DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and Egf

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_011238312.1 Gene:Egf / 13645 MGIID:95290 Length:1221 Species:Mus musculus


Alignment Length:1176 Identity:265/1176 - (22%)
Similarity:421/1176 - (35%) Gaps:331/1176 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   590 SCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMF 654
            :|:.|.:.|.: ||....|.|..|:.:....|.|:......:..:|.....:..:|.|::|..::
Mouse    33 NCQPGPLERSE-RSGTCAGPAPFLVFSQGKSISRIDPDGTNHQQLVVDAGISADMDIHYKKERLY 96

  Fly   655 WSDVSTDVIKMVYMNGTRVRDVIKWGLE-------SPGGIAVDWIHDLLFWTDSGTRRVEVSNFQ 712
            |.||...|:..|::|||        |||       ...|:|:|||.|.:.|.|.....:.|::..
Mouse    97 WVDVERQVLLRVFLNGT--------GLEKVCNVERKVSGLAIDWIDDEVLWVDQQNGVITVTDMT 153

  Fly   713 G-NLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAI 776
            | |.|.:::|  |..|..|.|.|.|.|.|||. .....:.||::.|...|.::..|..  :.|.:
Mouse   154 GKNSRVLLSS--LKHPSNIAVDPIERLMFWSS-EVTGSLHRAHLKGVDVKTLLETGGI--SVLTL 213

  Fly   777 DFPNSKIYWADAK---QHAI--ECSNLDGSDRNKILSTHLPHPF-ALTLFEDTMYWTDWNTKTVS 835
            |..:.:::|....   .||.  .|....||.|  ::.....|.. ::..|.|.::::...:|.:.
Mouse   214 DVLDKRLFWVQDSGEGSHAYIHSCDYEGGSVR--LIRHQARHSLSSMAFFGDRIFYSVLKSKAIW 276

  Fly   836 AADKITGKEFRAV--HENFHFPMDIHAYHPARQPEYADR------------------------CQ 874
            .|:|.|||:...:  |.:|..|..:...||..||...|.                        |:
Mouse   277 IANKHTGKDTVRINLHPSFVTPGKLMVVHPRAQPRTEDAAKDPGESLDPELLKQRGRPCRFGLCE 341

  Fly   875 KDRR------------------------------------------------------------- 878
            :|.:                                                             
Mouse   342 RDPKSHSSACAEGYTLSRDRKYCEDVNECATQNHGCTLGCENTPGSYHCTCPTGFVLLPDGKQCH 406

  Fly   879 ------GLRGGCSHLCLPNKTSRRCGCPIGLSLKEDGKTC------------------------- 912
                  |....|||.|:......||.||.|..|..|||||                         
Mouse   407 ELVSCPGNVSKCSHGCVLTSDGPRCICPAGSVLGRDGKTCTGCSSPDNGGCSQICLPLRPGSWEC 471

  Fly   913 ------------KSTA----DKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWC 961
                        ||.|    ..|:|.|..:|||..|.     |..|..:::. ..:....|||:.
Mouse   472 DCFPGYDLQSDRKSCAASGPQPLLLFANSQDIRHMHF-----DGTDYKVLLS-RQMGMVFALDYD 530

  Fly   962 SDTDFIYWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTN 1026
            .....||:.......|.:|:::||.::|::...:.:..|||||||..::||||...:.:..:..:
Mouse   531 PVESKIYFAQTALKWIERANMDGSQRERLITEGVDTLEGLALDWIGRRIYWTDSGKSVVGGSDLS 595

  Fly  1027 GKMRTLLIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAID 1091
            ||...::|.|::.:||.|.|:|....:||:|.|..|.||.|::.|.:||.|.|..|:.|:|:.||
Mouse   596 GKHHRIIIQERISRPRGIAVHPRARRLFWTDVGMSPRIESASLQGSDRVLIASSNLLEPSGITID 660

  Fly  1092 YEKSKIYFVDGGTKTLENMNFDGS-GRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTG 1155
            |....:|:.|.....:|..|.||| .|::|.|.:||||.|.|.|..::.:||...||:..||.||
Mouse   661 YLTDTLYWCDTKRSVIEMANLDGSKRRRLIQNDVGHPFSLAVFEDHLWVSDWAIPSVIRVNKRTG 725

  Fly  1156 KDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTC 1220
            ::...:..:......:.|.|...:...:.|...||||.|:|..:..:..|.|..|.....|...|
Mouse   726 QNRVRLQGSMLKPSSLVVVHPLAKPGADPCLYRNGGCEHICQESLGTARCLCREGFVKAWDGKMC 790

