Protein Alignment CycD and Ccnb1

DIOPT Version :10

• Sequence 1: NP_523355.2
• Gene: CycD / 32551
• FlyBaseID: FBgn0010315
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_758505.2
• Gene: Ccnb1 / 268697
• MGIID: 88302
• Length: 430
• Species: Mus musculus
• Alignment Length: 372
• Identity: 81/372 - (21%)
• Similarity: 147/372 - (39%)
• Gaps: 66/372 - (17%)

  Fly    21 NKRQQQMSSPAIIRDQSSICSSLGDAESDSHPDAQNNAVVCNMKELVYIYASVDSAAKNP----- 80
            ||..:::.:...::.::....: |.....:.|.......||.        ..|:.|...|
Mouse    50 NKVSEELQARVPLKREAKTLGT-GKGTVKALPKPVEKVPVCE--------PEVELAEPEPEPELE 105

  Fly    81 ----EQLEPPPPPPPPPPPPPTATQSIQSYPRYISQEPPTSHCQRLDERLTTTADPPATDNVNTA 141
                |:|.|.|.....|.|.|..|........|:        ||...:.:...:|..|.|.
Mouse   106 HVREEKLSPEPILVDNPSPSPMETSGCAPAEEYL--------CQAFSDVILAVSDVDADDG---- 158

  Fly   142 IGDPTLYSD--RCLENFLKVEEKHHKIPDTYFSIQKDITPPMRKIVAEWMMEVCAEENCQEEVVL 204
             .||.|.|:  :.:..:|:..|:...:...|.. .:::|..||.|:.:|:::|..:....:|.:.
Mouse   159 -ADPNLCSEYVKDIYAYLRQLEEEQSVRPKYLQ-GREVTGNMRAILIDWLIQVQMKFRLLQETMY 221

  Fly   205 LALNYMDRFLSSKSVRKTQLQILAAACLLLASKLRE--PSCRALSVDLLVVYTDNSIYKDDLIKW 267
            :.::.:|||:.:..|.|..||::....:.:|||..|  |.    .:......|:|:..|..:.:.
Mouse   222 MTVSIIDRFMQNSCVPKKMLQLVGVTAMFIASKYEEMYPP----EIGDFAFVTNNTYTKHQIRQM 282

  Fly   268 ELYVLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINIGK--VRGH--AQAFISLAAKEHKFA 328
            |:.:|..|.:.|....||.||..       .||      :|:  |..|  |:..:.|:..::...
Mouse   283 EMKILRVLNFSLGRPLPLHFLRR-------ASK------VGEVDVEQHTLAKYLMELSMLDYDMV 334

  Fly   329 KFSASTIAASSIAASM----NGLKWHLRSGHNLHF----LLSLMTDL 367
            .|:.|.|||.:...::    || :|.....|.|.:    ||.:|..|
Mouse   335 HFAPSQIAAGAFCLALKILDNG-EWTPTLQHYLSYSEDSLLPVMQHL 380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	CYCLIN_SF	144..278	CDD:477360	32/137 (23%)
		CYCLIN_CCND_rpt2	283..387	CDD:410220	25/97 (26%)
Ccnb1	NP_758505.2	CYCLIN_CCNB1_rpt1	164..292	CDD:410268	29/132 (22%)
		Interaction with CDK2. /evidence=ECO:0000250	166..174		0/7 (0%)
		Interaction with CDK2. /evidence=ECO:0000250	255..258		0/2 (0%)
		CYCLIN_SF	297..416	CDD:477360	25/98 (26%)