DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and ldlr

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	707	Identity:	266/707 - (37%)
Similarity:	372/707 - (52%)	Gaps:	67/707 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 RCISKYWLCDGDDDCGDYSDET--HCGARTNCTDDQFEC---LNGFCIPRTWVCDGENDCKDFSD 297
            :||...|:|||..:|.|.|||:  .|...| |..|.|.|   ||. |||..|.|||:.||::.||
Frog    40 KCIPYKWICDGSAECKDGSDESPETCKVVT-CGADHFSCGGRLNR-CIPLLWKCDGQTDCENGSD 102

  Fly   298 ETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDNSDELKCAAVINSCPEGEFKCRGGLGGAG 362
            |..|.|..|.|:.|||..|.||||.|.||.:.||:|.|||..|.|  .:|....|:|:
Frog   103 ENDCTRKVCADDQFTCRSGKCISLDFVCDEDLDCDDGSDESYCPA--PTCNPAMFQCK------- 158

  Fly   363 GPSGQCILNRFRCDGDNDCGDWSDEENC-------PQKPSLCTSNEYKCADGTCIPKRWKCDKEQ 420
             ..|.||...:.||||.||.|.|||::|       ..||  |:..|:.|..|.||...||||...
Frog   159 -DKGICIPKLWACDGDPDCEDGSDEQHCEGREPIKTDKP--CSPLEFHCGSGECIHMSWKCDGGY 220

  Fly   421 DCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAAGEDEVEC--HLQCDLG 483
            ||....||.||     ..| ||..|||.||:|.||..:..||...||....||..|  ..:|: |
Frog   221 DCKDKSDEKDC-----VKP-TCRPDEFQCNDGTCIHGSRQCDREYDCKDLSDEEGCVNVTKCE-G 278

  Fly   484 Q--FLCPTKQNLTNLKICVHQKHICDGHNECPAGEDE--ADCPKERKCSEPSPCEQLCIETTAGS 544
            .  |.|.:.:       |:....:|:...:|....||  .:|.:.........|..:|.:...|
Frog   279 PDVFKCRSGE-------CITMDKVCNKKRDCRDWSDEPIKECGENECMRNNGGCAHICNDLKIG- 335

  Fly   545 NECACRLGY-VMDKNKVNCTDIDECQYLTSP-VCSQKCHNTMGSFKCSCETGYILRPDLRSCKAL 607
            .||.|..|| ::||.:  |.||:||:   :| .|||.|.|..|.:||.|..||.:.|...|||::
Frog   336 YECLCNEGYRLVDKKR--CEDINECE---NPNTCSQICINLDGGYKCECREGYQMDPVTASCKSI 395

  Fly   608 GGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYM---- 668
            |....|...||.::|::||..:.|::.:..|.|.:|||.......::|||::...|....|
Frog   396 GTVAYLFFTNRHEVRKMTLDRSEYTSFIPRLKNVVALDMEIASNKIYWSDLTQRKIYSASMDKAD 460

  Fly   669 NGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVH 733
            |.:....||...:::|.||||||||..::||||....:.|:|.:|:.|..:.|.||.|||.|||.
Frog   461 NTSHHETVISSQIQAPDGIAVDWIHGNIYWTDSKFSTISVANTEGSKRKTLFSDDLAKPRDIVVD 525

  Fly   734 PGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAIECSNL 798
            |.:...:|:|||...|||:..::|..|..::::.:.||||:.:|..|.::||.|:|.|::.|.::
Frog   526 PSQGFMYWTDWGLPAKIEKGGLNGVDRYPLVTENIEWPNGITLDLTNQRLYWVDSKLHSLSCIDV 590

  Fly   799 DGSDRNKILS--THLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDIHAY 861
            .|.:|..::|  |||.|||.||:|||.::|||...:.:.:|:::||.....|.|:...|.||..|
Frog   591 TGQNRITVISDETHLAHPFGLTVFEDLVFWTDIENEAIFSANRLTGSNITKVAEDLLSPEDIVLY 655

  Fly   862 HPARQPEYADRCQKDRRGLRGGCSHLCLPNK--TSR----RCGCPIGLSLKEDGKTC 912
            |..|||:..:.|:....| .|||.:||||..  |||    .|.||.|:.|..|.::|
Frog   656 HNLRQPKAENWCESHHLG-NGGCEYLCLPAPLITSRSPKFTCACPDGMHLGADMRSC 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	18/36 (50%)
		LDLa	306..340	CDD:238060	19/33 (58%)
		LDLa	347..390	CDD:238060	16/42 (38%)
		LDLa	397..431	CDD:238060	14/33 (42%)
		LDLa	442..476	CDD:238060	15/33 (45%)
		LDLa	480..521	CDD:238060	9/44 (20%)
		FXa_inhibition	576..604	CDD:291342	12/27 (44%)
		LY	634..671	CDD:214531	11/40 (28%)
		NHL	<656..793	CDD:302697	54/140 (39%)
		LY	680..714	CDD:214531	15/33 (45%)
		NHL repeat	681..722	CDD:271320	17/40 (43%)
		NHL repeat	726..760	CDD:271320	15/33 (45%)
		LY	761..803	CDD:214531	13/41 (32%)
		NHL repeat	769..793	CDD:271320	11/23 (48%)
		FXa_inhibition	882..912	CDD:291342	16/35 (46%)
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841	9/19 (47%)
		Ldl_recept_a	68..106	CDD:365841	19/39 (49%)
		LDLa	111..145	CDD:238060	19/33 (58%)
		Ldl_recept_a	149..185	CDD:365841	16/43 (37%)
		Ldl_recept_a	195..231	CDD:365841	16/37 (43%)
		Ldl_recept_a	235..270	CDD:365841	16/34 (47%)
		LDLa	278..308	CDD:381805	6/36 (17%)
		FXa_inhibition	318..352	CDD:373209	10/36 (28%)
		EGF_CA	354..384	CDD:214542	15/32 (47%)
		LY	419..457	CDD:214531	10/37 (27%)
		Ldl_recept_b	439..482	CDD:278487	12/42 (29%)
		Ldl_recept_b	486..525	CDD:278487	16/38 (42%)
		Ldl_recept_b	529..569	CDD:278487	13/39 (33%)
		LY	555..595	CDD:214531	13/39 (33%)
		Ldl_recept_b	616..655	CDD:278487	12/38 (32%)
		FXa_inhibition	674..711	CDD:373209	16/36 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910