.:|....    :..|||
 Worm  1729 DDGVLATGSDLYGVSGMAVDPVVGSTYITLSIDGVGSVEVISADGKSRRVLAESSSSNPMKLPRD 1793

  Fly  1044 IVVNPIEGFM----FW-SDWGDDPMIERANMDGHE--RVTITSKKLIYPNGLAIDYEKSKIYFVD 1101
            |:      ||    || .|....|.|...:..|.:  ::.:.|..|.......:|...||||::.
 Worm  1794 IL------FMNTKLFWFEDSTSPPSIFSMSAAGDDLKKLKVNSTLLNKFYNPTVDRFYSKIYWIS 1852

  Fly  1102 GGTKTLENMNFDGSGRQV----ILNGLGH--PFGLDVNEGRVFWTDWDTKSVMSANKLT-----G 1155
            .| |.::   ||.....|    |..|.|:  ...:|:..|.:...::    :..||:.|     .
 Worm  1853 QG-KVIQ---FDPKSEVVQEIQIPGGDGNVSSIAVDMTNGDILIGEF----IRIANQTTIRRLGM 1909

  Fly  1156 KDTNVIIANSTDLM----DIRVF----HRTRRRIFNACDKLNGGCSHLCL-LNPTSYTCACTVGV 1211
            |.|..|...|..|:    .|:.|    ..|.:.:.:.|.|    |..||| .:...:.|.|:.|.
 Worm  1910 KGTKAIQRGSVMLVPLHSSIKFFLSTVDITAKNVPDECKK----CPSLCLRSSDKKFQCVCSQGF 1970

  Fly  1212 QLKEDRHTCSEGPTQYILFA------HRIDIRQISLDFD-------HLIDVVLPLPPISNAVALD 1263
            :|...:  | ..|.:.:.||      |.:...:.|...|       |.:...:....|...||  
 Worm  1971 ELVNGK--C-RSPDKRVFFATDDGSLHSVGWYKNSKTGDLIQKYRAHSLHSDIGKKRILKLVA-- 2030

  Fly  1264 VDRKTGYIYWSDTIENVIMSSSPDG--LHV------QKIVGDSLENPDGLVVDSIGRT------I 1314
             |.|...:| ..|.:|.:...:.:|  .|:      .:|...:|:...|.::.|...:      |
 Worm  2031 -DAKNDLVY-VVTRQNEVWKCATNGSFAHIVYSTNSHRIAAITLDRVTGYLLVSARESISPKGFI 2093

  Fly  1315 YWADAGRHTIEVASLDGSNRHVIAYKDLES-PRGLALDYEAGLLFWTDWGHYRKIERSHLDGNER 1378
            ...|..||:..:        |.:..:|.:. |..:|:|...|.|||..   ...|:.|:..|.|.
 Worm  2094 VLIDPDRHSEAI--------HQVIVEDEDKIPYEIAVDPPKGKLFWAS---SSCIKSSNYYGTEA 2147

  Fly  1379 SRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGN--QRKLIM---SSLHHPYALALSD 1438
            ..||:.:.  .:.:::|....|:.:||:....:|..||.||  ||.:.|   ..:....:|..:.
 Worm  2148 KCIVSKSS--ISAIAIDENRSRLCFVDSEKAAVDCVDYNGNNEQRNVAMFKAQPMGDIVSLVFNG 2210

  Fly  1439 DNIYWTD--------------------WKSKALHMTERRNISAKRDIITNIDGLMDIKIIYQNQN 1483
            |.:|:.|                    .|...:.:..|:.|.     :.:.| :||:|       
 Worm  2211 DEMYFFDKFNSSGSIVRGLVQQDGSVVLKDSLVKVHPRQKIR-----VIDFD-VMDVK------- 2262

  Fly  1484 QSTMKNACGNNNGNCSHLCLRNPSGYS------CQCPIGLRLRQNSTTQCQNLPEDYLLIALRSG 1542
            .|.:..||.||||.|.|||:..||..|      |.|....||...|   |.: .:.::.....:.
 Worm  2263 SSVLFTACSNNNGGCEHLCITTPSENSPTVRKECLCVHSTRLDNGS---CGS-SDSFIAFTRFTS 2323

  Fly  1543 IGMISLNSGDFM--DVVLPINGV----HGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKV 1601
            |..:|...||..  :..:..||.    .|||..|  ..:..::|||.:...|..||...  ...|
 Worm  2324 IEFLSTKPGDLTSPNKQITSNGCVMSKIGAVTAD--ATRGRIYFADYDKFRITAVNFDG--TGCV 2384

