DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and Ccnd2

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_071603.2	Gene:	Ccnd2 / 64033	RGDID:	621083	Length:	288	Species:	Rattus norvegicus

Alignment Length:	298	Identity:	112/298 - (37%)
Similarity:	170/298 - (57%)	Gaps:	34/298 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 ERLTTTADPPATDNVNTAIGDPTLYSDRCLENFLKVEEKHHKIPD-TYFS-IQKDITPPMRKIVA 186
            |.|....||     |..|:.|..|..||.|:|.|.:||::  :|. :||. :||||.|.||::||
  Rat     2 ELLCCEVDP-----VRRAVPDRNLLEDRVLQNLLTIEERY--LPQCSYFKCVQKDIQPYMRRMVA 59

  Fly   187 EWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAAACLLLASKLREPSCRALSVDLL 251
            .||:|||.|:.|:|||..||:||:||||:.....||.||:|.|.|:.|||||:|..  .|:.:.|
  Rat    60 TWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGAVCMFLASKLKETI--PLTAEKL 122

  Fly   252 VVYTDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINIGKVRGHAQA 316
            .:|||||:...:|::|||.||.:|.|:|::|||.||:|.::.:||...:     .:..:|.|||.
  Rat   123 CIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQKE-----KLSLIRKHAQT 182

  Fly   317 FISLAAKEHKFAKFSASTIAASSIAASMNGLKWHLR-SGHNLHFLLSLMTDLTSVE-------QA 373
            ||:|.|.:.|||.:..|.||..|:.|::.||:.... :......|..|:..:|..:       |.
  Rat   183 FIALCATDFKFAMYPPSMIATGSVGAAICGLQQDEEVNALTCDALTELLAKITHTDVDCLKACQE 247

  Fly   374 QVRDCMLHMEDIFKEH----SRNLEPFLVNIDPKEMST 407
            |:...:|:....|::.    |:::|      ||.:.:|
  Rat   248 QIEAVLLNSLQQFRQEQHNGSKSVE------DPDQATT 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	62/126 (49%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	34/121 (28%)
Ccnd2	NP_071603.2	CYCLIN_SF	1..149	CDD:424085	72/155 (46%)
		CYCLIN_CCND2_rpt2	154..258	CDD:410280	31/108 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..288		5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340004
Domainoid	1	1.000	125	1.000	Domainoid score	I5329
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37525
Inparanoid	1	1.050	184	1.000	Inparanoid score	I3854
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001275
OrthoInspector	1	1.000	-	-		otm45483
orthoMCL	1	0.900	-	-		OOG6_105230
Panther	1	1.100	-	-	LDO	PTHR10177
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1298
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890