DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and Ccnd3

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001075104.1	Gene:	Ccnd3 / 12445	MGIID:	88315	Length:	292	Species:	Mus musculus

Alignment Length:	319	Identity:	112/319 - (35%)
Similarity:	162/319 - (50%)	Gaps:	56/319 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DPTLYSD-RCLENFLKVEEKHHKIP-DTYFS-IQKDITPPMRKIVAEWMMEVCAEENCQEEVVLL 205
            ||.|..| |.|::.|::||::  :| .:||. :||:|.|.|||::|.||:|||.|:.|:|:|..|
Mouse    18 DPRLLGDQRVLQSLLRLEERY--VPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPL 80

  Fly   206 ALNYMDRFLSSKSVRKTQLQILAAACLLLASKLREPSCRALSVDLLVVYTDNSIYKDDLIKWELY 270
            |:||:||:||....||.|||:|...||||||||||.:  .|:::.|.:|||.::....|.:||:.
Mouse    81 AMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETT--PLTIEKLCIYTDQAVAPWQLREWEVL 143

  Fly   271 VLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINIGKVRGHAQAFISLAAKEHKFAKFSASTI 335
            ||.:|.|||::|...|||.|::.||     :.|......|:.|||.|::|.|.::.||.:..|.|
Mouse   144 VLGKLKWDLAAVIAHDFLALILHRL-----SLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMI 203

  Fly   336 AASSIAASMNGLKWHLRSGHNLHFLLSLMTDLTSVEQAQVRDCMLHMEDIFKEHSRNLEPFLVNI 400
            |..||.|::.||.....|...   |..|:..:|..|...:|.|...:|...:|..|
Mouse   204 ATGSIGAAVLGLGACSMSADE---LTELLAGITGTEVDCLRACQEQIEAALRESLR--------- 256

  Fly   401 DPKEMSTLYYKRRFQIHQSQHLSQISIRPLPLPKAPAECVEQHQQQHNFGSAAPHRTHT 459
                                  ......|.|:||||          ....|..|.:|.|
Mouse   257 ----------------------EAAQTAPSPVPKAP----------RGSSSQGPSQTST 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	60/126 (48%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	34/109 (31%)
Ccnd3	NP_001075104.1	CYCLIN_SF	2..151	CDD:424085	64/136 (47%)
		CYCLIN_SF	156..260	CDD:424085	34/142 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..292		11/69 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836338
Domainoid	1	1.000	125	1.000	Domainoid score	I5444
eggNOG	1	0.900	-	-		E1_KOG0656
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	174	1.000	Inparanoid score	I4065
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001275
OrthoInspector	1	1.000	-	-		otm43415
orthoMCL	1	0.900	-	-		OOG6_105230
Panther	1	1.100	-	-	O	PTHR10177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1298
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750