DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp2b

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:XP_021335953.2 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4602 Species:Danio rerio


Alignment Length:1792 Identity:586/1792 - (32%)
Similarity:865/1792 - (48%) Gaps:169/1792 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 NIGAQRGRTEIAGIRE-----TDRISSR------GRDGFIGGPSNKQK-----PFRVNLAV---- 184
            ||..::|.:.|..|:.     .|...||      ||......|:....     ||.:.|..    
Zfish   942 NIMLRKGISGIMNIKAYSADLQDLFKSRCNMIPNGRCSHFCFPTPASSRVCGCPFGMKLQENQRD 1006

  Fly   185 LVQDDPSQPGETYSNCQNSNESDENCN----PEED--AVPNLQR-----DCEKTGIHVMC----- 233
            .|:||...|            .|:||.    |.:.  .|||..|     ||......|.|     
Zfish  1007 CVKDDSEPP------------PDDNCGDYAFPCDGGRCVPNTYRCDGVNDCVDKTDEVNCTLPGA 1059

  Fly   234 ---PRTFRCISKY-----WLCDGDDDCGDYSDETHCGAR--TNCTDDQFECLNGFCIPRTWVCDG 288
               |..|.|.:|:     |.|||.|||||.||||:|..|  |.|:..||.|.||.|||:|||||.
Zfish  1060 TCSPYAFTCGNKHCIPARWRCDGHDDCGDGSDETNCPTRGPTTCSSSQFACTNGNCIPKTWVCDA 1124

  Fly   289 ENDCKDFSDETHCNR--TTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGE 351
            .|||.|.|||.|||.  |||....|.|.|..||..::.|||:.||.|.|||..|   :.:|...|
Zfish  1125 FNDCGDGSDERHCNSSITTCQPGFFLCPDHRCIYNSYVCDGDQDCLDGSDEKDC---VYTCGTYE 1186

  Fly   352 FKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENCP-QKPSLCTSNEYKC-ADGTCIPKRW 414
            |.|..|        .||:...:||||..||.|.|||..|| ::|.||..||::| .||.||||.|
Zfish  1187 FACASG--------DQCVSQSYRCDGVYDCKDHSDESGCPTRRPGLCHDNEFQCQVDGFCIPKEW 1243

  Fly   415 KCDKEQDC-DGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC-- 476
            :||...|| ||.::.|.|      .|.||.|.:|.|.||.|:.|.|:|||..||....||..|  
Zfish  1244 ECDGHPDCVDGSDEHNGC------PPRTCSSVQFQCANGNCVSKNWVCDGENDCRDMSDETNCPT 1302

  Fly   477 -HLQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCS-EPSPCEQLCIE 539
             ...|..||:||||.|      :|:....:|||..:||.|.||:....|..|. ....|...||:
Zfish  1303 PPFSCPSGQWLCPTDQ------VCIMNAQVCDGQRDCPNGADESPICNEDDCKVNNGGCSHGCIQ 1361

  Fly   540 TTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSC 604
            ...|: :|.|..|:.:..:...|.||:||  |....|||.|.|..|||:|.||.||.|.||.|:|
Zfish  1362 GPFGA-QCTCDPGFQLLNDSKTCDDINEC--LIPGFCSQTCFNERGSFRCYCEDGYQLEPDGRTC 1423

  Fly   605 KALG-GAMTLLVANRWDI--RRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMV 666
            :|.. |...||||.|..|  .|:.......|.||.|: :.:|:||.:....::|.|.|..:|...
Zfish  1424 RATSPGNALLLVARRSQIIGNRINFWPPIISPIVSGM-SIVAVDFDNVNKRVYWGDSSDKMIYSS 1487

  Fly   667 YMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIV 731
            :.|||..:.|...||..|..|||||:...::||||..:.:||:...|:.|.::.:.::..||.:|
Zfish  1488 FQNGTDKKQVFSSGLMVPESIAVDWVGRNIYWTDSVMQNIEVATLDGHFRKILITKNVTSPRGLV 1552

  Fly   732 VHPGE--ALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIE 794
            :.|..  .|.||||||.||:||:|.|||..|:.|::..|.|||||.:|:...::|:.||....|:
Zfish  1553 LDPRNHTNLMFWSDWGQNPRIEQASMDGLGRRAIVTSKVYWPNGLTLDYTTRRVYFVDAYLKYID 1617

