DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and CCNF

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001752.2	Gene:	CCNF / 899	HGNCID:	1591	Length:	786	Species:	Homo sapiens

Alignment Length:	332	Identity:	66/332 - (19%)
Similarity:	133/332 - (40%)	Gaps:	83/332 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 TAIGDPTLYSDRCLENFLKVEEKHHK--------------------------------------- 165
            |.:.||    .|||.:|.|:.:...|
Human   232 TDVSDP----GRCLHSFRKLRDYAAKGCWEAQLSLAKACANANQLGLEVRASSEIVCQLFQASQA 292

  Fly   166 -IPDTYFSIQKDITPPMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAA 229
             .....||:||.:...||.|:.:|::||...::.....:.|.:..:||:|..:.|.:.:||:|..
Human   293 VSKQQVFSVQKGLNDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYRLQLLGI 357

  Fly   230 ACLLLASKLREPSCRALSVDLLVV-----YTDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLE 289
            ||:::.:       |.:|.::|.:     .|||:...:||::....::|.|...:...|.:|:.|
Human   358 ACMVICT-------RFISKEILTIREAVWLTDNTYKYEDLVRMMGEIVSALEGKIRVPTVVDYKE 415

  Fly   290 LLMMRLPIGSKNFPDINIGKVRGHAQAFI-SLAAKEHKFAKFSASTIAASSIAASMNGLKWHLRS 353
            :|:..:|:..:.          .|..:|: .|:......:.::.:.:||:::      |...|..
Human   416 VLLTLVPVELRT----------QHLCSFLCELSLLHTSLSAYAPARLAAAAL------LLARLTH 464

  Fly   354 GHNLHFLLSLMTDLTSVEQAQVRDCMLHM-EDIFKEHSRNLEPFLVNIDPKEMSTLYYKRRFQIH 417
            |....:...|. |||......:..|:|.: :..|.:.:..        |.:::|....|:||:..
Human   465 GQTQPWTTQLW-DLTGFSYEDLIPCVLSLHKKCFHDDAPK--------DYRQVSLTAVKQRFEDK 520

  Fly   418 QSQHLSQ 424
            :...:||
Human   521 RYGEISQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	33/169 (20%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	20/111 (18%)
CCNF	NP_001752.2	Nuclear localization signal 1. /evidence=ECO:0000269\|PubMed:10716937	20..28
		F-box domain	29..76
		FBOX	35..73	CDD:197608
		TPR	<88..>146	CDD:223861
		SLR repeat	88..112	CDD:276807
		Cyclin_N	281..406	CDD:278560	30/131 (23%)
		Cyclin_C	421..531	CDD:281044	23/132 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..593
		Nuclear localization signal 2. /evidence=ECO:0000269\|PubMed:10716937	568..574
		PEST	582..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930