DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and Lrp8

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_011238756.1	Gene:	Lrp8 / 16975	MGIID:	1340044	Length:	1010	Species:	Mus musculus

Alignment Length:	803	Identity:	270/803 - (33%)
Similarity:	385/803 - (47%)	Gaps:	119/803 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 DAVPNLQ---RDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTDDQFECLN 276
            |.:|..|   ::||:.  ...| |..|||...|.||.|:||.|.|||..|..|| |.|..|.|.|
Mouse    29 DPLPGGQGPVKECEED--QFRC-RNERCIPLVWRCDEDNDCSDNSDEDDCPKRT-CADSDFTCDN 89

  Fly   277 GFCIPRTWVCDGENDCKDFSDETH--CNRTTCTDEHFTC--NDGYCISLAFRCDGEHDCNDNSDE 337
            |.|||..|.||||.:|.|.|||:.  |:...|..|..:|  ....|:..::|||||.||...:||
Mouse    90 GHCIPERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 154

  Fly   338 LKCAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEY 402
            ..|..:   |...||:|         .:..|:.:.|.||||:||||.|||..| ..|: |...|:
Mouse   155 AGCPTL---CAPHEFQC---------SNRSCLASVFVCDGDDDCGDGSDERGC-SDPA-CPPREF 205

  Fly   403 KC-ADGTCIPKRWKCDKEQDCDGGEDE--NDCGSLG---SEHPLTCG-SDEFTCNNGRCILKTWL 460
            :| ..|||||:||.||::.||:...||  ..||..|   :..|..|. :.:|||.:|.||...|.
Mouse   206 RCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTTATPAACAPTAQFTCRSGECIHLGWR 270

  Fly   461 CDGYPDCAAGEDEVECHL--QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPK 523
            |||..||....||.:|..  .|...:|.|..       ..||.....|:...:||.|.|||.|.:
Mouse   271 CDGDRDCKDKSDEADCSAPGPCRENEFQCGD-------GTCVLAIKRCNQERDCPDGSDEAGCLQ 328

  Fly   524 ERKCSEP-----------------------------------SP--------------------- 532
            |..|..|                                   :|
Mouse   329 ESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEPQKVCVAPSFPGNRRHPRGLNECLHNNGG 393

  Fly   533 CEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYIL 597
            |..:|.:...|. ||.|..|:.:...| .|.||||||  ....|||.|.|..|.|||.|..||.:
Mouse   394 CSHICTDLKIGF-ECTCPAGFQLLDQK-TCGDIDECQ--DPDACSQICVNYKGYFKCECHPGYEM 454

  Fly   598 RPDLRSCKALGG-AMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTD 661
            ....::|||:.| :.:|:..||.::||:.|....||.::..|.|.:|||.......::|.|:|..
Mouse   455 DTLTKNCKAVAGKSPSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVATNRIYWCDLSYR 519

  Fly   662 VIKMVYMNGTRVRD----VIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASY 722
            .|...:|:...:.|    :|...|.||.|:||||:|..::|||||.:.:.|:...|..|..:.|.
Mouse   520 KIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATTDGRRRCTLFSR 584

  Fly   723 DLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWAD 787
            :|.:||||.|.|.....:|||||...|||:|.::|..|:.::|..:.||||:.:|..:.::||.|
Mouse   585 ELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVD 649

  Fly   788 AKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHE 850
            :|.|.:...:.:|.:|..::  :..|.|||.:.:|||.::|||...:.:.:|:::.|.|...:.|
Mouse   650 SKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEIAILAE 714

  Fly   851 NFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLP------NKTSRRCGCPIGLSLKEDG 909
            |.:.|.||..:|..:||:.||.|....:. .|||.:||||      :.....|.||..:.|..|.
Mouse   715 NLNNPHDIVIFHELKQPKAADACDLSAQP-NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDM 778

  Fly   910 KTC----KSTADKLVLVARRKDI 928
            |.|    :||:...:..|..:.:
Mouse   779 KRCYRAPQSTSTTTLASAMTRTV 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	19/35 (54%)
		LDLa	306..340	CDD:238060	13/35 (37%)
		LDLa	347..390	CDD:238060	17/42 (40%)
		LDLa	397..431	CDD:238060	16/36 (44%)
		LDLa	442..476	CDD:238060	15/34 (44%)
		LDLa	480..521	CDD:238060	12/40 (30%)
		FXa_inhibition	576..604	CDD:291342	12/27 (44%)
		LY	634..671	CDD:214531	10/36 (28%)
		NHL	<656..793	CDD:302697	53/140 (38%)
		LY	680..714	CDD:214531	15/33 (45%)
		NHL repeat	681..722	CDD:271320	17/40 (43%)
		NHL repeat	726..760	CDD:271320	16/33 (48%)
		LY	761..803	CDD:214531	12/41 (29%)
		NHL repeat	769..793	CDD:271320	10/23 (43%)
		FXa_inhibition	882..912	CDD:291342	13/35 (37%)
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Lrp8	XP_011238756.1	LDLa	41..75	CDD:238060	17/36 (47%)
		LDLa	79..111	CDD:197566	18/32 (56%)
		LDLa	121..157	CDD:238060	13/35 (37%)
		LDLa	200..232	CDD:197566	14/31 (45%)
		LDLa	256..286	CDD:238060	14/29 (48%)
		LDLa	292..326	CDD:238060	12/40 (30%)
		LDLa	330..366	CDD:381805	2/35 (6%)
		FXa_inhibition	387..421	CDD:373209	8/35 (23%)
		EGF_CA	423..453	CDD:214542	17/31 (55%)
		LY	492..527	CDD:214531	9/34 (26%)
		LY	537..578	CDD:214531	17/40 (43%)
		Ldl_recept_b	599..639	CDD:278487	16/39 (41%)
		LY	623..665	CDD:214531	12/41 (29%)
		Ldl_recept_b	686..725	CDD:278487	12/38 (32%)
		FXa_inhibition	744..781	CDD:373209	13/36 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810