DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and lrp4

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_017212642.2 Gene:lrp4 / 110351181 ZFINID:ZDB-GENE-130129-1 Length:1913 Species:Danio rerio


Alignment Length:1829 Identity:777/1829 - (42%)
Similarity:1082/1829 - (59%) Gaps:134/1829 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 ESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTD 269
            :.|.:|....|....:...|.....|  | ...:||.:.||||||:||.|.|||..|..| .|.:
Zfish    54 DGDNDCGDHSDEDGCILPTCSPLDFH--C-ENGKCIRRSWLCDGDNDCEDDSDEQDCPPR-ECEE 114

  Fly   270 DQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDN 334
            |:|.|.||:||...|.|||:|||.|.||| .|::..|:|:.|.|.||.||:..:.|||:.||.|.
Zfish   115 DEFHCQNGYCIRSLWYCDGDNDCGDNSDE-QCDKRKCSDKEFRCTDGSCIAEHWYCDGDSDCKDG 178

  Fly   335 SDELKCAA--VINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENC-PQKPSL 396
            :||..|.:  :..:|...||:|         ..|:|||:.:.||||:||||||||.:| ..:|  
Zfish   179 TDEENCPSDVMTATCSVEEFQC---------AYGRCILDIYHCDGDDDCGDWSDESDCSSHQP-- 232

  Fly   397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLC 461
            |.|.|:.|:.|.||...|:||.|.|||...||.:|.:      ..|.:|:|.|.:|||:..:|.|
Zfish   233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNCST------SMCMADQFRCMSGRCVRLSWRC 291

  Fly   462 DGYPDCAAGEDEVECHL----QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE---A 519
            ||..||:.|.||..|..    .|...||||...:       |:.|:.:|:...:|..|.||   .
Zfish   292 DGEDDCSDGSDEEGCEKTETPPCAPDQFLCGNGR-------CIGQRKVCNDVKDCEDGTDEHPHQ 349

  Fly   520 DC---PKERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKC 580
            ||   ..:..|: ....|.|.| :.:.|..:|.|..||.:..:...|.|:|||  .....|||.|
Zfish   350 DCRSKSSDENCNVNNGGCSQKC-QMSRGLVQCTCHTGYTLTADGKTCRDVDEC--ADDGYCSQGC 411

  Fly   581 HNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALD 645
            .|..|.|:|.|..||.||||.|||||||....||.|||.|||:|....:.|:.::..|.||||||
Zfish   412 TNIEGGFQCWCVQGYELRPDKRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLSNLENAIALD 476

  Fly   646 FHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSN 710
            |||.:.|:|||||:.|.|....:||:.|.:|:..|||||||:|:||||:.|:||||||.|:||||
Zfish   477 FHHSQELVFWSDVTLDRIMRASLNGSNVEEVVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSN 541

  Fly   711 FQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLA 775
            ..|..|.|:....::|||||.:||.|...:|:|||..|:||.|.|||:.||:|....:.|||||.
Zfish   542 LDGTHRKVLLWQRMEKPRAIALHPIEGKIYWTDWGNMPRIEYANMDGSNRKIIADTHLFWPNGLT 606

  Fly   776 IDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKI 840
            ||:.:.::||.|||.|.||.::|||.:|..::|..||||||:|:|||::|||||:||::::|:|.
Zfish   607 IDYASHRMYWVDAKHHVIERADLDGKNRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 671

  Fly   841 TGKEFRAVHENFHFPMDIHAYHPARQPEYA-DRCQKDRRGLRGGCSHLCLPNKTSRRCGCPIGLS 904
            |||....:....|||||||..||.|||... :||..:    .|||||||||:..:..|.||.|..
Zfish   672 TGKNQEVIRNKLHFPMDIHTLHPQRQPAGGINRCGSN----NGGCSHLCLPSNKTYTCVCPTGFR 732

  Fly   905 LKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCS-DTD-FI 967
             |.|...|..:.||.:|.|||.|||    |.:......:|.::||.::::||||||.| |:: ||
Zfish   733 -KLDQHNCAQSLDKFLLFARRTDIR----RISFDTTEQLDAVIPLADVRNAVALDWDSLDSESFI 792

  Fly   968 YWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTL 1032
            |||||...:||:|..:||.|:.||.::|.||.|||:||:|.||||||..|:||||:.|:|.|||:
Zfish   793 YWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAIDWLTHKLYWTDAGTDRIEVSNTDGSMRTV 857

  Fly  1033 LIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKI 1097
            ||||.|.:||||||:||.|||:|:|||.:|.||||.||...|..|.|..|.:||||||||...::
Zfish   858 LIWENLDRPRDIVVDPIGGFMYWTDWGANPKIERAGMDAWNRTVIISSNLTWPNGLAIDYSTERL 922

