DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp1

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_036011543.1 Gene:Lrp1 / 16971 MGIID:96828 Length:4562 Species:Mus musculus


Alignment Length:2006 Identity:640/2006 - (31%)
Similarity:957/2006 - (47%) Gaps:331/2006 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 KTAVKRNAPH---YGIHPTNALGRW-DWNKHKQLHSDARIGHLEAG--NESRED----------- 73
            ||.::....|   ..:.|.|....| ||.:..:   |:|.|.||..  :.|..|           
Mouse   641 KTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPK---DSRRGRLERAWMDGSHRDIFVTSKTVLWP 702

  Fly    74 -QLSEELSKFGEKLFPVSNYPPYQQ------NNEDSQEV-------------HHSG--------E 110
             .||.::.  ..:|:.|..:  |.:      |..|.:.|             ||..        .
Mouse   703 NGLSLDIP--AGRLYWVDAF--YDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRS 763

  Fly   111 GRLHTMESSV----PSKTRISGGTNSNDTPKF---------RNIGAQRGRTEIAG---------- 152
            |.::.:|..|    |:.|.:    .|...|.|         :.:|..:.|....|          
Mouse   764 GSVYRLERGVAGAPPTVTLL----RSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSSLCLATPG 824

  Fly   153 ----------IRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNCQNSN--- 204
                      :.:||.::......::..|.                  .||||  ..|.|:.   
Mouse   825 SRQCACAEDQVLDTDGVTCLANPSYVPPPQ------------------CQPGE--FACANNRCIQ 869

  Fly   205 -----ESDENCNPEEDAVPNLQRDCEKTGIHVMCP------RTFRCISKYWLCDGDDDCGDYSDE 258
                 :.|.:|....|..|.|   |.:   |. ||      ...|||...||||||:|||:..||
Mouse   870 ERWKCDGDNDCLDNSDEAPAL---CHQ---HT-CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDE 927

  Fly   259 TH--CGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDET-HCNRTTCTD-EHFTCNDGYCI 319
            ::  |.||| |..:||.|.:|.|||.:|.||.::||.|.|||: .|...||.. ..||||:|.||
Mouse   928 SNATCSART-CPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCI 991

  Fly   320 SLAFRCDGEHDCNDNSDELKC--------------AAVINSCPEGEFKCRGGLGGAGGPSGQCIL 370
            ::.:|||.|.||.|.|||..|              |...:||...:|||.         ||:||.
Mouse   992 NINWRCDNEKDCGDGSDEKTCPEPADNDCGDNSDEAGCSHSCSSTQFKCN---------SGRCIP 1047

  Fly   371 NRFRCDGDNDCGDWSDE--ENCPQK----PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCDGGEDE 428
            ..:.|||||||||:|||  .||..:    |..|.|:|::| .||.|||.||:||.:.||....||
Mouse  1048 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHSDEFQCRLDGLCIPLRWRCDGDTDCMDSSDE 1112

  Fly   429 NDCGSLGSEHPLTCGSD-EFTC-NNGRCILKTWLCDGYPDCAAGEDEVECH-LQCDLGQFLCPTK 490
            ..|.  |..|  .|..: :|.| ::.|||.|.|:|||..||....||..|. |.|     ..|:.
Mouse  1113 KSCE--GVTH--VCDPNVKFGCKDSARCISKAWVCDGDSDCEDNSDEENCEALAC-----RPPSH 1168

  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEAD-CPKERKCS-EPSPCEQLCIETTAGSNECACRLGY 553
            ....|..:|:....:|||.::|..|.||.: |.   :|| ....|...|.........|:|.||.
Mouse  1169 PCANNTSVCLPPDKLCDGKDDCGDGSDEGELCD---QCSLNNGGCSHNCSVAPGEGIVCSCPLGM 1230

  Fly   554 VMDKNKVNCTDIDEC-QYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLV-A 616
            .:..:...|.....| ::|.   |||||.....|.||||..|::|.||..||::|......:: :
Mouse  1231 ELGSDNHTCQIQSYCAKHLK---CSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFS 1292

  Fly   617 NRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVI---KMVYMNG--TRVRDV 676
            ||.:|||:.|....||.:|.||.|.||||||..:..::|:||..|.|   |:: .||  |....|
Mouse  1293 NRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLL-DNGALTSFEVV 1356

  Fly   677 IKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFW 741
            |::||.:|.|:|||||...::|.:|...::||:...|.|||.:.:.|::.||||.:.|.:.:.||
Mouse  1357 IQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGILFW 1421

  Fly   742 SDWGPN-PKIERAYMDGTQRKVII----SKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGS 801
            :||..: |:||.|.|.|..|:.|.    |.|  |||||.:|:...:|.|.||:..||..:..|||
Mouse  1422 TDWDASLPRIEAASMSGAGRRTIHRETGSGG--WPNGLTVDYLEKRILWIDARSDAIYSARYDGS 1484

