DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrp4 and lrp4

DIOPT Version :9

Sequence 1:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster
Sequence 2:	XP_031756584.1	Gene:	lrp4 / 100101694	XenbaseID:	XB-GENE-494512	Length:	1998	Species:	Xenopus tropicalis

Alignment Length:	1818	Identity:	782/1818 - (43%)
Similarity:	1096/1818 - (60%)	Gaps:	115/1818 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 ESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTFRCISKYWLCDGDDDCGDYSDETHCGARTNCTD 269
            :.|.:|....|....:...|.....|  |... :||.:.|:||||:||.|.|||..|..| .|.:
Frog   152 DGDNDCGDHSDEDGCMLPTCSPLDFH--CDNG-KCIRRSWVCDGDNDCEDDSDEQDCPPR-ECEE 212

  Fly   270 DQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISLAFRCDGEHDCNDN 334
            |:|.|.||:||...|.|||:|||.|.||| .|:...|:::.|.|.||.||:..:.|||:.||.|.
Frog   213 DEFSCQNGYCIRSLWHCDGDNDCGDNSDE-QCDMRKCSEKEFGCADGSCIAEHWFCDGDTDCKDG 276

  Fly   335 SDELKCAAVI--NSCPEGEFKCRGGLGGAGGPSGQCILNRFRCDGDNDCGDWSDEENC-PQKPSL 396
            |||..|.:.:  .||...||:|         ..|:|||:.:.||||:||||||||.:| ..:|
Frog   277 SDEESCPSDVPAPSCSVEEFQC---------AYGRCILDIYHCDGDDDCGDWSDESDCSSHQP-- 330

  Fly   397 CTSNEYKCADGTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLC 461
            |.|.|:.|..|.||...|:||.:.|||...||.:|.:      ..|.||:|.|::|||:..:|.|
Frog   331 CRSGEFMCNSGLCINSGWRCDGDSDCDDQSDEKNCTT------SVCTSDQFRCSSGRCVRLSWRC 389

  Fly   462 DGYPDCAAGEDEVECHL----QCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEA--- 519
            ||..||:...||..|..    ||...||||...:       |:.|:.:|:|.|:|..|.||:
Frog   390 DGEDDCSDNSDERGCEKTGSPQCAQDQFLCSNGR-------CIGQRKLCNGVNDCGDGSDESPHQ 447

  Fly   520 DC-PK--ERKCS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKC 580
            :| |:  |..|: :...|||.| :|..|..:|.|:.||.:..:...|.|:|||  .....|||.|
Frog   448 NCRPRTGEENCNHQNGGCEQKC-QTVRGLVQCTCQTGYRLRDDGRTCQDVDEC--AEEGYCSQGC 509

  Fly   581 HNTMGSFKCSCETGYILRPDLRSCKALGGAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALD 645
            .|:.|.|:|.||.||.||||.|||||||....||.|||.|||:|....:.|:.::..|.||||||
Frog   510 SNSQGGFQCWCEAGYQLRPDKRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALD 574

  Fly   646 FHHRKGLMFWSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSN 710
            |||...|:|||||:.|.|....:||:.|.:|:..|||||||:|:|||||.||||||||.|:||||
Frog   575 FHHEHELVFWSDVTLDRIMRANLNGSNVEEVVSTGLESPGGLAIDWIHDKLFWTDSGTSRIEVSN 639

  Fly   711 FQGNLRTVIASYDLDKPRAIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLA 775
            ..|:.|.|:...:|:|||||.:||.|...:|:|||..|:||.:.|||:.|:||....:.|||||.
Frog   640 LDGSHRKVLLWNNLEKPRAIALHPMEGTIYWTDWGNVPRIEYSSMDGSNRRVIADTHLFWPNGLT 704

  Fly   776 IDFPNSKIYWADAKQHAIECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKI 840
            ||:...:|||.|||.|.||.::||||:|..::|..||||||:|:|||::|||||:||::::|:|.
Frog   705 IDYAGHRIYWVDAKHHVIERADLDGSNRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANKF 769

