DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and Ccne1

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_031659.2	Gene:	Ccne1 / 12447	MGIID:	88316	Length:	408	Species:	Mus musculus

Alignment Length:	421	Identity:	82/421 - (19%)
Similarity:	150/421 - (35%)	Gaps:	137/421 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EPPTSHCQRLDERLTTTADPPATDNVNTAIGDPTLYSDRCLENFL----KVEEKHHKIPDTYFSI 173
            :.|.....::|:.:.:.......|: |:|..||      |  :|:    |.|:...:.|.|.|..
Mouse    37 QDPDEEIAKIDKTVKSEDSSQPWDD-NSACVDP------C--SFIPTPNKEEDNELEYPRTAFQP 92

  Fly   174 QKDITPP-------------------------------------------MRKIVAEWMMEVCAE 195
            :| |.||                                           ||.::.:|:||||..
Mouse    93 RK-IRPPRASPLPVLNWGNREEVWRIMLNKEKTYLRDEHFLQRHPLLQARMRAVLLDWLMEVCEV 156

  Fly   196 ENCQEEVVLLALNYMDRFLSSK-SVRKTQLQILAAACLLLASKLRE---PSCRALSVDLLVVYTD 256
            .....|...||.::.||:::|: ::.||.||::..:.|.:||||.|   |.....:     ..||
Mouse   157 YKLHRETFYLAQDFFDRYMASQHNIIKTLLQLIGISALFIASKLEEIYPPKLHQFA-----YVTD 216

  Fly   257 NSIYKDDLIKWELYVLSRLGWDLSSVTPLDFL-------------ELLMMRLPIGSKNFPDINIG 308
            .:...|:::..||.::..|.|.||.:|.:.:|             |:||.:.|
Mouse   217 GACSGDEILTMELMMMKALKWRLSPLTIVSWLNVYVQVAYVNDTGEVLMPQYP------------ 269

  Fly   309 KVRGHAQAFISLA------AKEHKFAKFSASTIAASSIAASMNGLKWHLRSGHNLHFLLSLMTDL 367
                 .|.|:.:|      ..:....:|....:|||::        :|..|       |.||..:
Mouse   270 -----QQVFVQIAELLDLCVLDVGCLEFPYGVLAASAL--------YHFSS-------LELMQKV 314

  Fly   368 TSVEQAQVRDC------------------MLHMEDIFKEHSRNLEPFLVNIDPKEMSTLYYKRRF 414
            :..:...:..|                  :.|...:..|.|.|::....::|..:.:..  |:..
Mouse   315 SGYQWCDIEKCVKWMVPFAMVIREMGSSKLKHFRGVPMEDSHNIQTHTNSLDLLDKAQA--KKAI 377

  Fly   415 QIHQSQHLSQISIRPLPLPKAPAECVEQHQQ 445
            ...|::.....|:...|.|.:..:..||..:
Mouse   378 LSEQNRISPPPSVVLTPPPSSKKQSSEQETE 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	41/175 (23%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	22/146 (15%)
Ccne1	NP_031659.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Cyclin_N	113..240	CDD:278560	31/131 (24%)
		Cyclin_C	243..362	CDD:281044	23/150 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..408		6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840