DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and Lrp2

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001074557.1 Gene:Lrp2 / 14725 MGIID:95794 Length:4660 Species:Mus musculus


Alignment Length:1736 Identity:571/1736 - (32%)
Similarity:850/1736 - (48%) Gaps:167/1736 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 QDDPS------QPGETYSNCQNSN--------ESDENC--NPEEDAVPNLQRDCEKTGIHVMCPR 235
            :.||:      |.|.:...|.|..        :..::|  |.:|.....|...|..:..  .|..
Mouse  1013 EGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAF--TCVH 1075

  Fly   236 TFRCISKYWLCDGDDDCGDYSDETHCGAR---TNCTDDQFECLNGFCIPRTWVCDGENDCKDFSD 297
            ..:||...|.||..:||.|.|||.:|..|   :.|....|.|.|..|||:.||||.:|||.|.||
Mouse  1076 GGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSD 1140

  Fly   298 ETHCNRT-TCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGA 361
            |.:|..: ||....|.|.|..|||..:.|||:.||.|.|||..|  |:| |...:|||..|    
Mouse  1141 EKNCQASGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGC--VLN-CTSSQFKCADG---- 1198

  Fly   362 GGPSGQCILNRFRCDGDNDCGDWSDEENCPQK-PSLCTSNEYKC-ADGTCIPKRWKCDKEQDCDG 424
                ..||.:|:||||..||.|.|||..||.: |.:|..:|::| .||||||..|:||...||..
Mouse  1199 ----SSCINSRYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQ 1259

  Fly   425 GEDE-NDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQ---CDLGQF 485
            |.|| |.|      .|.||....|.|:||.||..:|:|||..||....||.:|..|   |...|:
Mouse  1260 GSDEHNGC------VPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQW 1318

  Fly   486 LCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCSE-PSPCEQLCIETTAGSNECAC 549
            .||      ...|||:...:|||..:||.|.||:....:..|.. ...|...||:...|:. |.|
Mouse  1319 QCP------GYSICVNLSALCDGVFDCPNGTDESPLCNQDSCLHFNGGCTHRCIQGPFGAT-CVC 1376

  Fly   550 RLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLL 614
            .:||.:..:...|.|::||.  ....|||.|.|..|||:|:|:..|.|..|.|:||.......||
Mouse  1377 PIGYQLANDTKTCEDVNECD--IPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTASENLLL 1439

  Fly   615 VANRWD---IRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDV 676
            |....|   :..:|...:...::|:.:...:||||....|.:||||:........:.|||..|.|
Mouse  1440 VVASRDKIIMDNITAHTHNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSAFQNGTDKRVV 1504

  Fly   677 IKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHP--GEALA 739
            ...||.....||||||...::|||.....:|||...|:.|||:.|.::.|||.:.:.|  |:.:.
Mouse  1505 HDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVM 1569

  Fly   740 FWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRN 804
            ||||||.:|:||||.||||.|.||:.:.:.||.||:||:||..||:.||....||..:.||.:|.
Mouse  1570 FWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNRR 1634

  Fly   805 KILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAYHPARQP 867
            :::::.  |.||.|||||||:::|||..|..|..|:|..|:....|..:...|:.|.|.||:|||
Mouse  1635 QVIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQANKWHGRNQSVVMYSVPQPLGIIAIHPSRQP 1699

  Fly   868 EYADRCQKDRRGLRGGCSHLCLPNKTSRR---CGCPIGLSLKEDGKTCKSTADKLVLVARRKDIR 929
            ...:.|..      ..||||||.:....|   |.||.|.:|.:|...| ...|:..|::.|:::.
Mouse  1700 SSPNPCAS------ATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNC-VRGDQPFLISVRENVI 1757

  Fly   930 LRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGSYQQRVVHSN 994
            .....|.:...||.  :||:..::|...:::.....||||.: ....|::...:||.:......:
Mouse  1758 FGISLDPEVKSNDA--MVPISGIQHGYDVEFDDSEQFIYWVE-NPGEIHRVKTDGSNRTAFAPLS 1819

