DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and CLB5

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_015445.1	Gene:	CLB5 / 856237	SGDID:	S000006324	Length:	435	Species:	Saccharomyces cerevisiae

Alignment Length:	437	Identity:	98/437 - (22%)
Similarity:	172/437 - (39%)	Gaps:	109/437 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LYRLNKRQQQMSSPAIIRDQSSICS----------------SLGDAESDSHPDAQNNAVVCNMKE 65
            :|..|:||...|:..|::::.::..                :|.|...:::|.:||..:|...|
Yeast    17 IYNENERQLCNSNLKILQNKRALSKNDSSSKQQVQDSKPRRALTDVPVNNNPLSQNKRIVAGSK- 80

  Fly    66 LVYIYASVDSAAK--NPEQLEPPPPPPPPPPPPPTATQSIQSYPRYISQEPPTSHCQRLDERLTT 128
                      |||  ..|.:.          |..:|.|..|.|....:.|      |..:|....
Yeast    81 ----------AAKVRREENIR----------PIVSAVQKRQIYNDRTAAE------QEEEEEEEG 119

  Fly   129 TADPPAT----------DNVNTAIG----------DPTLYSDRCLENFLKVEEKH-HKIPDTYFS 172
            ..|..|:          :.|:..:|          |..:.::...|.|..:..:. ..:|...:.
Yeast   120 EDDDAASIVNKKRRIDAEGVSEIVGWQDLDYVEKDDTAMVAEYSAEIFAFLYRRELETLPSHNYL 184

  Fly   173 IQKD----ITPPMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAAACLL 233
            :.|.    :.|.||.|:.:|::||..:..|..|.:.|::|.|||||:...|...:||:||...|.
Yeast   185 LDKTSKYYLRPSMRTILVDWLVEVHEKFQCYPETLFLSINLMDRFLAKNKVTMNKLQLLAVTSLF 249

  Fly   234 LASKLREPSCRALSVDLLVVY---TDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLELLMMRL 295
            :|:|..|     :::..|..|   ||.:..|:|:...|:::|:.|.:::....||:||.    |:
Yeast   250 IAAKFEE-----VNLPKLAEYAYITDGAASKNDIKNAEMFMLTSLEFNIGWPNPLNFLR----RI 305

  Fly   296 PIGSKNFP-DINIGKVRGHAQAFISLAAKEHKFAKFSASTIAASS--IAASM---------NGLK 348
            .......| :.||||.      .:..|...|:|.....||::|.:  ||..|         ||..
Yeast   306 SKADDYDPVNRNIGKF------ILEYAYCCHQFIHLPPSTVSAMAMYIARRMTNRNKNELWNGTL 364

  Fly   349 WHLRSG----HNLHFLLSLMTDLTSVEQAQVRDCMLHMEDIFKEHSR 391
            .|...|    |:..| .||..||..    .:.....|::.:..::.:
Yeast   365 QHYSGGIDPIHDEAF-QSLCIDLVK----DIASSKTHLDSLILKYKK 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	37/132 (28%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	30/126 (24%)
CLB5	NP_015445.1	COG5024	1..431	CDD:227357	98/437 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940