  Fly   795 CSNLDGSDRNKILSTH--LPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMD 857
            ..:.||.:|:::.::.  |..|..:|:|||.::|:|..|..:...:|..|.....:....:..|.
Zfish  1618 YCDYDGKNRHQVFASDIVLQQPHGITIFEDNIFWSDSYTSQIMRTNKFHGGNITTLLTGVYQCMG 1682

  Fly   858 IHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSR----RCGCPIGLSLKEDGKTCKSTADK 918
            |...||.:||...:.|:.:      .||.|||.: |.|    ||.|..|..|..||:||......
Zfish  1683 IVMDHPIKQPIAFNPCENN------PCSQLCLLS-TLRPRYYRCDCQSGWILASDGRTCTKDETP 1740

  Fly   919 LVLVARRKDIRLRHLRDNQADPNDV--DMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAH 981
            .::|.|  |..:..:..|   |||.  :.:.|:..:.....:|:.....|:||.. ....|.::.
Zfish  1741 FLMVVR--DTVIMGIPLN---PNDTSNNAMAPISGITQGRDIDFDDREQFVYWVQ-GTGAIYRSK 1799

  Fly   982 LNGSYQQRVVHSNLV-SPVGLALDWITDKLYWTDPSTNRIEVATTNGKM--RTLLIW-----EKL 1038
            .:|:.:.:...:.:: ||.|||.||||..:|:|:|:...|||...:|..  |..:|.     |..
Zfish  1800 TDGANRTQFAPAAIIGSPSGLAFDWITRIMYYTNPTIKAIEVIRVDGSQHYRKTIITNTGKPEGA 1864

  Fly  1039 YKPRDIVVNPIEGFMFWSDWGDD----PMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYF 1099
            .:|..|.::|..|.:||:|.|.|    |.|..|:|||.....:.:..|:....:|.|.|..|||:
Zfish  1865 GQPIGIALDPARGKLFWTDRGSDSGVPPKISSADMDGGNVKNLYTGNLVKVEFIAADIEARKIYW 1929

  Fly  1100 VDGGTKTLENMNFDGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIAN 1164
            ....|..:|....||:.|..|::||.||:|:.|.:..:::||.|.:.:...:|.||.|..|:.::
Zfish  1930 GVHQTGMIECGTMDGASRVTIVSGLSHPWGITVYQNYLYYTDLDFEVIERVDKNTGADMVVMRSS 1994

  Fly  1165 STDLMDIRVFHRTRRR-IFNACDKLNGGCSHLCLLNPTSY-TCACTVGVQLKEDRHTCSEGPTQY 1227
            ...|..::|..|.... ..|||...||||.||||..|... |||||.|....:|...|.:..:..
Zfish  1995 MAGLRSVKVHARDNSAGTTNACSTNNGGCPHLCLPKPQGQKTCACTTGFIPSQDGSHCEQYDSYA 2059

  Fly  1228 ILFAHRIDIRQISLDFDHLIDVVLPLPPISNAV--ALDVDRKTGYIYWSD--TIENV--IMSSSP 1286
            |:.:.:. ||...::.....:.::|:...:.::  .||:...:|::||:|  |..:.  |..:..
Zfish  2060 IVSSSKF-IRGFHINSSDHSEAMVPVGANTYSIIDKLDMHIASGFLYWTDNSTYSSYRGIYRTKT 2123

  Fly  1287 DGLHVQKIVGDSLENP--DGLVVDSIGRTIYWAD--AGRHTIEVASLDGSNRHVIAYKDLESPRG 1347
            ||.....:: ..|.|.  .||.||.|...:|:.:  ..:..|||..|:.|.:.::.....:.|:.
Zfish  2124 DGSRYSTVI-SQLGNGRIQGLAVDWIAGNLYFTNKFTTQTYIEVLRLNTSIQLILLKSSADRPQD 2187

  Fly  1348 LALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTID 1412
            ||:..:..||||||.|...|||.:.|||..|:.:.:.:|..|.||::|..:..:||||..|..|.
Zfish  2188 LAVSPKLRLLFWTDAGQSPKIESALLDGTNRTVLASESLSSPRGLTIDYTNDFLYWVDDTLDMIS 2252

