DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and egf

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001106478.1 Gene:egf / 100127663 XenbaseID:XB-GENE-951823 Length:1051 Species:Xenopus tropicalis


Alignment Length:1011 Identity:214/1011 - (21%)
Similarity:386/1011 - (38%) Gaps:295/1011 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   613 LLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMVYMNGT---RVR 674
            |:.::..||..:.........:|....:.:.:||..::..::|.|.:...::.:|:||:   |:|
 Frog    49 LIFSHGNDIFTINSDGTNLRKVVPSAGSTLQIDFIQQENRLYWLDQNRGFLQRMYLNGSKHERLR 113

  Fly   675 DVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPRAIVVHPGEALA 739
            .|.|..:    |.|:||.|:::||.:.....:|::: :...|:.:....|..|:.:.:.|.|.|.
 Frog   114 AVGKGSI----GFAIDWKHNVIFWANQQKGTIELTS-RNEKRSRVLLRGLFNPKFVAIDPLEGLL 173

  Fly   740 FWSDWGPNPKIERAYMDGTQRKVIIS-KGVTWPNGLAIDFPNSKIYW----ADAKQHAIECSNLD 799
            |||.......|::|.:||:....||. .|..  .||.:|..:.||:|    .|.:...|...:.:
 Frog   174 FWSSNKSWTIIQKATLDGSNVTSIIELSGAL--KGLTLDTDDKKIFWILSKIDREDSVIGSCSYN 236

  Fly   800 GSD----RNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVH--ENFHFPMDI 858
            |..    :|..|||.. |...::|..:.:|:::..:.::...:|.|||:..:|:  .:.....:|
 Frog   237 GDSVMIVKNLRLSTKY-HVLGVSLLYNHIYYSERKSGSIKVINKFTGKDIVSVNLKPSIMEIRNI 300

  Fly   859 HAYHPARQPEYADRCQKDRRGLRG------GCSHLCLPNKTSRRCGCPIGLSLKEDGKTCKSTAD 917
            ...:|.|  .|:.......:|.:.      .|:..|..:..:::|.|..|..|..:|:.|:    
 Frog   301 KVVYPVR--SYSIPNSSSNQGAKSCSISNKHCTKTCEIDAENQKCHCMNGFVLSSNGRYCE---- 359

  Fly   918 KLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHL 982
                                 |.|:                  |:     .|.  ...|:...::
 Frog   360 ---------------------DINE------------------CA-----LWN--HGCTLGCENI 378

  Fly   983 NGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVN 1047
            .|||                        :.|.|                                
 Frog   379 PGSY------------------------FCTCP-------------------------------- 387

  Fly  1048 PIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNF 1112
              ||::...|          |...|::....::.:...:| .:...|..:.....|:...|    
 Frog   388 --EGYVLLPD----------NKTCHDKTPCLTEHIECSHG-CVQTTKGPLCTCPEGSVLSE---- 435

  Fly  1113 DGSGRQVILNGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRT 1177
            ||.                                 |....|..|                    
 Frog   436 DGK---------------------------------SCTGCTSPD-------------------- 447

  Fly  1178 RRRIFNACDKLNGGCSHLCLLN-PTSYTCACTVGVQLKEDRHTC-SEGPTQYILFAHRIDIRQIS 1240
                       ||||||:|::: |.::.|.|..|..|:.||..| :.||..|::||:..|||:|:
 Frog   448 -----------NGGCSHICIMSGPGTWECDCFPGYNLQLDRKQCLASGPRPYLMFANVHDIRRIN 501

  Fly  1241 LD---FDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENP 1302
            .|   ::.::|     ..|....|||.|.....:|::.|....|.|::.||...:|::...|...
 Frog   502 FDGTNYESVLD-----SQIGRVFALDYDPVEDRMYFAHTALKCIESANMDGSDRKKMISGDLSTL 561

