Protein Alignment Lrp4 and lrp4

DIOPT Version :10

• Sequence 1: NP_727914.1
• Gene: Lrp4 / 32552
• FlyBaseID: FBgn0030706
• Length: 2009
• Species: Drosophila melanogaster
• Sequence 2: XP_073763685.1
• Gene: lrp4 / 110351181
• ZFINID: ZDB-GENE-130129-1
• Length: 1913
• Species: Danio rerio
• Alignment Length: 1829
• Identity: 777/1829 - (42%)
• Similarity: 1082/1829 - (59%)
• Gaps: 134/1829 - (7%)

  Fly   205 ESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTD 269
            :.|.:|....|....:...|.....|  | ...:||.:.||||||:||.|.|||..|..| .|.:
Zfish    54 DGDNDCGDHSDEDGCILPTCSPLDFH--C-ENGKCIRRSWLCDGDNDCEDDSDEQDCPPR-ECEE 114

  Fly   270 DQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDN 334
            |:|.|.||:||...|.|||:|||.|.||| .|::..|:|:.|.|.||.||:..:.|||:.||.|.
Zfish   115 DEFHCQNGYCIRSLWYCDGDNDCGDNSDE-QCDKRKCSDKEFRCTDGSCIAEHWYCDGDSDCKDG 178

  Fly   335 SDELKCAA--VINSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENC-PQKPSL 396
            :||..|.:  :..:|...||:|         ..|:|||:.:.||||:||||||||.:| ..:|
Zfish   179 TDEENCPSDVMTATCSVEEFQC---------AYGRCILDIYHCDGDDDCGDWSDESDCSSHQP-- 232

  Fly   397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLC 461
            |.|.|:.|:.|.||...|:||.|.|||...||.:|.:      ..|.:|:|.|.:|||:..:|.|
Zfish   233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNCST------SMCMADQFRCMSGRCVRLSWRC 291

  Fly   462 DGYPDCAAGEDEVECHL----QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE---A 519
            ||..||:.|.||..|..    .|...||||...:       |:.|:.:|:...:|..|.||   .
Zfish   292 DGEDDCSDGSDEEGCEKTETPPCAPDQFLCGNGR-------CIGQRKVCNDVKDCEDGTDEHPHQ 349

  Fly   520 DC---PKERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKC 580
            ||   ..:..|: ....|.|.| :.:.|..:|.|..||.:..:...|.|:|||  .....|||.|
Zfish   350 DCRSKSSDENCNVNNGGCSQKC-QMSRGLVQCTCHTGYTLTADGKTCRDVDEC--ADDGYCSQGC 411

  Fly   581 HNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALD 645
            .|..|.|:|.|..||.||||.|||||||....||.|||.|||:|....:.|:.::..|.||||||
Zfish   412 TNIEGGFQCWCVQGYELRPDKRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLSNLENAIALD 476

  Fly   646 FHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSN 710
            |||.:.|:|||||:.|.|....:||:.|.:|:..|||||||:|:||||:.|:||||||.|:||||
Zfish   477 FHHSQELVFWSDVTLDRIMRASLNGSNVEEVVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSN 541

  Fly   711 FQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLA 775
            ..|..|.|:....::|||||.:||.|...:|:|||..|:||.|.|||:.||:|....:.|||||.
Zfish   542 LDGTHRKVLLWQRMEKPRAIALHPIEGKIYWTDWGNMPRIEYANMDGSNRKIIADTHLFWPNGLT 606

  Fly   776 IDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKI 840
            ||:.:.::||.|||.|.||.::|||.:|..::|..||||||:|:|||::|||||:||::::|:|.
Zfish   607 IDYASHRMYWVDAKHHVIERADLDGKNRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 671

  Fly   841 TGKEFRAVHENFHFPMDIHAYHPARQPEYA-DRCQKDRRGLRGGCSHLCLPNKTSRRCGCPIGLS 904
            |||....:....|||||||..||.|||... :||..:    .|||||||||:..:..|.||.|..
Zfish   672 TGKNQEVIRNKLHFPMDIHTLHPQRQPAGGINRCGSN----NGGCSHLCLPSNKTYTCVCPTGFR 732