  Fly  1413 SCDYTGNQRKLIM--SSLHHPYALALSDDNIYWTDWKSKALHMTER--RNISAKRDIITNIDGLM 1473
            .....|:||:::.  |....||::|:..:.:.|.|.|...|....:  .|......|...||.|.
Zfish  2253 RMAPDGSQREIVRFGSRYPAPYSVAIFGEYMLWVDRKLGKLFQASKVPGNTDTPEVIRDGIDDLT 2317

  Fly  1474 DIKIIYQNQNQSTMK-----NACGNNNGNCSHLCLRNPSGY--SCQCPIGLRLRQNSTTQCQNLP 1531
            |: .::.:..|.|..     |.|.::||.|...|...|...  .|.|..|..|  ::...|....
Zfish  2318 DV-AVFDSHVQPTSANLVGFNPCHDDNGRCQQFCFALPDQQEPKCACAHGSLL--SNGVSCGFGL 2379

  Fly  1532 EDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFAD---VNLDVIRRVNL 1593
            ::||:......:..:.|:..|........|..:|.:.:::.::...:||..   :....|..:..
Zfish  2380 DEYLIFTTDYSVSSMRLDPEDHSVPFPTFNMGYGVLAIEFDFQDKRVFFTQYVGLGRSKIGYIIT 2444

  Fly  1594 LNLTESKVIVGTDVLTPNGIAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGD-PRSLI 1657
            .:.|...|.:.:|:..|.|:|.||:...||::|...:.::...:||..|..|..   || ||:::
Zfish  2445 TSSTSPPVTIASDLDDPEGLAYDWVHKRLYFTDYYNRSVQSMGIDGQNRSLIAH---GDRPRAIV 2506

  Fly  1658 VHPKKAYLFWSDWSSPAKIERSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQV 1722
            |.|...||:|:||.|||||||:.|.|:.|..:|.:.:..|..|::|:..|.|.|||:..|.|.:.
Zfish  2507 VDPCYGYLYWTDWGSPAKIERATLGGNFRIPVINTSLSQPNALSLDYEERLLYWADSTLDKIERS 2571

  Fly  1723 DFNGKRRQTIVPYAPHPFGLTLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIR 1787
            ...|:.|:.|:....:||.||:|:..|:||||..:.|||:.|  ..|.|......|......||.
Zfish  2572 SLTGENREVILTQTQYPFALTVFQQDIYWTDWNTRIVYRASK--DDGSGLTIMATDLQYRPNDIH 2634