  Fly  1098 YFVDGGTKTLENMNFDGSGRQVILNG-LGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVI 1161
            |:.|...||:|..|||||||||::.. |.|||||.::|.|::||||.:||:.||:||||.|...:
Zfish   923 YWADASVKTIEYGNFDGSGRQVLIGSQLPHPFGLTLHEDRIYWTDWQSKSIQSADKLTGLDRKTL 987

  Fly  1162 IANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNPT--SYTCACTVGVQLKEDRHTCSEGP 1224
            ..|..:||||.:||..|.::...|...||||||||||.|.  |::|||..|:.|:.|..||:...
Zfish   988 AENLENLMDIHMFHNHRTKVQTGCLVNNGGCSHLCLLAPAPKSWSCACPTGINLQADGKTCAHAM 1052

  Fly  1225 TQYILFAHRIDIRQISLDFDHLIDVVLPL-PPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDG 1288
            ..:::||.|.|||.||||..:..||||.: ..:.|.:|:.||...|.:||||:....|..|:.:|
Zfish  1053 NSFLVFARRTDIRMISLDIPYFADVVLAVNTSMKNTIAIGVDPIEGKVYWSDSTLKKISRSNING 1117

  Fly  1289 LHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYE 1353
            ...:.|:...|...|||.|||:||.|||.|.|.:.||||:|:||.|.|:.:::|:|||.:||.:|
Zfish  1118 TEHEDIISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNGSMRKVLVWQNLDSPRAIALYHE 1182

  Fly  1354 AGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTG 1418
            .|.::|||||.:.|:|||.:||::|..::..||||||||::|....::.|.||..:.|::.|..|
Zfish  1183 MGYMYWTDWGEHAKLERSSMDGSDRVVLINNNLGWPNGLAVDKAGSQLLWADAHTERIEASDLNG 1247

  Fly  1419 NQRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDGLMDIKIIYQNQN 1483
            :.|:.::|.:.|||.|.:...::|||||:|:::|..::........|.:::.|||||:.:  ::.
Zfish  1248 SNRRTLVSPVQHPYGLTVLGSHMYWTDWQSRSIHRADKNTGENAIIIRSSLPGLMDIQAV--DRT 1310

  Fly  1484 QSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISL 1548
            .|...|.||..||.||||||...:|.||.||.|:.|:.:..: |::|||.|||.:.|..:..|||
Zfish  1311 ASAGLNKCGRRNGGCSHLCLPRLNGTSCACPTGVLLKADGRS-CEDLPETYLLFSNRVSVRRISL 1374

  Fly  1549 NSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGI 1613
            ::.|..||.:|:..:...:.|||...:..|::.||:|||||||| |:.::.:.::.:.:.|.:|:
Zfish  1375 DTHDHTDVFVPVAELQNVISLDYDSVERKLYYTDVSLDVIRRVN-LDGSDMETVISSGLKTTDGL 1438

  Fly  1614 AVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAKIER 1678
            ||||:|.|:||:||.|..|||:.|||:.||.:|.::|.:||::.|.|.|.:|||:||...|||||
Zfish  1439 AVDWVARNMYWTDTGRNTIEVAHLDGTSRKVLVNNSLDEPRAIAVFPSKGFLFWTDWGHIAKIER 1503

  Fly  1679 SYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLT 1743
            ::|||::|.|:|.:.:|:|.|||:|:..||:.|.||..|.|...|.|||.||.::....|||.||
Zfish  1504 AFLDGTDRKVLINTDLGWPNGLTLDYDTRRIFWVDAHLDRIESSDLNGKLRQILISPVSHPFALT 1568

  Fly  1744 LF----------------ENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLS 1792
            ..                |..|:||||..||:.|..|  .:|.... .|...:.|.:||..||..
Zfish  1569 QLKPVYSPLTPFSRISQQERWIYWTDWQTKSIQRVDK--HTGRSKE-TVLANVEGLMDIIVVSPQ 1630

  Fly  1793 RQPKSVNHCAQDNGGCTHLCLNRNVDYVCACPDVMDPKDVACSIKPKVLVH--ANLENDQLLEYS 1855
            || ...||||.:|||||||||.|:..::|||||..|.:  .||   .:..|  |:.|.|      
Zfish  1631 RQ-SGTNHCAANNGGCTHLCLARSNSFICACPDEADSR--PCS---TIAGHVPASPEKD------ 1683

  Fly  1856 DESTDDSTPPELLGESNDHG-----------------DDGHTKKSDQEREFFVLVALGVVIVMVV 1903
              :|...||.:...|....|                 .:........|......|..|.:.::.:
Zfish  1684 --TTGTQTPRKQATEKPHQGLSLVNCTEMNLSLEDCFQNSVISAPRDESPHISYVIGGALSILAI 1746

  Fly  1904 IIILVIFMLAFNTSKKKNKRNSRGSSRSVLTFSNPNYNVD------GTPMEPKTNIWKRFKYDKT 1962
            :|::..|::   ...||.|....|.|.  ||:|||:|...      .|..:|..|...|:|    
Zfish  1747 LILIAAFII---YRHKKFKFADPGVSN--LTYSNPSYRTSTQEVKIETAQKPAINSQLRYK---- 1802