  Fly   905 LKEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCS-DTD-FI 967
             |.|...|..:.||.:|.|||.|||    |.:......:|.::||.::::||||||.| |:: ||
Zfish   733 -KLDQHNCAQSLDKFLLFARRTDIR----RISFDTTEQLDAVIPLADVRNAVALDWDSLDSESFI 792

  Fly   968 YWTDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTL 1032
            |||||...:||:|..:||.|:.||.::|.||.|||:||:|.||||||..|:||||:.|:|.|||:
Zfish   793 YWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAIDWLTHKLYWTDAGTDRIEVSNTDGSMRTV 857

  Fly  1033 LIWEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKI 1097
            ||||.|.:||||||:||.|||:|:|||.:|.||||.||...|..|.|..|.:||||||||...::
Zfish   858 LIWENLDRPRDIVVDPIGGFMYWTDWGANPKIERAGMDAWNRTVIISSNLTWPNGLAIDYSTERL 922

  Fly  1098 YFVDGGTKTLENMNFDGSGRQVILNG-LGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVI 1161
            |:.|...||:|..|||||||||::.. |.|||||.::|.|::||||.:||:.||:||||.|...:
Zfish   923 YWADASVKTIEYGNFDGSGRQVLIGSQLPHPFGLTLHEDRIYWTDWQSKSIQSADKLTGLDRKTL 987

  Fly  1162 IANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNPT--SYTCACTVGVQLKEDRHTCSEGP 1224
            ..|..:||||.:||..|.::...|...||||||||||.|.  |::|||..|:.|:.|..||:...
Zfish   988 AENLENLMDIHMFHNHRTKVQTGCLVNNGGCSHLCLLAPAPKSWSCACPTGINLQADGKTCAHAM 1052

  Fly  1225 TQYILFAHRIDIRQISLDFDHLIDVVLPL-PPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDG 1288
            ..:::||.|.|||.||||..:..||||.: ..:.|.:|:.||...|.:||||:....|..|:.:|
Zfish  1053 NSFLVFARRTDIRMISLDIPYFADVVLAVNTSMKNTIAIGVDPIEGKVYWSDSTLKKISRSNING 1117

  Fly  1289 LHVQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYE 1353
            ...:.|:...|...|||.|||:||.|||.|.|.:.||||:|:||.|.|:.:::|:|||.:||.:|
Zfish  1118 TEHEDIISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNGSMRKVLVWQNLDSPRAIALYHE 1182

  Fly  1354 AGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTG 1418
            .|.::|||||.:.|:|||.:||::|..::..||||||||::|....::.|.||..:.|::.|..|
Zfish  1183 MGYMYWTDWGEHAKLERSSMDGSDRVVLINNNLGWPNGLAVDKAGSQLLWADAHTERIEASDLNG 1247

  Fly  1419 NQRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDGLMDIKIIYQNQN 1483
            :.|:.::|.:.|||.|.:...::|||||:|:::|..::........|.:::.|||||:.:  ::.
Zfish  1248 SNRRTLVSPVQHPYGLTVLGSHMYWTDWQSRSIHRADKNTGENAIIIRSSLPGLMDIQAV--DRT 1310

  Fly  1484 QSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISL 1548
            .|...|.||..||.||||||...:|.||.||.|:.|:.:..: |::|||.|||.:.|..:..|||
Zfish  1311 ASAGLNKCGRRNGGCSHLCLPRLNGTSCACPTGVLLKADGRS-CEDLPETYLLFSNRVSVRRISL 1374

  Fly  1549 NSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNGI 1613
            ::.|..||.:|:..:...:.|||...:..|::.||:|||||||| |:.::.:.::.:.:.|.:|:
Zfish  1375 DTHDHTDVFVPVAELQNVISLDYDSVERKLYYTDVSLDVIRRVN-LDGSDMETVISSGLKTTDGL 1438

  Fly  1614 AVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAKIER 1678
            ||||:|.|:||:||.|..|||:.|||:.||.:|.::|.:||::.|.|.|.:|||:||...|||||
Zfish  1439 AVDWVARNMYWTDTGRNTIEVAHLDGTSRKVLVNNSLDEPRAIAVFPSKGFLFWTDWGHIAKIER 1503