  Fly  1788 AVSLSRQPKSVNHCAQDNGGCTHLCLNRNVDYVCACP 1824
            ..|.|||....:.|...||||:|:|:.......|.||
Zfish  2635 VFSASRQESCSSPCQLFNGGCSHVCVPGPAGPECQCP 2671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 21/33 (64%)
LDLa 306..340 CDD:238060 15/33 (45%)
LDLa 347..390 CDD:238060 17/42 (40%)
LDLa 397..431 CDD:238060 18/35 (51%)
LDLa 442..476 CDD:238060 16/33 (48%)
LDLa 480..521 CDD:238060 17/40 (43%)
FXa_inhibition 576..604 CDD:464251 17/27 (63%)
LY 634..671 CDD:214531 11/36 (31%)
LY 680..714 CDD:214531 14/33 (42%)
LY 718..760 CDD:214531 19/43 (44%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 14/41 (34%)
LY 806..838 CDD:214531 9/33 (27%)
FXa_inhibition 882..912 CDD:464251 14/33 (42%)
LY 946..985 CDD:214531 6/38 (16%)
NHL <967..1142 CDD:302697 58/186 (31%)
LY 988..1030 CDD:214531 16/44 (36%)
NHL repeat 998..1037 CDD:271333 17/45 (38%)
NHL repeat 1038..1080 CDD:271333 15/45 (33%)
NHL repeat 1084..1119 CDD:271333 11/34 (32%)
FXa_inhibition 1185..1220 CDD:464251 17/35 (49%)
NHL 1260..>1445 CDD:302697 59/196 (30%)
NHL repeat 1260..1296 CDD:271320 10/41 (24%)
LY 1292..1334 CDD:214531 13/45 (29%)
NHL repeat 1302..1337 CDD:271320 11/38 (29%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:464251 6/27 (22%)
LY 1600..1640 CDD:214531 11/39 (28%)
LY 1643..1686 CDD:214531 21/43 (49%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:464251 10/24 (42%)
lrp2bXP_021335953.2 LDLa 25..59 CDD:238060
LDLa 63..96 CDD:197566
LDLa 105..139 CDD:238060
LDLa 148..176 CDD:238060
LDLa 180..214 CDD:238060
LDLa 219..253 CDD:238060
LDLa 260..294 CDD:238060
FXa_inhibition 349..374 CDD:464251
Ldl_recept_b 429..469 CDD:459654
LY 454..494 CDD:214531
LY 496..541 CDD:214531
LY 544..584 CDD:214531
FXa_inhibition 656..697 CDD:464251
YncE 724..942 CDD:442618 586/1792 (33%)
Ldl_recept_b 833..874 CDD:459654
LY 859..899 CDD:214531
LDLa 1020..1054 CDD:238060 9/33 (27%)
LDLa 1061..1095 CDD:238060 17/33 (52%)
LDLa 1103..1137 CDD:238060 21/33 (64%)
LDLa 1144..1178 CDD:238060 15/33 (45%)
LDLa 1182..1217 CDD:238060 17/42 (40%)
LDLa 1225..1259 CDD:238060 17/33 (52%)
LDLa 1266..1300 CDD:238060 16/33 (48%)
LDLa 1307..1339 CDD:197566 15/37 (41%)
FXa_inhibition 1348..1383 CDD:464251 8/35 (23%)
EGF_CA 1385..1423 CDD:214542 22/39 (56%)
Ldl_recept_b 1473..1512 CDD:459654 14/38 (37%)
LY 1495..1537 CDD:214531 16/41 (39%)
Ldl_recept_b 1560..1601 CDD:459654 23/40 (58%)
LY 1584..1626 CDD:214531 14/41 (34%)
FXa_inhibition 1700..1734 CDD:464251 14/40 (35%)
LY 1814..1849 CDD:214531 16/34 (47%)
LY 1862..1904 CDD:214531 16/41 (39%)
LY 1947..1983 CDD:214531 11/35 (31%)
FXa_inhibition 2016..2052 CDD:464251 17/35 (49%)
Vgb <2100..2286 CDD:443399 56/186 (30%)
Ldl_recept_b 2195..2236 CDD:459654 18/40 (45%)
LY 2220..2261 CDD:214531 12/40 (30%)
YncE <2431..2562 CDD:442618 44/133 (33%)
LY 2538..2578 CDD:214531 12/39 (31%)
Ldl_recept_b 2598..2636 CDD:459654 14/39 (36%)
FXa_inhibition 2648..2685 CDD:464251 10/24 (42%)
LDLa 2692..2724 CDD:197566
LDLa 2734..2768 CDD:238060
LDLa 2775..2810 CDD:238060
LDLa 2814..2847 CDD:197566
LDLa 2856..2888 CDD:197566
LDLa 2898..2930 CDD:197566
LDLa 2940..2977 CDD:197566
LDLa 2986..3020 CDD:238060
LDLa 3024..3056 CDD:197566
Ldl_recept_a 3067..3102 CDD:395011
FXa_inhibition 3115..3143 CDD:464251
vWFA <3140..3183 CDD:469594
LY 3214..3254 CDD:214531
LY 3255..3297 CDD:214531
Ldl_recept_b 3328..3367 CDD:459654
LY 3352..3392 CDD:214531
LY 3399..3434 CDD:214531
LDLa 3505..3537 CDD:197566
LDLa 3546..3577 CDD:197566
LDLa 3586..3618 CDD:197566
LDLa 3627..3659 CDD:197566
LDLa 3671..3707 CDD:238060
LDLa 3714..3747 CDD:238060
LDLa 3752..3786 CDD:238060
LDLa 3791..3825 CDD:238060
LDLa 3835..3866 CDD:197566
LDLa 3879..3908 CDD:197566
LDLa 3921..3955 CDD:238060
EGF_CA 4000..4039 CDD:214542
LY 4132..4167 CDD:214531
LY 4168..4211 CDD:214531
LY 4212..4255 CDD:214531
FXa_inhibition 4329..>4349 CDD:464251
Blue background indicates that the domain is not in the aligned region.

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