DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp2b

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021335953.1 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4577 Species:Danio rerio


Alignment Length:1792 Identity:586/1792 - (32%)
Similarity:865/1792 - (48%) Gaps:169/1792 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 NIGAQRGRTEIAGIRE-----TDRISSR------GRDGFIGGPSNKQK-----PFRVNLAV---- 184
            ||..::|.:.|..|:.     .|...||      ||......|:....     ||.:.|..    
Zfish   917 NIMLRKGISGIMNIKAYSADLQDLFKSRCNMIPNGRCSHFCFPTPASSRVCGCPFGMKLQENQRD 981

  Fly   185 LVQDDPSQPGETYSNCQNSNESDENCN----PEED--AVPNLQR-----DCEKTGIHVMC----- 233
            .|:||...|            .|:||.    |.:.  .|||..|     ||......|.|     
Zfish   982 CVKDDSEPP------------PDDNCGDYAFPCDGGRCVPNTYRCDGVNDCVDKTDEVNCTLPGA 1034

  Fly   234 ---PRTFRCISKY-----WLCDGDDDCGDYSDETHCGAR--TNCTDDQFECLNGFCIPRTWVCDG 288
               |..|.|.:|:     |.|||.|||||.||||:|..|  |.|:..||.|.||.|||:|||||.
Zfish  1035 TCSPYAFTCGNKHCIPARWRCDGHDDCGDGSDETNCPTRGPTTCSSSQFACTNGNCIPKTWVCDA 1099

  Fly   289 ENDCKDFSDETHCNR--TTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGE 351
            .|||.|.|||.|||.  |||....|.|.|..||..::.|||:.||.|.|||..|   :.:|...|
Zfish  1100 FNDCGDGSDERHCNSSITTCQPGFFLCPDHRCIYNSYVCDGDQDCLDGSDEKDC---VYTCGTYE 1161

  Fly   352 FKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCP-QKPSLCTSNEYKC-ADGTCIPKRW 414
            |.|..|        .||:...:||||..||.|.|||..|| ::|.||..||::| .||.||||.|
Zfish  1162 FACASG--------DQCVSQSYRCDGVYDCKDHSDESGCPTRRPGLCHDNEFQCQVDGFCIPKEW 1218

  Fly   415 KCDKEQDC-DGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC-- 476
            :||...|| ||.::.|.|      .|.||.|.:|.|.||.|:.|.|:|||..||....||..|  
Zfish  1219 ECDGHPDCVDGSDEHNGC------PPRTCSSVQFQCANGNCVSKNWVCDGENDCRDMSDETNCPT 1277

  Fly   477 -HLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIE 539
             ...|..||:||||.|      :|:....:|||..:||.|.||:....|..|. ....|...||:
Zfish  1278 PPFSCPSGQWLCPTDQ------VCIMNAQVCDGQRDCPNGADESPICNEDDCKVNNGGCSHGCIQ 1336

  Fly   540 TTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSC 604
            ...|: :|.|..|:.:..:...|.||:||  |....|||.|.|..|||:|.||.||.|.||.|:|
Zfish  1337 GPFGA-QCTCDPGFQLLNDSKTCDDINEC--LIPGFCSQTCFNERGSFRCYCEDGYQLEPDGRTC 1398

  Fly   605 KALG-GAMTLLVANRWDI--RRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMV 666
            :|.. |...||||.|..|  .|:.......|.||.|: :.:|:||.:....::|.|.|..:|...
Zfish  1399 RATSPGNALLLVARRSQIIGNRINFWPPIISPIVSGM-SIVAVDFDNVNKRVYWGDSSDKMIYSS 1462

  Fly   667 YMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIV 731
            :.|||..:.|...||..|..|||||:...::||||..:.:||:...|:.|.::.:.::..||.:|
Zfish  1463 FQNGTDKKQVFSSGLMVPESIAVDWVGRNIYWTDSVMQNIEVATLDGHFRKILITKNVTSPRGLV 1527

  Fly   732 VHPGE--ALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIE 794
            :.|..  .|.||||||.||:||:|.|||..|:.|::..|.|||||.:|:...::|:.||....|:
Zfish  1528 LDPRNHTNLMFWSDWGQNPRIEQASMDGLGRRAIVTSKVYWPNGLTLDYTTRRVYFVDAYLKYID 1592