  Fly   802 DRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPA 864
            ...::|..|  |.||||:||:...:|||||.|.|::.|:|.||.....|......|.|:..|||:
Mouse  1485 GHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPS 1549

  Fly   865 RQPEYADRCQKDRRGLRGGCSHLCLPN-KTSRRCGCPIGLSLKEDGKTCKSTADKLVLVARRKDI 928
            |||...:.|:.:  |.||.||||||.| ..:..|.||..:.|.:|..||.. ..|.:|.||:.:|
Mouse  1550 RQPMAPNPCEAN--GGRGPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYE-FKKFLLYARQMEI 1611

  Fly   929 RLRHLRDNQADPNDVDMIVPLDN---------LKHAVALDWCSDTDFIYWTDVERSTINKAHLNG 984
            |            .||:..|..|         :.:...||:.:....:||:||....|.:|.:||
Mouse  1612 R------------GVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING 1664

  Fly   985 SYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNR--IEVATTNGKMRTLLIWEKLYKPRDIVVN 1047
            :..:.||.::|.:..|||:||::..|:||...||:  |.||..:|..:..:: :.|.:|..:||:
Mouse  1665 TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVH 1728

  Fly  1048 PIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNF 1112
            |:.|.::|:| ||:  |..|||||.....:.|.:. .|.|||||:.:||:|::..|..|:...|.
Mouse  1729 PLRGKLYWTD-GDN--ISMANMDGSNHTLLFSGQK-GPVGLAIDFPESKLYWISSGNHTINRCNL 1789

  Fly  1113 DGSGRQVI---LNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDL-MDIRV 1173
            |||..:||   .:.||....|.:...:::|.|..::.:.:.||..|.. :|::.|||.| |.::|
Mouse  1790 DGSELEVIDTMRSQLGKATALAIMGDKLWWADQVSEKMGTCNKADGSG-SVVLRNSTTLVMHMKV 1853

  Fly  1174 FHRT---RRRIFNACDKLNGGCSHLCLLNPTSYT---CACTVGVQLKEDRHTCSEGPTQYILFAH 1232
            :..:   .....|.|...||.||.|||  |||.|   |.||.|..|:..:..| ||...::|::.
Mouse  1854 YDESIQLEHEGTNPCSVNNGDCSQLCL--PTSETTRSCMCTAGYSLRSGQQAC-EGVGSFLLYSV 1915

  Fly  1233 RIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGD 1297
            ...||.|.||.:...|.::|:...|.||.:|...:...|||.|...:.|..:..|....:.:|.:
Mouse  1916 HEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWREDVVTN 1980

  Fly  1298 SLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDW 1362
            .:...:|:.||.|...|||.|.|...||||.|:||.|:|:..:.|:.||.:.:..|.|.||||:|
Mouse  1981 GIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEW 2045

  Fly  1363 GHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDY-TGNQRKLIMS 1426
            |||.:||||.|||.||..:|..::.||||:|:|.:..::||.|||:..|:..|. ||..|::::|
Mouse  2046 GHYPRIERSRLDGTERVVLVNVSISWPNGISVDYQGGKLYWCDARMDKIERIDLETGENREVVLS 2110

  Fly  1427 SLH-HPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDG-----------LMDIKIIY 1479
            |.: ..:::::.:|.|||:|        ....|.|.||....|...           |.|||:..
Mouse  2111 SNNMDMFSVSVFEDFIYWSD--------RTHANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFN 2167

  Fly  1480 QNQNQSTMKNACGNNNGNCSHLCLRNPSGY-SCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGI 1543
            :::.:.|  |.|...||.|..|||....|. :|.|..|:.....::  |:.. ..|||.:.|:.:
Mouse  2168 RDRQKGT--NVCAVANGGCQQLCLYRGGGQRACACAHGMLAEDGAS--CREY-AGYLLYSERTIL 2227

  Fly  1544 GMISLNSGDFMDVVLPI------NGVHGAVVLDYHYR-------KNLLFFADVNLDVIRRVNLLN 1595
            ..|.|:  |..::..|:      ..:...:.|.:.||       .|.:||:|::...|:::|  :
Mouse  2228 KSIHLS--DERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIN--D 2288

  Fly  1596 LTESKVIVGTDVLTPNGIAVDWIADNLYW-----SDTDRKLIEVSRLDGSCRKRIVEDNLGD--P 1653
            ....:..:..:|.:..|:|.....|.|||     |...|..::.:| .|:..:..|....||  |
Mouse  2289 DGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTR-PGAFERETVITMSGDDHP 2352

  Fly  1654 RSLIVHPKKAYLFWSDWSS--PAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALE 1716
            |:.::...:..:||::|:.  |: |.|:.|.|:|...:|...|..|.||.||....:|.::||..
Mouse  2353 RAFVLDECQNLMFWTNWNELHPS-IMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2416