  Fly  1602 IVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGD-------------- 1652
            ::..||.....:|.|.:...||:...:...|        .|..:.::||..              
 Worm  2385 VIAEDVGVVPSMAYDEVHTELYFVRANPASI--------WRINVADNNLESYPTEPKIVLTLTVR 2441

  Fly  1653 --PRSLIVHPKKAYLFWSDWS-SPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADA 1714
              ||.:.:||.:..||:::.: :.:.|||.|..|..|..|:...:....|||||..:.:|.::|:
 Worm  2442 DRPRHIAIHPCRMLLFFTNNAITGSVIERVYFSGFKRDQIVQEDLHDLRGLTIDLDSEKLYFSDS 2506

  Fly  1715 LEDNIGQVDFNGKRRQTIVPYAP----HPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFE 1775
            .:..|.:.||:|..|:.:|....    |||.|:::::.|.:|||..:||....|:..|...|...
 Worm  2507 KDFKISRCDFDGSHRELVVSNTDIPSIHPFELSIYDDEIIFTDWVRRSVVGVNKITGSDNRNINR 2571

  Fly  1776 VRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLC-LNRNVDYVCAC 1823
            ..|...|.:   .|...|:..:.:.||.:...|...| |..|....|||
 Worm  2572 ATDVPVGLV---VVDTKREYCTSDACADNELKCEDYCRLMANGQASCAC 2617

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 13/35 (37%)
LDLa 306..340 CDD:238060 11/33 (33%)
LDLa 347..390 CDD:238060 16/42 (38%)
LDLa 397..431 CDD:238060 12/37 (32%)
LDLa 442..476 CDD:238060 17/34 (50%)
LDLa 480..521 CDD:238060 18/81 (22%)
FXa_inhibition 576..604 CDD:291342 10/27 (37%)
LY 634..671 CDD:214531 15/39 (38%)
NHL <656..793 CDD:302697 48/144 (33%)
LY 680..714 CDD:214531 12/33 (36%)
NHL repeat 681..722 CDD:271320 13/40 (33%)
NHL repeat 726..760 CDD:271320 13/34 (38%)
LY 761..803 CDD:214531 18/45 (40%)
NHL repeat 769..793 CDD:271320 12/23 (52%)
FXa_inhibition 882..912 CDD:291342 10/30 (33%)
LY 946..985 CDD:214531 12/49 (24%)
NHL <967..1142 CDD:302697 49/195 (25%)
LY 988..1030 CDD:214531 12/45 (27%)
NHL repeat 998..1037 CDD:271320 11/40 (28%)
NHL repeat 1038..1080 CDD:271320 12/48 (25%)
NHL repeat 1084..1119 CDD:271320 9/34 (26%)
FXa_inhibition 1185..1220 CDD:291342 10/35 (29%)
NHL 1260..>1445 CDD:302697 47/204 (23%)
NHL repeat 1260..1296 CDD:271320 10/43 (23%)
NHL repeat 1302..1337 CDD:271320 7/40 (18%)
NHL repeat 1345..1383 CDD:271320 12/37 (32%)
FXa_inhibition <1499..1525 CDD:291342 11/31 (35%)
LY 1600..1640 CDD:214531 8/39 (21%)
LY 1643..1686 CDD:214531 13/59 (22%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:291342 9/24 (38%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531 1/12 (8%)
LY 707..758 CDD:214531 10/56 (18%)
LY 759..801 CDD:214531 11/41 (27%)
LDLa 968..1000 CDD:197566 11/31 (35%)
LDLa 1013..1047 CDD:238060 11/33 (33%)
LDLa 1053..1087 CDD:238060 16/42 (38%)
LDLa 1098..1129 CDD:238060 11/30 (37%)
LDLa 1144..1175 CDD:238060 15/30 (50%)
LDLa 1182..1216 CDD:238060 8/34 (24%)
FXa_inhibition 1276..1305 CDD:291342 10/29 (34%)
LY 1421..1463 CDD:214531 14/41 (34%)
LY 1465..1508 CDD:214531 13/42 (31%)
LY 1521..1555 CDD:214531 15/33 (45%)
LY 2480..2521 CDD:214531 12/40 (30%)
LDLa 2681..2715 CDD:238060
LDLa 2717..2751 CDD:238060
LDLa <2774..2798 CDD:238060
LDLa 2819..2851 CDD:238060
LDLa 2856..2891 CDD:238060
LDLa 2904..2938 CDD:238060
LDLa 2988..3020 CDD:197566
LY 3231..3270 CDD:214531
Ldl_recept_b 3296..3336 CDD:278487
LY 3319..3362 CDD:214531
LY 3363..3404 CDD:214531
LDLa 3481..3514 CDD:197566
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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