  Fly   795 CSNLDGSDRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMD 857
            ..:.||.:|:::.::.  |..|..:|:|||.::|:|..|..:...:|..|.....:....:..|.
Zfish  1593 YCDYDGKNRHQVFASDIVLQQPHGITIFEDNIFWSDSYTSQIMRTNKFHGGNITTLLTGVYQCMG 1657

  Fly   858 IHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSR----RCGCPIGLSLKEDGKTCKSTADK 918
            |...||.:||...:.|:.:      .||.|||.: |.|    ||.|..|..|..||:||......
Zfish  1658 IVMDHPIKQPIAFNPCENN------PCSQLCLLS-TLRPRYYRCDCQSGWILASDGRTCTKDETP 1715

  Fly   919 LVLVARRKDIRLRHLRDNQADPNDV--DMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAH 981
            .::|.|  |..:..:..|   |||.  :.:.|:..:.....:|:.....|:||.. ....|.::.
Zfish  1716 FLMVVR--DTVIMGIPLN---PNDTSNNAMAPISGITQGRDIDFDDREQFVYWVQ-GTGAIYRSK 1774

  Fly   982 LNGSYQQRVVHSNLV-SPVGLALDWITDKLYWTDPSTNRIEVATTNGKM--RTLLIW-----EKL 1038
            .:|:.:.:...:.:: ||.|||.||||..:|:|:|:...|||...:|..  |..:|.     |..
Zfish  1775 TDGANRTQFAPAAIIGSPSGLAFDWITRIMYYTNPTIKAIEVIRVDGSQHYRKTIITNTGKPEGA 1839

  Fly  1039 YKPRDIVVNPIEGFMFWSDWGDD----PMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYF 1099
            .:|..|.::|..|.:||:|.|.|    |.|..|:|||.....:.:..|:....:|.|.|..|||:
Zfish  1840 GQPIGIALDPARGKLFWTDRGSDSGVPPKISSADMDGGNVKNLYTGNLVKVEFIAADIEARKIYW 1904

  Fly  1100 VDGGTKTLENMNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIAN 1164
            ....|..:|....||:.|..|::||.||:|:.|.:..:::||.|.:.:...:|.||.|..|:.::
Zfish  1905 GVHQTGMIECGTMDGASRVTIVSGLSHPWGITVYQNYLYYTDLDFEVIERVDKNTGADMVVMRSS 1969

  Fly  1165 STDLMDIRVFHRTRRR-IFNACDKLNGGCSHLCLLNPTSY-TCACTVGVQLKEDRHTCSEGPTQY 1227
            ...|..::|..|.... ..|||...||||.||||..|... |||||.|....:|...|.:..:..
Zfish  1970 MAGLRSVKVHARDNSAGTTNACSTNNGGCPHLCLPKPQGQKTCACTTGFIPSQDGSHCEQYDSYA 2034

  Fly  1228 ILFAHRIDIRQISLDFDHLIDVVLPLPPISNAV--ALDVDRKTGYIYWSD--TIENV--IMSSSP 1286
            |:.:.:. ||...::.....:.::|:...:.::  .||:...:|::||:|  |..:.  |..:..
Zfish  2035 IVSSSKF-IRGFHINSSDHSEAMVPVGANTYSIIDKLDMHIASGFLYWTDNSTYSSYRGIYRTKT 2098

  Fly  1287 DGLHVQKIVGDSLENP--DGLVVDSIGRTIYWAD--AGRHTIEVASLDGSNRHVIAYKDLESPRG 1347
            ||.....:: ..|.|.  .||.||.|...:|:.:  ..:..|||..|:.|.:.::.....:.|:.
Zfish  2099 DGSRYSTVI-SQLGNGRIQGLAVDWIAGNLYFTNKFTTQTYIEVLRLNTSIQLILLKSSADRPQD 2162

  Fly  1348 LALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTID 1412
            ||:..:..||||||.|...|||.:.|||..|:.:.:.:|..|.||::|..:..:||||..|..|.
Zfish  2163 LAVSPKLRLLFWTDAGQSPKIESALLDGTNRTVLASESLSSPRGLTIDYTNDFLYWVDDTLDMIS 2227

