Protein Alignment CycD and CCNE1

DIOPT Version :10

• Sequence 1: NP_523355.2
• Gene: CycD / 32551
• FlyBaseID: FBgn0010315
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_001229.1
• Gene: CCNE1 / 898
• HGNCID: 1589
• Length: 410
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 61/271 - (22%)
• Similarity: 116/271 - (42%)
• Gaps: 54/271 - (19%)

  Fly   160 EEKHHKIPDTYFSIQKD-ITPPMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSS-KSVRKT 222
            :||.: :.|.:|..|.. :.|.||.|:.:|:||||.......|...||.::.||:::: ::|.||
Human   123 KEKTY-LRDQHFLEQHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRYMATQENVVKT 186

  Fly   223 QLQILAAACLLLASKLRE---PSCRALSVDLLVVYTDNSIYKDDLIKWELYVLSRLGWDLSSVTP 284
            .||::..:.|.:|:||.|   |.....:     ..||.:...|:::..||.::..|.|.||.:|.
Human   187 LLQLIGISSLFIAAKLEEIYPPKLHQFA-----YVTDGACSGDEILTMELMIMKALKWRLSPLTI 246

  Fly   285 LDFLELLM----------MRLPIGSKNFPDINIGKVRGHAQAFISLA-----------AKEHKFA 328
            :.:|.:.|          :.||    .:|.          |.||.:|           ..|..:.
Human   247 VSWLNVYMQVAYLNDLHEVLLP----QYPQ----------QIFIQIAELLDLCVLDVDCLEFPYG 297

  Fly   329 KFSASTI---AASSIAASMNGLKWHLRSGHNLHFLLSLMTDLTSVEQAQVRDCMLHMEDIFKEHS 390
            ..:||.:   ::|.:...::|.:|     .::...:..|.....|.:......:.|...:..|.:
Human   298 ILAASALYHFSSSELMQKVSGYQW-----CDIENCVKWMVPFAMVIRETGSSKLKHFRGVADEDA 357

  Fly   391 RNLEPFLVNID 401
            .|::....::|
Human   358 HNIQTHRDSLD 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	CYCLIN_SF	144..278	CDD:477360	36/122 (30%)
		CYCLIN_CCND_rpt2	283..387	CDD:410220	19/127 (15%)
CCNE1	NP_001229.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		CYCLIN_CCNE1_rpt1	103..239	CDD:410282	36/121 (30%)
		CYCLIN_CCNE1_rpt2	243..356	CDD:410284	19/131 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	378..410