  Fly   995 LV-SPVGLALDWITDKLYWTDPSTNRIEVATTNGKMR---TLLIWE----KLYKPRDIVVNPIEG 1051
            |: |.:||||||::..:|:|.|::..|||.|..|..|   ||:..:    .:..|..|.|:|..|
Mouse  1820 LLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARG 1884

  Fly  1052 FMFWSDWGDD----PMIERANMDGHERVTITSKKLIYPNGL------AIDYEKSKIYFVDGGTKT 1106
            .::|||.|.|    ..|..|||||      ||.|:::...:      .:|.::.|:|:.......
Mouse  1885 KLYWSDHGTDSGVPAKIASANMDG------TSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGV 1943

  Fly  1107 LENMNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDI 1171
            :|..|.||:.|.::::.|.||:||.|:...::::|...:.:...:|.:|.:..|...|...|..:
Mouse  1944 IERGNVDGTERMILVHHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGL 2008

  Fly  1172 RVFHRTRRRIFNACDKLNG------GCSHLCLLNPTS-YTCACTVGVQLKEDRHTCSEGP-TQYI 1228
            ||:|..     ||.|..||      .|..:||..|.. ::|||..|.:|..|..:||  | ..:|
Mouse  2009 RVYHHR-----NAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCS--PYNSFI 2066

  Fly  1229 LFAHRIDIRQISLDFDHLIDVVLPLPPIS-NAVALDVDRKTGYIYWSDTIENVIMSS-----SPD 1287
            :.:....:|..||:.....:.::|:.... |.:..|||...|:|||.|...:|..|:     .|:
Mouse  2067 VVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPN 2131

  Fly  1288 GLHVQKIV--GDSLENPDGLVVDSIGRTIYWADAGRH--TIEVASLDGSNRHVIAYKDLESPRGL 1348
            |.:...||  |.......|:.||.:...:|:.:|..:  .|||..::.:.|.|:....::.||.:
Mouse  2132 GSNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHI 2196

  Fly  1349 ALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDS 1413
            .:|.:...|||.|:|...|||||.||...|:.:|:..:..|.||::|..:..|||||..|..|..
Mouse  2197 VVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIAR 2261

  Fly  1414 CDYTGNQRKLIM--SSLHHPYALALSDDNIYWTDWKSKALHMTERR--NISAKRDIITNIDGLMD 1474
            ....|.:.:::.  |....||.:.:..::|.|.|...:.:....::  |......|..:|:.|.|
Mouse  2262 IHRDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASKQPGNTDPPTVIRDSINLLRD 2326

  Fly  1475 IKIIYQN-QNQSTMK---NACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYL 1535
            :.|..:: |..|..:   |.|..:||.|||.|...|...:.:|.......::....|....||:|
Mouse  2327 VTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPKCGCAFGTLEDDGKNCATSREDFL 2391

  Fly  1536 LIALRSGIGMISLNSGDFMDVVLPIN--GVHG-AVVLDYHYRKNLLFFADVNLDVIR----RVNL 1593
            :.:|.:.:..:..   |..|..||..  .|.| |:.|||..|.|.:||.. .|:.||    .|||
Mouse  2392 IYSLNNSLRSLHF---DPQDHNLPFQAISVEGMAIALDYDRRNNRIFFTQ-KLNPIRGQISYVNL 2452

  Fly  1594 LNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIV 1658
            .:...|..|:.:::...:|||.|||...:|:||...:.|.....|||  .|.|...:..||::::
Mouse  2453 YSGASSPTILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGS--NRAVIARVSKPRAIVL 2515

  Fly  1659 HPKKAYLFWSDWSSPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVD 1723
            .|.:.|::|:||.:.|||||:.|.|:.|..|:.:.:.:|.|||:|.....|.||||....|.:..
Mouse  2516 DPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERST 2580

  Fly  1724 FNGKRRQTIVPYAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDAL-------- 1780
            ..|..|:.::..|.|.||||::...|:|||:|.|.:||:         |.::..|.:        
Mouse  2581 LTGSNREVVISTAFHSFGLTVYGQYIYWTDFYTKKIYRA---------NKYDGSDLIAMTTRLPT 2636

  Fly  1781 --SGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCLNRNVDYVCACP 1824
              ||   |..|..::|.:..|.|.|.||||:|:|........|.||
Mouse  2637 QPSG---ISTVVKTQQQQCSNPCDQFNGGCSHICAPGPNGAECQCP 2679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 18/33 (55%)
LDLa 306..340 CDD:238060 16/33 (48%)
LDLa 347..390 CDD:238060 18/42 (43%)
LDLa 397..431 CDD:238060 18/35 (51%)
LDLa 442..476 CDD:238060 15/33 (45%)
LDLa 480..521 CDD:238060 15/40 (38%)
FXa_inhibition 576..604 CDD:464251 14/27 (52%)
LY 634..671 CDD:214531 11/36 (31%)
LY 680..714 CDD:214531 14/33 (42%)
LY 718..760 CDD:214531 22/43 (51%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 18/41 (44%)
LY 806..838 CDD:214531 15/33 (45%)
FXa_inhibition 882..912 CDD:464251 13/32 (41%)
LY 946..985 CDD:214531 8/38 (21%)
NHL <967..1142 CDD:302697 58/192 (30%)
LY 988..1030 CDD:214531 16/42 (38%)
NHL repeat 998..1037 CDD:271333 17/45 (38%)
NHL repeat 1038..1080 CDD:271333 17/45 (38%)
NHL repeat 1084..1119 CDD:271333 8/40 (20%)
FXa_inhibition 1185..1220 CDD:464251 13/41 (32%)
NHL 1260..>1445 CDD:302697 59/195 (30%)
NHL repeat 1260..1296 CDD:271320 14/42 (33%)
LY 1292..1334 CDD:214531 11/45 (24%)
NHL repeat 1302..1337 CDD:271320 9/36 (25%)
NHL repeat 1345..1383 CDD:271320 16/37 (43%)
FXa_inhibition <1499..1525 CDD:464251 5/25 (20%)
LY 1600..1640 CDD:214531 12/39 (31%)
LY 1643..1686 CDD:214531 16/42 (38%)
LY 1688..1729 CDD:214531 13/40 (33%)
FXa_inhibition 1801..>1825 CDD:464251 11/24 (46%)
Lrp2NP_001074557.1 LDLa 28..62 CDD:238060
LDLa 67..99 CDD:197566
LDLa 108..142 CDD:238060
LDLa 148..179 CDD:238060
LDLa 183..217 CDD:238060
LDLa 222..256 CDD:238060
LDLa 265..299 CDD:238060
YncE <427..576 CDD:442618
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 435..477
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 478..520
LY 502..547 CDD:214531
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 521..567
LY 550..590 CDD:214531
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 568..612
FXa_inhibition 662..703 CDD:464251
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 752..794
LY 775..817 CDD:214531
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 795..836
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 837..880
Ldl_recept_b 837..878 CDD:459654
LY 863..903 CDD:214531
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 881..924
FXa_inhibition 980..1012 CDD:464251
LDLa 1025..1059 CDD:238060 6/33 (18%)
Ldl_recept_a 1065..1101 CDD:395011 13/37 (35%)
LDLa 1110..1144 CDD:238060 18/33 (55%)
LDLa 1150..1184 CDD:238060 16/33 (48%)
LDLa 1188..1223 CDD:238060 18/42 (43%)
LDLa 1231..1263 CDD:197566 15/31 (48%)
LDLa 1272..1306 CDD:238060 15/33 (45%)
LDLa 1313..1345 CDD:197566 13/37 (35%)
FXa_inhibition 1354..1389 CDD:464251 9/35 (26%)
EGF_CA 1391..1430 CDD:214542 17/40 (43%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1479..1521 17/41 (41%)
LY 1502..1544 CDD:214531 17/41 (41%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1522..1564 15/41 (37%)
LY 1546..1590 CDD:214531 22/43 (51%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1567..1610 24/42 (57%)
LY 1592..1633 CDD:214531 18/40 (45%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1611..1655 18/43 (42%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1656..1696 13/39 (33%)