  Fly   841 TGKEFRAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRRCGCPIGLSL 905
            |||....:....|||||||..||.|||..|:||..|    .|||||||||...:..|.||.|..
Frog   770 TGKNQEVIRSKLHFPMDIHTLHPQRQPTGANRCGVD----NGGCSHLCLPGGQTFSCACPTGFR- 829

  Fly   906 KEDGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDV-DMIVPLDNLKHAVALDWCSDTDFIYW 969
            |....||..:.||.:|.|||.|||....     |.:|: |.::||.:::.||||||.:..|.:||
Frog   830 KTGLNTCAKSLDKFLLFARRTDIRRISF-----DTDDLSDDVIPLSDVRSAVALDWDATEDLMYW 889

  Fly   970 TDVERSTINKAHLNGSYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLI 1034
            ||:...:||:|..:||.|:.::.::|.||.|||:||:|.||||||..|:||||:.|:|.:|::||
Frog   890 TDITTDSINRAKWDGSEQEVIIDTSLESPAGLAIDWVTHKLYWTDAGTDRIEVSNTDGSLRSVLI 954

  Fly  1035 WEKLYKPRDIVVNPIEGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYF 1099
            ||.|.:||||||:||.|||:|:|||.:|.||||.||...|:.|.|..|.:|||||||||..::|:
Frog   955 WENLDRPRDIVVDPIGGFMYWTDWGANPKIERAGMDASSRLVIISSNLTWPNGLAIDYESERLYW 1019

  Fly  1100 VDGGTKTLENMNFDGSGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIA 1163
            .|.|.||:|:...:|:.|.|:: ..|.|||||.:...:::||||.:||:.:|::.||.....:.|
Frog  1020 ADAGMKTIESAKLNGADRMVLIGTDLPHPFGLTLYGDQIYWTDWQSKSIETADRKTGLGRRTVQA 1084

  Fly  1164 NSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLL--NPTSYTCACTVGVQLKEDRHTCSEGPTQ 1226
            |..:||||.||||.|.::.:||...||||||:|||  .|..::|||..||.|..|..|||.|..:
Frog  1085 NLENLMDIHVFHRHRTQVPSACSIDNGGCSHICLLAPKPKGHSCACPTGVNLLSDGRTCSSGMDR 1149

  Fly  1227 YILFAHRIDIRQISLDFDHLIDVVLPL-PPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLH 1290
            :::||.|.|||.:|||..:..|||:|: ..:.|.:|:.||...|.|||:|:....|..::.||.:
Frog  1150 FLIFARRTDIRSVSLDIPYFADVVVPINATMKNTIAVGVDPLKGLIYWADSTLRKISRAALDGSN 1214

  Fly  1291 VQKIVGDSLENPDGLVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAG 1355
            .|.|:...|...|||.||:|||.:||.|.|.:.||||:|||:.|.|:.:::|.|||.:||.:|.|
Frog  1215 HQDIITTGLVTTDGLAVDAIGRKLYWTDTGTNRIEVANLDGTMRKVLVWQNLGSPRAIALYHEMG 1279

  Fly  1356 LLFWTDWGHYRKIERSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQ 1420
            .::|:|||...|:||:.:||:||..:::.||||||||::|....::.|.||..:.|::.|..|..
Frog  1280 YMYWSDWGENAKLERAGMDGSERMVLISLNLGWPNGLAVDKAGSQLLWADAHTERIEASDLMGRN 1344

  Fly  1421 RKLIMSSLHHPYALALSDDNIYWTDWKSKALHMTER---RNISAKRDIITNIDGLMDIKIIYQNQ 1482
            |::::|.:.|||.|.|.|.:||||||:::::...::   .||...||   |:.|||||:.:  ::
Frog  1345 RRILVSPVQHPYGLTLLDAHIYWTDWQTRSIQRADKDTGGNIIVVRD---NLPGLMDIQAV--DR 1404