  Fly  1303 DGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRK 1367
            :||.||:|.|.:||.|.|:..||.:.|:|..|.::..::...|||:.:...|..||||..|...:
 Frog   562 EGLTVDAINRKLYWTDRGKSCIERSDLNGKYRKILIQENNIQPRGICVHPLAKKLFWTHVGANPR 626

  Fly  1368 IERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTG-NQRKLIMSSLHHP 1431
            ||.|.|:|:||..|::.:|.||:|:::|..:..|||.||:...|:|.:..| |::....:.:.||
 Frog   627 IESSDLEGSEREVIISKDLIWPSGITVDHLTDVIYWCDAKKSVIESANLDGSNRQSFSQNDVGHP 691

  Fly  1432 YALALSDDNIYWTDWKSKALHMTERRNISAKRDIITNIDGLMDIKIIY----------------- 1479
            :|:::.:|:::.:||...:|...|:||......:..|:.....:.|::                 
 Frog   692 FAISVFEDHLWVSDWVQPSLIRIEKRNTQNWVRLRGNMQRPSSVVIVHPLAKPVIADDIPLPRKE 756

  Fly  1480 -QNQNQST------------------MKNACGNNNG----------------NC---SHLCLRNP 1506
             .:.||:.                  .:.|..:.||                :|   :| |:.:.
 Frog   757 KDSNNQTAHSESFFPGPLSTSNAEMGTREAPSSRNGLLAEIMVSDDSGCIDIHCDINAH-CVSSE 820

  Fly  1507 SGYSCQCPIGL----RLRQNSTTQCQNLPEDYLLIA 1538
            .|..|||..|.    ||       |.::.|..|.||
 Frog   821 DGPKCQCLEGFTGNGRL-------CHDIDECSLHIA 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342
LY 634..671 CDD:214531 7/36 (19%)
NHL <656..793 CDD:302697 39/144 (27%)
LY 680..714 CDD:214531 8/33 (24%)
NHL repeat 681..722 CDD:271320 9/40 (23%)
NHL repeat 726..760 CDD:271320 11/33 (33%)
LY 761..803 CDD:214531 12/50 (24%)
NHL repeat 769..793 CDD:271320 7/27 (26%)
FXa_inhibition 882..912 CDD:291342 7/35 (20%)
LY 946..985 CDD:214531 3/38 (8%)
NHL <967..1142 CDD:302697 18/174 (10%)
LY 988..1030 CDD:214531 2/41 (5%)
NHL repeat 998..1037 CDD:271320 2/38 (5%)
NHL repeat 1038..1080 CDD:271320 5/41 (12%)
NHL repeat 1084..1119 CDD:271320 6/34 (18%)
FXa_inhibition 1185..1220 CDD:291342 14/35 (40%)
NHL 1260..>1445 CDD:302697 62/185 (34%)
NHL repeat 1260..1296 CDD:271320 11/35 (31%)
NHL repeat 1302..1337 CDD:271320 15/34 (44%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:291342 9/29 (31%)
LY 1600..1640 CDD:214531
LY 1643..1686 CDD:214531
LY 1688..1729 CDD:214531
FXa_inhibition 1801..>1825 CDD:291342
egfNP_001106478.1 LY 152..194 CDD:214531 12/41 (29%)
vWFA <346..398 CDD:320736 18/169 (11%)
FXa_inhibition 412..440 CDD:317114 6/65 (9%)
FXa_inhibition 447..480 CDD:317114 15/63 (24%)
LY 508..550 CDD:214531 12/46 (26%)
LY 554..593 CDD:214531 15/38 (39%)
Ldl_recept_b 615..654 CDD:278487 17/38 (45%)
LY 638..680 CDD:214531 14/41 (34%)
EGF_3 810..838 CDD:315598 10/35 (29%)
EGF_3 851..880 CDD:315598
EGF_3 886..>914 CDD:315598
PHA02887 <927..>967 CDD:333467
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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