DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lrp4 and lrp6

DIOPT Version :10

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001128156.2 Gene:lrp6 / 100003877 ZFINID:ZDB-GENE-090821-1 Length:1619 Species:Danio rerio


Alignment Length:1529 Identity:541/1529 - (35%)
Similarity:810/1529 - (52%) Gaps:169/1529 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 CKALGGAMTLLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMV 666
            |..:.|...||.|||.|:|.|..::.|.:|  ::.||.:|.|:|:.:.:||::|||||.:.||..
Zfish    14 CLQIRGLPLLLYANRRDLRLVDAAHGRANATLVMGGLEDAAAVDYIYAQGLIYWSDVSEESIKRT 78

  Fly   667 YMNGTR---VRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPR 728
            ..||:.   |:..:..||.||.|:|.||:.:.|:||||.|.|:||:...|..|.|:...|||:||
Zfish    79 LFNGSAPSGVQTTVISGLASPDGLACDWMGNKLYWTDSETNRIEVAELDGTHRKVLFWQDLDQPR 143

  Fly   729 AIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAI 793
            ||.:.||....:|:|||..||||||.|||:.|.||:...:.|||||.:|:...::||||||.:.|
Zfish   144 AIALDPGRGFMYWTDWGEIPKIERAGMDGSLRSVIVETEIYWPNGLTLDYQQQQLYWADAKFNCI 208

  Fly   794 ECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDI 858
            ..||||||.|..::...|||||||||:|||::||||||.::.:..|.||:..|.||.|...||||
Zfish   209 HRSNLDGSSREVVVKGSLPHPFALTLYEDTLFWTDWNTHSIHSCHKHTGENSREVHSNIFSPMDI 273

  Fly   859 HAYHPARQP-EYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTADKLV 920
            |.|...||| :.|..|..    ..||||||||  |.|...:|.||.|:.|.||.|:|:....:|:
Zfish   274 HVYSQQRQPMDVASPCSV----RNGGCSHLCLLSPAKPYYQCACPTGVQLLEDHKSCRDGPSQLL 334

  Fly   921 LVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNGS 985
            |:|||.|:|    |.:...|:..|:::..::::||:|:|:......|||||.|...|.::.|:||
Zfish   335 LLARRTDLR----RISLDTPDFTDIVLQAEDIRHAIAIDYDPVEGHIYWTDDEVRAIRRSLLDGS 395

  Fly   986 YQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPIE 1050
            ..|.||.|.:..|.|:|:|||...|||||..|:||||...||.||.:||.|.|.:||.||::|:.
Zfish   396 DAQLVVTSQVNHPDGIAVDWIARNLYWTDTGTDRIEVTRLNGTMRKILISEDLDEPRAIVLDPVA 460

  Fly  1051 GFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGS 1115
            |:|:|:|||:.|.||||.:||.:|:.:.:..|.:|||||:||.:.|||:.|..|..:|.|..|||
Zfish   461 GYMYWTDWGEVPKIERAALDGSQRMVMVNTSLGWPNGLALDYSERKIYWGDAKTDVIEVMEMDGS 525

  Fly  1116 GRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRV--FHRT 1177
            ||:|:| :.|.|.||..:....::||||..:|:...:| ...:..|||....|||.|:.  .|:|
Zfish   526 GRRVLLEDNLPHVFGFTLLGDYIYWTDWQRRSIERVHK-RSTEREVIIDQLPDLMGIKATFVHQT 589

  Fly  1178 RRRIF--NACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQIS 1240
                |  |.|...|||||||||..|...:|||.:|::|..|..||.. |..::||:...|||:||
Zfish   590 ----FGVNPCAWANGGCSHLCLYRPQGVSCACPIGLELMADLSTCIV-PEAFLLFSRHTDIRRIS 649

  Fly  1241 LDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDGL 1305
            |:.:: .:|.:||..:..|.|||.|.....|||:|.....|..:..:|..::.:|...|:.|:|:
Zfish   650 LETNN-NNVAIPLTGVKEASALDFDITDNRIYWTDITLKTISRAFMNGSSLEHVVEFGLDYPEGM 713

  Fly  1306 VVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIER 1370
            .||.:|:.:||||.|.:.||||.|||.:|.|:.:|||:|||.||||...|.::||:||...||:|
Zfish   714 AVDWLGKNLYWADTGTNRIEVAKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGRPKIDR 778

  Fly  1371 SHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALA 1435
            :.:||:.|..:| .|:|..|||::|...:|:||.|.....|:|.:..|.:|::|...|.||:.|.
Zfish   779 AAMDGSGRITLV-PNVGRANGLTIDYAERRLYWTDLDTTLIESSNMLGLEREVIADDLPHPFGLT 842

  Fly  1436 LSDDNIYWTDWKSKALHMTERRNISA--KRDIIT-NIDGLMDIKIIYQNQNQSTMKNACGNNNGN 1497
            ...|.||||||..:::   ||.|.::  .|.:|. ::|.:||| :::.:..||.. |||...||:
Zfish   843 QYQDYIYWTDWSQRSI---ERANKTSGQNRTVIQGHLDYVMDI-LVFHSSRQSGW-NACAATNGH 902

