DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Ldlr

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_034830.2 Gene:Ldlr / 16835 MGIID:96765 Length:862 Species:Mus musculus


Alignment Length:747 Identity:257/747 - (34%)
Similarity:378/747 - (50%) Gaps:72/747 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 EDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDET--HCGARTNCTDDQFECLN 276
            ||:....:..|          |..:||:..|:|||..:|.|.|||:  .|.:.| |..:||.|..
Mouse    24 EDSCSRNEFQC----------RDGKCIASKWVCDGSPECPDGSDESPETCMSVT-CQSNQFSCGG 77

  Fly   277 --GFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELK 339
              ..|||.:|.|||:.||::.|||..|...||:.:.|.|.||.|||..|.|||:.||.|.|||..
Mouse    78 RVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKCISPQFVCDGDRDCLDGSDEAH 142

  Fly   340 CAAVINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDE--ENCPQK-------PS 395
            |.|  .:|....|:|...:         ||.:.:.||||.||.|.|||  :||..:       .|
Mouse   143 CQA--TTCGPAHFRCNSSI---------CIPSLWACDGDVDCVDGSDEWPQNCQGRDTASKGVSS 196

  Fly   396 LCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWL 460
            .|:|.|:.|....||.:.|.||.|.||....||..|.      ..||..|||.|.:|.||..:..
Mouse   197 PCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCA------VATCRPDEFQCADGSCIHGSRQ 255

  Fly   461 CDGYPDCAAGEDEVEC--HLQCD-LGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE--AD 520
            ||...||....||:.|  ..||| ..:|.|.:.:       |:....:||...:|....||  .:
Mouse   256 CDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGE-------CISLDKVCDSARDCQDWSDEPIKE 313

  Fly   521 CPKERKCSEPS-PCEQLCIETTAGSNECACRLGY-VMDKNKVNCTDIDECQYLTSPVCSQKCHNT 583
            | |..:|.:.: .|..:|.:...|| ||.|..|: ::|.::  |.||||||  ....|||.|.|.
Mouse   314 C-KTNECLDNNGGCSHICKDLKIGS-ECLCPSGFRLVDLHR--CEDIDECQ--EPDTCSQLCVNL 372

  Fly   584 MGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHH 648
            .||:||.|:.|:.:.|..|.|||:|....||..||.::|::||..:.|::::..|.|.:|||...
Mouse   373 EGSYKCECQAGFHMDPHTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPNLKNVVALDTEV 437

  Fly   649 RKGLMFWSDVSTDVIKMVYMN---GTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSN 710
            ....::|||:|...|....|:   ......:|...|.:|.|:||||||..::||||....|.|::
Mouse   438 TNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVAD 502

  Fly   711 FQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLA 775
            .:|..|..:......:||||||.|.....:|:|||...||::..::|.....::::.:.||||:.
Mouse   503 TKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGIT 567

  Fly   776 IDFPNSKIYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAAD 838
            :|..:.::||.|:|.|:|...:::|.:|..||  ...|.|||:|.::||.:||||...:.:.:|:
Mouse   568 LDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSAN 632

  Fly   839 KITGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCL------PNKTSRRC 897
            ::||.:...|.||...|.||..:|...||...:.|:.......|||.:|||      |:.....|
Mouse   633 RLTGSDVNLVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTC 697

  Fly   898 GCPIGLSLKEDGKTCKSTADKLVLVARRKDIR 929
            .||.|:.|.:|.::|.:..|.::.......:|
Mouse   698 ACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVR 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 16/35 (46%)
LDLa 306..340 CDD:238060 18/33 (55%)
LDLa 347..390 CDD:238060 15/44 (34%)
LDLa 397..431 CDD:238060 14/33 (42%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 480..521 CDD:238060 10/43 (23%)
FXa_inhibition 576..604 CDD:291342 13/27 (48%)
LY 634..671 CDD:214531 11/39 (28%)
NHL <656..793 CDD:302697 47/139 (34%)
LY 680..714 CDD:214531 15/33 (45%)
NHL repeat 681..722 CDD:271320 17/40 (43%)
NHL repeat 726..760 CDD:271320 14/33 (42%)
LY 761..803 CDD:214531 12/41 (29%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 13/35 (37%)
LY 946..985 CDD:214531
NHL <967..1142 CDD:302697
LY 988..1030 CDD:214531
NHL repeat 998..1037 CDD:271320
NHL repeat 1038..1080 CDD:271320
NHL repeat 1084..1119 CDD:271320
FXa_inhibition 1185..1220 CDD:291342
NHL 1260..>1445 CDD:302697
NHL repeat 1260..1296 CDD:271320
NHL repeat 1302..1337 CDD:271320
NHL repeat 1345..1383 CDD:271320
FXa_inhibition <1499..1525 CDD:291342
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
LdlrNP_034830.2 Ldl_recept_a 25..58 CDD:278486 12/42 (29%)
Ldl_recept_a 66..104 CDD:278486 17/38 (45%)
Ldl_recept_a 107..143 CDD:278486 19/35 (54%)
Ldl_recept_a 146..184 CDD:278486 15/46 (33%)
Ldl_recept_a 196..232 CDD:278486 15/35 (43%)
Ldl_recept_a 236..271 CDD:278486 15/34 (44%)
Ldl_recept_a 279..309 CDD:278486 6/36 (17%)
FXa_inhibition 319..>347 CDD:291342 9/28 (32%)
EGF_CA 355..389 CDD:214542 17/35 (49%)
LDL-receptor class B 1 398..439 13/40 (33%)
LY 420..458 CDD:214531 11/37 (30%)
LDL-receptor class B 2 440..485 14/44 (32%)
Ldl_recept_b 440..482 CDD:278487 11/41 (27%)
LDL-receptor class B 3 486..528 15/41 (37%)
Ldl_recept_b 486..525 CDD:278487 13/38 (34%)
LDL-receptor class B 4 529..572 12/42 (29%)
Ldl_recept_b 529..569 CDD:278487 11/39 (28%)
LY 553..595 CDD:214531 12/41 (29%)
LDL-receptor class B 5 573..615 15/41 (37%)
LDL-receptor class B 6 616..658 15/41 (37%)
Ldl_recept_b 616..655 CDD:278487 14/38 (37%)
FXa_inhibition 675..712 CDD:291342 13/36 (36%)
Clustered O-linked oligosaccharides 722..770 1/8 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 730..761 257/747 (34%)
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 813..862
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 825..830
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.