DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lrp4 and lrp6

DIOPT Version :9

Sequence 1:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster
Sequence 2:NP_001128156.1 Gene:lrp6 / 100003877 ZFINID:ZDB-GENE-090821-1 Length:1620 Species:Danio rerio


Alignment Length:1530 Identity:541/1530 - (35%)
Similarity:810/1530 - (52%) Gaps:170/1530 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 CKALGGAMTLLVANRWDIRRVTLSNNRYSA--IVKGLHNAIALDFHHRKGLMFWSDVSTDVIKMV 666
            |..:.|...||.|||.|:|.|..::.|.:|  ::.||.:|.|:|:.:.:||::|||||.:.||..
Zfish    14 CLQIRGLPLLLYANRRDLRLVDAAHGRANATLVMGGLEDAAAVDYIYAQGLIYWSDVSEESIKRT 78

  Fly   667 YMNGTR---VRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIASYDLDKPR 728
            ..||:.   |:..:..||.||.|:|.||:.:.|:||||.|.|:||:...|..|.|:...|||:||
Zfish    79 LFNGSAPSGVQTTVISGLASPDGLACDWMGNKLYWTDSETNRIEVAELDGTHRKVLFWQDLDQPR 143

  Fly   729 AIVVHPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIYWADAKQHAI 793
            ||.:.||....:|:|||..||||||.|||:.|.||:...:.|||||.:|:...::||||||.:.|
Zfish   144 AIALDPGRGFMYWTDWGEIPKIERAGMDGSLRSVIVETEIYWPNGLTLDYQQQQLYWADAKFNCI 208

  Fly   794 ECSNLDGSDRNKILSTHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRAVHENFHFPMDI 858
            ..||||||.|..::...|||||||||:|||::||||||.::.:..|.||:..|.||.|...||||
Zfish   209 HRSNLDGSSREVVVKGSLPHPFALTLYEDTLFWTDWNTHSIHSCHKHTGENSREVHSNIFSPMDI 273

  Fly   859 HAYHPARQP-EYADRCQKDRRGLRGGCSHLCL--PNKTSRRCGCPIGLSLKEDGKTCKSTA-DKL 919
            |.|...||| :.|..|..    ..||||||||  |.|...:|.||.|:.|.||.|:|:... .:|
Zfish   274 HVYSQQRQPMDVASPCSV----RNGGCSHLCLLSPAKPYYQCACPTGVQLLEDHKSCRDGGPSQL 334

  Fly   920 VLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWTDVERSTINKAHLNG 984
            :|:|||.|:|    |.:...|:..|:::..::::||:|:|:......|||||.|...|.::.|:|
Zfish   335 LLLARRTDLR----RISLDTPDFTDIVLQAEDIRHAIAIDYDPVEGHIYWTDDEVRAIRRSLLDG 395

  Fly   985 SYQQRVVHSNLVSPVGLALDWITDKLYWTDPSTNRIEVATTNGKMRTLLIWEKLYKPRDIVVNPI 1049
            |..|.||.|.:..|.|:|:|||...|||||..|:||||...||.||.:||.|.|.:||.||::|:
Zfish   396 SDAQLVVTSQVNHPDGIAVDWIARNLYWTDTGTDRIEVTRLNGTMRKILISEDLDEPRAIVLDPV 460

  Fly  1050 EGFMFWSDWGDDPMIERANMDGHERVTITSKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDG 1114
            .|:|:|:|||:.|.||||.:||.:|:.:.:..|.:|||||:||.:.|||:.|..|..:|.|..||
Zfish   461 AGYMYWTDWGEVPKIERAALDGSQRMVMVNTSLGWPNGLALDYSERKIYWGDAKTDVIEVMEMDG 525

  Fly  1115 SGRQVIL-NGLGHPFGLDVNEGRVFWTDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRV--FHR 1176
            |||:|:| :.|.|.||..:....::||||..:|:...:| ...:..|||....|||.|:.  .|:
Zfish   526 SGRRVLLEDNLPHVFGFTLLGDYIYWTDWQRRSIERVHK-RSTEREVIIDQLPDLMGIKATFVHQ 589

  Fly  1177 TRRRIF--NACDKLNGGCSHLCLLNPTSYTCACTVGVQLKEDRHTCSEGPTQYILFAHRIDIRQI 1239
            |    |  |.|...|||||||||..|...:|||.:|::|..|..||.. |..::||:...|||:|
Zfish   590 T----FGVNPCAWANGGCSHLCLYRPQGVSCACPIGLELMADLSTCIV-PEAFLLFSRHTDIRRI 649

