Protein Alignment CycD and CCND2

DIOPT Version :9

• Sequence 1: NP_523355.2
• Gene: CycD / 32551
• FlyBaseID: FBgn0010315
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_001750.1
• Gene: CCND2 / 894
• HGNCID: 1583
• Length: 289
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 106/268 - (39%)
• Similarity: 161/268 - (60%)
• Gaps: 20/268 - (7%)

  Fly   136 DNVNTAIGDPTLY-SDRCLENFLKVEEKHHKIPD-TYFS-IQKDITPPMRKIVAEWMMEVCAEEN 197
            |.|..|:.|..|. .||.|:|.|.:||::  :|. :||. :||||.|.||::||.||:|||.|:.
Human     9 DPVRRAVRDRNLLRDDRVLQNLLTIEERY--LPQCSYFKCVQKDIQPYMRRMVATWMLEVCEEQK 71

  Fly   198 CQEEVVLLALNYMDRFLSSKSVRKTQLQILAAACLLLASKLREPSCRALSVDLLVVYTDNSIYKD 262
            |:|||..||:||:||||:.....|:.||:|.|.|:.|||||:|.|  .|:.:.|.:||||||...
Human    72 CEEEVFPLAMNYLDRFLAGVPTPKSHLQLLGAVCMFLASKLKETS--PLTAEKLCIYTDNSIKPQ 134

  Fly   263 DLIKWELYVLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINIGKVRGHAQAFISLAAKEHKF 327
            :|::|||.||.:|.|:|::|||.||:|.::.:||...:     .:..:|.|||.||:|.|.:.||
Human   135 ELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQRE-----KLSLIRKHAQTFIALCATDFKF 194

  Fly   328 AKFSASTIAASSIAASMNGLKWHLR-SGHNLHFLLSLMTDLTSVE-------QAQVRDCMLHMED 384
            |.:..|.||..|:.|::.||:.... |......|..|:..:|:.:       |.|:...:|:...
Human   195 AMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTELLAKITNTDVDCLKACQEQIEAVLLNSLQ 259

  Fly   385 IFKEHSRN 392
            .:::..|:
Human   260 QYRQDQRD 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	63/126 (50%)
		Cyclin_C	282..>392	CDD:281044	33/117 (28%)
CCND2	NP_001750.1	Cyclin_N	25..152	CDD:365896	65/130 (50%)
		Cyclin_C	154..>257	CDD:367282	33/107 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..289		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146240
Domainoid	1	1.000	126	1.000	Domainoid score	I5412
eggNOG	1	0.900	-	-		E1_KOG0656
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37525
Inparanoid	1	1.050	180	1.000	Inparanoid score	I4005
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001275
OrthoInspector	1	1.000	-	-		otm41358
orthoMCL	1	0.900	-	-		OOG6_105230
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4378
SonicParanoid	1	1.000	-	-		X1298
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.780