DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and CORIN

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	NP_006578.2	Gene:	CORIN / 10699	HGNCID:	19012	Length:	1042	Species:	Homo sapiens

Alignment Length:	718	Identity:	176/718 - (24%)
Similarity:	254/718 - (35%)	Gaps:	257/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 SNCQNSNESDENCNPEEDAVPNLQRDC----EKTGIHVMCPR--TFRCISKYWL-----CDGDDD 251
            |..:|..||.           |:.|.|    ::.|..::|.|  .|.|.|...:     |:|.:|
Human   241 SQFRNQTESS-----------NVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYND 294

  Fly   252 CGDYSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTC--TDEHFTCN 314
            |.|:|||.||    ||:::.|.|..|.|:..:.||||.:||.|.|||.:|:   |  |.|| .|.
Human   295 CDDWSDEAHC----NCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEH-RCG 351

  Fly   315 DGYCISLAFRCDGEHDCNDNSDELKCAAVINSC-PEGEFKCRGGLGGAGGPSGQCILNRFRCDGD 378
            ||.||::.:.|||:|||.|.|||:.|     || .:|..:||         :||||.:.|:||||
Human   352 DGRCIAMEWVCDGDHDCVDKSDEVNC-----SCHSQGLVECR---------NGQCIPSTFQCDGD 402

  Fly   379 NDCGDWSDEENCPQKPSLCTSNEYKCADGTCIPK------------------------------- 412
            .||.|.||||||....:.|...:.:|....|:..
Human   403 EDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLP 467

  Fly   413 --------------------RW---------------------------KCD------------- 417
                                .|                           |||
Human   468 YNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRAL 532

  Fly   418 --------------------KEQDCDGGEDENDCGS---LGSEHPLTCGSDEFTCNNGRCILKTW 459
                                ::.||....:||....   :..|:...|....|.|.:|:|:|.:.
Human   533 CEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASR 597

  Fly   460 LCDGYPDCAAGEDEVECHL-QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPK 523
            .|||..||....||..|.. :.||.:  ||:.      |.|:....||||..:||      |...
Human   598 RCDGQADCDDDSDEENCGCKERDLWE--CPSN------KQCLKHTVICDGFPDCP------DYMD 648

  Fly   524 ERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDID---ECQYLTSPVCSQK---CHN 582
            |:.||.....|..|......|.:..|       ..:.:|:|..   :|..|:..|.|..   .|.
Human   649 EKNCSFCQDDELECANHACVSRDLWC-------DGEADCSDSSDEWDCVTLSINVNSSSFLMVHR 706

  Fly   583 TMGSFKCSCETGYILRPDLRSCKALG---GAMTLLVAN-----RWDIRRVTLSNNRYSAIVKGLH 639
            ....... |..|:.......:||.:|   .::|.|:..     ||    :||.:|..|.....||
Human   707 AATEHHV-CADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRW----LTLHSNWESLNGTTLH 766

  Fly   640 NAIALDFHHRKGLMFWSDVSTDVIKM-------VYMN----GTRVRDVIKW----GLES-PGG-- 686
            ..:.    :.:.....|.:|....|.       ..||    |.|.....:|    .|:| |.|
Human   767 ELLV----NGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHI 827

  Fly   687 -----IAVDWIHDLLFWTDSGTRRVEVSN-FQGN-----LRTVIASYDLDKP---------RAIV 731
                 ||..|:             :.|:: |:|.     .:.|:...:||.|         :.|:
Human   828 CGCVLIAKKWV-------------LTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTII 879

  Fly   732 VHP 734
            :||
Human   880 LHP 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	15/33 (45%)
		LDLa	306..340	CDD:238060	19/35 (54%)
		LDLa	347..390	CDD:238060	20/43 (47%)
		LDLa	397..431	CDD:238060	11/144 (8%)
		LDLa	442..476	CDD:238060	13/33 (39%)
		LDLa	480..521	CDD:238060	12/40 (30%)
		FXa_inhibition	576..604	CDD:291342	4/30 (13%)
		LY	634..671	CDD:214531	7/47 (15%)
		NHL	<656..793	CDD:302697	25/117 (21%)
		LY	680..714	CDD:214531	9/42 (21%)
		NHL repeat	681..722	CDD:271320	11/54 (20%)
		NHL repeat	726..760	CDD:271320	4/18 (22%)
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
CORIN	NP_006578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		DDNN motif	26..29
		CRD_corin_1	135..263	CDD:143554	7/32 (22%)
		LDLa	269..304	CDD:238060	13/34 (38%)
		LDLa	306..340	CDD:238060	15/33 (45%)
		Ldl_recept_a	347..377	CDD:278486	17/30 (57%)
		LDLa	387..414	CDD:238060	18/35 (51%)
		CRD_corin_2	454..575	CDD:143579	8/120 (7%)
		LDLa	580..614	CDD:238060	13/33 (39%)
		LDLa	655..689	CDD:238060	6/40 (15%)
		SR	690..786	CDD:214555	21/104 (20%)
		Tryp_SPc	801..1030	CDD:214473	20/95 (21%)
		Tryp_SPc	802..1033	CDD:238113	20/94 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910