  Fly  1240 SLDFDHLIDVVLPLPPISNAVALDVDRKTGYIYWSDTIENVIMSSSPDGLHVQKIVGDSLENPDG 1304
            ||:.:: .:|.:||..:..|.|||.|.....|||:|.....|..:..:|..::.:|...|:.|:|
Zfish   650 SLETNN-NNVAIPLTGVKEASALDFDITDNRIYWTDITLKTISRAFMNGSSLEHVVEFGLDYPEG 713

  Fly  1305 LVVDSIGRTIYWADAGRHTIEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIE 1369
            :.||.:|:.:||||.|.:.||||.|||.:|.|:.:|||:|||.||||...|.::||:||...||:
Zfish   714 MAVDWLGKNLYWADTGTNRIEVAKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGRPKID 778

  Fly  1370 RSHLDGNERSRIVTANLGWPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYAL 1434
            |:.:||:.|..:| .|:|..|||::|...:|:||.|.....|:|.:..|.:|::|...|.||:.|
Zfish   779 RAAMDGSGRITLV-PNVGRANGLTIDYAERRLYWTDLDTTLIESSNMLGLEREVIADDLPHPFGL 842

  Fly  1435 ALSDDNIYWTDWKSKALHMTERRNISA--KRDIIT-NIDGLMDIKIIYQNQNQSTMKNACGNNNG 1496
            ....|.||||||..:::   ||.|.::  .|.:|. ::|.:||| :::.:..||.. |||...||
Zfish   843 TQYQDYIYWTDWSQRSI---ERANKTSGQNRTVIQGHLDYVMDI-LVFHSSRQSGW-NACAATNG 902

  Fly  1497 NCSHLCLRNP-SGYSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPI 1560
            :||||||..| ..::|.||....|..::.| | :.|..:||.:.::.|..:.::.....|::|||
Zfish   903 HCSHLCLAVPVCSFTCGCPAHYSLNTDNKT-C-SAPTSFLLFSQKTAINRMVMDELQSPDIILPI 965

  Fly  1561 NGVHGAVVLDYHYRKNLLFFADVNLDVIRRV----NLLNLTESKVIVGTDV-LTPNGIAVDWIAD 1620
            :.:.....:||......|::.|...:||||.    |......|..:.|::: |.|..:::|..:.
Zfish   966 HSLRNVRAIDYDPLDRHLYWIDAKQNVIRRAQEDGNQSVTVVSGAVGGSNLGLQPYDLSIDIYSR 1030

  Fly  1621 NLYWSDTDRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDWS--SPAKIERSYLDG 1683
            .:||:.....:|.|:|.|||....::......||::.|:|::.|:::|:..  || ||||..|||
Zfish  1031 FIYWTSELTNVINVTRTDGSRVGVVLRGEHDKPRAIAVNPERGYMYFSNLQERSP-KIERCALDG 1094

  Fly  1684 SNRTVIITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIV-PYAPHPFGLTLFEN 1747
            :.|.|:..|.:|.|..|.:|....:|.|.|.....|...|.:|..|..|. .....|.|||:|.|
Zfish  1095 TEREVLFFSNLGRPVALAVDNELGKLFWVDMDLRRIESSDLSGANRIVIEDSNILQPVGLTVFGN 1159

  Fly  1748 SIFWTDWYNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAV-SLSRQPKSVNHCAQDNGGCTHL 1811
            .::|.|...:.:.|..|:.|.|   ..:::..::...||.|| .|..|..|.:.|..|||||||:
Zfish  1160 FLYWIDRQQQMIERIHKVTREG---RTKIQARIASLSDIHAVHQLDMQEYSKHPCTSDNGGCTHI 1221

  Fly  1812 CLNRNVDYV-CACPD--VMDPKDVAC----SIKPKVLVHANLENDQL--------LEYSDESTDD 1861
            |:.:..... |:||.  |:...:::|    :..|:.....:.|.|.:        ....|:|:|:
Zfish  1222 CIVKGDGTTRCSCPIHLVLLQDELSCGEPPTCSPEQFSCVSGEVDCIPQAWRCDGFAECDDSSDE 1286

  Fly  1862 STPP-------------------ELLGESN--DHGDD--------------------GHTKKSD- 1884
            ...|                   ...||.|  |..|:                    |..||.| 
Zfish  1287 RDCPVCSSREFQCDSRQCVDAALRCNGEINCQDRSDENKCEVLCPADQFTCSNGQCIGRHKKCDN 1351

  Fly  1885 ----------------QEREFFVLVALG--VVIVMVVIIILVIFMLAFNTSKKKNKRNSRGSSRS 1931
                            :|..|.....:|  |.:|||:.::..::.:.......:.|.::.     
Zfish  1352 NMDCTDNSDEIGCYATEEPSFAPTNTIGSIVGVVMVLFVVGAVYFVCQRVLCPQMKDDAD----- 1411