  Fly  1498 CSHLCLRNP-SGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPIN 1561
            ||||||..| ..::|.||....|..::.| | :.|..:||.:.::.|..:.::.....|::|||:
Zfish   903 CSHLCLAVPVCSFTCGCPAHYSLNTDNKT-C-SAPTSFLLFSQKTAINRMVMDELQSPDIILPIH 965

  Fly  1562 GVHGAVVLDYHYRKNLLFFADVNLDVIRRV----NLLNLTESKVIVGTDV-LTPNGIAVDWIADN 1621
            .:.....:||......|::.|...:||||.    |......|..:.|::: |.|..:::|..:..
Zfish   966 SLRNVRAIDYDPLDRHLYWIDAKQNVIRRAQEDGNQSVTVVSGAVGGSNLGLQPYDLSIDIYSRF 1030

  Fly  1622 LYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIERSYLDGS 1684
            :||:.....:|.|:|.|||....::......||::.|:|::.|:::|:..  || ||||..|||:
Zfish  1031 IYWTSELTNVINVTRTDGSRVGVVLRGEHDKPRAIAVNPERGYMYFSNLQERSP-KIERCALDGT 1094

  Fly  1685 NRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIV-PYAPHPFGLTLFENS 1748
            .|.|:..|.:|.|..|.:|....:|.|.|.....|...|.:|..|..|. .....|.|||:|.|.
Zfish  1095 EREVLFFSNLGRPVALAVDNELGKLFWVDMDLRRIESSDLSGANRIVIEDSNILQPVGLTVFGNF 1159

  Fly  1749 IFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAV-SLSRQPKSVNHCAQDNGGCTHLC 1812
            ::|.|...:.:.|..|:.|.|   ..:::..::...||.|| .|..|..|.:.|..|||||||:|
Zfish  1160 LYWIDRQQQMIERIHKVTREG---RTKIQARIASLSDIHAVHQLDMQEYSKHPCTSDNGGCTHIC 1221

  Fly  1813 LNRNVDYV-CACPD--VMDPKDVAC----SIKPKVLVHANLENDQL--------LEYSDESTDDS 1862
            :.:..... |:||.  |:...:::|    :..|:.....:.|.|.:        ....|:|:|:.
Zfish  1222 IVKGDGTTRCSCPIHLVLLQDELSCGEPPTCSPEQFSCVSGEVDCIPQAWRCDGFAECDDSSDER 1286

  Fly  1863 TPP-------------------ELLGESN--DHGDD--------------------GHTKKSD-- 1884
            ..|                   ...||.|  |..|:                    |..||.|  
Zfish  1287 DCPVCSSREFQCDSRQCVDAALRCNGEINCQDRSDENKCEVLCPADQFTCSNGQCIGRHKKCDNN 1351

  Fly  1885 ---------------QEREFFVLVALG--VVIVMVVIIILVIFMLAFNTSKKKNKRNSRGSSRSV 1932
                           :|..|.....:|  |.:|||:.::..::.:.......:.|.::.      
Zfish  1352 MDCTDNSDEIGCYATEEPSFAPTNTIGSIVGVVMVLFVVGAVYFVCQRVLCPQMKDDAD------ 1410

  Fly  1933 LTFSNPNYNVDGTPMEPKTNI------------WKRFK----------------YDKTHQERAGV 1969
             |.:| ::.|.|.|..|...:            ..|.|                ||:.|...|. 
Zfish  1411 -TMTN-DFVVHGPPPVPLGYVPHPASLSGSLPGMSRGKSVMGSLSIMGGSSGPPYDRAHVTGAS- 1472

  Fly  1970 YEERSLTTETASSSLFVPTPSPMASPSTKTIQLT 2003
                |.::.:...:.|.|..:|..||:|...|.|
Zfish  1473 ----SSSSSSTKGAYFPPILNPPPSPATVRSQYT 1502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:464251 541/1529 (35%)
LY 634..671 CDD:214531 15/36 (42%)
LY 680..714 CDD:214531 17/33 (52%)
LY 718..760 CDD:214531 23/41 (56%)
Ldl_recept_b 740..777 CDD:459654 21/36 (58%)
LY 761..803 CDD:214531 21/41 (51%)
LY 806..838 CDD:214531 18/31 (58%)
FXa_inhibition 882..912 CDD:464251 18/31 (58%)
LY 946..985 CDD:214531 12/38 (32%)
NHL <967..1142 CDD:302697 85/175 (49%)
LY 988..1030 CDD:214531 22/41 (54%)
NHL repeat 998..1037 CDD:271333 22/38 (58%)
NHL repeat 1038..1080 CDD:271333 20/41 (49%)
NHL repeat 1084..1119 CDD:271333 19/34 (56%)
FXa_inhibition 1185..1220 CDD:464251 17/34 (50%)
NHL 1260..>1445 CDD:302697 76/184 (41%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
LY 1292..1334 CDD:214531 19/41 (46%)
NHL repeat 1302..1337 CDD:271320 18/34 (53%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:464251 10/26 (38%)
LY 1600..1640 CDD:214531 10/40 (25%)
LY 1643..1686 CDD:214531 15/44 (34%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:464251 11/24 (46%)
lrp6NP_001128156.2 None
Blue background indicates that the domain is not in the aligned region.

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