  Fly  1413 SCDYTGNQRKLIM--SSLHHPYALALSDDNIYWTDWKSKALHMTER--RNISAKRDIITNIDGLM 1473
            .....|:||:::.  |....||::|:..:.:.|.|.|...|....:  .|......|...||.|.
Zfish  2228 RMAPDGSQREIVRFGSRYPAPYSVAIFGEYMLWVDRKLGKLFQASKVPGNTDTPEVIRDGIDDLT 2292

  Fly  1474 DIKIIYQNQNQSTMK-----NACGNNNGNCSHLCLRNPSGY--SCQCPIGLRLRQNSTTQCQNLP 1531
            |: .::.:..|.|..     |.|.::||.|...|...|...  .|.|..|..|  ::...|....
Zfish  2293 DV-AVFDSHVQPTSANLVGFNPCHDDNGRCQQFCFALPDQQEPKCACAHGSLL--SNGVSCGFGL 2354

  Fly  1532 EDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFAD---VNLDVIRRVNL 1593
            ::||:......:..:.|:..|........|..:|.:.:::.::...:||..   :....|..:..
Zfish  2355 DEYLIFTTDYSVSSMRLDPEDHSVPFPTFNMGYGVLAIEFDFQDKRVFFTQYVGLGRSKIGYIIT 2419

  Fly  1594 LNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGD-PRSLI 1657
            .:.|...|.:.:|:..|.|:|.||:...||::|...:.::...:||..|..|..   || ||:::
Zfish  2420 TSSTSPPVTIASDLDDPEGLAYDWVHKRLYFTDYYNRSVQSMGIDGQNRSLIAH---GDRPRAIV 2481

  Fly  1658 VHPKKAYLFWSDWSSPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQV 1722
            |.|...||:|:||.|||||||:.|.|:.|..:|.:.:..|..|::|:..|.|.|||:..|.|.:.
Zfish  2482 VDPCYGYLYWTDWGSPAKIERATLGGNFRIPVINTSLSQPNALSLDYEERLLYWADSTLDKIERS 2546

  Fly  1723 DFNGKRRQTIVPYAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIR 1787
            ...|:.|:.|:....:||.||:|:..|:||||..:.|||:.|  ..|.|......|......||.
Zfish  2547 SLTGENREVILTQTQYPFALTVFQQDIYWTDWNTRIVYRASK--DDGSGLTIMATDLQYRPNDIH 2609