FXa_inhibition 1710..1741 CDD:464251 13/30 (43%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1791..1833 15/42 (36%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1834..1883 15/48 (31%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1884..1931 16/52 (31%)
Ldl_recept_b 1884..1929 CDD:459654 15/50 (30%)
LY 1912..1954 CDD:214531 8/41 (20%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1932..1973 13/40 (33%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1974..2014 9/39 (23%)
YncE 2035..2277 CDD:442618 71/243 (29%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2108..2157 15/48 (31%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2158..2202 10/43 (23%)
LY 2183..2226 CDD:214531 16/42 (38%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2203..2246 18/42 (43%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2247..2290 11/42 (26%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2291..2333 9/41 (22%)
FXa_inhibition 2347..2383 CDD:464251 9/35 (26%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2432..2478 16/46 (35%)
LY 2460..2501 CDD:214531 14/42 (33%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2479..2519 12/41 (29%)
LY 2503..2543 CDD:214531 15/39 (38%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2520..2563 18/42 (43%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2564..2605 14/40 (35%)
LY <2595..2626 CDD:214531 14/39 (36%)
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2606..2647 14/52 (27%)
FXa_inhibition 2656..2693 CDD:464251 11/24 (46%)
LDLa 2700..2732 CDD:197566
LDLa 2742..2776 CDD:238060
LDLa 2783..2818 CDD:238060
LDLa 2822..2855 CDD:197566
LDLa 2865..2899 CDD:238060
LDLa 2908..2939 CDD:197566
LDLa 2950..2986 CDD:197566
LDLa 2995..3029 CDD:238060
LDLa 3034..3066 CDD:238060
LDLa 3077..3111 CDD:238060
FXa_inhibition 3124..3152 CDD:464251
vWFA <3149..3192 CDD:469594
LY 3221..3262 CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3241..3283
LY 3264..3306 CDD:214531
Ldl_recept_b 3284..3332 CDD:459654
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3335..3378
Ldl_recept_b 3335..3376 CDD:459654
LY 3360..3401 CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3379..3421
LY 3406..3443 CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3422..3462
FXa_inhibition 3471..>3500 CDD:464251
LDLa 3514..3548 CDD:238060
LDLa 3555..3586 CDD:197566
LDLa 3595..3627 CDD:197566
LDLa 3636..3668 CDD:197566
LDLa 3684..3716 CDD:238060
LDLa 3723..3756 CDD:238060
LDLa 3761..3795 CDD:238060
LDLa 3800..3834 CDD:238060
LDLa 3844..3876 CDD:238060
LDLa 3887..3917 CDD:197566
LDLa 3930..3964 CDD:238060
EGF_CA 4009..4049 CDD:214542
LY 4143..4178 CDD:214531
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4199..4242
Ldl_recept_b 4199..4240 CDD:459654
LY 4224..4266 CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4244..4285
FXa_inhibition 4340..>4358 CDD:464251
SH3-binding. /evidence=ECO:0000255 4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4460..4465
Endocytosis signal. /evidence=ECO:0000255 4522..4527
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4558..4660
Interaction with DAB2. /evidence=ECO:0000250|UniProtKB:P98164 4597..4610
NPXY motif 4603..4606
SH2-binding. /evidence=ECO:0000255 4606..4609
SH3-binding. /evidence=ECO:0000255 4619..4630
Blue background indicates that the domain is not in the aligned region.

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