DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lrp4 and LOC100536757

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_021334054.1	Gene:	LOC100536757 / 100536757	-ID:	-	Length:	600	Species:	Danio rerio

Alignment Length:	579	Identity:	163/579 - (28%)
Similarity:	244/579 - (42%)	Gaps:	125/579 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 CTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAGGPSGQCIL 370
            ||...|.|.:..|:||:.|||..:||.|.|||:.|.    :|..|.|.|..        |..|:.
Zfish    38 CTVLQFVCANSRCVSLSSRCDAVNDCGDGSDEISCW----NCTNGSFHCVA--------SESCVS 90

  Fly   371 NRFRCDGDNDCGDWSDE--ENCP--QKPSLCTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDC 431
            :...|||..||.|.:||  :.|.  .:...|..:|:.|.:|.|:|..|:||...||..|.||.||
Zfish    91 SSSVCDGRPDCADGADEQLDTCTSFSQAQPCARSEFTCTNGQCVPNSWRCDHSSDCKDGSDEEDC 155

  Fly   432 GSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVECHLQCDLGQFLCPTKQNLTNL 496
                 :|      :|...|||.|
Zfish   156 -----DH------NECAVNNGGC------------------------------------------ 167

  Fly   497 KICVHQKHICDGHNECPAGEDEADCPKERKCSEPSPCEQLCIETTAGSNECACRLGYVMDKNKVN 561
                  .|.|   .:.|.| ...||||..:..:.:.||                   |:|:
Zfish   168 ------SHTC---IDLPFG-FRCDCPKGMRLVQDTHCE-------------------VVDQ---- 199

  Fly   562 CTDIDECQYLTSPVCSQKCHNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTL 626
            |.|.|        ||.|.|.::.||..|.|:.||.|......|:|.||...:.|:.:..|:.:.|
Zfish   200 CLDAD--------VCDQICVHSNGSVVCDCQDGYQLTAGTGQCRATGGLAHVAVSTQEGIKMMDL 256

  Fly   627 SNNRYSAIV-KGLH--NAIALDFHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPG--G 686
            |.:....|. |.|.  ...||:.|:   .::||....|:|..:.::....|..: |...|.|  |
Zfish   257 SGSEERNITDKRLSPGPVSALNAHN---TLYWSSPENDIIYRMSLDSGDHRPAV-WLKASKGIVG 317

  Fly   687 IAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIE 751
            :||||||:.|:|..:.||.:.:::.:...:.::.| .|.||.|:.|.|.....||::.|.:.:||
Zfish   318 LAVDWIHESLYWISTSTRALHMASLKNTKQRLLIS-GLSKPTAVAVQPLLGYVFWAEGGESARIE 381

  Fly   752 RAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNLDGSDRNKILST--HLPHP 814
            |..:||..|..::...|..|..:::|.|...:||||:...:|.....||..|..::.:  :|..|
Zfish   382 RVGLDGESRFALVVSFVRNPVAISLDIPRGLLYWADSGLRSISRVLFDGQYRKTVVESNGYLDQP 446

  Fly   815 FALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHE-NFHFPMDIHAYHPARQPEYADR 872
            |.|.:||..:||:|..|.::.:|||..|...|.... ....|..:...||..||  ||:
Zfish   447 FGLAIFESRVYWSDQLTNSICSADKHNGTMLRVPQRLGSASPAGLVILHPLLQP--ADK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060
		LDLa	306..340	CDD:238060	16/33 (48%)
		LDLa	347..390	CDD:238060	14/44 (32%)
		LDLa	397..431	CDD:238060	14/33 (42%)
		LDLa	442..476	CDD:238060	5/33 (15%)
		LDLa	480..521	CDD:238060	4/40 (10%)
		FXa_inhibition	576..604	CDD:291342	10/27 (37%)
		LY	634..671	CDD:214531	10/39 (26%)
		NHL	<656..793	CDD:302697	42/138 (30%)
		LY	680..714	CDD:214531	13/35 (37%)
		NHL repeat	681..722	CDD:271320	13/42 (31%)
		NHL repeat	726..760	CDD:271320	13/33 (39%)
		LY	761..803	CDD:214531	11/41 (27%)
		NHL repeat	769..793	CDD:271320	7/23 (30%)
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
LOC100536757	XP_021334054.1	LDLa	38..72	CDD:238060	16/33 (48%)
		PRKCSH-like	<45..>112	CDD:193472	28/78 (36%)
		LDLa	121..155	CDD:238060	14/33 (42%)
		FXa_inhibition	160..193	CDD:317114	12/84 (14%)
		Ldl_recept_b	367..407	CDD:278487	11/39 (28%)
		LY	393..433	CDD:214531	11/39 (28%)
		LY	434..476	CDD:214531	14/41 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900