  Fly  1483 NQSTMKNACGNNNGNCSHLCLRNPSGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMIS 1547
            ..:...|.||:.||.||||||.|.:.:||.||.|::|:.:..| |...|:.|||.:.|..|..||
Frog  1405 THALGYNKCGDKNGGCSHLCLPNSTSFSCACPTGIQLKDDGKT-CNPSPDTYLLFSSRGSIRRIS 1468

  Fly  1548 LNSGDFMDVVLPINGVHGAVVLDYHYRKNLLFFADVNLDVIRRVNLLNLTESKVIVGTDVLTPNG 1612
            |::.|..||.:||..:|..:.|||...:..:::.||.||||||.:|.. |..:.::|..:.|.:|
Frog  1469 LDTEDHTDVYVPIPELHNVISLDYDSVEGKIYYTDVFLDVIRRSDLTG-TGMETVIGEGLKTTDG 1532

  Fly  1613 IAVDWIADNLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWSSPAKIE 1677
            :||||:|.||||:||.|..||||||||..||.:|.::|.:||::.|.|:|.:|||:||...||||
Frog  1533 LAVDWVARNLYWTDTGRNTIEVSRLDGRHRKVLVNNSLDEPRAIAVFPRKGFLFWTDWGQVAKIE 1597

  Fly  1678 RSYLDGSNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGL 1742
            |::||||:|..||.:.:|:|.|||:|:.:||:.|.||..|.|...|.|||.|..::....|||.|
Frog  1598 RAHLDGSDRRTIINTDLGWPNGLTLDYDSRRIYWVDAHLDRIENADLNGKMRHVLISQVSHPFAL 1662

  Fly  1743 TLFENSIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGG 1807
            |.....|:||||..||:.|..|.  || .|...|...:.|.:||..||..|| ..:|.|..:|||
Frog  1663 TQEGRWIYWTDWQTKSIQRVDKF--SG-RNKETVLGNVEGLMDIIVVSPHRQ-TGINPCGINNGG 1723

  Fly  1808 CTHLCLNRNVDYVCACPD--------------VMDPKDVACSIKPKVLVHANLENDQ---LLEYS 1855
            |:|||..|::||||||||              ..||.....|.|......:|.|:||   .|..:
Frog  1724 CSHLCFARSIDYVCACPDEPDSEPCFLLPGYQPSDPHPTNSSEKSSGPFISNTESDQDDSTLRAT 1788

  Fly  1856 DESTDDSTPPELLGESND----HGDDGHTKKSDQEREFFVLV-ALGVVIVMVVIIILVIFMLAFN 1915
            ..|..|.|...:|..||.    |.       .|:.|..:::. :|.::.:::::..|:|:
Frog  1789 PRSCSDETGSPVLCASNGPVPAHA-------GDRLRVPYIIAGSLSLLCLLLLLCALLIY----- 1841