  Fly  1221 SEGPTQY-ILFAHRIDIRQISLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSS 1284
            .  |..| ||.....|:.:             .:..:||:...:|....|  ..|.|:...||.|
Mouse   791 L--PQDYPILSGENADLSK-------------EVTSLSNSTQAEVPDDDG--TESSTLVAEIMVS 838

  Fly  1285 SPDGLHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRH--------TIEVASLDGSNRH------ 1335
               |::.:...|     |.|              .|.|        |.|...|.|..|.      
Mouse   839 ---GMNYEDDCG-----PGG--------------CGSHARCVSDGETAECQCLKGFARDGNLCSD 881

  Fly  1336 ----VIAYKDLESPRGLALDYEAGLLFWTDWGH---------YRKIERSHLDGNERSRIVTANLG 1387
                |:|..|..|.....::.|.|.:.....|:         ..:.:|...:..|.:.......|
Mouse   882 IDECVLARSDCPSTSSRCINTEGGYVCRCSEGYEGDGISCFDIDECQRGAHNCGENAACTNTEGG 946

  Fly  1388 WPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKALH 1452
            :                        :|...|......:|.........|.:|.           |
Mouse   947 Y------------------------NCTCAGRPSSPGLSCPDSTAPSLLGEDG-----------H 976

  Fly  1453 MTERRNISAKRDIITNIDGLMDIKIIYQNQNQSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGL 1517
            ..:|.:...   ..::.||.                  | .|.|.|.|  :.:...|:|.|.||.
Mouse   977 HLDRNSYPG---CPSSYDGY------------------C-LNGGVCMH--IESLDSYTCNCVIGY 1017

  Fly  1518 RLRQNSTTQCQ--------------NLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVV 1568
                 |..:||              ....|.:::|    :.|::|       |:|.:.|:.|.  
Mouse  1018 -----SGDRCQTRDLRWWELRHAGYGQKHDIMVVA----VCMVAL-------VLLLVLGMWGT-- 1064

  Fly  1569 LDYHYR 1574
              |:||
Mouse  1065 --YYYR 1068

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251 4/13 (31%)
LY 634..671 CDD:214531 10/36 (28%)
LY 680..714 CDD:214531 13/41 (32%)
LY 718..760 CDD:214531 14/41 (34%)
Ldl_recept_b 740..777 CDD:459654 9/36 (25%)
LY 761..803 CDD:214531 10/46 (22%)
LY 806..838 CDD:214531 4/32 (13%)
FXa_inhibition 882..912 CDD:464251 13/29 (45%)
LY 946..985 CDD:214531 7/38 (18%)
NHL <967..1142 CDD:302697 63/175 (36%)
LY 988..1030 CDD:214531 14/41 (34%)
NHL repeat 998..1037 CDD:271333 14/38 (37%)
NHL repeat 1038..1080 CDD:271333 17/41 (41%)
NHL repeat 1084..1119 CDD:271333 13/35 (37%)
FXa_inhibition 1185..1220 CDD:464251 11/34 (32%)
NHL 1260..>1445 CDD:302697 33/211 (16%)
NHL repeat 1260..1296 CDD:271320 8/35 (23%)
LY 1292..1334 CDD:214531 9/49 (18%)
NHL repeat 1302..1337 CDD:271320 9/52 (17%)
NHL repeat 1345..1383 CDD:271320 5/46 (11%)
FXa_inhibition <1499..1525 CDD:464251 7/25 (28%)
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:464251
EgfXP_011238312.1 LY <86..114 CDD:214531 11/35 (31%)
LY <125..156 CDD:214531 10/30 (33%)
LY 158..199 CDD:214531 15/43 (35%)
FXa_inhibition 370..405 CDD:464251 0/34 (0%)
FXa_inhibition 418..446 CDD:464251 13/27 (48%)
FXa_inhibition 449..486 CDD:464251 1/36 (3%)
LY 514..556 CDD:214531 9/42 (21%)
LY 557..599 CDD:214531 14/41 (34%)
LY 600..643 CDD:214531 16/42 (38%)
LY 643..686 CDD:214531 17/42 (40%)
LY 687..728 CDD:214531 18/40 (45%)
FXa_inhibition 755..790 CDD:464251 11/34 (32%)
EGF_CA 881..913 CDD:429571 6/31 (19%)
EGF_CA 923..951 CDD:429571 4/51 (8%)
PHA02887 <986..1023 CDD:165214 13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

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