DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and Ccna1

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001011949.1	Gene:	Ccna1 / 295052	RGDID:	1310639	Length:	421	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	88/322 - (27%)
Similarity:	140/322 - (43%)	Gaps:	52/322 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 TSHCQRLDERLTTTADPPATDNVNTAIGDPTLYSDRCLENFLKVEEKHHKIPDTYFSIQKDITPP 180
            |:|.|          ...|||..:..| :.|.|::. :..:|:..|..|:....|...|.|||..
  Rat   146 TAHAQ----------SEEATDFGSDVI-NVTEYAEE-IHRYLREAEVRHRPKAHYMRKQPDITEG 198

  Fly   181 MRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAAACLLLASKLRE--PSC 243
            ||.|:.:|::||..|...:.|.:.||:|::|||||..||.:.:||::..|.:|||||..|  |.
  Rat   199 MRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPP- 262

  Fly   244 RALSVDLLVVYTDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINIG 308
               .||..|..||::..|..|::.|..:|..|.:||:..|...||...:.|..:..:.   .|:.
  Rat   263 ---DVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRT---ENLA 321

  Fly   309 KVRGHAQAFISLAAKEHKFAKFSASTIAASSIAASMNGLKWHLRSGHNLHFLLSLMTDLTSVEQA 373
            |.    .|.:||...: .|.|:..|.:||::...: |.:.       |.||....:...|.....
  Rat   322 KY----VAELSLLEAD-PFLKYLPSLVAAAAYCLA-NYIV-------NRHFWPETLAAFTGYSLN 373

  Fly   374 QVRDCM--LHMEDIFKEHSRNLEPFLVNIDPKEMSTLYYKRRFQIHQSQHLSQISIRPLPLP 433
            ::..|:  ||...:...|.           |::.....||....:|.|     :...|:.||
  Rat   374 EIVPCLSELHKACLSIPHR-----------PQQAIREKYKASKYLHVS-----LMEPPVVLP 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	47/126 (37%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	23/111 (21%)
Ccna1	NP_001011949.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Cyclin_N2	27..>101	CDD:406812
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	55/163 (34%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	31/154 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840