  Fly  1916 TSKKKNKRNSRGSSRSVLTFSNPNYNVDGTPMEPKTNIWKRFKYDKTHQERAGVYEERSLTTE 1978
             ..::.|.:.:|  ...||:|||:|..  :..|.|....::.. ...|:.|.....:...|.|
Frog  1842 -RHRRAKLSDQG--LGTLTYSNPSYRT--STQEVKIEAVQKMN-TSLHRHRKEAVPDSGFTKE 1898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	19/33 (58%)
		LDLa	306..340	CDD:238060	16/33 (48%)
		LDLa	347..390	CDD:238060	20/42 (48%)
		LDLa	397..431	CDD:238060	15/33 (45%)
		LDLa	442..476	CDD:238060	16/33 (48%)
		LDLa	480..521	CDD:238060	14/43 (33%)
		FXa_inhibition	576..604	CDD:291342	17/27 (63%)
		LY	634..671	CDD:214531	19/36 (53%)
		NHL	<656..793	CDD:302697	74/136 (54%)
		LY	680..714	CDD:214531	26/33 (79%)
		NHL repeat	681..722	CDD:271320	28/40 (70%)
		NHL repeat	726..760	CDD:271320	18/33 (55%)
		LY	761..803	CDD:214531	22/41 (54%)
		NHL repeat	769..793	CDD:271320	14/23 (61%)
		FXa_inhibition	882..912	CDD:291342	14/29 (48%)
		LY	946..985	CDD:214531	16/38 (42%)
		NHL	<967..1142	CDD:302697	90/175 (51%)
		LY	988..1030	CDD:214531	22/41 (54%)
		NHL repeat	998..1037	CDD:271320	24/38 (63%)
		NHL repeat	1038..1080	CDD:271320	25/41 (61%)
		NHL repeat	1084..1119	CDD:271320	17/34 (50%)
		FXa_inhibition	1185..1220	CDD:291342	18/36 (50%)
		NHL	1260..>1445	CDD:302697	80/184 (43%)
		NHL repeat	1260..1296	CDD:271320	13/35 (37%)
		NHL repeat	1302..1337	CDD:271320	20/34 (59%)
		NHL repeat	1345..1383	CDD:271320	17/37 (46%)
		FXa_inhibition	<1499..1525	CDD:291342	12/25 (48%)
		LY	1600..1640	CDD:214531	22/39 (56%)
		LY	1643..1686	CDD:214531	22/42 (52%)
		LY	1688..1729	CDD:214531	19/40 (48%)
		FXa_inhibition	1801..>1825	CDD:291342	15/23 (65%)
lrp4	XP_031756584.1	LDLa	127..166	CDD:238060	3/13 (23%)
		Ldl_recept_a	170..205	CDD:395011	16/37 (43%)
		LDLa	210..242	CDD:238060	19/32 (59%)
		LDLa	248..282	CDD:238060	16/33 (48%)
		Ldl_recept_a	330..365	CDD:395011	16/36 (44%)
		LDLa	370..404	CDD:238060	16/33 (48%)
		LDLa	412..449	CDD:238060	14/43 (33%)
		FXa_inhibition	458..493	CDD:405372	11/35 (31%)
		EGF_CA	495..534	CDD:214542	22/40 (55%)
		LY	560..602	CDD:214531	21/41 (51%)
		LY	605..645	CDD:214531	28/39 (72%)
		LY	646..689	CDD:214531	20/42 (48%)
		LY	690..732	CDD:214531	22/41 (54%)
		LY	733..773	CDD:214531	22/39 (56%)
		FXa_inhibition	802..>829	CDD:405372	15/30 (50%)
		LY	866..906	CDD:214531	17/39 (44%)
		LY	908..948	CDD:214531	21/39 (54%)
		Ldl_recept_b	971..1011	CDD:395012	23/39 (59%)
		LY	996..1037	CDD:214531	19/40 (48%)
		LY	1039..1072	CDD:214531	13/32 (41%)
		FXa_inhibition	1106..1143	CDD:405372	18/36 (50%)
		NHL	<1185..1377	CDD:302697	83/191 (43%)
		LY	1218..1258	CDD:214531	21/39 (54%)
		Ldl_recept_b	1279..1319	CDD:395012	20/39 (51%)
		FXa_inhibition	1413..1448	CDD:405372	18/35 (51%)
		LY	1484..1518	CDD:214531	13/34 (38%)
		LY	1520..1562	CDD:214531	23/41 (56%)
		Ldl_recept_b	1583..1623	CDD:395012	22/39 (56%)
		LY	1607..1649	CDD:214531	19/41 (46%)
		FXa_inhibition	1717..>1741	CDD:405372	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8321
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H17964
Inparanoid	1	1.050	1508	1.000	Inparanoid score	I101
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D121310at2759
OrthoFinder	1	1.000	-	-		FOG0008268
OrthoInspector	1	1.000	-	-		oto103707
Panther	1	1.100	-	-	LDO	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1256
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160