Protein Alignment Lrp4 and LDLRAD3

DIOPT Version :10

• Sequence 1: NP_727914.1
• Gene: Lrp4 / 32552
• FlyBaseID: FBgn0030706
• Length: 2009
• Species: Drosophila melanogaster
• Sequence 2: NP_777562.1
• Gene: LDLRAD3 / 143458
• HGNCID: 27046
• Length: 345
• Species: Homo sapiens
• Alignment Length: 146
• Identity: 58/146 - (39%)
• Similarity: 78/146 - (53%)
• Gaps: 16/146 - (10%)

  Fly   294 DFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGL 358
            :|::|  ||    ...:|.|::|.||..|::|||..||.|.|||.:|....:.|....|.|..|:
Human    24 NFTNE--CN----IPGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGI 82

  Fly   359 GGAGGPSGQCILNRFRCDGDNDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPKRWKCDKEQDCD 423
                    .||:.||||:|..||.|.||||||...|.||::..|.|.:|.||.|.:.||.:.:|.
Human    83 --------HCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQ 139

  Fly   424 GGEDENDCGSLGSEHP 439
            ...||..|.|  |:.|
Human   140 DNSDEESCES--SQEP 153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	2/6 (33%)
		LDLa	306..340	CDD:238060	15/33 (45%)
		LDLa	347..390	CDD:238060	18/42 (43%)
		LDLa	397..431	CDD:238060	12/33 (36%)
		LDLa	442..476	CDD:238060
		LDLa	480..521	CDD:238060
		FXa_inhibition	576..604	CDD:464251
		LY	634..671	CDD:214531
		LY	680..714	CDD:214531
		LY	718..760	CDD:214531
		Ldl_recept_b	740..777	CDD:459654
		LY	761..803	CDD:214531
		LY	806..838	CDD:214531
		FXa_inhibition	882..912	CDD:464251
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271333
		NHL repeat	1038..1080	CDD:271333
		NHL repeat	1084..1119	CDD:271333
		FXa_inhibition	1185..1220	CDD:464251
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		LY	1292..1334	CDD:214531
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:464251
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:464251
LDLRAD3	NP_777562.1	(Microbial infection) Interaction with Venezuelan equine encephalitis virus/VEEV spike proteins E1 and E2. /evidence=ECO:0000269|PubMed:34646021	30..57		12/30 (40%)
		LDLa	32..64	CDD:238060	15/31 (48%)
		LDLa	71..106	CDD:238060	18/42 (43%)
		LDLa	113..147	CDD:238060	12/33 (36%)
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	256..259
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	270..345
		Involved in ITCH interaction. /evidence=ECO:0000269|PubMed:26854353	275..278