  Fly  1717 DNIGQVDFNGKRRQTIVPYAP-HPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDAL 1780
            |.|.:.:::|..|..|:...| |||||.::...||||||..::|.|:.|...|.           
Mouse  2417 DKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKYVGSD----------- 2470

  Fly  1781 SGALDIRAVSLSRQPKSV------------NHCAQDNGGCTHLCLNRNVDYV-CAC 1823
               :.:..|.:.:||..:            :.|..:||||..|||..:..:| |:|
Mouse  2471 ---MKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSC 2523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/34 (50%)
LDLa 306..340 CDD:238060 18/34 (53%)
LDLa 347..390 CDD:238060 20/44 (45%)
LDLa 397..431 CDD:238060 17/34 (50%)
LDLa 442..476 CDD:238060 15/35 (43%)
LDLa 480..521 CDD:238060 11/41 (27%)
FXa_inhibition 576..604 CDD:464251 14/27 (52%)
LY 634..671 CDD:214531 18/41 (44%)
LY 680..714 CDD:214531 13/33 (39%)
LY 718..760 CDD:214531 16/42 (38%)
Ldl_recept_b 740..777 CDD:459654 19/41 (46%)
LY 761..803 CDD:214531 18/45 (40%)
LY 806..838 CDD:214531 16/33 (48%)
FXa_inhibition 882..912 CDD:464251 13/30 (43%)
LY 946..985 CDD:214531 11/47 (23%)
NHL <967..1142 CDD:302697 63/179 (35%)
LY 988..1030 CDD:214531 17/43 (40%)
NHL repeat 998..1037 CDD:271333 14/40 (35%)
NHL repeat 1038..1080 CDD:271333 16/41 (39%)
NHL repeat 1084..1119 CDD:271333 15/34 (44%)
FXa_inhibition 1185..1220 CDD:464251 17/37 (46%)
NHL 1260..>1445 CDD:302697 72/186 (39%)
NHL repeat 1260..1296 CDD:271320 8/35 (23%)
LY 1292..1334 CDD:214531 17/41 (41%)
NHL repeat 1302..1337 CDD:271320 17/34 (50%)
NHL repeat 1345..1383 CDD:271320 21/37 (57%)
FXa_inhibition <1499..1525 CDD:464251 7/26 (27%)
LY 1600..1640 CDD:214531 10/44 (23%)
LY 1643..1686 CDD:214531 13/46 (28%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:464251 11/24 (46%)
Lrp1XP_036011543.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:464251
FXa_inhibition 159..189 CDD:464251
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:464251
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531 14/51 (27%)
LY <701..734 CDD:214531 6/36 (17%)
FXa_inhibition 808..843 CDD:464251 4/34 (12%)
LDLa 854..886 CDD:197566 8/51 (16%)
LDLa 896..929 CDD:238060 16/32 (50%)
LDLa 936..968 CDD:197566 16/32 (50%)
LDLa 979..1012 CDD:238060 17/32 (53%)
LDLa 1033..1066 CDD:238060 20/41 (49%)
LDLa 1080..1115 CDD:238060 17/34 (50%)
LDLa 1122..1158 CDD:238060 15/35 (43%)
LDLa 1163..1196 CDD:238060 9/37 (24%)
FXa_inhibition 1203..1239 CDD:464251 8/35 (23%)
Vgb 1328..>1521 CDD:443399 79/195 (41%)
LY 1354..1394 CDD:214531 15/39 (38%)
LY 1398..1441 CDD:214531 16/42 (38%)
LY 1631..1667 CDD:214531 10/35 (29%)
LY 1668..1711 CDD:214531 17/42 (40%)
LY 1715..1752 CDD:214531 16/40 (40%)
LY 1752..1793 CDD:214531 15/41 (37%)
FXa_inhibition 1868..1904 CDD:464251 17/37 (46%)
LY 1934..1974 CDD:214531 11/39 (28%)
LY 1977..2017 CDD:214531 17/39 (44%)
LY 2018..2061 CDD:214531 21/42 (50%)
LY 2063..2105 CDD:214531 16/41 (39%)
FXa_inhibition 2177..2212 CDD:464251 11/36 (31%)
LY 2293..2333 CDD:214531 9/39 (23%)
Ldl_recept_b 2362..2404 CDD:459654 15/42 (36%)
LY 2388..2429 CDD:214531 13/40 (33%)
FXa_inhibition 2500..2532 CDD:464251 11/24 (46%)
LDLa 2545..2575 CDD:238060
LDLa 2584..2618 CDD:238060
LDLa 2623..2657 CDD:238060
LDLa <2684..2706 CDD:238060
LDLa 2714..2748 CDD:238060
LDLa 2752..2783 CDD:197566
LDLa 2791..2824 CDD:197566
LDLa 2835..2867 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2925..2957 CDD:238060
FXa_inhibition 2969..2998 CDD:464251
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:464251
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
YncE 3880..4082 CDD:442618
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4072 CDD:459654
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.