  Fly  1788 AVSLSRQPKSVNHCAQDNGGCTHLCLNRNVDYVCACP 1824
            ..|.|||....:.|...||||:|:|:.......|.||
Zfish  2610 VFSASRQESCSSPCQLFNGGCSHVCVPGPAGPECQCP 2646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 21/33 (64%)
LDLa 306..340 CDD:238060 15/33 (45%)
LDLa 347..390 CDD:238060 17/42 (40%)
LDLa 397..431 CDD:238060 18/35 (51%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 480..521 CDD:238060 17/40 (43%)
FXa_inhibition 576..604 CDD:291342 17/27 (63%)
LY 634..671 CDD:214531 11/36 (31%)
NHL <656..793 CDD:302697 54/138 (39%)
LY 680..714 CDD:214531 14/33 (42%)
NHL repeat 681..722 CDD:271320 15/40 (38%)
NHL repeat 726..760 CDD:271320 19/35 (54%)
LY 761..803 CDD:214531 14/41 (34%)
NHL repeat 769..793 CDD:271320 9/23 (39%)
FXa_inhibition 882..912 CDD:291342 14/33 (42%)
LY 946..985 CDD:214531 6/38 (16%)
NHL <967..1142 CDD:302697 58/186 (31%)
LY 988..1030 CDD:214531 16/44 (36%)
NHL repeat 998..1037 CDD:271320 17/45 (38%)
NHL repeat 1038..1080 CDD:271320 15/45 (33%)
NHL repeat 1084..1119 CDD:271320 11/34 (32%)
FXa_inhibition 1185..1220 CDD:291342 17/35 (49%)
NHL 1260..>1445 CDD:302697 59/196 (30%)
NHL repeat 1260..1296 CDD:271320 10/41 (24%)
NHL repeat 1302..1337 CDD:271320 11/38 (29%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:291342 6/27 (22%)
LY 1600..1640 CDD:214531 11/39 (28%)
LY 1643..1686 CDD:214531 21/43 (49%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:291342 10/24 (42%)
lrp2bXP_021335953.1 LDLa 2..34 CDD:238060
LDLa 38..71 CDD:197566
LDLa 80..114 CDD:238060
LDLa 123..151 CDD:238060
LDLa 155..189 CDD:238060
LDLa 194..228 CDD:238060
LDLa 235..269 CDD:238060
FXa_inhibition 324..>347 CDD:317114
LY 429..469 CDD:214531
LY 471..516 CDD:214531
LY 519..559 CDD:214531
FXa_inhibition 631..672 CDD:317114
Ldl_recept_b 808..848 CDD:278487
LY 834..874 CDD:214531
FXa_inhibition 950..982 CDD:317114 6/31 (19%)
LDLa 995..1029 CDD:238060 9/33 (27%)
LDLa 1036..1070 CDD:238060 17/33 (52%)
LDLa 1078..1112 CDD:238060 21/33 (64%)
LDLa 1119..1153 CDD:238060 15/33 (45%)
LDLa 1157..1192 CDD:238060 17/42 (40%)
LDLa 1200..1234 CDD:238060 17/33 (52%)
LDLa 1241..1275 CDD:238060 16/33 (48%)
LDLa 1282..1314 CDD:197566 15/37 (41%)
FXa_inhibition 1323..1358 CDD:317114 8/35 (23%)
EGF_CA 1360..1398 CDD:214542 22/39 (56%)
YncE 1388..>1660 CDD:331368 95/272 (35%)
LY 1470..1512 CDD:214531 16/41 (39%)
Ldl_recept_b 1535..1575 CDD:278487 23/39 (59%)
LY 1559..1601 CDD:214531 14/41 (34%)
LY 1789..1824 CDD:214531 16/34 (47%)
LY 1837..1879 CDD:214531 16/41 (39%)
LY 1922..1958 CDD:214531 11/35 (31%)
FXa_inhibition 1991..2027 CDD:317114 17/35 (49%)
Ldl_recept_b 2170..2210 CDD:278487 18/39 (46%)
LY 2195..2236 CDD:214531 12/40 (30%)
LY 2427..2468 CDD:214531 12/40 (30%)
LY 2468..2510 CDD:214531 22/44 (50%)
LY 2513..2553 CDD:214531 12/39 (31%)
FXa_inhibition 2623..2660 CDD:317114 10/24 (42%)
LDLa 2667..2699 CDD:197566
LDLa 2709..2743 CDD:238060
LDLa 2750..2785 CDD:238060
LDLa 2789..2822 CDD:197566
LDLa 2831..2863 CDD:197566
LDLa 2873..2905 CDD:197566
LDLa 2915..2952 CDD:197566
LDLa 2961..2995 CDD:238060
LDLa 2999..3031 CDD:197566
Ldl_recept_a 3042..3077 CDD:278486
cEGF 3100..3123 CDD:315355
vWFA <3115..3158 CDD:320736
LY 3189..3229 CDD:214531
LY 3230..3272 CDD:214531
Ldl_recept_b 3303..3341 CDD:278487
LY 3327..3367 CDD:214531
LY 3374..3409 CDD:214531
LDLa 3480..3512 CDD:197566
LDLa 3521..3552 CDD:197566
LDLa 3561..3593 CDD:197566
LDLa 3602..3634 CDD:197566
LDLa 3646..3682 CDD:238060
LDLa 3689..3722 CDD:238060
LDLa 3727..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3810..3841 CDD:197566
LDLa 3854..3883 CDD:197566
LDLa 3896..3930 CDD:238060
EGF_CA 3975..4014 CDD:214542
LY 4107..4142 CDD:214531
LY 4143..4186 CDD:214531
LY 4187..4230 CDD:214531
FXa_inhibition 4306..>4324 CDD:317114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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