  Fly  1963 HQERAGVYE 1971
             :|..||.:
Zfish  1803 -KEVQGVVD 1810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 19/33 (58%)
LDLa 306..340 CDD:238060 16/33 (48%)
LDLa 347..390 CDD:238060 20/42 (48%)
LDLa 397..431 CDD:238060 16/33 (48%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 480..521 CDD:238060 12/43 (28%)
FXa_inhibition 576..604 CDD:291342 16/27 (59%)
LY 634..671 CDD:214531 19/36 (53%)
NHL <656..793 CDD:302697 71/136 (52%)
LY 680..714 CDD:214531 24/33 (73%)
NHL repeat 681..722 CDD:271320 26/40 (65%)
NHL repeat 726..760 CDD:271320 19/33 (58%)
LY 761..803 CDD:214531 20/41 (49%)
NHL repeat 769..793 CDD:271320 13/23 (57%)
FXa_inhibition 882..912 CDD:291342 15/29 (52%)
LY 946..985 CDD:214531 20/40 (50%)
NHL <967..1142 CDD:302697 102/175 (58%)
LY 988..1030 CDD:214531 24/41 (59%)
NHL repeat 998..1037 CDD:271320 26/38 (68%)
NHL repeat 1038..1080 CDD:271320 25/41 (61%)
NHL repeat 1084..1119 CDD:271320 20/34 (59%)
FXa_inhibition 1185..1220 CDD:291342 19/36 (53%)
NHL 1260..>1445 CDD:302697 78/184 (42%)
NHL repeat 1260..1296 CDD:271320 12/35 (34%)
NHL repeat 1302..1337 CDD:271320 21/34 (62%)
NHL repeat 1345..1383 CDD:271320 18/37 (49%)
FXa_inhibition <1499..1525 CDD:291342 12/25 (48%)
LY 1600..1640 CDD:214531 18/39 (46%)
LY 1643..1686 CDD:214531 21/42 (50%)
LY 1688..1729 CDD:214531 19/40 (48%)
FXa_inhibition 1801..>1825 CDD:291342 15/23 (65%)
lrp4XP_017212642.2 LDLa 29..68 CDD:238060 3/13 (23%)
Ldl_recept_a 72..107 CDD:278486 17/37 (46%)
LDLa 111..143 CDD:197566 17/31 (55%)
LDLa 150..184 CDD:238060 16/33 (48%)
LDLa 233..267 CDD:238060 16/33 (48%)
LDLa 272..306 CDD:238060 16/33 (48%)
LDLa 314..345 CDD:238060 10/37 (27%)
FXa_inhibition 360..395 CDD:317114 9/35 (26%)
EGF_CA 397..436 CDD:214542 21/40 (53%)
NHL 473..690 CDD:302697 115/216 (53%)
NHL repeat 473..511 CDD:271320 19/37 (51%)
LY 507..547 CDD:214531 26/39 (67%)
NHL repeat 515..551 CDD:271320 23/35 (66%)
NHL repeat 558..594 CDD:271320 20/35 (57%)
Ldl_recept_b 568..608 CDD:278487 19/39 (49%)
LY 592..634 CDD:214531 20/41 (49%)
NHL repeat 599..640 CDD:271320 19/40 (48%)
NHL repeat 644..681 CDD:271320 20/36 (56%)
FXa_inhibition 705..739 CDD:317114 16/38 (42%)
LY <777..810 CDD:214531 18/32 (56%)
LY 813..855 CDD:214531 24/41 (59%)
Ldl_recept_b 876..916 CDD:278487 23/39 (59%)
LY 901..942 CDD:214531 21/40 (53%)
LY 943..984 CDD:214531 22/40 (55%)
FXa_inhibition 1011..1048 CDD:317114 19/36 (53%)
NHL <1090..1282 CDD:302697 82/191 (43%)
NHL repeat 1090..1128 CDD:271320 12/37 (32%)
LY 1123..1163 CDD:214531 22/39 (56%)
NHL repeat 1133..1166 CDD:271320 20/32 (63%)
Ldl_recept_b 1184..1224 CDD:278487 21/39 (54%)
NHL repeat 1217..1249 CDD:271320 12/31 (39%)
NHL repeat 1258..1282 CDD:271320 10/23 (43%)
FXa_inhibition 1318..1353 CDD:317114 17/35 (49%)
LY 1389..1423 CDD:214531 15/34 (44%)
LY 1425..1467 CDD:214531 19/41 (46%)
Ldl_recept_b 1488..1528 CDD:278487 21/39 (54%)
LY 1512..1552 CDD:214531 17/39 (44%)
FXa_inhibition 1638..>1662 CDD:317114 15/23 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 80 1.000 Domainoid score I8573
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 1 1.000 - - FOG0008268
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1256
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.820

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