  Fly  1932 VLTFSNPNYNVDGTPMEPKTNI------------WKRFK----------------YDKTHQERAG 1968
              |.:| ::.|.|.|..|...:            ..|.|                ||:.|...|.
Zfish  1412 --TMTN-DFVVHGPPPVPLGYVPHPASLSGSLPGMSRGKSVMGSLSIMGGSSGPPYDRAHVTGAS 1473

  Fly  1969 VYEERSLTTETASSSLFVPTPSPMASPSTKTIQLT 2003
                 |.::.:...:.|.|..:|..||:|...|.|
Zfish  1474 -----SSSSSSTKGAYFPPILNPPPSPATVRSQYT 1503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lrp4NP_727914.1 LDLa 267..301 CDD:238060
LDLa 306..340 CDD:238060
LDLa 347..390 CDD:238060
LDLa 397..431 CDD:238060
LDLa 442..476 CDD:238060
LDLa 480..521 CDD:238060
FXa_inhibition 576..604 CDD:291342 541/1530 (35%)
LY 634..671 CDD:214531 15/36 (42%)
NHL <656..793 CDD:302697 66/139 (47%)
LY 680..714 CDD:214531 17/33 (52%)
NHL repeat 681..722 CDD:271320 19/40 (48%)
NHL repeat 726..760 CDD:271320 19/33 (58%)
LY 761..803 CDD:214531 21/41 (51%)
NHL repeat 769..793 CDD:271320 12/23 (52%)
FXa_inhibition 882..912 CDD:291342 18/31 (58%)
LY 946..985 CDD:214531 12/38 (32%)
NHL <967..1142 CDD:302697 85/175 (49%)
LY 988..1030 CDD:214531 22/41 (54%)
NHL repeat 998..1037 CDD:271320 22/38 (58%)
NHL repeat 1038..1080 CDD:271320 20/41 (49%)
NHL repeat 1084..1119 CDD:271320 19/34 (56%)
FXa_inhibition 1185..1220 CDD:291342 17/34 (50%)
NHL 1260..>1445 CDD:302697 76/184 (41%)
NHL repeat 1260..1296 CDD:271320 10/35 (29%)
NHL repeat 1302..1337 CDD:271320 18/34 (53%)
NHL repeat 1345..1383 CDD:271320 17/37 (46%)
FXa_inhibition <1499..1525 CDD:291342 10/26 (38%)
LY 1600..1640 CDD:214531 10/40 (25%)
LY 1643..1686 CDD:214531 15/44 (34%)
LY 1688..1729 CDD:214531 12/40 (30%)
FXa_inhibition 1801..>1825 CDD:291342 11/24 (46%)
lrp6NP_001128156.1 NHL <32..>158 CDD:302697 51/125 (41%)
NHL repeat 53..93 CDD:271320 15/39 (38%)
LY 89..131 CDD:214531 18/41 (44%)
NHL repeat 96..137 CDD:271320 19/40 (48%)
Ldl_recept_b 152..192 CDD:278487 21/39 (54%)
LY 177..218 CDD:214531 21/40 (53%)
LY 219..252 CDD:214531 18/32 (56%)
FXa_inhibition 289..326 CDD:291342 19/40 (48%)
LY 357..397 CDD:214531 13/39 (33%)
LY 401..441 CDD:214531 21/39 (54%)
LY 442..485 CDD:214531 22/42 (52%)
LY 489..528 CDD:214531 18/38 (47%)
LY 529..569 CDD:214531 12/40 (30%)
FXa_inhibition 596..631 CDD:291342 17/34 (50%)
LY 660..699 CDD:214531 13/38 (34%)
LY 701..743 CDD:214531 19/41 (46%)
LY 744..787 CDD:214531 21/42 (50%)
LY 787..829 CDD:214531 15/42 (36%)
LY 831..870 CDD:214531 15/41 (37%)
FXa_inhibition 897..933 CDD:291342 15/36 (42%)
LY 962..1002 CDD:214531 11/39 (28%)
LY 1054..1097 CDD:214531 15/43 (35%)
LY 1098..1140 CDD:214531 12/41 (29%)
FXa_inhibition 1211..1247 CDD:291342 13/35 (37%)
LDLa 1253..1289 CDD:238060 6/35 (17%)
LDLa 1292..1326 CDD:238060 5/33 (15%)
LDLa 1330..1364 CDD:238060 4/33 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D121310at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.820

Return to query results.
Submit another query.