  Fly  1679 SYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLT 1743
            ::|||::|.|:|.:.:|:|.|||:|:..||:.|.||..|.|...|.|||.||.::....|||.||
Zfish  1504 AFLDGTDRKVLINTDLGWPNGLTLDYDTRRIFWVDAHLDRIESSDLNGKLRQILISPVSHPFALT 1568

  Fly  1744 LF----------------ENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLS 1792
            ..                |..|:||||..||:.|..|  .:|.... .|...:.|.:||..||..
Zfish  1569 QLKPVYSPLTPFSRISQQERWIYWTDWQTKSIQRVDK--HTGRSKE-TVLANVEGLMDIIVVSPQ 1630

  Fly  1793 RQPKSVNHCAQDNGGCTHLCLNRNVDYVCACPDVMDPKDVACSIKPKVLVH--ANLENDQLLEYS 1855
            || ...||||.:|||||||||.|:..::|||||..|.:  .||   .:..|  |:.|.|
Zfish  1631 RQ-SGTNHCAANNGGCTHLCLARSNSFICACPDEADSR--PCS---TIAGHVPASPEKD------ 1683

  Fly  1856 DESTDDSTPPELLGESNDHG-----------------DDGHTKKSDQEREFFVLVALGVVIVMVV 1903
              :|...||.:...|....|                 .:........|......|..|.:.::.:
Zfish  1684 --TTGTQTPRKQATEKPHQGLSLVNCTEMNLSLEDCFQNSVISAPRDESPHISYVIGGALSILAI 1746

  Fly  1904 IIILVIFMLAFNTSKKKNKRNSRGSSRSVLTFSNPNYNVD------GTPMEPKTNIWKRFKYDKT 1962
            :|::..|::   ...||.|....|.|.  ||:|||:|...      .|..:|..|...|:|
Zfish  1747 LILIAAFII---YRHKKFKFADPGVSN--LTYSNPSYRTSTQEVKIETAQKPAINSQLRYK---- 1802

  Fly  1963 HQERAGVYE 1971
             :|..||.:
Zfish  1803 -KEVQGVVD 1810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	19/33 (58%)
		LDLa	306..340	CDD:238060	16/33 (48%)
		LDLa	347..390	CDD:238060	20/42 (48%)
		LDLa	397..431	CDD:238060	16/33 (48%)
		LDLa	442..476	CDD:238060	16/33 (48%)
		LDLa	480..521	CDD:238060	12/43 (28%)
		FXa_inhibition	576..604	CDD:464251	16/27 (59%)
		LY	634..671	CDD:214531	19/36 (53%)
		LY	680..714	CDD:214531	24/33 (73%)
		LY	718..760	CDD:214531	20/41 (49%)
		Ldl_recept_b	740..777	CDD:459654	19/36 (53%)
		LY	761..803	CDD:214531	20/41 (49%)
		LY	806..838	CDD:214531	18/31 (58%)
		FXa_inhibition	882..912	CDD:464251	15/29 (52%)
		LY	946..985	CDD:214531	20/40 (50%)
		NHL	<967..1142	CDD:302697	102/175 (58%)
		LY	988..1030	CDD:214531	24/41 (59%)
		NHL repeat	998..1037	CDD:271333	26/38 (68%)
		NHL repeat	1038..1080	CDD:271333	25/41 (61%)
		NHL repeat	1084..1119	CDD:271333	20/34 (59%)
		FXa_inhibition	1185..1220	CDD:464251	19/36 (53%)
		NHL	1260..>1445	CDD:302697	78/184 (42%)
		NHL repeat	1260..1296	CDD:271320	12/35 (34%)
		LY	1292..1334	CDD:214531	22/41 (54%)
		NHL repeat	1302..1337	CDD:271320	21/34 (62%)
		NHL repeat	1345..1383	CDD:271320	18/37 (49%)
		FXa_inhibition	<1499..1525	CDD:464251	12/25 (48%)
		LY	1600..1640	CDD:214531	18/39 (46%)
		LY	1643..1686	CDD:214531	21/42 (50%)
		LY	1688..1729	CDD:214531	19/40 (48%)
		FXa_inhibition	1801..>1825	CDD:464251	15/23 (65%)
lrp4	XP_073763685.1	None